Alexandre F R Stewart

Alexandre F R Stewart

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Alexandre F R Stewart

Alexandre F R Stewart

Publications by authors named "Alexandre F R Stewart"

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Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury.

Neural Regen Res 2018 Feb;13(2):252-256

Ottawa Hospital Research Institute; University of Ottawa, Brain and Mind Institute; Canadian Partnership for Storke Recovery, Ottawa, Canada.

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http://dx.doi.org/10.4103/1673-5374.226394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879896PMC
February 2018

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.

Lancet Neurol 2017 11;16(11):898-907

Institute of Neurogenomics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany; Neurologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30327-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755468PMC
November 2017

Partitioning the heritability of coronary artery disease highlights the importance of immune-mediated processes and epigenetic sites associated with transcriptional activity.

Cardiovasc Res 2017 Jul;113(8):973-983

Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa K1Y 4W1, Canada.

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http://dx.doi.org/10.1093/cvr/cvx019DOI Listing
July 2017

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

Authors:
Stephen Zewinger Marcus E Kleber Vinicius Tragante Raymond O McCubrey Amand F Schmidt Kenan Direk Ulrich Laufs Christian Werner Wolfgang Koenig Dietrich Rothenbacher Ute Mons Lutz P Breitling Herrmann Brenner Richard T Jennings Ioannis Petrakis Sarah Triem Mira Klug Alexandra Filips Stefan Blankenberg Christoph Waldeyer Christoph Sinning Renate B Schnabel Karl J Lackner Efthymia Vlachopoulou Ottar Nygård Gard Frodahl Tveitevåg Svingen Eva Ringdal Pedersen Grethe S Tell Juha Sinisalo Markku S Nieminen Reijo Laaksonen Stella Trompet Roelof A J Smit Naveed Sattar J Wouter Jukema Heinrich V Groesdonk Graciela Delgado Tatjana Stojakovic Anna P Pilbrow Vicky A Cameron A Mark Richards Robert N Doughty Yan Gong Rhonda Cooper-DeHoff Julie Johnson Markus Scholz Frank Beutner Joachim Thiery J Gustav Smith Ragnar O Vilmundarson Ruth McPherson Alexandre F R Stewart Sharon Cresci Petra A Lenzini John A Spertus Oliviero Olivieri Domenico Girelli Nicola I Martinelli Andreas Leiherer Christoph H Saely Heinz Drexel Axel Mündlein Peter S Braund Christopher P Nelson Nilesh J Samani Daniel Kofink Imo E Hoefer Gerard Pasterkamp Arshed A Quyyumi Yi-An Ko Jaana A Hartiala Hooman Allayee W H Wilson Tang Stanley L Hazen Niclas Eriksson Claes Held Emil Hagström Lars Wallentin Axel Åkerblom Agneta Siegbahn Igor Karp Christopher Labos Louise Pilote James C Engert James M Brophy George Thanassoulis Peter Bogaty Wojciech Szczeklik Marcin Kaczor Marek Sanak Salim S Virani Christie M Ballantyne Vei-Vei Lee Eric Boerwinkle Michael V Holmes Benjamin D Horne Aroon Hingorani Folkert W Asselbergs Riyaz S Patel Bernhard K Krämer Hubert Scharnagl Danilo Fliser Winfried März Thimoteus Speer

Lancet Diabetes Endocrinol 2017 07 26;5(7):534-543. Epub 2017 May 26.

Department of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/S2213-8587(17)30096-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651679PMC
July 2017

Loss of Cardioprotective Effects at the Locus as a Result of Gene-Smoking Interactions.

Circulation 2017 Jun 1;135(24):2336-2353. Epub 2017 May 1.

From Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (D.S., W.Z.); Center for Non-Communicable Diseases, Karachi, Pakistan (D.S., A.R., P.M.F., PROMIS); Department of Public Health and Primary Care, University of Cambridge, United Kingdom (R.Y., W.K.H., EPIC-CVD); Department of Cardiovascular Sciences, University of Leicester, United Kingdom (C.P.N., N.J.S.); Cardiology Division, Department of Medicine, Vanderbilt University, Nashville, TN (J.F.F., K.O.); Division of Cardiovascular Medicine, Radcliffe Department of Medicine & Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom (A.G., M.F.); The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (R.D.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.D.); Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Canada (A.F.R.S., R.M.); Institute for Genetic Medicine and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (J.H., H.A.); Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom (W.Z., J.C.C., J.K.); Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, United Kingdom (W.Z., J.C.C.); Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S.); Helsinki University Central Hospital HUCH Heart and Lung Center, Helsinki, Uusimaa, Finland (J.S.); Cardiology Division, Department of Medicine and the Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY (R.C.B., M.P.R.); William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.K., E.M., P.D.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (S.S., A.D.); Department of Dietetics-Nutrition, Harokopio University, Athens, Greece (E.M., G.D.); National Institute for Health and Welfare, Helsinki, Finland (K.K., A.J., V.S., K.K., M.P.); MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, United Kingdom (J.H.Z., R.S.); INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France (D.G., N.W.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.H.S.); Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V.G.); Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.v.Z., C.N.A.P.); Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC (A.J.C., D.W.B.); Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Germany (C.W., J.E.); DZHK (German Research Center for Cardiovascular Research) partner site Hamburg-Lübeck-Kiel, Germany (C.W., J.E.); Deutsches Herzzentrum München, Technische Universität München, Germany (T.K., L.Z., H.S.); Klinikum rechts der Isar, München, Germany (T.K.); DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Germany (L.Z., H.S.); Department of Genetics, Washington University School of Medicine, St. Louis, MO (M.A.P., M.F.F.); Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (A.G.); Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (A.G.); Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Sweden (L.L.); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (N.L.P.); Department of Biostatistics Boston University School of Public Health Framingham Heart Study, MA (C.C.W.); Faculty of Medicine, University of Iceland, Reykjavik (A.V.S., V.G.); University of Helsinki, Institute for Molecular Medicine, Finland (FIMM) (A.J., M.P.); Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Germany (M.E.K.); Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom (A.S.H.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany and Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria (W.M.); National Heart, Lung, and Blood Institute and the Framingham Heart Study, National Institutes of Health, Bethesda, MD (C.O'D.); Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden (E.I.); Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (E.I.); Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (U.D.F.); Lebanese American University, School of Medicine, Beirut (P.Z.); Department of Health Sciences, University of Leicester, United Kingdom (J.R.T.); Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.K.); Cardiovascular Science, National Heart and Lung Institute, Imperial College London, United Kingdom (J.K.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia (P.D.); deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland (G.T., K.S.); University of Iceland, School of Medicine, Reykjavik, Iceland (G.T., K.S.); Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge (S.K.); Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.K.); Center for Human Genetic Research, Massachusetts General Hospital, Boston (S.K.); Department of Medicine, Harvard Medical School, Boston, MA (S.K.); Department of Genetics, University of Pennsylvania, Philadelphia (D.J.R.); and Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.T.N., D.J.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612779PMC
June 2017

Transcriptomic Signature of Atherosclerosis in the Peripheral Blood: Fact or Fiction?

Curr Atheroscler Rep 2016 Dec;18(12):77

Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

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http://dx.doi.org/10.1007/s11883-016-0634-xDOI Listing
December 2016

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.

Sci Rep 2016 10 12;6:35278. Epub 2016 Oct 12.

Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1038/srep35278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059659PMC
October 2016

Increased genetic risk for obesity in premature coronary artery disease.

Eur J Hum Genet 2016 Apr 29;24(4):587-91. Epub 2015 Jul 29.

Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1038/ejhg.2015.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929880PMC
April 2016

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Authors:
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander W Drong James Abbott Simone Wahl Sian-Tsung Tan William R Scott Gianluca Campanella Marc Chadeau-Hyam Uzma Afzal Tarunveer S Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L Edwards Tõnu Esko Min Jin Go Sarah E Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea-Chuen Khor Marcus E Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F R Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Da Silva Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian'an Luan Leo-Pekka Lyytikäinen Quang N Nguyen Mark A Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R Braun Hui Cai Li-Ching Chang Chien-Hsiun Chen Ching-Yu Cheng Yap-Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D Do Pieter A Doevendans Ron T Gansevoort Yu-Tang Gao Tanja B Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L Hazen Jing He Chew-Kiat Heng James E Hixson Albert Hofman Chris Hsu Wei Huang Lise L N Husemoen Joo-Yeon Hwang Sahoko Ichihara Michiya Igase Masato Isono Johanne M Justesen Tomohiro Katsuya Muhammad G Kibriya Young Jin Kim Miyako Kishimoto Woon-Puay Koh Katsuhiko Kohara Meena Kumari Kenneth Kwek Nanette R Lee Jeannette Lee Jiemin Liao Wolfgang Lieb David C M Liewald Tatsuaki Matsubara Yumi Matsushita Thomas Meitinger Evelin Mihailov Lili Milani Rebecca Mills Nina Mononen Martina Müller-Nurasyid Toru Nabika Eitaro Nakashima Hong Kiat Ng Kjell Nikus Teresa Nutile Takayoshi Ohkubo Keizo Ohnaka Sarah Parish Lavinia Paternoster Hao Peng Annette Peters Son T Pham Mohitha J Pinidiyapathirage Mahfuzar Rahman Hiromi Rakugi Olov Rolandsson Michelle Ann Rozario Daniela Ruggiero Cinzia F Sala Ralhan Sarju Kazuro Shimokawa Harold Snieder Thomas Sparsø Wilko Spiering John M Starr David J Stott Daniel O Stram Takao Sugiyama Silke Szymczak W H Wilson Tang Lin Tong Stella Trompet Väinö Turjanmaa Hirotsugu Ueshima André G Uitterlinden Satoshi Umemura Marja Vaarasmaki Rob M van Dam Wiek H van Gilst Dirk J van Veldhuisen Jorma S Viikari Melanie Waldenberger Yiqin Wang Aili Wang Rory Wilson Tien-Yin Wong Yong-Bing Xiang Shuhei Yamaguchi Xingwang Ye Robin D Young Terri L Young Jian-Min Yuan Xueya Zhou Folkert W Asselbergs Marina Ciullo Robert Clarke Panos Deloukas Andre Franke Paul W Franks Steve Franks Yechiel Friedlander Myron D Gross Zhirong Guo Torben Hansen Marjo-Riitta Jarvelin Torben Jørgensen J Wouter Jukema Mika Kähönen Hiroshi Kajio Mika Kivimaki Jong-Young Lee Terho Lehtimäki Allan Linneberg Tetsuro Miki Oluf Pedersen Nilesh J Samani Thorkild I A Sørensen Ryoichi Takayanagi Daniela Toniolo Habibul Ahsan Hooman Allayee Yuan-Tsong Chen John Danesh Ian J Deary Oscar H Franco Lude Franke Bastiaan T Heijman Joanna D Holbrook Aaron Isaacs Bong-Jo Kim Xu Lin Jianjun Liu Winfried März Andres Metspalu Karen L Mohlke Dharambir K Sanghera Xiao-Ou Shu Joyce B J van Meurs Eranga Vithana Ananda R Wickremasinghe Cisca Wijmenga Bruce H W Wolffenbuttel Mitsuhiro Yokota Wei Zheng Dingliang Zhu Paolo Vineis Soterios A Kyrtopoulos Jos C S Kleinjans Mark I McCarthy Richie Soong Christian Gieger James Scott Yik-Ying Teo Jiang He Paul Elliott E Shyong Tai Pim van der Harst Jaspal S Kooner John C Chambers

Nat Genet 2015 11 21;47(11):1282-1293. Epub 2015 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ng.3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719169PMC
November 2015

9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.

Circulation 2015 Nov 20;132(21):1969-78. Epub 2015 Oct 20.

From Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ontario, Canada (N.A.M.A., D.A., R.O.V., S.X.Z., K.N.H., A.F.R.S.); Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ontario, Canada (N.A.M.A., D.A., R.O.V., A.F.R.S.); Center for Genetics and Inherited Diseases, Taibah University, Almadina, Saudi Arabia (N.A.M.A.); Ottawa Hospital Research Institute, Ontario, Canada (X.Z.); and Department of Medicine, University of Ottawa, Ontario, Canada (H.-H.C., A.F.R.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.015023DOI Listing
November 2015

Endothelial Gata5 transcription factor regulates blood pressure.

Nat Commun 2015 Nov 30;6:8835. Epub 2015 Nov 30.

Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H8M5.

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http://dx.doi.org/10.1038/ncomms9835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696516PMC
November 2015

IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.

Circ Res 2015 Sep 20;117(8):671-83. Epub 2015 Jul 20.

From the Department of Cellular and Molecular Medicine, University of Ottawa, and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (H.-H.C., K.K., X.Z., S.A.C., N.R.P., C.A.S., H.H., A.H.); the Department of Biochemistry, Microbiology and Immunology, University of Ottawa, and the University of Ottawa Heart Institute, Ottawa, Ontario, Canada (R.O.V., N.A.M.A., N.L.Y., T.H., M.G., R.M., K.J.R., A.F.R.S.); and Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada (H.H.C., R.M., A.F.R.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.114.30577
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.114.305777DOI Listing
September 2015

Effect of Bile Acid Sequestrants on the Risk of Cardiovascular Events: A Mendelian Randomization Analysis.

Circ Cardiovasc Genet 2015 Aug 4;8(4):618-27. Epub 2015 Jun 4.

From the Population Health Research Institute, Hamilton Health Sciences (S.R., M.D'M., S.S.A., J.E., G.P.), Department of Clinical Epidemiology & Biostatistics, Population Genomics Program (S.R., M.D'M., S.S.A., G.P.), Population Genomics Program, Chanchlani Research Centre (S.R., M.D'M., S.S.A., G.P.), Department of Medicine (S.S.A., J.E.), Department of Pathology & Molecular Medicine (G.P.), Thrombosis & Atherosclerosis Research Institute (G.P.), Hamilton Health Sciences, McMaster University, Hamilton; John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada (A.F.R.S., R.R.); Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (N.J.S.); National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom (N.J.S.); and Department of Medicine, University of Ottawa, Ottawa, ON, Canada (R.R.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000952DOI Listing
August 2015

Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies.

PLoS One 2014 2;9(9):e106294. Epub 2014 Sep 2.

Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106294PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152257PMC
May 2015

Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling.

Neuron 2015 Mar 5;85(6):1319-31. Epub 2015 Mar 5.

Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; Department of Cellular and Molecular Medicine, Ottawa, ON K1H8M5, Canada; Department of Medicine, University of Ottawa, Ottawa, ON K1H8M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.02.015DOI Listing
March 2015

Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community.

J Am Heart Assoc 2015 Mar 11;4(3):e001544. Epub 2015 Mar 11.

National Heart, Blood, and Lung Institute's Framingham Heart Study, Framingham, MA (B.M.K., S.R.P., A.S.B., Q.Y., S.S., R.S.V.) Sections of Preventive Medicine and Epidemiology and Cardiology, Boston University School of Medicine, Boston, MA (R.S.V.).

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http://dx.doi.org/10.1161/JAHA.114.001544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392437PMC
March 2015

Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound.

Biochem Biophys Res Commun 2015 Feb 24;458(1):21-7. Epub 2015 Jan 24.

Ottawa Hospital Research Institute, Canada; University of Ottawa, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.01.040DOI Listing
February 2015

Adiposity significantly modifies genetic risk for dyslipidemia.

J Lipid Res 2014 Nov 15;55(11):2416-22. Epub 2014 Sep 15.

Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Canada Ruddy Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada.

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http://www.jlr.org/lookup/doi/10.1194/jlr.P052522
Publisher Site
http://dx.doi.org/10.1194/jlr.P052522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617143PMC
November 2014

Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?

Curr Cardiol Rep 2014 Jul;16(7):502

Ottawa Hospital Research Institute, 451 Smyth Road, RGN Hall, Rm 2422, K1H 8M5, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1007/s11886-014-0502-7DOI Listing
July 2014

LMO4 is required to maintain hypothalamic insulin signaling.

Biochem Biophys Res Commun 2014 Jul 14;450(1):666-72. Epub 2014 Jun 14.

Ottawa Hospital Research Institute, Canada; University of Ottawa, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.06.026DOI Listing
July 2014

Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine.

Arterioscler Thromb Vasc Biol 2014 Jun 27;34(6):1307-13. Epub 2014 Mar 27.

From the Department of Preventive Medicine (J.H., H.A.) and Institute for Genetic Medicine (J.H., H.A.), Keck School of Medicine of the University of Southern California, Los Angeles; Department of Genetics (B.J.B.) and Nutrition Research Institute (B.J.B.), University of North Carolina, Chapel Hill, Kannapolis; Departments of Cardiovascular Medicine (W.H.W.T., Z.W., S.L.H.) and Cellular and Molecular Medicine (W.H.W.T., Z.W., S.L.H.) and Center for Cardiovascular Diagnostics and Prevention (W.H.W.T., Z.W., S.L.H.), Cleveland Clinic, OH; John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (A.F.R.S., R.R., R.M.); and Departments of Medicine (A.J.L.), Human Genetics (A.J.L.), and Microbiology, Immunology, and Molecular Genetics (A.J.L.), David Geffen School of Medicine of UCLA.

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http://dx.doi.org/10.1161/ATVBAHA.114.303252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035110PMC
June 2014

SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes.

Cell Rep 2014 May 24;7(3):834-47. Epub 2014 Apr 24.

Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON K1Y, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.051DOI Listing
May 2014

LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.

J Neurosci 2014 Jan;34(1):140-8

Center for Stroke Recovery, Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario K1H 8M5, Canada, and University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.3419-13.2014DOI Listing
January 2014

Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk.

Circ Cardiovasc Genet 2013 Aug 31;6(4):372-80. Epub 2013 May 31.

John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839299PMC
August 2013

Genomics in cardiovascular disease.

J Am Coll Cardiol 2013 May 21;61(20):2029-37. Epub 2013 Mar 21.

University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2012.12.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683584PMC
May 2013

Interferon-γ activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype.

J Am Coll Cardiol 2013 Jan 28;61(2):143-7. Epub 2012 Nov 28.

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2012.08.1020DOI Listing
January 2013

Large-scale association analysis identifies new risk loci for coronary artery disease.

Authors:
Panos Deloukas Stavroula Kanoni Christina Willenborg Martin Farrall Themistocles L Assimes John R Thompson Erik Ingelsson Danish Saleheen Jeanette Erdmann Benjamin A Goldstein Kathleen Stirrups Inke R König Jean-Baptiste Cazier Asa Johansson Alistair S Hall Jong-Young Lee Cristen J Willer John C Chambers Tõnu Esko Lasse Folkersen Anuj Goel Elin Grundberg Aki S Havulinna Weang K Ho Jemma C Hopewell Niclas Eriksson Marcus E Kleber Kati Kristiansson Per Lundmark Leo-Pekka Lyytikäinen Suzanne Rafelt Dmitry Shungin Rona J Strawbridge Gudmar Thorleifsson Emmi Tikkanen Natalie Van Zuydam Benjamin F Voight Lindsay L Waite Weihua Zhang Andreas Ziegler Devin Absher David Altshuler Anthony J Balmforth Inês Barroso Peter S Braund Christof Burgdorf Simone Claudi-Boehm David Cox Maria Dimitriou Ron Do Alex S F Doney NourEddine El Mokhtari Per Eriksson Krista Fischer Pierre Fontanillas Anders Franco-Cereceda Bruna Gigante Leif Groop Stefan Gustafsson Jörg Hager Göran Hallmans Bok-Ghee Han Sarah E Hunt Hyun M Kang Thomas Illig Thorsten Kessler Joshua W Knowles Genovefa Kolovou Johanna Kuusisto Claudia Langenberg Cordelia Langford Karin Leander Marja-Liisa Lokki Anders Lundmark Mark I McCarthy Christa Meisinger Olle Melander Evelin Mihailov Seraya Maouche Andrew D Morris Martina Müller-Nurasyid Kjell Nikus John F Peden N William Rayner Asif Rasheed Silke Rosinger Diana Rubin Moritz P Rumpf Arne Schäfer Mohan Sivananthan Ci Song Alexandre F R Stewart Sian-Tsung Tan Gudmundur Thorgeirsson C Ellen van der Schoot Peter J Wagner George A Wells Philipp S Wild Tsun-Po Yang Philippe Amouyel Dominique Arveiler Hanneke Basart Michael Boehnke Eric Boerwinkle Paolo Brambilla Francois Cambien Adrienne L Cupples Ulf de Faire Abbas Dehghan Patrick Diemert Stephen E Epstein Alun Evans Marco M Ferrario Jean Ferrières Dominique Gauguier Alan S Go Alison H Goodall Villi Gudnason Stanley L Hazen Hilma Holm Carlos Iribarren Yangsoo Jang Mika Kähönen Frank Kee Hyo-Soo Kim Norman Klopp Wolfgang Koenig Wolfgang Kratzer Kari Kuulasmaa Markku Laakso Reijo Laaksonen Ji-Young Lee Lars Lind Willem H Ouwehand Sarah Parish Jeong E Park Nancy L Pedersen Annette Peters Thomas Quertermous Daniel J Rader Veikko Salomaa Eric Schadt Svati H Shah Juha Sinisalo Klaus Stark Kari Stefansson David-Alexandre Trégouët Jarmo Virtamo Lars Wallentin Nicholas Wareham Martina E Zimmermann Markku S Nieminen Christian Hengstenberg Manjinder S Sandhu Tomi Pastinen Ann-Christine Syvänen G Kees Hovingh George Dedoussis Paul W Franks Terho Lehtimäki Andres Metspalu Pierre A Zalloua Agneta Siegbahn Stefan Schreiber Samuli Ripatti Stefan S Blankenberg Markus Perola Robert Clarke Bernhard O Boehm Christopher O'Donnell Muredach P Reilly Winfried März Rory Collins Sekar Kathiresan Anders Hamsten Jaspal S Kooner Unnur Thorsteinsdottir John Danesh Colin N A Palmer Robert Roberts Hugh Watkins Heribert Schunkert Nilesh J Samani

Nat Genet 2013 Jan 2;45(1):25-33. Epub 2012 Dec 2.

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http://dx.doi.org/10.1038/ng.2480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679547PMC
January 2013

Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk.

Arterioscler Thromb Vasc Biol 2012 Nov 13;32(11):2803-12. Epub 2012 Sep 13.

Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.112.253930
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http://dx.doi.org/10.1161/ATVBAHA.112.253930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499946PMC
November 2012

Genes and coronary artery disease: where are we?

J Am Coll Cardiol 2012 Oct 3;60(18):1715-21. Epub 2012 Oct 3.

John & Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2011.12.062DOI Listing
October 2012

Genetics of coronary artery disease in the 21st century.

Clin Cardiol 2012 Sep 15;35(9):536-40. Epub 2012 May 15.

John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada.

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http://dx.doi.org/10.1002/clc.22002DOI Listing
September 2012

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.

Authors:
Benjamin F Voight Gina M Peloso Marju Orho-Melander Ruth Frikke-Schmidt Maja Barbalic Majken K Jensen George Hindy Hilma Hólm Eric L Ding Toby Johnson Heribert Schunkert Nilesh J Samani Robert Clarke Jemma C Hopewell John F Thompson Mingyao Li Gudmar Thorleifsson Christopher Newton-Cheh Kiran Musunuru James P Pirruccello Danish Saleheen Li Chen Alexandre F R Stewart Arne Schillert Unnur Thorsteinsdottir Gudmundur Thorgeirsson Sonia Anand James C Engert Thomas Morgan John Spertus Monika Stoll Klaus Berger Nicola Martinelli Domenico Girelli Pascal P McKeown Christopher C Patterson Stephen E Epstein Joseph Devaney Mary-Susan Burnett Vincent Mooser Samuli Ripatti Ida Surakka Markku S Nieminen Juha Sinisalo Marja-Liisa Lokki Markus Perola Aki Havulinna Ulf de Faire Bruna Gigante Erik Ingelsson Tanja Zeller Philipp Wild Paul I W de Bakker Olaf H Klungel Anke-Hilse Maitland-van der Zee Bas J M Peters Anthonius de Boer Diederick E Grobbee Pieter W Kamphuisen Vera H M Deneer Clara C Elbers N Charlotte Onland-Moret Marten H Hofker Cisca Wijmenga W M Monique Verschuren Jolanda M A Boer Yvonne T van der Schouw Asif Rasheed Philippe Frossard Serkalem Demissie Cristen Willer Ron Do Jose M Ordovas Gonçalo R Abecasis Michael Boehnke Karen L Mohlke Mark J Daly Candace Guiducci Noël P Burtt Aarti Surti Elena Gonzalez Shaun Purcell Stacey Gabriel Jaume Marrugat John Peden Jeanette Erdmann Patrick Diemert Christina Willenborg Inke R König Marcus Fischer Christian Hengstenberg Andreas Ziegler Ian Buysschaert Diether Lambrechts Frans Van de Werf Keith A Fox Nour Eddine El Mokhtari Diana Rubin Jürgen Schrezenmeir Stefan Schreiber Arne Schäfer John Danesh Stefan Blankenberg Robert Roberts Ruth McPherson Hugh Watkins Alistair S Hall Kim Overvad Eric Rimm Eric Boerwinkle Anne Tybjaerg-Hansen L Adrienne Cupples Muredach P Reilly Olle Melander Pier M Mannucci Diego Ardissino David Siscovick Roberto Elosua Kari Stefansson Christopher J O'Donnell Veikko Salomaa Daniel J Rader Leena Peltonen Stephen M Schwartz David Altshuler Sekar Kathiresan

Lancet 2012 Aug 17;380(9841):572-80. Epub 2012 May 17.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/S0140-6736(12)60312-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419820PMC
August 2012

The genetics of coronary artery disease.

Curr Opin Cardiol 2012 May;27(3):221-7

University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1097/HCO.0b013e3283515b4bDOI Listing
May 2012

Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum.

Am J Physiol Heart Circ Physiol 2012 Mar 16;302(5):H1138-45. Epub 2011 Dec 16.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpheart.00872.2011DOI Listing
March 2012

Clinical and genetic association of serum ceruloplasmin with cardiovascular risk.

Arterioscler Thromb Vasc Biol 2012 Feb 10;32(2):516-22. Epub 2011 Nov 10.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Desk J3-4, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1161/ATVBAHA.111.237040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262121PMC
February 2012

9p21 and the genetic revolution for coronary artery disease.

Clin Chem 2012 Jan 20;58(1):104-12. Epub 2011 Oct 20.

Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2011.172759
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http://dx.doi.org/10.1373/clinchem.2011.172759DOI Listing
January 2012

Genomics: is it ready for primetime?

Med Clin North Am 2012 Jan;96(1):113-22

Faculty of Medicine, McGill University, McIntyre Medical Building, 3655 promenade Sir William Osler Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1016/j.mcna.2012.01.018DOI Listing
January 2012

A genomic revolution for cardiovascular disease-a progress report at five years.

Am Heart Hosp J 2011 ;9(1):E19-23

University of Ottawa Heart Institute, Ontario, Canada.

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December 2011

Blood pressure loci identified with a gene-centric array.

Authors:
Toby Johnson Tom R Gaunt Stephen J Newhouse Sandosh Padmanabhan Maciej Tomaszewski Meena Kumari Richard W Morris Ioanna Tzoulaki Eoin T O'Brien Neil R Poulter Peter Sever Denis C Shields Simon Thom Sasiwarang G Wannamethee Peter H Whincup Morris J Brown John M Connell Richard J Dobson Philip J Howard Charles A Mein Abiodun Onipinla Sue Shaw-Hawkins Yun Zhang George Davey Smith Ian N M Day Debbie A Lawlor Alison H Goodall F Gerald Fowkes Gonçalo R Abecasis Paul Elliott Vesela Gateva Peter S Braund Paul R Burton Christopher P Nelson Martin D Tobin Pim van der Harst Nicola Glorioso Hani Neuvrith Erika Salvi Jan A Staessen Andrea Stucchi Nabila Devos Xavier Jeunemaitre Pierre-François Plouin Jean Tichet Peeter Juhanson Elin Org Margus Putku Siim Sõber Gudrun Veldre Margus Viigimaa Anna Levinsson Annika Rosengren Dag S Thelle Claire E Hastie Thomas Hedner Wai K Lee Olle Melander Björn Wahlstrand Rebecca Hardy Andrew Wong Jackie A Cooper Jutta Palmen Li Chen Alexandre F R Stewart George A Wells Harm-Jan Westra Marcel G M Wolfs Robert Clarke Maria Grazia Franzosi Anuj Goel Anders Hamsten Mark Lathrop John F Peden Udo Seedorf Hugh Watkins Willem H Ouwehand Jennifer Sambrook Jonathan Stephens Juan-Pablo Casas Fotios Drenos Michael V Holmes Mika Kivimaki Sonia Shah Tina Shah Philippa J Talmud John Whittaker Chris Wallace Christian Delles Maris Laan Diana Kuh Steve E Humphries Fredrik Nyberg Daniele Cusi Robert Roberts Christopher Newton-Cheh Lude Franke Alice V Stanton Anna F Dominiczak Martin Farrall Aroon D Hingorani Nilesh J Samani Mark J Caulfield Patricia B Munroe

Am J Hum Genet 2011 Dec 17;89(6):688-700. Epub 2011 Nov 17.

Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.1016/j.ajhg.2011.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234370PMC
December 2011

Recent success in the discovery of coronary artery disease genes.

Can J Physiol Pharmacol 2011 Aug 4;89(8):609-15. Epub 2011 Aug 4.

University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.

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http://dx.doi.org/10.1139/y11-041DOI Listing
August 2011

Mouse viruses and human disease.

Lancet Infect Dis 2011 Apr;11(4):264-5

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http://dx.doi.org/10.1016/S1473-3099(11)70082-2DOI Listing
April 2011

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Authors:
Heribert Schunkert Inke R König Sekar Kathiresan Muredach P Reilly Themistocles L Assimes Hilma Holm Michael Preuss Alexandre F R Stewart Maja Barbalic Christian Gieger Devin Absher Zouhair Aherrahrou Hooman Allayee David Altshuler Sonia S Anand Karl Andersen Jeffrey L Anderson Diego Ardissino Stephen G Ball Anthony J Balmforth Timothy A Barnes Diane M Becker Lewis C Becker Klaus Berger Joshua C Bis S Matthijs Boekholdt Eric Boerwinkle Peter S Braund Morris J Brown Mary Susan Burnett Ian Buysschaert John F Carlquist Li Chen Sven Cichon Veryan Codd Robert W Davies George Dedoussis Abbas Dehghan Serkalem Demissie Joseph M Devaney Patrick Diemert Ron Do Angela Doering Sandra Eifert Nour Eddine El Mokhtari Stephen G Ellis Roberto Elosua James C Engert Stephen E Epstein Ulf de Faire Marcus Fischer Aaron R Folsom Jennifer Freyer Bruna Gigante Domenico Girelli Solveig Gretarsdottir Vilmundur Gudnason Jeffrey R Gulcher Eran Halperin Naomi Hammond Stanley L Hazen Albert Hofman Benjamin D Horne Thomas Illig Carlos Iribarren Gregory T Jones J Wouter Jukema Michael A Kaiser Lee M Kaplan John J P Kastelein Kay-Tee Khaw Joshua W Knowles Genovefa Kolovou Augustine Kong Reijo Laaksonen Diether Lambrechts Karin Leander Guillaume Lettre Mingyao Li Wolfgang Lieb Christina Loley Andrew J Lotery Pier M Mannucci Seraya Maouche Nicola Martinelli Pascal P McKeown Christa Meisinger Thomas Meitinger Olle Melander Pier Angelica Merlini Vincent Mooser Thomas Morgan Thomas W Mühleisen Joseph B Muhlestein Thomas Münzel Kiran Musunuru Janja Nahrstaedt Christopher P Nelson Markus M Nöthen Oliviero Olivieri Riyaz S Patel Chris C Patterson Annette Peters Flora Peyvandi Liming Qu Arshed A Quyyumi Daniel J Rader Loukianos S Rallidis Catherine Rice Frits R Rosendaal Diana Rubin Veikko Salomaa M Lourdes Sampietro Manj S Sandhu Eric Schadt Arne Schäfer Arne Schillert Stefan Schreiber Jürgen Schrezenmeir Stephen M Schwartz David S Siscovick Mohan Sivananthan Suthesh Sivapalaratnam Albert Smith Tamara B Smith Jaapjan D Snoep Nicole Soranzo John A Spertus Klaus Stark Kathy Stirrups Monika Stoll W H Wilson Tang Stephanie Tennstedt Gudmundur Thorgeirsson Gudmar Thorleifsson Maciej Tomaszewski Andre G Uitterlinden Andre M van Rij Benjamin F Voight Nick J Wareham George A Wells H-Erich Wichmann Philipp S Wild Christina Willenborg Jaqueline C M Witteman Benjamin J Wright Shu Ye Tanja Zeller Andreas Ziegler Francois Cambien Alison H Goodall L Adrienne Cupples Thomas Quertermous Winfried März Christian Hengstenberg Stefan Blankenberg Willem H Ouwehand Alistair S Hall Panos Deloukas John R Thompson Kari Stefansson Robert Roberts Unnur Thorsteinsdottir Christopher J O'Donnell Ruth McPherson Jeanette Erdmann Nilesh J Samani

Nat Genet 2011 Mar 6;43(4):333-8. Epub 2011 Mar 6.

Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany.

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http://dx.doi.org/10.1038/ng.784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119261PMC
March 2011

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.

Authors:
Nicole Soranzo Serena Sanna Eleanor Wheeler Christian Gieger Dörte Radke Josée Dupuis Nabila Bouatia-Naji Claudia Langenberg Inga Prokopenko Elliot Stolerman Manjinder S Sandhu Matthew M Heeney Joseph M Devaney Muredach P Reilly Sally L Ricketts Alexandre F R Stewart Benjamin F Voight Christina Willenborg Benjamin Wright David Altshuler Dan Arking Beverley Balkau Daniel Barnes Eric Boerwinkle Bernhard Böhm Amélie Bonnefond Lori L Bonnycastle Dorret I Boomsma Stefan R Bornstein Yvonne Böttcher Suzannah Bumpstead Mary Susan Burnett-Miller Harry Campbell Antonio Cao John Chambers Robert Clark Francis S Collins Josef Coresh Eco J C de Geus Mariano Dei Panos Deloukas Angela Döring Josephine M Egan Roberto Elosua Luigi Ferrucci Nita Forouhi Caroline S Fox Christopher Franklin Maria Grazia Franzosi Sophie Gallina Anuj Goel Jürgen Graessler Harald Grallert Andreas Greinacher David Hadley Alistair Hall Anders Hamsten Caroline Hayward Simon Heath Christian Herder Georg Homuth Jouke-Jan Hottenga Rachel Hunter-Merrill Thomas Illig Anne U Jackson Antti Jula Marcus Kleber Christopher W Knouff Augustine Kong Jaspal Kooner Anna Köttgen Peter Kovacs Knut Krohn Brigitte Kühnel Johanna Kuusisto Markku Laakso Mark Lathrop Cécile Lecoeur Man Li Mingyao Li Ruth J F Loos Jian'an Luan Valeriya Lyssenko Reedik Mägi Patrik K E Magnusson Anders Mälarstig Massimo Mangino María Teresa Martínez-Larrad Winfried März Wendy L McArdle Ruth McPherson Christa Meisinger Thomas Meitinger Olle Melander Karen L Mohlke Vincent E Mooser Mario A Morken Narisu Narisu David M Nathan Matthias Nauck Chris O'Donnell Konrad Oexle Nazario Olla James S Pankow Felicity Payne John F Peden Nancy L Pedersen Leena Peltonen Markus Perola Ozren Polasek Eleonora Porcu Daniel J Rader Wolfgang Rathmann Samuli Ripatti Ghislain Rocheleau Michael Roden Igor Rudan Veikko Salomaa Richa Saxena David Schlessinger Heribert Schunkert Peter Schwarz Udo Seedorf Elizabeth Selvin Manuel Serrano-Ríos Peter Shrader Angela Silveira David Siscovick Kjioung Song Timothy D Spector Kari Stefansson Valgerdur Steinthorsdottir David P Strachan Rona Strawbridge Michael Stumvoll Ida Surakka Amy J Swift Toshiko Tanaka Alexander Teumer Gudmar Thorleifsson Unnur Thorsteinsdottir Anke Tönjes Gianluca Usala Veronique Vitart Henry Völzke Henri Wallaschofski Dawn M Waterworth Hugh Watkins H-Erich Wichmann Sarah H Wild Gonneke Willemsen Gordon H Williams James F Wilson Juliane Winkelmann Alan F Wright Carina Zabena Jing Hua Zhao Stephen E Epstein Jeanette Erdmann Hakon H Hakonarson Sekar Kathiresan Kay-Tee Khaw Robert Roberts Nilesh J Samani Mark D Fleming Robert Sladek Gonçalo Abecasis Michael Boehnke Philippe Froguel Leif Groop Mark I McCarthy W H Linda Kao Jose C Florez Manuela Uda Nicholas J Wareham Inês Barroso James B Meigs

Diabetes 2010 Dec 21;59(12):3229-39. Epub 2010 Sep 21.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K.

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http://dx.doi.org/10.2337/db10-0502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992787PMC
December 2010

Gene dosage of the common variant 9p21 predicts severity of coronary artery disease.

J Am Coll Cardiol 2010 Aug;56(6):479-86

John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2009.10.092DOI Listing
August 2010

The genome-wide association study--a new era for common polygenic disorders.

J Cardiovasc Transl Res 2010 Jun 27;3(3):173-82. Epub 2010 Mar 27.

The Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada.

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http://link.springer.com/10.1007/s12265-010-9178-6
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http://dx.doi.org/10.1007/s12265-010-9178-6DOI Listing
June 2010

Genomics in coronary artery disease: past, present and future.

Can J Cardiol 2010 Mar;26 Suppl A:56A-59A

The Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada.

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March 2010

Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.

Circ Res 2009 Dec 22;105(12):1232-9. Epub 2009 Oct 22.

Cardiovascular Systems Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.205427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862555PMC
December 2009

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.

PLoS Genet 2009 Dec 11;5(12):e1000768. Epub 2009 Dec 11.

Departments of Medicine, Human Genetics, and Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1000768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781107PMC
December 2009

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

Nat Genet 2009 Nov 11;41(11):1182-90. Epub 2009 Oct 11.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108459PMC
November 2009

Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle and associates with diet-induced weight loss.

FASEB J 2009 Jun 13;23(6):1705-9. Epub 2009 Feb 13.

Department of Biochemistry, Microbiology, and Immunology, Program of Human and Molecular Genetics, Faculty of Medicine, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1096/fj.08-120998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934840PMC
June 2009

Extracellular ATP-dependent upregulation of the transcription cofactor LMO4 promotes neuron survival from hypoxia.

Exp Cell Res 2007 Aug 3;313(14):3106-16. Epub 2007 May 3.

Ottawa Health Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.yexcr.2007.04.026DOI Listing
August 2007

Characterization of cardiac gene promoter activity: reporter constructs and heterologous promoter studies.

Methods Mol Biol 2007 ;366:217-25

University of Ottawa Health Research Intitute, Canada.

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http://dx.doi.org/10.1007/978-1-59745-030-0_12DOI Listing
July 2007

LMO4 mRNA stability is regulated by extracellular ATP in F11 cells.

Biochem Biophys Res Commun 2007 May 28;357(1):56-61. Epub 2007 Mar 28.

Ottawa Health Research Institute, Neuroscience, Centre for Stroke Recovery, 451 Smyth Road, Ottawa, Ont., Canada K1H 8M5.

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http://dx.doi.org/10.1016/j.bbrc.2007.03.113DOI Listing
May 2007

Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation.

N Engl J Med 2006 Jun;354(25):2677-88

Arrhythmia Research Laboratory and Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada.

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http://dx.doi.org/10.1056/NEJMoa052800DOI Listing
June 2006

Angiotensin II and stretch activate NADPH oxidase to destabilize cardiac Kv4.3 channel mRNA.

Circ Res 2006 Apr 23;98(8):1040-7. Epub 2006 Mar 23.

Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1161/01.RES.0000218989.52072.e7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457039PMC
April 2006

Troponin I protein kinase C phosphorylation sites and ventricular function.

Cardiovasc Res 2004 Aug;63(2):245-55

Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.cardiores.2004.04.010DOI Listing
August 2004

Transcription cofactor Vgl-2 is required for skeletal muscle differentiation.

Genesis 2004 Aug;39(4):273-9

Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1002/gene.20055DOI Listing
August 2004

Gene expression changes associated with fibronectin-induced cardiac myocyte hypertrophy.

Physiol Genomics 2004 Aug 11;18(3):273-83. Epub 2004 Aug 11.

Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00104.2004DOI Listing
August 2004

Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.

J Biol Chem 2004 Jul 12;279(29):30800-6. Epub 2004 May 12.

Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1074/jbc.M400154200DOI Listing
July 2004

Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation.

J Biol Chem 2002 Dec 9;277(50):48889-98. Epub 2002 Oct 9.

Cardiovascular Institute, School of Medicine, University of Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1074/jbc.M206858200DOI Listing
December 2002

Differential expression of a transcription regulatory factor, the LIM domain only 4 protein Lmo4, in muscle sensory neurons.

Development 2002 Nov;129(21):4879-89

Department of Neurobiology, University of Pittsburgh, PA 15261, USA.

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November 2002

TEF-1 transcription factors regulate activity of the mouse mammary tumor virus LTR.

Biochem Biophys Res Commun 2002 Sep;296(5):1279-85

Cardiovascular Institute, School of Medicine, University of Pittsburgh, BST 1704.3, 200 Lothrop Street, 15213, Pittsburgh, PA, USA.

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September 2002

Alpha(1)-adrenergic activation of the cardiac ankyrin repeat protein gene in cardiac myocytes.

Gene 2002 Sep;297(1-2):1-9

Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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September 2002

Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes.

J Biol Chem 2002 Jul 1;277(27):24346-52. Epub 2002 May 1.

Cardiovascular Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1074/jbc.M201171200DOI Listing
July 2002

TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters.

Biochem Biophys Res Commun 2002 Jun;294(4):791-7

Cardiovascular Institute, School of Medicine, University of Pittsburgh, BST 1704.3, PA 15213, USA.

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http://dx.doi.org/10.1016/S0006-291X(02)00556-9DOI Listing
June 2002