Publications by authors named "Alexander J Lazar"

100Publications

INSM1 Expression in Angiosarcoma.

Am J Clin Pathol 2020 Nov 19. Epub 2020 Nov 19.

Departments of Pathology.

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http://dx.doi.org/10.1093/ajcp/aqaa168DOI Listing
November 2020

Radiation-associated sarcomas other than malignant peripheral nerve sheath tumours demonstrate loss of histone H3K27 trimethylation.

Histopathology 2020 Jul 31. Epub 2020 Jul 31.

Departments of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/his.14223DOI Listing
July 2020

Diagnosis of digestive system tumours.

Int J Cancer 2020 Jul 16. Epub 2020 Jul 16.

WHO Classification of Tumours Group, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.

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http://dx.doi.org/10.1002/ijc.33210DOI Listing
July 2020

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.

NPJ Breast Cancer 2020 12;6:17. Epub 2020 May 12.

21Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC Australia.

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http://dx.doi.org/10.1038/s41523-020-0156-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217863PMC
May 2020

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group.

NPJ Breast Cancer 2020 12;6:16. Epub 2020 May 12.

74Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.

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http://dx.doi.org/10.1038/s41523-020-0154-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217824PMC
May 2020

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.

Cancer Cell 2020 05;37(5):639-654.e6

The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328015PMC
May 2020

Certain risk factors for patients with desmoid tumors warrant reconsideration of local therapy strategies.

Cancer 2020 Jul 28;126(14):3265-3273. Epub 2020 Apr 28.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncr.32921DOI Listing
July 2020

Diagnostic Value of TLE1 in Synovial Sarcoma: A Systematic Review and Meta-Analysis.

Sarcoma 2020 29;2020:7192347. Epub 2020 Jan 29.

Department of Orthopaedic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1155/2020/7192347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166261PMC
January 2020

The immune microenvironment of uterine adenosarcomas.

Clin Sarcoma Res 2020 28;10. Epub 2020 Mar 28.

4Department of Medical Oncology, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215 USA.

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http://dx.doi.org/10.1186/s13569-020-0127-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103067PMC
March 2020

Genomics, Morphoproteomics, and Treatment Patterns of Patients with Alveolar Soft Part Sarcoma and Response to Multiple Experimental Therapies.

Mol Cancer Ther 2020 05 3;19(5):1165-1172. Epub 2020 Mar 3.

Department of Investigational Cancer Therapeutics (Phase 1 Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0579DOI Listing
May 2020

Are ALK rearrangements found in smooth muscle tumours of the gastrointestinal tract?

Histopathology 2020 03 24;76(4):627-628. Epub 2020 Jan 24.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/his.14013DOI Listing
March 2020

Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the , , and Genes: A Study of the College of American Pathologists Molecular Oncology Committee.

Arch Pathol Lab Med 2019 10 10;143(10):1203-1211. Epub 2019 Apr 10.

From the Office of the Director, The Joint Pathology Center, Silver Spring, Maryland (Dr Moncur); the Department of Pathology, St Joseph Mercy Hospital, Ypsilanti, Michigan (Dr Bartley); the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha (Dr Bridge); the Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada (Dr Kamel-Reid); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Lazar); the Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs Lindeman and Kim); Biostatistics (Mr Long) and Proficiency Testing (Ms Vasalos), College of American Pathologists, Northfield, Illinois; the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill (Dr Merker); the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York (Dr Rai); the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Dr Rimm); and the Department of Pathology and Laboratory Medicine, Strong Memorial Hospital, University of Rochester Medical Center and Pathology and Laboratory Medicine, Molecular Diagnostic Laboratory, Rochester, New York (Dr Rothberg). Dr Moncur is employed by the US Army. The identification of specific products or scientific instrumentation is considered an integral part of the scientific endeavor and does not constitute endorsement or implied endorsement on the part of the authors, the Department of Defense, or any component agency. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or US government. The other authors have no relevant financial interest in the products or companies described in this article.

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http://dx.doi.org/10.5858/arpa.2018-0396-CPDOI Listing
October 2019

Toward an effective use of β-catenin immunohistochemistry in the evaluation of challenging melanocytic lesions.

Virchows Arch 2019 05 13;474(5):535-537. Epub 2019 Mar 13.

Departments of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 85, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s00428-019-02552-6DOI Listing
May 2019

Tyrosine Kinase Inhibitor and Immune Checkpoint Inhibitor Responses in KIT-Mutant Metastatic Melanoma.

J Invest Dermatol 2019 03 25;139(3):728-731. Epub 2018 Oct 25.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.10.009DOI Listing
March 2019

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer Cell 2019 02;35(2):204-220.e9

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.006DOI Listing
February 2019

Long-Term Outcomes for Patients With Desmoid Fibromatosis Treated With Radiation Therapy: A 10-Year Update and Re-evaluation of the Role of Radiation Therapy for Younger Patients.

Int J Radiat Oncol Biol Phys 2019 04 12;103(5):1167-1174. Epub 2018 Dec 12.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.012DOI Listing
April 2019

Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing-Based Oncology Assays.

Arch Pathol Lab Med 2019 04 30;143(4):463-471. Epub 2018 Oct 30.

From the Departments of Pathology and Laboratory Medicine & Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill (Dr Merker); the Departments of Pathology (Drs Devereaux and Montgomery, and Mr Smail) and Genetics (Dr Montgomery), Stanford University School of Medicine, and the Biomedical Informatics Program (Mr Smail), Stanford University, Stanford, California; the Department of Pathology, Massachusetts General Hospital (Dr Iafrate), and the Department of Pathology, Brigham and Women's Hospital (Drs Kim and Lindeman), Harvard University, Boston; the Departments of Pathology and Clinical Laboratory Genetics, The University Health Network and the University of Toronto, Toronto, Ontario, Canada (Dr Kamel-Reid); the Department of Pathology, Walter Reed National Military Medical Center, Bethesda, Maryland (Dr Moncur); PierianDx, St Louis, Missouri (Dr Nagarajan); the Department of Global Medical Affairs, Roche, Tucson, Arizona (Dr Portier); the Departments of Hematopathology (Dr Routbort) and Pathology, Genomic Medicine, and Translational Molecular Pathology (Dr Lazar), he University of Texas MD Anderson Cancer Center, Houston (Dr Routbort); the Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia (Dr Surrey); and Proficiency Testing, College of American Pathologists, Northfield, Illinois (Ms Vasalos).

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-033
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http://dx.doi.org/10.5858/arpa.2018-0336-CPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910717PMC
April 2019

Gene Expression Analysis Identifies Novel Targets for Cervical Cancer Therapy.

Front Immunol 2018 19;9:2102. Epub 2018 Sep 19.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02102
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http://dx.doi.org/10.3389/fimmu.2018.02102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156434PMC
September 2019

Positive Tumor Response to Combined Checkpoint Inhibitors in a Patient With Refractory Alveolar Soft Part Sarcoma: A Case Report.

J Glob Oncol 2018 09 6;4:1-6. Epub 2017 Jul 6.

Anthony P. Conley, Van Anh Trinh, Chrystia M. Zobniw, Kristi Posey, Wei-Lien Wang, Alexander J. Lazar, Neeta Somaiah, Jason Roszik, and Shreyaskumar R. Patel, The University of Texas MD Anderson Cancer Center, Houston, TX; Jaime D. Martinez, Universidad Nacional Autonoma de Mexico; and Oscar G. Arrieta, Instituto Nacional de Cancerologia, Mexico City, Mexico.

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http://dx.doi.org/10.1200/JGO.2017.009993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180844PMC
September 2018

Assessing inter-component heterogeneity of biphasic uterine carcinosarcomas.

Gynecol Oncol 2018 11 5;151(2):243-249. Epub 2018 Sep 5.

Graduate School of Biomedical Sciences, University of Texas at Houston Health Science Center, Houston, TX, United States; University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.08.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214727PMC
November 2018

Targeting the HGF/MET Axis Counters Primary Resistance to KIT Inhibition in -Mutant Melanoma.

JCO Precis Oncol 2018 5;2018. Epub 2018 Jun 5.

Junna Oba, Sun-Hee Kim, Wei-Lien Wang, Mariana P. Macedo, Fernando Carapeto, Meredith A McKean, John Van Arnam, Agda K. Eterovic, Shiraj Sen, Charuta R. Kale, Xiaoxing Yu, Cara L. Haymaker, Mark Routbort, Lauren E. Haydu, Chantale Bernatchez, Alexander J. Lazar, Elizabeth A. Grimm, David S. Hong, and Scott E. Woodman, The University of Texas MD Anderson Cancer Center, Houston, TX; and Mariana P. Macedo, AC Camargo Cancer Center, São Paulo, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080631PMC
http://dx.doi.org/10.1200/PO.18.00055DOI Listing
June 2018

TERT promoter mutations in solitary fibrous tumour.

Histopathology 2018 Nov 19;73(5):843-851. Epub 2018 Sep 19.

Pathology and Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/his.13703DOI Listing
November 2018

PAX7 expression in sarcomas bearing the EWSR1-NFATC2 translocation.

Mod Pathol 2019 01 9;32(1):154-156. Epub 2018 Jul 9.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41379-018-0095-6DOI Listing
January 2019

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma.

Cancer Cell 2018 06 31;33(6):1128-1141.e7. Epub 2018 May 31.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA; Epigenomics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791822PMC
June 2018

Nuclear β-catenin localization and mutation of the CTNNB1 gene: a context-dependent association.

Mod Pathol 2018 10 24;31(10):1553-1559. Epub 2018 May 24.

Department of Pathology, Unit 85, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41379-018-0080-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168348PMC
October 2018

Role of Elevated Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma.

Clin Cancer Res 2018 09 18;24(17):4119-4125. Epub 2018 May 18.

Center for Melanoma Research and Treatment, California Pacific Medical Center (CPMC) Research Institute, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125189PMC
September 2018

The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center.

J Surg Oncol 2018 Jun 3;117(8):1799-1805. Epub 2018 May 3.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/jso.25082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904950PMC
June 2018

Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Cancer Cell 2018 04 2;33(4):676-689.e3. Epub 2018 Apr 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Cancer Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA; Department of Pathology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028190PMC
April 2018

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Cell Rep 2018 04;23(1):227-238.e3

Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916809PMC
April 2018

Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology.

Curr Oncol Rep 2018 03 26;20(5):37. Epub 2018 Mar 26.

Department of Sarcoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s11912-018-0668-zDOI Listing
March 2018

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review.

J Clin Oncol 2018 06 5;36(16):1631-1641. Epub 2018 Mar 5.

Jason D. Merker and Maximilian Diehn, Stanford University School of Medicine; Stanford, CA; Geoffrey R. Oxnard, Dana Farber Cancer Institute and Harvard Medical School; Neal Lindeman, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Carolyn Compton, Arizona State University, Tempe, AZ; Patricia Hurley, Richard L. Schilsky, Thomas K. Oliver, and Suanna S. Bruinooge, American Society of Clinical Oncology, Alexandria, VA; Alexander J. Lazar and Apostolia M. Tsimberidou, The University of Texas MD Anderson Cancer Center, Houston, TX; Christina M. Lockwood, University of Washington, Seattle, WA; Alex J. Rai, Columbia University Medical Center, New York, NY; Patricia Vasalos and Brooke L. Billman, College of American Pathologists, Northfield, IL; Daniel F. Hayes, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; and Nicholas C. Turner, Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.76.8671DOI Listing
June 2018

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review.

Arch Pathol Lab Med 2018 10 5;142(10):1242-1253. Epub 2018 Mar 5.

Jason D. Merker and Maximilian Diehn, Stanford University School of Medicine; Stanford, CA; Geoffrey R. Oxnard, Dana Farber Cancer Institute and Harvard Medical School; Neal Lindeman, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Carolyn Compton, Arizona State University, Tempe, AZ; Patricia Hurley, Richard L. Schilsky, Thomas K. Oliver, and Suanna S. Bruinooge, American Society of Clinical Oncology, Alexandria, VA; Alexander J. Lazar and Apostolia M. Tsimberidou, The University of Texas MD Anderson Cancer Center, Houston, TX; hristina M. Lockwood, University of Washington, Seattle, WA; Alex J. Rai, Columbia University Medical Center, New York, NY; Patricia Vasalos and Brooke L. Billman, College of American Pathologists, Northfield, IL; Daniel F. Hayes, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; and Nicholas C. Turner, Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-090
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http://dx.doi.org/10.5858/arpa.2018-0901-SADOI Listing
October 2018

PanCancer insights from The Cancer Genome Atlas: the pathologist's perspective.

J Pathol 2018 04 22;244(5):512-524. Epub 2018 Feb 22.

Departments of Pathology, Genomic Medicine, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/path.5028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240356PMC
April 2018

Overview of the TREC 2017 Precision Medicine Track.

Text Retr Conf 2017 Nov;26

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410346PMC
November 2017

Primary chondro-osseous melanoma (chondrosarcomatous and osteosarcomatous melanoma).

J Cutan Pathol 2018 Feb 6;45(2):146-150. Epub 2017 Dec 6.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1111/cup.13067DOI Listing
February 2018