Dr Alexandre Arcaro, PhD - University of Zürich - PD Dr.

Dr Alexandre Arcaro

PhD

University of Zürich

PD Dr.

Zürich, Zurich | Switzerland

Main Specialties: Oncology

Additional Specialties: Oncology

Dr Alexandre Arcaro, PhD - University of Zürich - PD Dr.

Dr Alexandre Arcaro

PhD

Introduction

Primary Affiliation: University of Zürich - Zürich, Zurich , Switzerland

Specialties:

Additional Specialties:

Publications

44Publications

895Reads

3Profile Views

693PubMed Central Citations

Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.

PLoS One 2014 9;9(4):e94132. Epub 2014 Apr 9.

Department of Clinical Research, University of Bern, Bern, Switzerland; Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094132PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981776PMC
June 2015
31 Reads
12 Citations
3.234 Impact Factor

Targeting PI3K/mTOR Signaling in Cancer.

Authors:
Alexandre Arcaro

Front Oncol 2014 22;4:84. Epub 2014 Apr 22.

Department of Clinical Research, Division of Pediatric Hematology/Oncology, University of Bern , Bern , Switzerland.

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http://dx.doi.org/10.3389/fonc.2014.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001057PMC
May 2014
5 Reads
5 Citations

NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.

Acta Neuropathol Commun 2014 Apr 7;2:39. Epub 2014 Apr 7.

Department of Oncology, University Children's Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1186/2051-5960-2-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023630PMC
April 2014
49 Reads
11 Citations

Emerging metabolic targets in the therapy of hematological malignancies.

Biomed Res Int 2013 18;2013:946206. Epub 2013 Aug 18.

University of Bern, Department of Clinical Research, Division of Pediatric Hematology/Oncology, Murtenstrasse 31, 3010 Bern, Switzerland.

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http://dx.doi.org/10.1155/2013/946206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759275PMC
April 2014
5 Reads
4 Citations

The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease.

PLoS One 2013 23;8(8):e73173. Epub 2013 Aug 23.

Institute of Physiology, University of Zurich, Zürich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073173PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751888PMC
April 2014
14 Reads
10 Citations
3.234 Impact Factor

Involvement of autophagy in the response of tumor cells to PtdIns3K inhibitors: therapeutic implications.

Authors:
Alexandre Arcaro

Autophagy 2013 Apr 16;9(4):607-8. Epub 2013 Jan 16.

Department of Clinical Research, University of Bern, Switzerland.

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http://dx.doi.org/10.4161/auto.23461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627675PMC
April 2013
4 Reads
1 Citation
11.753 Impact Factor

Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.

PLoS One 2012 12;7(9):e44945. Epub 2012 Sep 12.

Department of Clinical Research, University of Bern, Bern, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044945PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440356PMC
March 2013
11 Reads
4 Citations
3.234 Impact Factor

Targeting the insulin-like growth factor-1 receptor in human cancer.

Authors:
Alexandre Arcaro

Front Pharmacol 2013 22;4:30. Epub 2013 Mar 22.

Division of Pediatric Hematology/Oncology, Department of Clinical Research, University of Bern Bern, Switzerland.

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http://dx.doi.org/10.3389/fphar.2013.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605519PMC
March 2013
10 Reads
29 Citations

Targeting phosphoinositide 3-kinase signalling in lung cancer.

Crit Rev Oncol Hematol 2011 Nov 11;80(2):278-90. Epub 2011 Feb 11.

Department of Clinical Research, University of Bern, Switzerland.

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http://dx.doi.org/10.1016/j.critrevonc.2011.01.007DOI Listing
November 2011
3 Reads
6 Citations
4.030 Impact Factor

MicroRNA-21 suppression impedes medulloblastoma cell migration.

Eur J Cancer 2011 Nov 19;47(16):2479-90. Epub 2011 Jul 19.

Oncology Department, University Children's Hospital of Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ejca.2011.06.041DOI Listing
November 2011
18 Reads
19 Citations
5.420 Impact Factor

Lipid rafts and caveolae in signaling by growth factor receptors.

Open Biochem J 2007 13;1:12-32. Epub 2007 Sep 13.

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

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http://dx.doi.org/10.2174/1874091X00701010012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570545PMC
July 2011
7 Reads
18 Citations

Phosphatidylinositol 3-kinase isoforms as novel drug targets.

Curr Drug Targets 2011 Jun;12(7):1056-81

University of Bern, Department of Clinical Research, Bern, Switzerland.

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http://dx.doi.org/10.2174/138945011795677773DOI Listing
June 2011
9 Reads
8 Citations
3.021 Impact Factor

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

Cell Signal 2011 Mar 5;23(3):529-41. Epub 2010 Nov 5.

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, 8032 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.cellsig.2010.10.021DOI Listing
March 2011
12 Reads
2 Citations
4.320 Impact Factor

The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors.

Mol Cancer Ther 2010 Dec 1;9(12):3145-57. Epub 2010 Oct 1.

Department of Oncology, University Children's Hospital of Zurich, Switzerland.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0539DOI Listing
December 2010
39 Reads
3 Citations
5.683 Impact Factor

Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD.

Mol Cancer Ther 2010 Jan 6;9(1):167-79. Epub 2010 Jan 6.

Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0586DOI Listing
January 2010
74 Reads
10 Citations
5.683 Impact Factor

Pulse mTOR inhibitor treatment effectively controls cyst growth but leads to severe parenchymal and glomerular hypertrophy in rat polycystic kidney disease.

Am J Physiol Renal Physiol 2009 Dec 23;297(6):F1597-605. Epub 2009 Sep 23.

Zurich Center for Integrative Human Physiology (ZIHP), Zürich, Switzerland.

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http://dx.doi.org/10.1152/ajprenal.00430.2009DOI Listing
December 2009
21 Reads
15 Citations

Targeting Myc in pediatric malignancies of the central and peripheral nervous system.

Curr Cancer Drug Targets 2009 Mar;9(2):176-88

Department of Oncology, University Children's Hospital Zurich, Steinwiesstrasse 75, Zurich, Switzerland.

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March 2009
6 Reads
6 Citations
3.522 Impact Factor

Recent patents of gene sequences relative to the phosphatidylinositol 3-kinase/Akt pathway and their relevance to drug discovery.

Recent Pat DNA Gene Seq 2007 ;1(1):9-23

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

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February 2009
16 Reads

Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.

Clin Cancer Res 2008 Nov;14(21):6761-9

Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0385DOI Listing
November 2008
21 Reads
29 Citations
8.722 Impact Factor

Immortalization of human alveolar epithelial cells to investigate nanoparticle uptake.

Am J Respir Cell Mol Biol 2008 Nov 6;39(5):591-7. Epub 2008 Jun 6.

Lung Cell Biology, National Heart and Lung Institute, Imperial College, London, UK.

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http://dx.doi.org/10.1165/rcmb.2007-0334OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643209PMC
November 2008
33 Reads
28 Citations
3.985 Impact Factor

Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.

Clin Cancer Res 2008 Feb;14(4):1172-81

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0737DOI Listing
February 2008
21 Reads
18 Citations
8.722 Impact Factor

Current status of clinical trials for small cell lung cancer.

Rev Recent Clin Trials 2008 Jan;3(1):40-61

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

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January 2008
7 Reads
11 Citations

Targeting receptor tyrosine kinase signaling in acute myeloid leukemia.

Crit Rev Oncol Hematol 2007 Sep 19;63(3):215-30. Epub 2007 Jul 19.

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.critrevonc.2007.05.005DOI Listing
September 2007
3 Reads
20 Citations
4.030 Impact Factor

Mitotic activation of Akt signalling pathway in Han:SPRD rats with polycystic kidney disease.

Nephrology (Carlton) 2007 Aug;12(4):357-63

Physiological Institute and Zurich Center for Human Integrative Human Physiology, Zurich, Switzerland.

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http://dx.doi.org/10.1111/j.1440-1797.2007.00811.xDOI Listing
August 2007
25 Reads
13 Citations
1.864 Impact Factor

Novel role for insulin as an autocrine growth factor for malignant brain tumour cells.

Biochem J 2007 Aug;406(1):57-66

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, CH-8032 Zurich, Switzerland.

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http://dx.doi.org/10.1042/BJ20070309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948991PMC
August 2007
9 Reads
17 Citations
4.400 Impact Factor

Targeting mTOR signaling in lung cancer.

Crit Rev Oncol Hematol 2007 Aug 30;63(2):172-82. Epub 2007 May 30.

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.critrevonc.2007.04.002DOI Listing
August 2007
5 Reads
30 Citations
4.030 Impact Factor

The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.

Curr Genomics 2007 Aug;8(5):271-306

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

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http://dx.doi.org/10.2174/138920207782446160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652403PMC
August 2007
23 Reads
45 Citations
2.342 Impact Factor

Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): what have we learned so far?

Cancer Treat Rev 2007 Jun 26;33(4):391-406. Epub 2007 Mar 26.

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ctrv.2007.01.006DOI Listing
June 2007
40 Reads
21 Citations
7.590 Impact Factor

Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling.

Cell Signal 2007 May 29;19(5):1081-92. Epub 2006 Dec 29.

Lung Cancer Biology Group, Division of Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom.

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http://dx.doi.org/10.1016/j.cellsig.2006.12.003DOI Listing
May 2007
17 Reads
51 Citations
4.320 Impact Factor

Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells.

BMC Cancer 2007 Jan 25;7:19. Epub 2007 Jan 25.

Neuro-Oncology Program, University Children's Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.1186/1471-2407-7-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794252PMC
January 2007
13 Reads
11 Citations
3.362 Impact Factor

Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition.

Int J Cancer 2006 Dec;119(11):2527-38

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, CH-8032 Zurich, Switzerland.

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http://dx.doi.org/10.1002/ijc.22126DOI Listing
December 2006
14 Reads
5 Citations
5.085 Impact Factor

Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions.

Blood 2006 Nov 18;108(10):3352-9. Epub 2006 Jul 18.

Service of Hematology, CHUV, Lausanne, Switzerland.

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http://dx.doi.org/10.1182/blood-2006-04-013912DOI Listing
November 2006
15 Reads
21 Citations
10.452 Impact Factor

Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.

Mol Biol Cell 2006 Sep 14;17(9):3729-44. Epub 2006 Jun 14.

Ludwig Institute for Cancer Research, Royal Free and University College Hospital Medical School, London W1W 7BS, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e05-11-1083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1593155PMC
September 2006
38 Reads
24 Citations
4.470 Impact Factor

IGF-IR: potential role in antitumor agents.

Drug News Perspect 2006 Jun;19(5):261-72

Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Switzerland.

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http://dx.doi.org/10.1358/dnp.2006.19.5.985933DOI Listing
June 2006
33 Reads
9 Citations

Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.

EMBO J 2002 Oct;21(19):5097-108

Lung Cancer Biology Group, Division of Medicine, Imperial College Faculty of Medicine, Du Cane Road, London W12 0NN, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129034PMC
http://dx.doi.org/10.1093/emboj/cdf512DOI Listing
October 2002
4 Reads
23 Citations
10.434 Impact Factor

Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis.

J Biol Chem 2002 Apr 28;277(14):12040-6. Epub 2002 Jan 28.

Cancer Research United Kingdom Lung Cancer Biology Group and the Medical Research Council Clinical Sciences Centre, Hammersmith Campus of Imperial College, Ducane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109006200DOI Listing
April 2002
15 Reads
33 Citations
4.573 Impact Factor