Alexandra H Filipovich

Alexandra H Filipovich

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Alexandra H Filipovich

Publications by authors named "Alexandra H Filipovich"

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Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients.

Biol Blood Marrow Transplant 2016 Apr 29;22(4):690-697. Epub 2015 Dec 29.

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.bbmt.2015.12.016DOI Listing
April 2016

A challenging undertaking: Stem cell transplantation for immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.

J Allergy Clin Immunol 2016 Mar 11;137(3):953-5.e4. Epub 2015 Nov 11.

Division of Bone Marrow Transplantation and Immune deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.jaci.2015.09.030DOI Listing
March 2016

MicroRNA activation signature in patients with hemophagocytic lymphohistiocytosis and reversibility with disease-specific therapy.

J Allergy Clin Immunol 2016 Jan 17;137(1):309-312. Epub 2015 Jul 17.

Division of Bone Marrow Transplantation and Immune Deficiency, Blood and Cancer Research Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Faculty of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.jaci.2015.06.006DOI Listing
January 2016

Alemtuzumab levels impact acute GVHD, mixed chimerism, and lymphocyte recovery following alemtuzumab, fludarabine, and melphalan RIC HCT.

Blood 2016 Jan 7;127(4):503-12. Epub 2015 Dec 7.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital, Cincinnati, OH.

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http://dx.doi.org/10.1182/blood-2015-07-659672DOI Listing
January 2016

Activated phosphoinositide 3-kinase δ syndrome in a patient with a former diagnosis of common variable immune deficiency, bronchiectasis, and lymphoproliferative disease.

Ann Allergy Asthma Immunol 2015 Nov 12;115(5):452-4. Epub 2015 Sep 12.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2015.08.009DOI Listing
November 2015

Accuracy of flow cytometric perforin screening for detecting patients with FHL due to PRF1 mutations.

Blood 2015 Oct;126(15):1858-60

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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http://dx.doi.org/10.1182/blood-2015-06-648659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828082PMC
October 2015

Pathogenesis of Hemophagocytic Lymphohistiocytosis.

Hematol Oncol Clin North Am 2015 Oct 21;29(5):895-902. Epub 2015 Aug 21.

Immunodeficiency and Histiocytosis Program, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2015.06.007DOI Listing
October 2015

Peripheral Blood CD38 Bright CD8+ Effector Memory T Cells Predict Acute Graft-versus-Host Disease.

Biol Blood Marrow Transplant 2015 Jul 13;21(7):1215-22. Epub 2015 Apr 13.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.bbmt.2015.04.010DOI Listing
July 2015

AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.

Science 2015 Jul;349(6246):436-40

Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA. Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center/ University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1126/science.aaa1663DOI Listing
July 2015

Outcomes of donor lymphocyte infusion for treatment of mixed donor chimerism after a reduced-intensity preparative regimen for pediatric patients with nonmalignant diseases.

Biol Blood Marrow Transplant 2015 Feb 18;21(2):288-92. Epub 2014 Oct 18.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.10.010DOI Listing
February 2015

Reduced-intensity conditioning hematopoietic cell transplantation is an effective treatment for patients with SLAM-associated protein deficiency/X-linked lymphoproliferative disease type 1.

Biol Blood Marrow Transplant 2014 Oct 9;20(10):1641-5. Epub 2014 Jun 9.

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.bbmt.2014.06.003DOI Listing
October 2014

Bortezomib for refractory autoimmunity in pediatrics.

Biol Blood Marrow Transplant 2014 10 28;20(10):1654-9. Epub 2014 Jun 28.

Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.bbmt.2014.06.032DOI Listing
October 2014

A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.

N Engl J Med 2014 Oct;371(15):1407-17

From the Departments of Biotherapy (S.H.-B.-A., J. Blondeau, L.C., F.T., M.C.) and Immunology and Pediatric Hematology (S.B., G.C., D.M., B.N., C.P., F.T., A.F.) and the Centre d'Étude des Déficits Immunitaires (C.P.), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), the Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, AP-HP, INSERM (S.H.-B.-A., J. Blondeau, L.C., F.T., M.C.), Unité de Technologies Chimiques et Biologiques pour la Santé, Centre National de la Recherche Scientifique, 8258-INSERM Unité 1022, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes (S.H.-B.-A.), Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Sud, AP-HP, Le Kremlin-Bicêtre (S.H.-B.-A.), Imagine Institute, Paris Descartes-Sorbonne Paris Cité University (S.B., J. Blondeau, L.C., D.M., B.N., C.P., E.S., A.F., M.C.), INSERM Unités Mixtes de Recherche 1163, Laboratory of Human Lymphohematopoiesis (J. Blondeau, L.C., E.S., F.T., A.F., M.C.), Groupe Immunoscope, Immunology Department, Institut Pasteur (A.L.), and Collège de France (A.F.) - all in Paris; Division of Hematology-Oncology (S.-Y.P., H.B., D.G., C.E.H., G.H., L.E.L., W.B.L., D.A.W.) and Division of Immunology (L.D.N.), Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute (S.-Y.P., D.G., L.E.L., W.B.L., D.A.W.), Harvard Medical School (S.-Y.P., M.A., L.E.L., W.B.L., J.R., L.E.S., A.T., L.D.N., D.A.W.), Center for Human Cell Therapy, Program in Cellular and Molecular Medicine, Boston Children's Hospital (M.A., J.R., L.E.S., A.T.), Division of Hematologic Malignancies, Dana-Farber Cancer Institute (J.R.), and the Manton Center for Orphan Disease Research (L.D.N.) - all in Boston; Great Ormond Street Hospital for Children NHS Foundation Trust (H.B.G., J.X.-B., A.J.T.) and Section of Molecular and Cellular Immunology, University College London Institute of Child Health (H.B.G., K.F.B., A.

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http://dx.doi.org/10.1056/NEJMoa1404588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274995PMC
October 2014

Clinical flow cytometric screening of SAP and XIAP expression accurately identifies patients with SH2D1A and XIAP/BIRC4 mutations.

Cytometry B Clin Cytom 2014 Jul 19;86(4):263-71. Epub 2014 Feb 19.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/cyto.b.21166DOI Listing
July 2014

The 253-kb inversion and deep intronic mutations in UNC13D are present in North American patients with familial hemophagocytic lymphohistiocytosis 3.

Pediatr Blood Cancer 2014 Jun 28;61(6):1034-40. Epub 2014 Jan 28.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.24955DOI Listing
June 2014

Downbeat nystagmus secondary to familial hemophagocytic lymphohistiocytosis.

J Neuroophthalmol 2014 Mar;34(1):57-60

Columbia University College of Physicians and Surgeons (CXC), New York, New York; Departments of Ophthalmology (FSS, JGO), Radiology (AL), and Pathology (TG); Columbia University Medical Center, New York Presbyterian Hospital, New York, New York; and Department of Clinical Immunology (AHF), Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, Ohio.

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http://dx.doi.org/10.1097/WNO.0000000000000064DOI Listing
March 2014

The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients.

Pediatr Transplant 2014 Feb 30;18(1):94-102. Epub 2013 Oct 30.

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA.

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http://dx.doi.org/10.1111/petr.12183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167786PMC
February 2014

Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency.

Cytokine 2014 Jan 29;65(1):74-8. Epub 2013 Sep 29.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2013.09.007DOI Listing
January 2014

Hemophagocytic lymphohistiocytosis: advances in pathophysiology, diagnosis, and treatment.

J Pediatr 2013 Nov 15;163(5):1253-9. Epub 2013 Aug 15.

Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2013.06.053DOI Listing
November 2013

Primary immunodeficiencies predisposed to Epstein-Barr virus-driven haematological diseases.

Br J Haematol 2013 Sep 11;162(5):573-86. Epub 2013 Jun 11.

Paediatric Infectious Diseases Research Centre, Children's Medical Centre, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/bjh.12422DOI Listing
September 2013

Flow cytometric measurement of SLAM-associated protein and X-linked inhibitor of apoptosis.

Methods Mol Biol 2013 ;979:189-97

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1007/978-1-62703-290-2_15DOI Listing
August 2013

Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.

Front Immunol 2013 22;4:72. Epub 2013 Mar 22.

Immunodeficiency and Histiocytosis Program, Division of Bone Marrow Transplantation, Cincinnati Children's Hospital Medical Center Cincinnati, OH, USA.

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http://dx.doi.org/10.3389/fimmu.2013.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605512PMC
March 2013

Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis.

Blood 2013 Feb 20;121(7):e14-24. Epub 2012 Dec 20.

Divisions of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2012-05-425769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575760PMC
February 2013

Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab.

Pediatr Blood Cancer 2013 Jan 22;60(1):101-9. Epub 2012 Apr 22.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1002/pbc.24188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410971PMC
January 2013

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.

Blood 2012 Sep 5;120(12):2484-92. Epub 2012 Jul 5.

Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA.

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http://dx.doi.org/10.1182/blood-2012-05-430603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448260PMC
September 2012

Munc18b/STXBP2 is required for platelet secretion.

Blood 2012 Sep 12;120(12):2493-500. Epub 2012 Jul 12.

Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1182/blood-2012-05-430629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448261PMC
September 2012

Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.

Am J Physiol Cell Physiol 2012 May 29;302(10):C1504-12. Epub 2012 Feb 29.

Department of Internal Medicine, 231 Albert Sabin Way, University of Cincinnati, Cincinnati, OH 45267-0585, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00263.2011
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http://dx.doi.org/10.1152/ajpcell.00263.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362003PMC
May 2012

Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation.

Pediatr Transplant 2012 Mar 5;16(2):E39-42. Epub 2010 Nov 5.

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1111/j.1399-3046.2010.01408.xDOI Listing
March 2012

The expanding spectrum of hemophagocytic lymphohistiocytosis.

Curr Opin Allergy Clin Immunol 2011 Dec;11(6):512-6

Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1097/ACI.0b013e32834c22f5DOI Listing
December 2011

Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH.

Blood 2011 Nov 31;118(22):5794-8. Epub 2011 Aug 31.

Division of Human Genetics, Children's Hospital Medical Center, University of Cincinnati College of Medicie, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2011-07-370148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228496PMC
November 2011

Familial hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease.

Ann N Y Acad Sci 2011 Nov;1238:106-21

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Ohio 45229, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06265.xDOI Listing
November 2011

Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2011 Oct 6;17(10):1512-9. Epub 2011 Mar 6.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.bbmt.2011.02.012DOI Listing
October 2011

How I treat hemophagocytic lymphohistiocytosis.

Blood 2011 Oct 9;118(15):4041-52. Epub 2011 Aug 9.

Divisions of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-03-27
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http://dx.doi.org/10.1182/blood-2011-03-278127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204727PMC
October 2011

Reduced-intensity conditioning haematopoietic cell transplantation for haemophagocytic lymphohistiocytosis: an important step forward.

Br J Haematol 2011 Sep 28;154(5):556-63. Epub 2011 Jun 28.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08785.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155668PMC
September 2011

Impaired immune function in children with Fanconi anaemia.

Br J Haematol 2011 Jul 4;154(2):234-40. Epub 2011 May 4.

Divisions of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08721.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922775PMC
July 2011

Hemophagocytosis causes a consumptive anemia of inflammation.

J Exp Med 2011 Jun 30;208(6):1203-14. Epub 2011 May 30.

Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1084/jem.20102538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173248PMC
June 2011

Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis.

Blood 2011 Apr 16;117(15):e151-60. Epub 2011 Feb 16.

Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1182/blood-2010-08-300046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087540PMC
April 2011

Contemporary diagnostic methods for hemophagocytic lymphohistiocytic disorders.

J Immunol Methods 2011 Feb 24;364(1-2):1-13. Epub 2010 Nov 24.

Immunotherapy Center, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA, USA.

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http://dx.doi.org/10.1016/j.jim.2010.11.006DOI Listing
February 2011

Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation.

Blood 2010 Dec 20;116(26):5824-31. Epub 2010 Sep 20.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2010-04-282392DOI Listing
December 2010

X-linked lymphoproliferative syndromes: brothers or distant cousins?

Blood 2010 Nov 26;116(18):3398-408. Epub 2010 Jul 26.

Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1182/blood-2010-03-275909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981470PMC
November 2010

Using flow cytometry to screen patients for X-linked lymphoproliferative disease due to SAP deficiency and XIAP deficiency.

J Immunol Methods 2010 Oct 9;362(1-2):1-9. Epub 2010 Sep 9.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.jim.2010.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964414PMC
October 2010

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease.

Blood 2010 Aug 20;116(7):1079-82. Epub 2010 May 20.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2010-01-256099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938130PMC
August 2010

STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.

Pediatr Blood Cancer 2010 Jul;55(1):134-40

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1002/pbc.22499DOI Listing
July 2010

Hemophagocytic lymphohistiocytosis (HLH) and related disorders.

Hematology Am Soc Hematol Educ Program 2009 :127-31

Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1182/asheducation-2009.1.127DOI Listing
March 2010

Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment.

Biol Blood Marrow Transplant 2009 Jan;15(1 Suppl):84-90

Department of Pediatrics, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1016/j.bbmt.2008.10.007DOI Listing
January 2009

Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels.

J Allergy Clin Immunol 2008 Jun 14;121(6):1473-83, 1483.e1-4. Epub 2008 Apr 14.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1016/j.jaci.2008.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749495PMC
June 2008

Diagnosis and manifestations of chronic graft-versus-host disease.

Best Pract Res Clin Haematol 2008 Jun;21(2):251-7

Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152169260800009
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http://dx.doi.org/10.1016/j.beha.2008.02.008DOI Listing
June 2008

Hemophagocytic lymphohistiocytosis and other hemophagocytic disorders.

Immunol Allergy Clin North Am 2008 May;28(2):293-313, viii

Division of Hematology/Oncology, Immunodeficiency and Histiocytosis Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1016/j.iac.2008.01.010DOI Listing
May 2008

Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis.

Br J Haematol 2008 Feb 10;140(3):327-35. Epub 2007 Dec 10.

Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06922.xDOI Listing
February 2008

Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis.

J Pediatr Gastroenterol Nutr 2007 Jul;45(1):22-31

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1097/MPG.0b013e318043c097DOI Listing
July 2007

Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease: a mimicker of sepsis in the pediatric intensive care unit.

Pediatrics 2007 May 2;119(5):e1212-8. Epub 2007 Apr 2.

Division of Pediatric Critical Care Medicine, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1542/peds.2006-1534DOI Listing
May 2007

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.

Pediatr Blood Cancer 2007 Feb;48(2):124-31

Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://www.ourmayagirl.com/resources/HLH_2004_diagnosis_and_
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http://dx.doi.org/10.1002/pbc.21039DOI Listing
February 2007

Hemophagocytic lymphohistiocytosis and related disorders.

Curr Opin Allergy Clin Immunol 2006 Dec;6(6):410-5

Cincinnati Children's Hospital Medical Center, ML 7015, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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https://insights.ovid.com/crossref?an=00130832-200612000-000
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http://dx.doi.org/10.1097/01.all.0000246626.57118.d9DOI Listing
December 2006

Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis.

J Allergy Clin Immunol 2006 Dec 7;118(6):1312-9. Epub 2006 Nov 7.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.jaci.2006.09.007DOI Listing
December 2006

Patients of African ancestry with hemophagocytic lymphohistiocytosis share a common haplotype of PRF1 with a 50delT mutation.

J Pediatr 2006 Jul;149(1):134-7

Divisions of Hematology/Oncology and Human Genetics, Cincinnati Children's Hospital Medical Center and the Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1016/j.jpeds.2006.03.003DOI Listing
July 2006

Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.

J Clin Invest 2006 Jan 22;116(1):182-92. Epub 2005 Dec 22.

Division of Allergy/Immunology and Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1172/JCI26217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1319223PMC
January 2006

Life-threatening hemophagocytic syndromes: current outcomes with hematopoietic stem cell transplantation.

Pediatr Transplant 2005 Dec;9 Suppl 7:87-91

Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

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http://doi.wiley.com/10.1111/j.1399-3046.2005.00449.x
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http://dx.doi.org/10.1111/j.1399-3046.2005.00449.xDOI Listing
December 2005

Healing hemophagocytosis.

Clin Immunol 2005 Nov 11;117(2):121-4. Epub 2005 Jul 11.

Center for Heritable Immune Deficiencies, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1016/j.clim.2005.06.006DOI Listing
November 2005

Two novel CHS1 (LYST) mutations: clinical correlations in an infant with Chediak-Higashi syndrome.

Mol Genet Metab 2005 Jun 25;85(2):125-32. Epub 2005 Mar 25.

Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109671920500074
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http://dx.doi.org/10.1016/j.ymgme.2005.02.011DOI Listing
June 2005

Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis.

Br J Haematol 2005 Jun;129(5):622-30

Childhood Cancer Research Unit, Institution for Woman and Child Health, Karolinska Institutet, Department of Paediatric Haematology and Oncology, Karolinska Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2141.2005.05501.xDOI Listing
June 2005

Rapid detection of intracellular SH2D1A protein in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members.

Blood 2005 Apr 4;105(8):3066-71. Epub 2005 Jan 4.

Division of Hematology/Oncology and Division of Human Genetics, Children's Hospital Medical Center, MLC 7015, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1182/blood-2004-09-3651DOI Listing
April 2005

Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels.

J Physiol 2005 Apr 27;564(Pt 1):131-43. Epub 2005 Jan 27.

Department of Internal Medicine, 231 Albert Sabin Way, University of Cincinnati, Cincinnati, OH 45267-0585, USA.

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http://doi.wiley.com/10.1113/jphysiol.2004.081893
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http://dx.doi.org/10.1113/jphysiol.2004.081893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456048PMC
April 2005

Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency.

J Pediatr Hematol Oncol 2004 Sep;26(9):601-5

Pediatric Residency Training Program, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1097/01.mph.0000135283.77668.6aDOI Listing
September 2004

Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.

J Allergy Clin Immunol 2004 Jan 12;113(1):115-9. Epub 2003 Dec 12.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1016/j.jaci.2003.10.049DOI Listing
January 2004

Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation.

J Immunol 2003 Jan;170(2):695-702

Departments of. Internal Medicine, and Molecular and Cellular Physiology, University of Cincinnati, OH 45267, USA.

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http://dx.doi.org/10.4049/jimmunol.170.2.695DOI Listing
January 2003