Publications by authors named "Alexander M Snoek"

2 Publications

  • Page 1 of 1

Pseudomyxoma Peritonei After a Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm With Colloid Carcinoma in Lynch Syndrome.

Pancreas 2019 01;48(1):135-138

Radiology, St Antonius Hospital, Nieuwegein, the Netherlands.

We report a case of pseudomyxoma peritonei (PMP) arising in a 62-year-old male patient with Lynch syndrome (LS). The patient's medical history included an adenocarcinoma of the colon for which a right hemicolectomy was performed and a pancreatectomy due to an intraductal papillary mucinous neoplasm (IPMN) with invasive colloid carcinoma. It was considered that the PMP could be a metastasis of the earlier colonic or pancreatic carcinoma. The pancreatic carcinoma, colon carcinoma, and PMP tissues were examined, and immunohistochemical and molecular analyses were performed to determine the PMP origin. Histopathologic examination revealed morphological similarities with the pancreatic colloid carcinoma, and further immunohistochemical and molecular analyses, including a shared GNAS mutation, confirmed the pancreatic origin of the PMP. In conclusion, this is a unique case of a patient with LS presenting with PMP originating from an IPMN with invasive colloid carcinoma, several years after pancreatectomy. The present case has important diagnostic implications. The IPMN should be considered as a rare extracolonic manifestation of LS, and pancreatic carcinoma origin should be considered in patients presenting with PMP. This case report highlights the added value of molecular diagnostics in daily pathology practice.
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http://dx.doi.org/10.1097/MPA.0000000000001201DOI Listing
January 2019

Cerebral fat embolism after bone fractures.

Lancet 2015 Oct 25;386(10001):e16. Epub 2015 Jun 25.

Department of Intensive Care, Sint Antonius Ziekenhuis, Nieuwegein, Netherlands; Department of Anaesthesiology, Sint Antonius Ziekenhuis, Nieuwegein, Netherlands.

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http://dx.doi.org/10.1016/S0140-6736(15)60064-2DOI Listing
October 2015