Alexandra C Newton

Alexandra C Newton

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Alexandra C Newton

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PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.

Elife 2019 08 13;8. Epub 2019 Aug 13.

Department of Pharmacology, University of California, San Diego, San Diego, United States.

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http://dx.doi.org/10.7554/eLife.48609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692130PMC
August 2019

Protein kinases in tune.

IUBMB Life 2019 06 6;71(6):670-671. Epub 2019 May 6.

Department of Pharmacology, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1002/iub.2065DOI Listing
June 2019

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Mol Cell 2019 04 20;74(2):378-392.e5. Epub 2019 Mar 20.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504549PMC
April 2019

Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation.

Nat Cell Biol 2019 03 25;21(3):359-371. Epub 2019 Feb 25.

Department of Pharmacology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41556-019-0291-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546105PMC
March 2019

Protein kinase C: perfectly balanced.

Crit Rev Biochem Mol Biol 2018 04;53(2):208-230

a Department of Pharmacology , University of California at San Diego , La Jolla , CA , USA.

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http://dx.doi.org/10.1080/10409238.2018.1442408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901981PMC
April 2018

Protein kinase C as a tumor suppressor.

Semin Cancer Biol 2018 02 2;48:18-26. Epub 2017 May 2.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0721, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668200PMC
February 2018

Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor.

Trends Pharmacol Sci 2017 05 8;38(5):438-447. Epub 2017 Mar 8.

Laboratory of Cell and Developmental Signaling, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Cancer Research UK Manchester Institute, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403564PMC
May 2017

PHLPPing through history: a decade in the life of PHLPP phosphatases.

Biochem Soc Trans 2016 12;44(6):1675-1682

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0721, U.S.A.

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http://dx.doi.org/10.1042/BST20160170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783572PMC
December 2016

KinView: a visual comparative sequence analysis tool for integrated kinome research.

Mol Biosyst 2016 11;12(12):3651-3665

Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA. and Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1039/c6mb00466kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508867PMC
November 2016

Protein kinase C mechanisms that contribute to cardiac remodelling.

Clin Sci (Lond) 2016 09;130(17):1499-510

Department of Pharmacology, Columbia University, New York, NY 10032, U.S.A.

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http://dx.doi.org/10.1042/CS20160036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024564PMC
September 2016

Second Messengers.

Cold Spring Harb Perspect Biol 2016 08 1;8(8). Epub 2016 Aug 1.

Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195.

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http://dx.doi.org/10.1101/cshperspect.a005926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968160PMC
August 2016

Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity.

J Biol Chem 2016 Jul 13;291(27):13964-73. Epub 2016 May 13.

From the Departments of Pediatrics and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093,

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http://dx.doi.org/10.1074/jbc.M115.695866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933157PMC
July 2016

Protein Scaffolds Control Localized Protein Kinase Cζ Activity.

J Biol Chem 2016 Jun 3;291(26):13809-22. Epub 2016 May 3.

From the Department of Pharmacology and

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http://dx.doi.org/10.1074/jbc.M116.729483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919463PMC
June 2016

Bacterial spore coat protein kinases: A new twist to an old story.

Proc Natl Acad Sci U S A 2016 06 10;113(25):6811-2. Epub 2016 Jun 10.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093.

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http://dx.doi.org/10.1073/pnas.1607004113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922189PMC
June 2016

Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease.

Sci Signal 2016 May 10;9(427):pc11. Epub 2016 May 10.

Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aaf9436DOI Listing
May 2016

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Sci Signal 2016 05 10;9(427):ra47. Epub 2016 May 10.

Department of Neurosciences and Division of Biology, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/scisignal.aaf6209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154619PMC
May 2016

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.

Cell Rep 2015 Aug 13;12(8):1252-60. Epub 2015 Aug 13.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551583PMC
August 2015

Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.

J Biol Chem 2015 Jun 7;290(26):16272-80. Epub 2015 May 7.

From the Department of Orthopedic Surgery, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905 and

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http://dx.doi.org/10.1074/jbc.M114.612937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481226PMC
June 2015

Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.

Proc Natl Acad Sci U S A 2015 Mar 17;112(9):E937-46. Epub 2015 Feb 17.

Departments of Medicine and Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1073/pnas.1420140112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352799PMC
March 2015

Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation.

Chem Biol 2015 Jan 31;22(1):98-106. Epub 2014 Dec 31.

Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311772PMC
January 2015

Tuning the signalling output of protein kinase C.

Biochem Soc Trans 2014 Dec;42(6):1477-83

*Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, U.S.A.

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http://dx.doi.org/10.1042/BST20140172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783555PMC
December 2014

Turning off AKT: PHLPP as a drug target.

Annu Rev Pharmacol Toxicol 2014 ;54:537-58

Department of Pharmacology, University of California, San Diego, La Jolla, California 92093; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-011112-140338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082184PMC
September 2014

Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.

Biochemistry 2014 Jun 12;53(24):3971-81. Epub 2014 Jun 12.

Department of Pharmacology, University of California San Diego , La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/bi500428jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072346PMC
June 2014

Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

Mol Cell 2014 May 3;54(3):378-91. Epub 2014 Apr 3.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA; Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019712PMC
May 2014

Imaging kinase activity at protein scaffolds.

Methods Mol Biol 2014 ;1071:129-37

Department of Pharmacology, University of California at San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1007/978-1-62703-622-1_10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043534PMC
April 2014

Intramolecular conformational changes optimize protein kinase C signaling.

Chem Biol 2014 Apr 13;21(4):459-469. Epub 2014 Mar 13.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020788PMC
April 2014

Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling.

Mol Cell Proteomics 2013 Dec 20;12(12):3498-508. Epub 2013 Jun 20.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-0721;

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http://newtonlab.ucsd.edu/documents/AntalandNewton2013.pdf
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http://www.mcponline.org/lookup/doi/10.1074/mcp.R113.029819
Publisher Site
http://dx.doi.org/10.1074/mcp.R113.029819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861703PMC
December 2013

Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα.

J Biol Chem 2013 Jun 15;288(23):16905-15. Epub 2013 Apr 15.

Department of Pharmacology, University of California San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M113.467456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675623PMC
June 2013

Protein kinase C pharmacology: refining the toolbox.

Biochem J 2013 Jun;452(2):195-209

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1042/BJ20130220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079666PMC
June 2013

Suppression of survival signalling pathways by the phosphatase PHLPP.

FEBS J 2013 Jan 16;280(2):572-83. Epub 2012 Mar 16.

Biomedical Sciences Graduate Program, University of California, San Diego, CA 92093-0721, USA.

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http://doi.wiley.com/10.1111/j.1742-4658.2012.08537.x
Publisher Site
http://dx.doi.org/10.1111/j.1742-4658.2012.08537.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770140PMC
January 2013

Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging.

J Biol Chem 2012 Nov 17;287(45):37891-906. Epub 2012 Sep 17.

Department of Pharmacology, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M112.412635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488061PMC
November 2012

Shedding light on local kinase activation.

BMC Biol 2012 Jul 17;10:61. Epub 2012 Jul 17.

Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine,1959 Pacific Ave, NE, Seattle, WA 98195 USA.

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http://dx.doi.org/10.1186/1741-7007-10-61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398854PMC
July 2012

Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.

J Biol Chem 2012 Apr 8;287(16):13262-78. Epub 2012 Feb 8.

Department of Pharmacology, Graduate Program, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M112.349753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339987PMC
April 2012

Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory.

J Biol Chem 2012 Apr 29;287(16):12879-85. Epub 2012 Feb 29.

Department of Pharmacology, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M112.357244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339930PMC
April 2012

Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.

J Biol Chem 2012 Feb 5;287(6):3610-6. Epub 2011 Dec 5.

Department of Pharmacology, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.R111.318675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281723PMC
February 2012

Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2.

J Biol Chem 2011 Nov 9;286(45):39122-9. Epub 2011 Sep 9.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M111.278747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234737PMC
November 2011

Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

J Biol Chem 2011 Aug 29;286(33):28922-30. Epub 2011 Jun 29.

Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M111.272526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190699PMC
August 2011

Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1).

J Biol Chem 2011 Jul 11;286(26):23552-8. Epub 2011 May 11.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M111.258004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123118PMC
July 2011

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells.

J Immunol 2011 May 15;186(10):5533-7. Epub 2011 Apr 15.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4E3.

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http://dx.doi.org/10.4049/jimmunol.1002126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015973PMC
May 2011

Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases.

J Biol Chem 2010 Dec 19;285(53):41896-910. Epub 2010 Oct 19.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M110.184028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009917PMC
December 2010

Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.

J Med Chem 2010 Oct;53(19):6899-911

Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093.

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http://dx.doi.org/10.1021/jm100331dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951065PMC
October 2010

Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes.

J Biol Chem 2010 Jul 2;285(30):22748-52. Epub 2010 Jun 2.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.C110.123133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906264PMC
July 2010

Protein kinase C: poised to signal.

Am J Physiol Endocrinol Metab 2010 Mar 24;298(3):E395-402. Epub 2009 Nov 24.

Dept. of Pharmacology, Univ. of California at San Diego, La Jolla, 92093, USA.

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http://dx.doi.org/10.1152/ajpendo.00477.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838521PMC
March 2010

Interaction with AKAP79 modifies the cellular pharmacology of PKC.

Mol Cell 2010 Feb;37(4):541-50

Department of Pharmacology, 360 Med Surge II, University of California, Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014287PMC
February 2010

Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock.

Proc Natl Acad Sci U S A 2010 Jan 4;107(4):1642-7. Epub 2010 Jan 4.

Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1073/pnas.0910292107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824391PMC
January 2010

Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters.

Curr Protoc Chem Biol 2009 Dec;1(1):17-18

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0721.

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http://dx.doi.org/10.1002/9780470559277.ch090106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146362PMC
December 2009

The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity.

J Biol Chem 2009 Sep 6;284(36):24653-61. Epub 2009 Jul 6.

Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.024547
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http://dx.doi.org/10.1074/jbc.M109.024547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782054PMC
September 2009

Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.

J Biol Chem 2009 May 26;284(22):15215-23. Epub 2009 Mar 26.

Department of Pharmacology and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0721, USA.

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http://newtonlab.ucsd.edu/documents/Brognardetal.2009.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M901468200
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http://dx.doi.org/10.1074/jbc.M901468200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685702PMC
May 2009

Lipid activation of protein kinases.

J Lipid Res 2009 Apr 24;50 Suppl:S266-71. Epub 2008 Nov 24.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1194/jlr.R800064-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674703PMC
April 2009

The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.

J Biol Chem 2009 Feb 17;284(8):4921-35. Epub 2008 Dec 17.

Pharmacology Department, University of California, San Diego, La Jolla, California 92039-0721, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M808436200
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http://dx.doi.org/10.1074/jbc.M808436200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643500PMC
February 2009

Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm.

IUBMB Life 2008 Dec;60(12):782-9

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1002/iub.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718795PMC
December 2008

Protein kinase C.

IUBMB Life 2008 Nov;60(11):765-8

Department of Pharmacology, University of California San Diego, La Jolla, CA 92130-0721, USA.

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http://dx.doi.org/10.1002/iub.118DOI Listing
November 2008

AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.

Mol Cell 2008 Oct;32(2):169-79

Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169907PMC
October 2008

PHLiPPing the switch on Akt and protein kinase C signaling.

Trends Endocrinol Metab 2008 Aug 27;19(6):223-30. Epub 2008 May 27.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0721, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104327600800081
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http://dx.doi.org/10.1016/j.tem.2008.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963565PMC
August 2008

The life and death of protein kinase C.

Curr Drug Targets 2008 Aug;9(8):614-25

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0721, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783564PMC
http://dx.doi.org/10.2174/138945008785132411DOI Listing
August 2008

The phosphatase PHLPP controls the cellular levels of protein kinase C.

J Biol Chem 2008 Mar 27;283(10):6300-11. Epub 2007 Dec 27.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M707319200
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http://dx.doi.org/10.1074/jbc.M707319200DOI Listing
March 2008

Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy.

J Biol Chem 2008 Mar 10;283(12):7885-93. Epub 2008 Jan 10.

Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1074/jbc.M709943200DOI Listing
March 2008

Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007).

IUBMB Life 2007 Dec;59(12):741-3

Department of Pharmacology, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1080/15216540701697438DOI Listing
December 2007

Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.

J Biol Chem 2007 Nov 24;282(46):33776-87. Epub 2007 Sep 24.

Department of Pharmacology, Molecular Pathology Graduate Program, University of California at San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M703320200DOI Listing
November 2007

Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.

J Biol Chem 2007 Mar 21;282(9):6733-42. Epub 2006 Dec 21.

Department of Pharmacology and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M608086200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921767PMC
March 2007

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.

Mol Cell 2007 Mar;25(6):917-31

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650700117
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http://dx.doi.org/10.1016/j.molcel.2007.02.017DOI Listing
March 2007

A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production.

J Biol Chem 2007 Jan 27;282(2):826-30. Epub 2006 Oct 27.

Biomedical Sciences Graduate Program and Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.C600268200DOI Listing
January 2007

Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling.

J Biol Chem 2006 Oct 10;281(41):30947-56. Epub 2006 Aug 10.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA.

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October 2006

Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70.

J Biol Chem 2006 Oct 5;281(43):32461-8. Epub 2006 Sep 5.

Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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October 2006

Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment.

J Biol Chem 2006 Jan 17;281(3):1660-9. Epub 2005 Nov 17.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M510251200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913972PMC
January 2006

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.

Mol Cell 2005 Apr;18(1):13-24

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.03.008DOI Listing
April 2005

Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.

J Biol Chem 2005 Feb 6;280(7):5581-7. Epub 2004 Dec 6.

Department of Pharmacology and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M411534200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913970PMC
February 2005

The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.

J Biol Chem 2004 Sep 21;279(36):37518-27. Epub 2004 Jun 21.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-0721, USA.

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September 2004

Diacylglycerol's affair with protein kinase C turns 25.

Trends Pharmacol Sci 2004 Apr;25(4):175-7

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0640, USA.

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http://dx.doi.org/10.1016/j.tips.2004.02.010DOI Listing
April 2004

The ins and outs of protein kinase C.

Methods Mol Biol 2003 ;233:3-7

Department of Pharmacology, University of California at San Diego, La Jolla, USA.

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http://dx.doi.org/10.1385/1-59259-397-6:3DOI Listing
February 2004

Measuring the interaction of protein kinase C with membranes: an introduction.

Methods Mol Biol 2003 ;233:89-92

Department of Pharmacology, University of California at San Diego, La Jolla, USA.

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February 2004

Measuring the binding of protein kinase C to sucrose-loaded vesicles.

Methods Mol Biol 2003 ;233:105-13

Department of Pharmacology, University of California at San Diego, La Jolla, USA.

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February 2004

Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C.

Methods Mol Biol 2003 ;233:115-28

US Genomics, Woburn, MA, USA.

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February 2004

Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis.

J Biol Chem 2004 Feb 1;279(6):4829-39. Epub 2003 Nov 1.

Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California 92093-0640, USA.

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February 2004

Pathway illuminated: visualizing protein kinase C signaling.

IUBMB Life 2003 Dec;55(12):653-60

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0640, USA.

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http://dx.doi.org/10.1080/152165401310001642216DOI Listing
December 2003

Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light.

Biochem J 2003 Sep;374(Pt 2):537-43

Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0640, USA.

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http://dx.doi.org/10.1042/BJ20030408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223618PMC
September 2003

Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C.

Biochemistry 2003 Sep;42(38):11194-202

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-0640, USA.

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http://dx.doi.org/10.1021/bi0350046DOI Listing
September 2003

A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.

Proc Natl Acad Sci U S A 2003 Aug 24;100(16):9470-5. Epub 2003 Jul 24.

Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1073/pnas.1633695100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC170942PMC
August 2003

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C.

J Cell Biol 2003 Jun 2;161(5):899-909. Epub 2003 Jun 2.

Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA.

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http://dx.doi.org/10.1083/jcb.200302125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172956PMC
June 2003

Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions.

J Org Chem 2003 Jun;68(13):5028-36

Departments of Chemistry and Pharmacology, University of California, San Diego, La Jolla, California 92093, USA.

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June 2003