Publications by authors named "Alexander M Menzies"

100Publications

Design and Testing of a Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA.

Cancers (Basel) 2020 Aug 10;12(8). Epub 2020 Aug 10.

Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia.

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http://dx.doi.org/10.3390/cancers12082228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465941PMC
August 2020

Duration of immunotherapy - should we continue ad infinitum?

Intern Med J 2020 Jul;50(7):865-868

Queen Elizabeth Hospital, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/imj.14919DOI Listing
July 2020

The Landmark Series: Neoadjuvant Systemic Therapy (NAST) for Stage 3 Melanoma Patients - A Potential Paradigm Shift in Management.

Ann Surg Oncol 2020 Jul 14;27(7):2188-2200. Epub 2020 May 14.

Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1245/s10434-020-08566-8DOI Listing
July 2020

Thyroid Toxicity Following Immune Checkpoint Inhibitor Treatment in Advanced Cancer.

Thyroid 2020 May 8. Epub 2020 May 8.

Nothern Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.

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http://dx.doi.org/10.1089/thy.2020.0032DOI Listing
May 2020

Intratumoural immunotherapies in oncology.

Eur J Cancer 2020 03 18;127:1-11. Epub 2020 Jan 18.

Melanoma Institute Australia, The University of Sydney, Australia; Royal North Shore and Mater Hospitals, Sydney, Australia.

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http://dx.doi.org/10.1016/j.ejca.2019.12.007DOI Listing
March 2020

Immunotherapy-related acute kidney injury: Kidney biopsy or not?

Nephrology (Carlton) 2020 Jan 12. Epub 2020 Jan 12.

Oncology and Renal Departments, Royal North Shore Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/nep.13687DOI Listing
January 2020

Current management of patients with melanoma who are found to be sentinel node-positive.

ANZ J Surg 2020 04 30;90(4):491-496. Epub 2019 Oct 30.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/ans.15491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216885PMC
April 2020

Preferences for Immunotherapy in Melanoma: A Systematic Review.

Ann Surg Oncol 2020 Feb 29;27(2):571-584. Epub 2019 Oct 29.

NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, NSW, Australia.

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http://dx.doi.org/10.1245/s10434-019-07963-yDOI Listing
February 2020

Checkpoint Inhibitor-Associated Autoimmune Diabetes Is Distinct From Type 1 Diabetes.

J Clin Endocrinol Metab 2019 11;104(11):5499-5506

Melanoma Institute Australia and the University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1210/jc.2019-00423DOI Listing
November 2019

Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia.

Cancer Chemother Pharmacol 2019 04 19;83(4):693-704. Epub 2019 Jan 19.

Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1007/s00280-019-03780-yDOI Listing
April 2019

Has the melanoma information tsunami become a maelstrom?

Melanoma Manag 2017 Dec 14;4(4):179-182. Epub 2017 Sep 14.

Melanoma Institute Australia, The University of Sydney, Sydney NSW 20160, Australia.

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http://dx.doi.org/10.2217/mmt-2017-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094604PMC
December 2017

Omitting radiosurgery in melanoma brain metastases: a drastic and dangerous de-escalation - Authors' reply.

Lancet Oncol 2018 08;19(8):e367

Disciplines of Medical Oncology, Melanoma Institute Australia, University of Sydney, Sydney, NSW 2065, Australia; Royal North Shore and Mater Hospitals, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/S1470-2045(18)30508-4DOI Listing
August 2018

Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study.

Lancet Oncol 2018 05 27;19(5):672-681. Epub 2018 Mar 27.

Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia; Medical, Dental and Health Sciences, University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1016/S1470-2045(18)30139-6DOI Listing
May 2018

Fall in thyroid stimulating hormone (TSH) may be an early marker of ipilimumab-induced hypophysitis.

Pituitary 2018 Jun;21(3):274-282

Department of Endocrinology, St Vincent's Hospital, Darlinghurst, Australia.

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http://dx.doi.org/10.1007/s11102-018-0866-6DOI Listing
June 2018

Survival and prognostic factors for patients with melanoma brain metastases in the era of modern systemic therapy.

Pigment Cell Melanoma Res 2018 07 10;31(4):509-515. Epub 2018 Jan 10.

Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW, Australia.

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http://doi.wiley.com/10.1111/pcmr.12682
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http://dx.doi.org/10.1111/pcmr.12682DOI Listing
July 2018

The spectrum, incidence, kinetics and management of endocrinopathies with immune checkpoint inhibitors for metastatic melanoma.

Eur J Endocrinol 2018 Feb 29;178(2):173-180. Epub 2017 Nov 29.

Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia.

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http://dx.doi.org/10.1530/EJE-17-0810DOI Listing
February 2018

Metastasis-specific patterns of response and progression with anti-PD-1 treatment in metastatic melanoma.

Pigment Cell Melanoma Res 2018 05 7;31(3):404-410. Epub 2017 Dec 7.

Melanoma Institute Australia, Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/pcmr.12675DOI Listing
May 2018

Radiological manifestations of immune-related adverse effects observed in patients with melanoma undergoing immunotherapy.

J Med Imaging Radiat Oncol 2017 Dec 11;61(6):759-766. Epub 2017 Oct 11.

Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/1754-9485.12653DOI Listing
December 2017

Leptomeningeal melanoma-A case series in the era of modern systemic therapy.

Pigment Cell Melanoma Res 2018 01 17;31(1):120-124. Epub 2017 Oct 17.

Department of Medical Oncology, Royal North Shore Hospital, Sydney, Australia.

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http://dx.doi.org/10.1111/pcmr.12652DOI Listing
January 2018

Immune mediated neuropathy following checkpoint immunotherapy.

J Clin Neurosci 2017 Nov 29;45:14-17. Epub 2017 Jul 29.

Department of Neurology, Royal North Shore Hospital, Sydney, NSW, Australia; The University of Sydney, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2017.07.014DOI Listing
November 2017

Mechanisms and strategies to overcome resistance to molecularly targeted therapy for melanoma.

Cancer 2017 06;123(S11):2118-2129

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/cncr.30435DOI Listing
June 2017

Immune Checkpoint Inhibitors for Brain Metastases.

Curr Oncol Rep 2017 Jun;19(6):38

Royal North Shore Hospital, St Leonards, NSW, Australia.

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http://dx.doi.org/10.1007/s11912-017-0596-3DOI Listing
June 2017

Optimum dosing of ipilimumab in melanoma: too little, too late?

Lancet Oncol 2017 05 27;18(5):558-559. Epub 2017 Mar 27.

Melanoma Institute Australia, Royal North Shore and Mater Hospitals, The University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/S1470-2045(17)30228-0DOI Listing
May 2017

Immune checkpoint inhibitors in challenging populations.

Cancer 2017 06 27;123(11):1904-1911. Epub 2017 Feb 27.

Department of Medicine, Melanoma Institute Australia, University of Sydney Royal North Shore and Mater Hospitals, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/cncr.30642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445005PMC
June 2017

Survival of patients with melanoma brain metastasis treated with stereotactic radiosurgery and active systemic drug therapies.

Eur J Cancer 2017 04 23;75:169-178. Epub 2017 Feb 23.

Melanoma Institute Australia, The University of Sydney, NSW, Australia; Genesis Cancer Care, Mater Radiation Oncology, North Sydney, Australia; Mater Hospital, North Sydney NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.01.007DOI Listing
April 2017

A multireferral centre retrospective cohort analysis on the experience in treatment of metastatic uveal melanoma and utilization of sequential liver-directed treatment and immunotherapy.

Melanoma Res 2017 06;27(3):243-250

aDepartment of Medical Oncology, Royal North Shore Hospital bDepartment of Medical Oncology Melanoma Institute Australia cDepartment of Medical Oncology, The University of Sydney, Sydney, New South Wales, Australia dDepartment of Medical Oncology, Istituto Nazionale Tumori 'Fondazione Pascale', Naples, Campania, Italy.

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http://dx.doi.org/10.1097/CMR.0000000000000343DOI Listing
June 2017

Cessation of targeted therapy after a complete response in BRAF-mutant advanced melanoma: a case series.

Br J Cancer 2016 Nov 6;115(11):1280-1284. Epub 2016 Oct 6.

Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione 'G. Pascale', Via Mariano Semmola, 80131 Napoli, Italy.

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http://dx.doi.org/10.1038/bjc.2016.321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129828PMC
November 2016

Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.

J Clin Oncol 2017 Mar 30;35(7):709-717. Epub 2016 Sep 30.

Jarushka Naidoo, Kaitlin M. Woo, Tunc Iyriboz, Darragh Halpenny, Jane Cunningham, Jamie E. Chaft, Neil H. Segal, Margaret K. Callahan, Alexander M. Lesokhin, Jonathan Rosenberg, Martin H. Voss, Charles M. Rudin, Hira Rizvi, Xue Hou, Katherine Rodriguez, Melanie Albano, Ruth-Ann Gordon, Charles Leduc, Natasha Rekhtman, Bianca Harris, Jedd D. Wolchok, Michael A. Postow, and Matthew D. Hellmann, Memorial Sloan Kettering Cancer Center; Jamie E. Chaft, Neil H. Segal, Margaret K. Callahan, Alexander M. Lesokhin, Jonathan Rosenberg, Martin H. Voss, Charles M. Rudin, Jedd D. Wolchok, Michael A. Postow, and Matthew D. Hellmann, Weill Cornell Medical College, New York, NY; Jarushka Naidoo, Sidney Kimmel Cancer Center at Johns Hopkins University, Baltimore, MD; Xuan Wang, Peking University Cancer Hospital and Institute, Beijing; Xue Hou, Sun Yat-sen University Cancer Center, Guangdong Province, People's Republic of China; Xuan Wang, Matteo S. Carlino, Benjamin Y. Kong, and Georgina V. Long, The University of Sydney; Alexander M. Menzies and Alexander D. Guminski, Royal North Shore and Mater Hospital; and Matteo S. Carlino and Benjamin Y. Kong, Westmead and Blacktown Hospitals, Sydney, Australia.

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http://dx.doi.org/10.1200/JCO.2016.68.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559901PMC
March 2017

Recent Developments in Melanoma Therapy.

JAMA Oncol 2016 Oct;2(10):1259-1260

Melanoma Institute Australia, Sydney, Australia2The University of Sydney, Sydney, Australia3Royal North Shore Hospital, Sydney, Australia4Mater Hospital, Sydney, Australia.

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http://dx.doi.org/10.1001/jamaoncol.2016.3418DOI Listing
October 2016

Comparison of whole-exome sequencing of matched fresh and formalin fixed paraffin embedded melanoma tumours: implications for clinical decision making.

Pathology 2016 Apr 9;48(3):261-6. Epub 2016 Mar 9.

Melanoma Institute Australia, North Sydney, NSW, Australia; Discipline of Pathology, Sydney Medical School, The University of Sydney, NSW, Australia; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

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http://dx.doi.org/10.1016/j.pathol.2016.01.001DOI Listing
April 2016

The molecular profile of metastatic melanoma in Australia.

Pathology 2016 Feb 18;48(2):188-93. Epub 2016 Jan 18.

Melanoma Institute Australia, Sydney, NSW, Australia; The University of Sydney, Sydney, NSW, Australia; Royal North Shore Hospital, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2015.12.008DOI Listing
February 2016

PD-L1 Negative Status is Associated with Lower Mutation Burden, Differential Expression of Immune-Related Genes, and Worse Survival in Stage III Melanoma.

Clin Cancer Res 2016 08 9;22(15):3915-23. Epub 2016 Mar 9.

Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Camperdown, New South Wales, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1714DOI Listing
August 2016

Biology and treatment of BRAF mutant metastatic melanoma.

Melanoma Manag 2016 Mar 12;3(1):33-45. Epub 2016 Feb 12.

Melanoma Institute Australia, North Sydney, NSW 2060, Australia.

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http://dx.doi.org/10.2217/mmt.15.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097549PMC
March 2016

Dose Escalation of Tamoxifen in Patients with Low Endoxifen Level: Evidence for Therapeutic Drug Monitoring-The TADE Study.

Clin Cancer Res 2016 07 4;22(13):3164-71. Epub 2016 Feb 4.

Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, Australia. Sydney Medical School - Westmead, University of Sydney, Sydney, Australia. Faculty of Medicine and Health Sciences, Macquarie University, Sydney Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1470DOI Listing
July 2016

Cutaneous Toxic Effects of BRAF Inhibitors Alone and in Combination With MEK Inhibitors for Metastatic Melanoma.

JAMA Dermatol 2015 Oct;151(10):1103-9

Department of Dermatology, Westmead Hospital, Sydney, Australia2University of Sydney Medical Faculty, Sydney Medical School, University of Sydney, Sydney, Australia.

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2015.1745DOI Listing
October 2015

PD-L1 Expression and Tumor-Infiltrating Lymphocytes Define Different Subsets of MAPK Inhibitor-Treated Melanoma Patients.

Clin Cancer Res 2015 Jul 21;21(14):3140-8. Epub 2015 Jan 21.

Melanoma Institute Australia, North Sydney, New South Wales, Australia. Sydney Medical School, the University of Sydney, Sydney, New South Wales, Australia. Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2023DOI Listing
July 2015

PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials.

Pigment Cell Melanoma Res 2015 May 22;28(3):245-53. Epub 2014 Dec 22.

Melanoma Institute Australia, Sydney, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

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http://doi.wiley.com/10.1111/pcmr.12340
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http://dx.doi.org/10.1111/pcmr.12340DOI Listing
May 2015

Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma.

Nat Commun 2014 Dec 2;5:5694. Epub 2014 Dec 2.

1] Precision Cancer Therapy Laboratory, Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales 2109, Australia [2] Westmead Institute for Cancer Research, The University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1038/ncomms6694DOI Listing
December 2014

Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cutaneous melanomas.

J Invest Dermatol 2015 Feb 22;135(2):532-541. Epub 2014 Sep 22.

Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California, USA; Sequencing Center, John Wayne Cancer Institute, Santa Monica, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307785PMC
February 2015

Reply to M. Perier-Muzet et al.

J Clin Oncol 2014 Oct 2;32(28):3203. Epub 2014 Sep 2.

Melanoma Institute Australia; and Sydney Medical School, The University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1200/JCO.2014.56.8477DOI Listing
October 2014

Systemic treatment for BRAF-mutant melanoma: where do we go next?

Lancet Oncol 2014 Aug;15(9):e371-81

Melanoma Institute Australia, Sydney, NSW, Australia; University of Sydney, Sydney, NSW, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045147007
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http://dx.doi.org/10.1016/S1470-2045(14)70072-5DOI Listing
August 2014

Features and management of pyrexia with combined dabrafenib and trametinib in metastatic melanoma.

Melanoma Res 2014 Oct;24(5):468-74

aWestmead Hospital bWestmead Institute for Cancer Research, Westmead cMelanoma Institute Australia dSydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1097/CMR.0000000000000110DOI Listing
October 2014

The nature and management of metastatic melanoma after progression on BRAF inhibitors: effects of extended BRAF inhibition.

Cancer 2014 Oct 1;120(20):3142-53. Epub 2014 Jul 1.

Melanoma Institute Australia, Sydney, New South Wales, Australia; Department of Medical Oncology, Crown Princess Mary Cancer Center, Westmead Hospital, Sydney, New South Wales, Australia; University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/cncr.28851DOI Listing
October 2014