Publications by authors named "Alexander Jais"

21Publications

PNOC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding.

Neuron 2020 06 16;106(6):1009-1025.e10. Epub 2020 Apr 16.

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes, and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2020.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303947PMC
June 2020

Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.

J Allergy Clin Immunol 2020 01 8;145(1):283-300.e8. Epub 2019 Aug 8.

Department of Dermatology, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.07.033DOI Listing
January 2020

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

Cell 2019 05;177(6):1536-1552.e23

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193050
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http://dx.doi.org/10.1016/j.cell.2019.05.008DOI Listing
May 2019

CerS1-Derived C Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.

Cell Rep 2019 01;26(1):1-10.e7

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.031DOI Listing
January 2019

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.

Cell Rep 2018 10;25(2):383-397.e10

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183147
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http://dx.doi.org/10.1016/j.celrep.2018.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349418PMC
October 2018

VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans.

Mol Metab 2018 05 12;11:129-136. Epub 2018 Feb 12.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal 14558, Germany; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany; Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin 12200, Germany.

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http://dx.doi.org/10.1016/j.molmet.2018.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001408PMC
May 2018

Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.

J Diabetes Res 2017 19;2017:4108768. Epub 2017 Feb 19.

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1155/2017/4108768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337352PMC
June 2017

Hypothalamic inflammation in obesity and metabolic disease.

J Clin Invest 2017 01 3;127(1):24-32. Epub 2017 Jan 3.

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http://dx.doi.org/10.1172/JCI88878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199695PMC
January 2017

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Cell 2016 May 28;165(4):882-95. Epub 2016 Apr 28.

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph Stelzmann Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Land Strasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.03.033DOI Listing
May 2016

Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells.

Cell 2014 Aug;158(4):874-888

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.024DOI Listing
August 2014

Gene expression profile of vascular endothelial growth factor (VEGF) and its receptors in various cell types of the canine lymph node using laser capture microdissection (LCM).

Vet Immunol Immunopathol 2011 Apr 15;140(3-4):207-14. Epub 2010 Dec 15.

VetOMICS Core Facility for Research, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A-1210 Vienna, Austria.

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http://dx.doi.org/10.1016/j.vetimm.2010.12.005DOI Listing
April 2011