Publications by authors named "Alexander N Gorelick"

7Publications

TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors.

Authors:
Emiliano Cocco Ji Eun Lee Srinivasaraghavan Kannan Alison M Schram Helen H Won Sophie Shifman Amanda Kulick Laura Baldino Eneda Toska Amaia Arruabarrena-Aristorena Srushti Kittane Fan Wu Yanyan Cai Sabrina Arena Benedetta Mussolin Ram Kannan Neil Vasan Alexander N Gorelick Michael F Berger Ofra Novoplansky Sankar Jagadeeshan Yi Liao Uwe Rix Sandra Misale Barry S Taylor Alberto Bardelli Jaclyn F Hechtman David M Hyman Moshe Elkabets Elisa de Stanchina Chandra S Verma Andrea Ventura Alexander Drilon Maurizio Scaltriti

Cancer Discov 2020 Oct 1. Epub 2020 Oct 1.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article and Find Full Text PDF
October 2020

Leveraging Systematic Functional Analysis to Benchmark an Framework Distinguishes Driver from Passenger MEK Mutants in Cancer.

Authors:
Aphrothiti J Hanrahan Brooke E Sylvester Matthew T Chang Arijh Elzein Jianjiong Gao Weiwei Han Ye Liu Dong Xu Sizhi P Gao Alexander N Gorelick Alexis M Jones Amber J Kiliti Moriah H Nissan Clare A Nimura Abigail N Poteshman Zhan Yao Yijun Gao Wenhuo Hu Hannah C Wise Elena I Gavrila Alexander N Shoushtari Shakuntala Tiwari Agnes Viale Omar Abdel-Wahab Taha Merghoub Michael F Berger Neal Rosen Barry S Taylor David B Solit

Cancer Res 2020 10 8;80(19):4233-4243. Epub 2020 Jul 8.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article and Find Full Text PDF
October 2020

Phase and context shape the function of composite oncogenic mutations.

Authors:
Alexander N Gorelick Francisco J Sánchez-Rivera Yanyan Cai Craig M Bielski Evan Biederstedt Philip Jonsson Allison L Richards Neil Vasan Alexander V Penson Noah D Friedman Yu-Jui Ho Timour Baslan Chaitanya Bandlamudi Maurizio Scaltriti Nikolaus Schultz Scott W Lowe Ed Reznik Barry S Taylor

Nature 2020 06 27;582(7810):100-103. Epub 2020 May 27.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

View Article and Find Full Text PDF
June 2020

Putative Drivers of Aggressiveness in TCEB1-mutant Renal Cell Carcinoma: An Emerging Entity with Variable Clinical Course.

Authors:
Renzo G DiNatale Alexander N Gorelick Vladimir Makarov Kyle A Blum Andrew W Silagy Benjamin Freeman Diego Chowell Julian Marcon Roy Mano Alex Sanchez Kyrollis Attalla Stanley Weng Martin Voss Robert J Motzer Paul Russo Jonathan A Coleman Victor E Reuter Ying-Bei Chen Timothy A Chan Ed Reznik Satish K Tickoo A Ari Hakimi

Eur Urol Focus 2019 Dec 6. Epub 2019 Dec 6.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

View Article and Find Full Text PDF
December 2019

Efficacy and Determinants of Response to HER Kinase Inhibition in -Mutant Metastatic Breast Cancer.

Authors:
Lillian M Smyth Sarina A Piha-Paul Helen H Won Alison M Schram Cristina Saura Sherene Loi Janice Lu Geoffrey I Shapiro Dejan Juric Ingrid A Mayer Carlos L Arteaga Macarena I de la Fuente Adam M Brufksy Iben Spanggaard Morten Mau-Sørensen Monica Arnedos Victor Moreno Valentina Boni Joohyuk Sohn Lee S Schwartzberg Xavier Gonzàlez-Farré Andrés Cervantes François-Clement Bidard Alexander N Gorelick Richard B Lanman Rebecca J Nagy Gary A Ulaner Sarat Chandarlapaty Komal Jhaveri Elena I Gavrila Catherine Zimel S Duygu Selcuklu Myra Melcer Aliaksandra Samoila Yanyan Cai Maurizio Scaltriti Grace Mann Feng Xu Lisa D Eli Melanie Dujka Alshad S Lalani Richard Bryce José Baselga Barry S Taylor David B Solit Funda Meric-Bernstam David M Hyman

Cancer Discov 2020 02 5;10(2):198-213. Epub 2019 Dec 5.

Memorial Sloan Kettering Cancer Center, New York, New York.

View Article and Find Full Text PDF
February 2020

Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis.

Authors:
Justin Taylor Maria Sendino Alexander N Gorelick Alessandro Pastore Matthew T Chang Alexander V Penson Elena I Gavrila Connor Stewart Ella M Melnik Florisela Herrejon Chavez Lillian Bitner Akihide Yoshimi Stanley Chun-Wei Lee Daichi Inoue Bo Liu Xiao J Zhang Anthony R Mato Ahmet Dogan Michael G Kharas Yuhong Chen Demin Wang Rajesh K Soni Ronald C Hendrickson Gorka Prieto Jose A Rodriguez Barry S Taylor Omar Abdel-Wahab

Cancer Discov 2019 10 8;9(10):1452-1467. Epub 2019 Jul 8.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article and Find Full Text PDF
October 2019

V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer.

Authors:
Yijun Gao Ann Maria Na Na Arnaud da Cruz Paula Alexander N Gorelick Jaclyn F Hechtman Julianne Carson Robert A Lefkowitz Britta Weigelt Barry S Taylor HuiYong Zhao Jorge S Reis-Filho Elisa de Stanchina Neal Rosen Zhan Yao Rona Yaeger

Cancer Discov 2019 09 21;9(9):1182-1191. Epub 2019 Jun 21.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article and Find Full Text PDF
September 2019