Publications by authors named "Alexander Marx"

100Publications

[Thymoma and squamous thymic carcinoma diagnosis; experience from the RYTHMIC network].

Ann Pathol 2020 Dec 10. Epub 2020 Dec 10.

Inserm U1163, service d'anatomie pathologique, institut imagine, université de Paris, hôpital universitaire Necker-Enfants malades, AP-HP centre, 149, rue de Sèvres, 75015 Paris, France. Electronic address:

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December 2020

Cancer Acidity and Hypertonicity Contribute to Dysfunction of Tumor-Associated Dendritic Cells: Potential Impact on Antigen Cross-Presentation Machinery.

Cancers (Basel) 2020 Aug 24;12(9). Epub 2020 Aug 24.

Institute of Pathology, University Hospital Mannheim, University of Heidelberg, 68167 Mannheim, Germany.

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August 2020

Programmed death-ligand 1 expression profiling in thymic epithelial cell tumors: Clinicopathological features and quantitative digital image analyses.

Lung Cancer 2020 07 6;145:40-47. Epub 2020 May 6.

Division of Thoracic Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan. Electronic address:

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July 2020

Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma.

Virchows Arch 2020 Feb 10;476(2):323-327. Epub 2019 Aug 10.

Institute of Pathology, University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

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February 2020

Bilateral Inguinal Ulcerations as First Presentation of Acute Myeloid Leukaemia.

Acta Derm Venereol 2019 Oct;99(11):1041-1042

Department of Dermatology, Venereology and Allergy, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim, 68167 Mannheim, Germany.

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October 2019

Signs heralding appearance of thymomas after extended thymectomy for myasthenia gravis.

Neurol Clin Pract 2019 Feb;9(1):48-52

Departments of Neurology (ES, AMS) and Pathology (CL), Clinical Immunology (A. Marinho) Hospital Santo Antonio/ Centro Hospitalar Universitario do Porto; Instituto de Ciencias Biomedicas de Abel Salazar (ES, AMS, GG), University of Porto, Portugal; Institute of Pathology (PS), University Medical Center Göttingen, University of Göttingen, Germany; Neurosciences Group (NW, MIL), Nuffield Department of Clinical Neurology, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, UK; and Institute of Pathology (A. Marx), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.

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February 2019

MicroRNA and mRNA expression associated with ectopic germinal centers in thymus of myasthenia gravis.

PLoS One 2018 11;13(10):e0205464. Epub 2018 Oct 11.

Department of Neurology, George Washington University, Washington, D.C., United States of America.

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March 2019

Extensive intraperitoneal lavage to eliminate intraperitoneal tumor cells in gastrectomy with D2 lymphadenectomy for gastric cancer.

Tumori 2018 Oct 5;104(5):361-368. Epub 2018 Sep 5.

2 Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.

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October 2018

Prostate cancer treatment by the latest focal HIFU device with MRI/TRUS-fusion control biopsies: A prospective evaluation.

Urol Oncol 2018 09 6;36(9):401.e1-401.e9. Epub 2018 Aug 6.

Department of Urology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

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September 2018

gene amplification is a rare event in atypical fibroxanthoma and pleomorphic dermal sarcoma.

Oncotarget 2018 Apr 20;9(30):21182-21189. Epub 2018 Apr 20.

Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.

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April 2018

Author Correction: Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

Sci Rep 2018 Apr 18;8(1):6361. Epub 2018 Apr 18.

Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.

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April 2018

GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.

Biochem Biophys Res Commun 2018 02 1;497(1):32-38. Epub 2018 Feb 1.

Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Center of Excellence in Dermatology, Mannheim, Germany; European Center for Angioscience, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address:

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February 2018

Challenging the current model of early-onset myasthenia gravis pathogenesis in the light of the MGTX trial and histological heterogeneity of thymectomy specimens.

Ann N Y Acad Sci 2018 02 28;1413(1):82-91. Epub 2018 Jan 28.

Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.

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February 2018

Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

Sci Rep 2018 01 10;8(1):313. Epub 2018 Jan 10.

Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.

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January 2018

Insulin-like growth factor 2 expression in prostate cancer is regulated by promoter-specific methylation.

Mol Oncol 2018 02 4;12(2):256-266. Epub 2018 Jan 4.

Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Germany.

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February 2018

AB thymoma with atypical type A component with delayed multiple lung and brain metastases.

J Thorac Dis 2017 Sep;9(9):E808-E814

Department of Pathology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.

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September 2017

Prevalence and Incidence of Autoimmune Pancreatitis in the Population Living in the Southwest of Germany.

Digestion 2017 11 29;96(4):187-198. Epub 2017 Sep 29.

Department of Medicine II, University Medical Centre Mannheim, Medical Faculty of the University of Heidelberg, Mannheim, Germany.

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November 2017

Modeling of Immunotherapy and Stroma-Targeting Therapies in Human Colorectal Cancer.

Cancer Res 2017 11 18;77(22):6442-6452. Epub 2017 Sep 18.

Department of Medical Oncology and Internal Medicine VI, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

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November 2017

P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1.

Int J Cancer 2017 11 24;141(9):1879-1890. Epub 2017 Jul 24.

Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, University of Heidelberg, Germany.

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November 2017

Diagnosing autoimmune pancreatitis with the Unifying-Autoimmune-Pancreatitis-Criteria.

Pancreatology 2017 May - Jun;17(3):381-394. Epub 2017 Mar 18.

Department of Medicine II, University Medical Centre Mannheim, University of Heidelberg, Germany; Department of Clinical Science, Intervention & Technology, Karolinska Institute, Stockholm, Sweden.

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March 2018

Identification of a characteristic vascular belt zone in human colorectal cancer.

PLoS One 2017 2;12(3):e0171378. Epub 2017 Mar 2.

Institute of Pathology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.

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August 2017

Sentinel node metastasis mitotic rate (SN-MMR) as a prognostic indicator of rapidly progressing disease in patients with sentinel node-positive melanomas.

Int J Cancer 2017 04;140(8):1907-1917

Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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April 2017

Metastatic type A thymoma: morphological and genetic correlation.

Histopathology 2017 Apr 1;70(5):704-710. Epub 2017 Feb 1.

Institute of Pathology, University Medical Center, Georg-August University, Göttingen, Germany.

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April 2017

Scores for standardization of on-tissue digestion of formalin-fixed paraffin-embedded tissue in MALDI-MS imaging.

Biochim Biophys Acta Proteins Proteom 2017 Jul 6;1865(7):907-915. Epub 2016 Sep 6.

Center for Applied Research in Biomedical Mass Spectrometry (ABIMAS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany; Institute of Medical Technology (IMT), University of Heidelberg and Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany. Electronic address:

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July 2017

Randomized Trial of Thymectomy in Myasthenia Gravis.

N Engl J Med 2016 08;375(6):511-22

From the Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo (G.I.W.), the Department of Neurology, University of Rochester Medical Center, Rochester (E.C.), and the Section of General Thoracic Surgery, Columbia University Medical Center, New York (J.R.S., A.J.) - all in New York; the Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC (H.J.K.); the Department of Biostatistics, University of Alabama at Birmingham, Birmingham (I.B.A., G.M., H.-C.K., G.R.C.); the Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Mannheim (A.M.), the Institute of Pathology, University of Göttingen, Göttingen (P.S.), and the Department of Neurology, Johannes Gutenberg University, Mainz (W.N.) - all in Germany; the Department of Neurology, University of Buenos Aires, Buenos Aires (C.M.); the Division of Neurology, University of British Columbia, Vancouver (J. Oger), and the Department of Neurology, McGill University, Montreal (C.H.C.) - both in Canada; the Department of Neurology, University of Chile, Santiago (J.G.C.); the Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa (J.M.H.); the Department of Neurology, Catholic University (A.E.), and the Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome (G.A.) - both in Rome; the Division of Neurology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (R.W.); the Department of Neurology, University of Melbourne, Melbourne, VIC, Australia (J.O.K.); the Department of Neurology, University of Southern California, Los Angeles (S.R.B.), and the Department of Neurology, University of California Irvine Medical Center, Orange (T.M.) - both in California; the Department of Neurology, Medical College of Wisconsin, Milwaukee (A.C.B.); the Department of Neurology, Harvard Medical School, Boston (A.A.A.); Nerve and M

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August 2016

Multi-class texture analysis in colorectal cancer histology.

Sci Rep 2016 06 16;6:27988. Epub 2016 Jun 16.

Institute of Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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June 2016

Clinicopathological analysis of 241 thymic epithelial tumors-experience in the Shanghai Chest Hospital from 1997-2004.

J Thorac Dis 2016 Apr;8(4):718-26

1 Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200032, China ; 2 Institute of Pathology, 3 Department of Medical Statistics and Biomathematics, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany ; 4 Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200032, China.

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April 2016

EDISON-WMW: Exact Dynamic Programing Solution of the Wilcoxon-Mann-Whitney Test.

Genomics Proteomics Bioinformatics 2016 Feb 29;14(1):55-61. Epub 2016 Jan 29.

Chair for Clinical Bioinformatics, Medical Faculty, Saarland University, Saarbrücken 66123, Germany. Electronic address:

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February 2016

New Colors for Histology: Optimized Bivariate Color Maps Increase Perceptual Contrast in Histological Images.

PLoS One 2015 30;10(12):e0145572. Epub 2015 Dec 30.

Computer Assisted Clinical Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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June 2016

Myf5 and Myogenin in the development of thymic myoid cells - Implications for a murine in vivo model of myasthenia gravis.

Exp Neurol 2016 Mar 18;277:76-85. Epub 2015 Dec 18.

Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address:

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March 2016

Prognostic Significance and Functional Role of CEP57 in Prostate Cancer.

Transl Oncol 2015 Dec;8(6):487-96

Molecular Urooncology, Department of Urology, Medical Faculty Heidelberg, University of Heidelberg, Im Neuenheimer Feld 517, D-69120 Heidelberg, Germany; Department of Urology, University of Heidelberg School of Medicine, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany. Electronic address:

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December 2015

Direct observation of collective modes coupled to molecular orbital-driven charge transfer.

Science 2015 Dec;350(6267):1501-5

Max Planck Institute for the Structure and Dynamics of Matter, Center for Free Electron Laser Science, Luruper Chaussee 149, 22761 Hamburg, Germany. Hamburg Centre for Ultrafast Imaging, University of Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany. Departments of Chemistry and Physics, University of Toronto, Toronto, Ontario M5S 3H6, Canada.

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December 2015

Choroidal metastases from thymic carcinoma during pregnancy: Case Report.

BMC Cancer 2015 Dec 16;15:972. Epub 2015 Dec 16.

Medizinische Universitaetsklinik Tuebingen, Innere Medizin II fuer Onkologie, Haematologie, Immunologie, Rheumatologie und Pulmologie, Otfried Mueller Str. 10, D-72076, Tuebingen, Germany.

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December 2015

State of the art: diagnostic tools and innovative therapies for treatment of advanced thymoma and thymic carcinoma.

Eur J Cardiothorac Surg 2016 Jun 15;49(6):1545-52. Epub 2015 Dec 15.

Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

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June 2016

Response to Comment on "A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression".

J Immunol 2015 Oct;195(8):3505-6

Department of Molecular Immunology, BIOSS Centre for Biological Signaling Studies, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany; and Center for Chronic Immunodeficiency, University of Freiburg Medical Center, 79104 Freiburg, Germany.

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October 2015

cFLIP overexpression in T cells in thymoma-associated myasthenia gravis.

Ann Clin Transl Neurol 2015 Sep 22;2(9):894-905. Epub 2015 Jul 22.

Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg Mannheim, Germany.

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September 2015

Mesenchymal tumours of the mediastinum--part II.

Virchows Arch 2015 Nov 10;467(5):501-17. Epub 2015 Sep 10.

Department of Pathology, Universitätsmedizin Göttingen, Göttingen, Germany.

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November 2015

Mesenchymal tumours of the mediastinum--part I.

Virchows Arch 2015 Nov 10;467(5):487-500. Epub 2015 Sep 10.

Department of Pathology, Universitätsmedizin Göttingen, Göttingen, Germany.

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November 2015

On the representation of cells in bone marrow pathology by a scalar field: propagation through serial sections, co-localization and spatial interaction analysis.

Diagn Pathol 2015 Sep 2;10:151. Epub 2015 Sep 2.

Computer Assisted Clinical Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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September 2015

The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes.

J Thorac Oncol 2015 Oct;10(10):1383-95

*Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany; †Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China; ‡Department of Pathology, Institut Bergonié, Bordeaux, France; §Department of Thoracic Surgery, Yale University School of Medicine, New Haven, Connecticut; ‖Department of Respiratory Medicine, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France; ¶Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; #Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; **Gemeinschaftspraxis für Pathologie, Zurich, Switzerland; ††Department of Diagnostic Imaging, The Chaim Sheba Medical Center, Tel Hashomer, Israel; ‡‡Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York; §§Department of Diagnostic Pathology, Saiseikai Central Hospital, Tokyo, Japan; ‖‖Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, New York; and ¶¶Department of Pathology, Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.

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October 2015

Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart.

J Thorac Oncol 2015 Sep;10(9):1240-1242

Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.

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September 2015

Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression.

Tumour Biol 2015 Dec 4;36(12):9567-77. Epub 2015 Jul 4.

Division of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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December 2015

Erythematous nodule on the earlobe in a patient from Iraq.

J Dtsch Dermatol Ges 2015 Jun 22;13(6):588-90. Epub 2015 May 22.

Department of Dermatology, Venereology and Allergology, University Hospital Mannheim, Heidelberg University, Mannheim.

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June 2015

Generalized Eruptive Histiocytosis Associated With FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia.

JAMA Dermatol 2015 Jul;151(7):766-9

Department of Dermatology, Venereology, and Allergology, University Medical Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany2Center of Excellence in Dermatology, Mannheim, Germany.

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July 2015

Thymoma related myasthenia gravis in humans and potential animal models.

Exp Neurol 2015 Aug 18;270:55-65. Epub 2015 Feb 18.

Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 13, D-68167 Mannheim, Germany. Electronic address:

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August 2015

The impact of thymoma histotype on prognosis in a worldwide database.

J Thorac Oncol 2015 Feb;10(2):367-72

*Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany; †Section of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut; ‡Division of Thoracic Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut; §Department of Pathology, Regina Elena National Cancer Institute, Rome, Italy; ║Department of Histopathology, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College London, London, United Kingdom; ¶Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York; and #Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.

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February 2015

Sunitinib in thymic carcinoma: enigmas still unresolved.

Lancet Oncol 2015 Feb 13;16(2):124-5. Epub 2015 Jan 13.

Institute of Pathology, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

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February 2015

Prognostic value of immune cell infiltration, tertiary lymphoid structures and PD-L1 expression in Merkel cell carcinomas.

Int J Clin Exp Pathol 2014 15;7(11):7610-21. Epub 2014 Oct 15.

Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg Mannheim, Germany.

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September 2015

Adenocarcinoma of the thymus, enteric type: report of 2 cases, and proposal for a novel subtype of thymic carcinoma.

Am J Surg Pathol 2015 Apr;39(4):541-8

*Department of Thoracic Surgery, Division of Surgery Departments of †Pathology §Radiology, Medical University Vienna ∥Department of Pulmology and Karl Landsteiner Institute of Clinical and Experimental Pneumology, Hietzing Hospital, Vienna, Austria ‡Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Germany.

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April 2015

State of the art of genetic alterations in thymic epithelial tumors.

J Thorac Oncol 2014 Sep;9(9 Suppl 2):S131-6

*Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, Bethesda, MD; †Respiratory Medicine, Thoracic Oncology Service, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, France; and ‡Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.

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September 2014

Histologic classification of thymoma: a practical guide for routine cases.

J Thorac Oncol 2014 Sep;9(9 Suppl 2):S125-30

*Department of Pathology, Maasstad Hospital, Rotterdam, The Netherlands; †Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; ‡Department of Pathology, University of Heidelberg, University Medical Centre Mannheim, Germany; and §Department of Pathology, Regina Elena National Cancer Institute, Rome, Italy.

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September 2014

Type A and AB thymomas: histological features associated with increased stage.

Histopathology 2015 May 10;66(6):884-91. Epub 2014 Nov 10.

Department of Histopathology, Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, UK.

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May 2015