Alexander J Groffen

Alexander J Groffen

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Alexander J Groffen

Alexander J Groffen

Publications by authors named "Alexander J Groffen"

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Doc2b Ca binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength.

Sci Rep 2019 Oct 8;9(1):14408. Epub 2019 Oct 8.

Department of Functional Genomics, Faculty of Science, Center for Neurogenomics and Cognitive Research, Vrije Universiteit, De Boelelaan 1085, 1081HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-50684-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783474PMC
October 2019

Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models.

Mol Neurobiol 2019 May 17;56(5):3313-3325. Epub 2018 Aug 17.

Department of Physiology, University of Toronto, 1 King's College Circle, 3306 Medical Sciences Building, Toronto, ON, M5S 1A8, Canada.

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http://dx.doi.org/10.1007/s12035-018-1290-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477017PMC
May 2019

SICT: automated detection and supervised inspection of fast Ca transients.

Sci Rep 2018 10 19;8(1):15523. Epub 2018 Oct 19.

Department of Functional Genomics, Faculty of Science, Center for Neurogenomics and Cognitive Research, Vrije Universiteit, De Boelelaan 1085, 1081HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-33847-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195629PMC
October 2018

δ-Catenin () missense mutation in familial cortical myoclonic tremor and epilepsy.

Neurology 2017 Dec 10;89(23):2341-2350. Epub 2017 Nov 10.

From the Departments of Neurology and Clinical Neurophysiology (A.-F.v.R., A.B., M.A.J.T.), Academic Medical Centre, Amsterdam Neuroscience, University of Amsterdam; Departments of Functional Genomics and Clinical Genetics (A.J.G.), CNCR, Neuroscience Campus Amsterdam, VU University and VU Medical Centre; Departments of Human Genetics (B.d.V., S.K., L.S.V., A.M.J.M.v.d.M.), Clinical Genetics (G.W.E.S.), and Neurology (A.M.J.M.v.d.M.), Leiden University Medical Centre; and Department of Neurology (P.M.C.C., M.A.J.T.), University Medical Centre Groningen, University of Groningen, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000004709DOI Listing
December 2017

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.

Elife 2017 12 23;6. Epub 2017 Dec 23.

Neuronal Secretion Group, Department of Neuroscience, University of Copenhagen, København, Denmark.

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http://dx.doi.org/10.7554/eLife.27000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758110PMC
December 2017

Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.

PLoS One 2017 26;12(7):e0180912. Epub 2017 Jul 26.

Department of Functional Genomics, Centre for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180912PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529015PMC
October 2017

Tomosyn interacts with the SUMO E3 ligase PIASγ.

PLoS One 2014 10;9(3):e91697. Epub 2014 Mar 10.

Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, Netherlands; Department of Clinical Genetics, VU Medical Center, Amsterdam, Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091697PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948876PMC
March 2016

Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence.

Eur J Hum Genet 2015 Sep 24;23(9):1151-7. Epub 2014 Dec 24.

1] Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands [2] Department of Functional Genomics, Center for Neurogenomics and Cognition Research, VU University, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2014.273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538208PMC
September 2015

Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes.

Nat Commun 2015 Sep 23;6:8387. Epub 2015 Sep 23.

Department of Functional Genomics and Clinical Genetics, CNCR, NCA, VU University and VU Medical Center, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncomms9387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598560PMC
September 2015

Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.

Brain Struct Funct 2015 Jul 18;220(4):1971-82. Epub 2014 Apr 18.

Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV, Amsterdam, The Netherlands.

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http://link.springer.com/content/pdf/10.1007%2Fs00429-014-07
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http://link.springer.com/10.1007/s00429-014-0766-0
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http://dx.doi.org/10.1007/s00429-014-0766-0DOI Listing
July 2015

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

Diabetologia 2014 Oct 9;57(10):2173-82. Epub 2014 Jul 9.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.1007/s00125-014-3312-yDOI Listing
October 2014

TRIM3 regulates the motility of the kinesin motor protein KIF21B.

PLoS One 2013 24;8(9):e75603. Epub 2013 Sep 24.

Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075603PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782429PMC
July 2014

Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release.

J Neurosci 2013 Oct;33(42):16459-70

Department of Neuroscience and Pharmacology, Faculty of Health Sciences, and Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, 2200 Copenhagen N, Denmark, Center for Neurogenomics and Cognitive Research, Department of Functional Genomics, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands, and VU Medical Center, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1523/JNEUROSCI.2656-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618527PMC
October 2013

Genetic and phenotypic heterogeneity in sporadic and familial forms of paroxysmal dyskinesia.

J Neurol 2013 Jan 30;260(1):93-9. Epub 2012 Jun 30.

Departments of Clinical Genetics and Functional Genomics, Center of Neurogenomics and Cognitive Research (CNCR), VU University and VU Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00415-012-6592-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535363PMC
January 2013

Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity.

Diabetes 2012 Oct 14;61(10):2424-32. Epub 2012 Jun 14.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.2337/db11-1525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447898PMC
October 2012

Paroxysmal kinesigenic dyskinesia: cortical or non-cortical origin.

Parkinsonism Relat Disord 2012 Jun 30;18(5):645-8. Epub 2012 Mar 30.

Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.parkreldis.2012.03.006DOI Listing
June 2012

Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality.

PLoS One 2011 29;6(11):e28137. Epub 2011 Nov 29.

Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028137PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226659PMC
April 2012

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

Trends Neurosci 2011 Sep 9;34(9):487-97. Epub 2011 Aug 9.

Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam and VU Medical Center, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.tins.2011.07.003DOI Listing
September 2011

Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures.

Brain Res 2009 Dec 1;1302:1-9. Epub 2009 Sep 1.

Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000689930901810
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http://dx.doi.org/10.1016/j.brainres.2009.08.071DOI Listing
December 2009

DOC2B acts as a calcium switch and enhances vesicle fusion.

J Neurosci 2008 Jul;28(27):6794-806

Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1523/JNEUROSCI.0538-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673511PMC
July 2008

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties.

J Neurochem 2006 May 3;97(3):818-33. Epub 2006 Mar 3.

Department of Functional Genomics, Center for Neurogenomics and Cognition Research, Vrije Universiteit (VU) and VU Medical Centre, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/j.1471-4159.2006.03755.xDOI Listing
May 2006

Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.

J Neurochem 2005 Feb;92(3):554-68

Department of Functional Genomics, Center for Neurogenomics and Cognition Research, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands.

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http://doi.wiley.com/10.1111/j.1471-4159.2004.02890.x
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http://dx.doi.org/10.1111/j.1471-4159.2004.02890.xDOI Listing
February 2005

Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane.

J Biol Chem 2004 May 21;279(22):23740-7. Epub 2004 Mar 21.

Department of Functional Genomics, Center for Neurogenomics and Cognition Research, Vrije Universiteit, De Boelelaan 1085, Amsterdam 1081 HV, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M400731200
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http://dx.doi.org/10.1074/jbc.M400731200DOI Listing
May 2004