Alexander J Lazar

Alexander J Lazar

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Alexander J Lazar

Alexander J Lazar

Publications by authors named "Alexander J Lazar"

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100Publications

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Role of Elevated Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma.

Clin Cancer Res 2018 Sep 18;24(17):4119-4125. Epub 2018 May 18.

Center for Melanoma Research and Treatment, California Pacific Medical Center (CPMC) Research Institute, San Francisco, California.

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September 2018

Assessing inter-component heterogeneity of biphasic uterine carcinosarcomas.

Gynecol Oncol 2018 Sep 4. Epub 2018 Sep 4.

Graduate School of Biomedical Sciences, University of Texas at Houston Health Science Center, Houston, TX, United States; University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

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September 2018

PAX7 expression in sarcomas bearing the EWSR1-NFATC2 translocation.

Mod Pathol 2018 Jul 9. Epub 2018 Jul 9.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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July 2018

TERT Promoter Mutations in Solitary Fibrous Tumor.

Histopathology 2018 Jul 9. Epub 2018 Jul 9.

Pathology and Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

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July 2018

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review.

J Clin Oncol 2018 Jun 5;36(16):1631-1641. Epub 2018 Mar 5.

Jason D. Merker and Maximilian Diehn, Stanford University School of Medicine; Stanford, CA; Geoffrey R. Oxnard, Dana Farber Cancer Institute and Harvard Medical School; Neal Lindeman, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Carolyn Compton, Arizona State University, Tempe, AZ; Patricia Hurley, Richard L. Schilsky, Thomas K. Oliver, and Suanna S. Bruinooge, American Society of Clinical Oncology, Alexandria, VA; Alexander J. Lazar and Apostolia M. Tsimberidou, The University of Texas MD Anderson Cancer Center, Houston, TX; Christina M. Lockwood, University of Washington, Seattle, WA; Alex J. Rai, Columbia University Medical Center, New York, NY; Patricia Vasalos and Brooke L. Billman, College of American Pathologists, Northfield, IL; Daniel F. Hayes, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; and Nicholas C. Turner, Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.

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June 2018

The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center.

J Surg Oncol 2018 Jun 3;117(8):1799-1805. Epub 2018 May 3.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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June 2018

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma.

Cancer Cell 2018 Jun 31;33(6):1128-1141.e7. Epub 2018 May 31.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA; Epigenomics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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June 2018

Targeting the HGF/MET Axis Counters Primary Resistance to KIT Inhibition in -Mutant Melanoma.

JCO Precis Oncol 2018 5;2018. Epub 2018 Jun 5.

Junna Oba, Sun-Hee Kim, Wei-Lien Wang, Mariana P. Macedo, Fernando Carapeto, Meredith A McKean, John Van Arnam, Agda K. Eterovic, Shiraj Sen, Charuta R. Kale, Xiaoxing Yu, Cara L. Haymaker, Mark Routbort, Lauren E. Haydu, Chantale Bernatchez, Alexander J. Lazar, Elizabeth A. Grimm, David S. Hong, and Scott E. Woodman, The University of Texas MD Anderson Cancer Center, Houston, TX; and Mariana P. Macedo, AC Camargo Cancer Center, São Paulo, Brazil.

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June 2018

Nuclear β-catenin localization and mutation of the CTNNB1 gene: a context-dependent association.

Mod Pathol 2018 May 24. Epub 2018 May 24.

Department of Pathology, Unit 85, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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May 2018

PanCancer insights from The Cancer Genome Atlas: the pathologist's perspective.

J Pathol 2018 Apr 22;244(5):512-524. Epub 2018 Feb 22.

Departments of Pathology, Genomic Medicine, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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April 2018

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Cell Rep 2018 Apr;23(1):227-238.e3

Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address:

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April 2018

Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Cancer Cell 2018 Apr 2;33(4):676-689.e3. Epub 2018 Apr 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Cancer Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA; Department of Pathology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address:

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April 2018

Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology.

Curr Oncol Rep 2018 Mar 26;20(5):37. Epub 2018 Mar 26.

Department of Sarcoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, 77030, USA.

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March 2018

Primary chondro-osseous melanoma (chondrosarcomatous and osteosarcomatous melanoma).

J Cutan Pathol 2018 Feb 6;45(2):146-150. Epub 2017 Dec 6.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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February 2018

Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas.

Histopathology 2018 Jan 19;72(2):239-247. Epub 2017 Oct 19.

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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January 2018

Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual.

CA Cancer J Clin 2017 Nov 13;67(6):472-492. Epub 2017 Oct 13.

Professor of Melanoma and Surgical Oncology, Melanoma Institute Australia, The University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

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November 2017

Risk assessment in solitary fibrous tumors: validation and refinement of a risk stratification model.

Mod Pathol 2017 10 21;30(10):1433-1442. Epub 2017 Jul 21.

Department of Pathology and Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

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October 2017

EWSR1 fusion proteins mediate PAX7 expression in Ewing sarcoma.

Mod Pathol 2017 09 23;30(9):1312-1320. Epub 2017 Jun 23.

Departments of Pathology &Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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September 2017

Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy.

Ann Surg Oncol 2017 Aug 10;24(8):2145-2154. Epub 2017 Apr 10.

Department of Orthopaedic Oncology - Unit 1448, MD Anderson Cancer Center, Houston, TX, USA.

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August 2017

Molecular profiling of sarcomas: new vistas for precision medicine.

Virchows Arch 2017 Aug 29;471(2):243-255. Epub 2017 Jun 29.

Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Boulevard-Unit 85, Houston, TX, 77030-4009, USA.

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August 2017

Overexpressed PRAME is a potential immunotherapy target in sarcoma subtypes.

Clin Sarcoma Res 2017 15;7:11. Epub 2017 Jun 15.

Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030 USA.

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June 2017

Synovial Sarcoma of the Head and Neck: A Single Institution Review.

Sarcoma 2017 5;2017:2016752. Epub 2017 Jun 5.

Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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June 2017

The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours.

Histopathology 2017 May 9;70(6):946-953. Epub 2017 Feb 9.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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May 2017

Trends in hepatocyte growth factor, insulin-like growth factor 1, thyroid-stimulating hormone, and leptin expression levels in uveal melanoma patient serum and tumor tissues: correlation to disease progression.

Melanoma Res 2017 04;27(2):126-133

Departments of aMelanoma Medical Oncology bOrbital Oncology and Ophthalmic Plastic Surgery cPlastic Surgery and Biostatistics dPathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA eDepartment of Pathology, AC Camargo Cancer Center, São Paulo, Brazil.

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April 2017

Undifferentiated "round" cell ("Ewing-like") sarcoma: not always so-round nor Ewing-like.

Virchows Arch 2017 04 13;470(4):371-372. Epub 2017 Feb 13.

Departments of Pathology & Translational Molecular Pathology; Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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April 2017

IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma.

J Natl Cancer Inst 2016 Dec 30;108(12). Epub 2016 Aug 30.

Departments of Sarcoma Medical Oncology (SELC, BAM, VR, RSB, RR, JAL), Hematopathology (DV, HMA), Bioinformatics and Computational Biology (YW, JW), Investigational Cancer Therapeutics (AN, VS), Pediatrics-Patient Care (NCD), Experimental Therapeutics (IF, SS, WP), and Pathology (AJL), The University of Texas MD Anderson Cancer Center, Houston, TX; Departments of Radiology (EMR) and Molecular & Human Genetics (RLM), Baylor College of Medicine, Houston, TX; Department of Pediatric-Oncology, Texas Children's Hospital. Houston, TX (ASB); Departments of Chemical and Biomolecular Engineering and Bioengineering, Rice University, Houston, TX (AGM)

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December 2016

Sarcoma Brain Metastases: 28 Years of Experience at a Single Institution.

Ann Surg Oncol 2016 12 19;23(Suppl 5):962-967. Epub 2016 Sep 19.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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December 2016

Cutaneous nodular fasciitis with genetic analysis: a case series.

J Cutan Pathol 2016 Dec;43(12):1143-1149

Department of Pathology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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December 2016

PAX7 Expression in Rhabdomyosarcoma, Related Soft Tissue Tumors, and Small Round Blue Cell Neoplasms.

Am J Surg Pathol 2016 10;40(10):1305-15

Departments of *Pathology ‡Pediatrics, Stanford University School of Medicine, Stanford, CA †Department of Medical Oncology, Institut Gustave-Roussy, Villejuif, France §Department of Internal Medicine, and Sylvester Comprehensive Cancer Center, Division of Hematology/Oncology, University of Miami Miller School of Medicine, Miami, FL ∥Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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October 2016

Myxofibrosarcoma.

Surg Oncol Clin N Am 2016 10 30;25(4):775-88. Epub 2016 Jul 30.

Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1484, Houston, TX 77030, USA.

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October 2016

American Joint Committee on Cancer acceptance criteria for inclusion of risk models for individualized prognosis in the practice of precision medicine.

CA Cancer J Clin 2016 09 19;66(5):370-4. Epub 2016 Jan 19.

Professor, Life Science, Arizona State University, Tempe, AZ; Professor, Laboratory Medicine and Pathology, Mayo Clinic School of Medicine, Rochester, MN; Chief Medical Officer, National Biomarker Development Alliance, Scottsdale, AZ.

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September 2016

Prognosis of T1 synovial sarcoma depends upon surgery by oncologic surgeons.

J Surg Oncol 2016 Sep 24;114(4):490-4. Epub 2016 May 24.

Department of Orthopedic Oncology, MD Anderson Cancer Center, Houston, Texas.

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September 2016

Non-Radiographic Risk Factors Differentiating Atypical Lipomatous Tumors from Lipomas.

Front Oncol 2016 22;6:197. Epub 2016 Sep 22.

Department of Orthopaedic Oncology, MD Anderson Cancer Center, Houston, TX, USA; Sarcoma Research Center, Houston, TX, USA; MD Anderson Cancer Center, Houston, TX, USA.

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September 2016

How Do We Make Clinical Molecular Testing for Cancer Standard of Care for Pathology Departments?

J Natl Compr Canc Netw 2016 06;14(6):787-92

From the Departments of Hematopathology, Pathology, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston Texas.

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June 2016

MRI may be used as a prognostic indicator in patients with extra-abdominal desmoid tumours.

Br J Radiol 2016 18;89(1058):20150308. Epub 2015 Nov 18.

1 Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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May 2016

SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma.

Clin Cancer Res 2016 Mar 16;22(5):1150-60. Epub 2015 Oct 16.

The Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Surgical Oncology, Comprehensive Cancer Center, The Ohio State University (OSU), Columbus, Ohio. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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March 2016

Somatic Copy Number Alterations at Oncogenic Loci Show Diverse Correlations with Gene Expression.

Sci Rep 2016 Jan 20;6:19649. Epub 2016 Jan 20.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030.

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January 2016

Radiation-induced Sarcomas Occurring in Desmoid-type Fibromatosis Are Not Always Derived From the Primary Tumor.

Am J Surg Pathol 2015 Dec;39(12):1701-7

Departments of *Medical Oncology †Pathology ∥Radiation Oncology, Leiden University Medical Centre, Leiden, The Netherlands ‡Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Centre, Nashville, TN §Department of Pathology, Sarcoma Research Center, The University of Texas M.D. Anderson Cancer Center, Houston, TX ¶Robert J. Tomsich Pathology and Laboratory Medicine Institute, and Molecular Genetics, Cleveland Clinic, Taussig Cancer Centre and Lerner Research Institute, Cleveland, OH.

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December 2015

Dual Roles of RNF2 in Melanoma Progression.

Cancer Discov 2015 Dec 8;5(12):1314-27. Epub 2015 Oct 8.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute for Health Transformation, The University of Texas System, Houston, Texas.

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December 2015

Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors.

Cancer 2015 Nov 8;121(22):4088-96. Epub 2015 Sep 8.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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November 2015

The hepatocyte growth factor receptor as a potential therapeutic target for dedifferentiated liposarcoma.

Lab Invest 2015 Aug 1;95(8):951-61. Epub 2015 Jun 1.

1] Department of Surgical Oncology, University of Texas MD Anderson Cancer Center (MDACC), Houston, TX, USA [2] The Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA [3] Department of Surgical Oncology, Comprehensive Cancer Center, The Ohio State University (OSU), Columbus, OH, USA.

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August 2015

Histologic variability in solitary fibrous tumors reflects angiogenic and growth factor signaling pathway alterations.

Hum Pathol 2015 Jul 15;46(7):1015-26. Epub 2015 Apr 15.

Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston TX 70030.

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July 2015