Publications by authors named "Alexander M Tsankov"

19Publications

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Cell Stem Cell 2017 04;20(4):547-557.e7

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.01.010DOI Listing
April 2017

A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs.

Nat Biotechnol 2015 Nov 26;33(11):1173-81. Epub 2015 Oct 26.

Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847940PMC
November 2015

A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.

J Cell Biol 2015 Sep;210(7):1257-68

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138 Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138

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http://dx.doi.org/10.1083/jcb.201502035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586752PMC
September 2015

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.

Nat Genet 2015 May 30;47(5):469-78. Epub 2015 Mar 30.

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [3] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414868PMC
May 2015

Transcription factor binding dynamics during human ES cell differentiation.

Nature 2015 Feb;518(7539):344-9

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA [3] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature14233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499331PMC
February 2015

A comparison of non-integrating reprogramming methods.

Nat Biotechnol 2015 Jan 1;33(1):58-63. Epub 2014 Dec 1.

1] Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [3] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329913PMC
January 2015

Toward a unified physical model of nucleosome patterns flanking transcription start sites.

Proc Natl Acad Sci U S A 2013 Apr 18;110(14):5719-24. Epub 2013 Mar 18.

Department of Physics, Harvard University, Cambridge, MA 02138, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1214048110
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http://dx.doi.org/10.1073/pnas.1214048110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619296PMC
April 2013

Communication between levels of transcriptional control improves robustness and adaptivity.

Mol Syst Biol 2006 28;2:65. Epub 2006 Nov 28.

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/msb4100106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682026PMC
March 2007