Publications by authors named "Alexandra Florin"

36Publications

CD74 is dispensable for development of chronic lymphocytic leukemia in -TCL1 transgenic mice.

Leuk Lymphoma 2020 Jul 15:1-12. Epub 2020 Jul 15.

University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Germany.

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http://dx.doi.org/10.1080/10428194.2020.1791851DOI Listing
July 2020

The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids.

Cancer Res 2018 08 18;78(16):4533-4548. Epub 2018 Jun 18.

Interdisciplinary Cluster for Applied Genoproteomics (GIGA), GIGA-Molecular Biology of Diseases, University of Liege, CHU, Sart-Tilman, Liège, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3149DOI Listing
August 2018

LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia.

Cancer Cell 2016 10;30(4):610-622

Department I of Internal Medicine, University Hospital of Cologne, Center for Integrated Oncology Cologne-Bonn, CECAD Center of Excellence on "Cellular Stress Responses in Aging-Associated Diseases", University of Cologne, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.007DOI Listing
October 2016

The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.

Cancer Res 2016 05 15;76(9):2587-99. Epub 2016 Mar 15.

Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, Liège, Belgium. Laboratory of Medical Chemistry, GIGA Molecular Biology of Diseases, University of Liege, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), University of Liege, Liège, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1473DOI Listing
May 2016

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.

Clin Cancer Res 2016 05 2;22(10):2470-81. Epub 2015 Dec 2.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany. German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany. Neuroblastoma Genomics, B087, German Cancer Research Center (DKFZ), Heidelberg, Germany. Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1449DOI Listing
May 2016

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

J Exp Med 2015 Nov 2;212(12):2057-75. Epub 2015 Nov 2.

Interdisciplinary Cluster for Applied Genoproteomics, University of Liège, 4000 Liège, Belgium Laboratory of Medical Chemistry, University of Liège, 4000 Liège, Belgium GIGA-Signal Transduction, University of Liège, 4000 Liège, Belgium Walloon Excellence in Life Sciences and Biotechnology, 1300 Wavre, Belgium

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http://dx.doi.org/10.1084/jem.20142288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647259PMC
November 2015

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients.

J Thorac Oncol 2015 Jul;10(7):1049-57

*Institute of Pathology, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Cologne/Bonn, University Hospital of Cologne, Cologne, Germany; ‡Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; §Labor Dr. Quade und Kollegen GmbH, Cologne, Germany; ‖Institute of Human Genetics, University of Cologne, Cologne, Germany; ¶Targos Molecular Pathology GmbH, Kassel, Germany; #Department of Translational Genomics, University of Cologne, Cologne, Germany; **Cologne Center for Genomics, Cologne, Germany; ††GENterprise GENOMICS GmbH, Mainz, Germany; ‡‡Bristol-Myers Squibb R&D, Princeton, New Jersey; §§Evangelische Kliniken Johanniter, Bonn, Germany; ‖‖Malteser Krankenhaus, Lung Cancer Center, Bonn, Germany; ¶¶Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; ##Institute for Hematopathology Hamburg, Hamburg, Germany; and ***New Oncology, Cologne, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000570DOI Listing
July 2015

Enhanced FHL2 and TGF-β1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas.

Am J Clin Pathol 2015 Feb;143(2):248-56; quiz 307

From the Institute of Pathology, University of Cologne Medical School, Cologne, Germany;

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http://dx.doi.org/10.1309/AJCPXEC6CIT2TXAFDOI Listing
February 2015

Transient antiangiogenic treatment improves delivery of cytotoxic compounds and therapeutic outcome in lung cancer.

Cancer Res 2014 May 27;74(10):2816-24. Epub 2014 Mar 27.

Authors' Affiliations: Clinic I of Internal Medicine and Center for Integrated Oncology, University Hospital Cologne; Max Planck Institute for Neurological Research; Center for Molecular Medicine; Max Planck Institute for Biology of Aging; and Institute of Pathology, University Hospital Medical School, Cologne, GermanyAuthors' Affiliations: Clinic I of Internal Medicine and Center for Integrated Oncology, University Hospital Cologne; Max Planck Institute for Neurological Research; Center for Molecular Medicine; Max Planck Institute for Biology of Aging; and Institute of Pathology, University Hospital Medical School, Cologne, GermanyAuthors' Affiliations: Clinic I of Internal Medicine and Center for Integrated Oncology, University Hospital Cologne; Max Planck Institute for Neurological Research; Center for Molecular Medicine; Max Planck Institute for Biology of Aging; and Institute of Pathology, University Hospital Medical School, Cologne, Germany

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2986DOI Listing
May 2014

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

Cancer Discov 2014 Feb 3;4(2):246-57. Epub 2013 Dec 3.

1Department of Translational Genomics, University of Cologne; 2Max-Planck-Institute for Neurological Research; Institutes of 3Pathology and 4Virology, University of Cologne;5Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne; 6Blackfield AG, Cologne; 7Technical University Dortmund, Dortmund, Germany; 8Medical Oncology and 9Institute of Pathology, Cantonal Hospital, Luzern; 10Novartis Pharma AG, Basel, Switzerland; and 11Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0323DOI Listing
February 2014

Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts.

Int J Oncol 2011 Nov 9;39(5):1073-82. Epub 2011 Aug 9.

Department of Obstetrics and Gynecology, University of Würzburg, D-97080 Würzburg, Germany.

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http://dx.doi.org/10.3892/ijo.2011.1152DOI Listing
November 2011

Identification of ETS-1 target genes in human fibroblasts.

Int J Oncol 2011 Jun 21;38(6):1645-52. Epub 2011 Mar 21.

Universitätsfrauenklinik Würzburg, D-97080 Würzburg, Germany.

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http://www.spandidos-publications.com/10.3892/ijo.2011.981
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http://dx.doi.org/10.3892/ijo.2011.981DOI Listing
June 2011

Tumour-stroma interactions between metastatic prostate cancer cells and fibroblasts.

Int J Mol Med 2006 Nov;18(5):941-50

Institute of Pathology, University of Bonn, 53011 Bonn, Germany.

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November 2006

Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth.

Oncogene 2005 Aug;24(34):5384-8

Institute of Pathology, University of Bonn, PO Box 2120, 53011 Bonn, Germany.

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http://dx.doi.org/10.1038/sj.onc.1208761DOI Listing
August 2005

The Ets 1 transcription factor is upregulated during inflammatory angiogenesis in rheumatoid arthritis.

J Mol Med (Berl) 2002 Apr 24;80(4):258-66. Epub 2002 Jan 24.

Institute of Pathology, University of Bonn, P.O. Box 2120, 53011 Bonn, Germany.

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http://dx.doi.org/10.1007/s00109-001-0316-0DOI Listing
April 2002