Alexander Ghanem

Alexander Ghanem

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Alexander Ghanem

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Cryo EM structure of the rabies virus ribonucleoprotein complex.

Sci Rep 2019 Jul 3;9(1):9639. Epub 2019 Jul 3.

Institute of Virology, Department of Pathobiology, Universtiy of Veterinary Medicine Vienna, Vienna, Austria.

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http://dx.doi.org/10.1038/s41598-019-46126-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610074PMC
July 2019

Optical coherence tomography-guided versus angiography-guided implantation of everolimus-eluting bioresorbable vascular scaffolds: Comparison of coverage, apposition and clinical outcome. The ALSTER-OCT ABSORB registry.

Cardiol J 2018 7;25(4):459-469. Epub 2018 Mar 7.

Department of Cardiology, Asklepios Clinic St. Georg, Hamburg, Germany, Lohmuehlenstrasse 5, 20099 Hamburg, Germany; Department of Cardiology, University of Luebeck, Germany.

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http://dx.doi.org/10.5603/CJ.a2018.0021DOI Listing
May 2019

Anatomical projections of the dorsomedial hypothalamus to the periaqueductal grey and their role in thermoregulation: a cautionary note.

Physiol Rep 2018 07;6(14):e13807

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.13807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060107PMC
July 2018

Neuronal LRP4 regulates synapse formation in the developing CNS.

Development 2017 12 23;144(24):4604-4615. Epub 2017 Oct 23.

Department of Physiological Genomics, Ludwig-Maximilians-University, Grosshaderner Str. 9, D-82152 Planegg-Martinsried, Germany

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http://dev.biologists.org/lookup/doi/10.1242/dev.150110
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http://dx.doi.org/10.1242/dev.150110DOI Listing
December 2017

Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice.

Mediators Inflamm 2016 14;2016:7174127. Epub 2016 Jun 14.

Department of Cardiac Surgery, University Clinical Center, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.

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http://downloads.hindawi.com/journals/mi/2016/7174127.pdf
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http://www.hindawi.com/journals/mi/2016/7174127/
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http://dx.doi.org/10.1155/2016/7174127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923606PMC
May 2017

TNFα drives mitochondrial stress in POMC neurons in obesity.

Nat Commun 2017 05 10;8:15143. Epub 2017 May 10.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Division of Metabolic Diseases, Department of Medicine, Technische Universität München, German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany.

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http://www.nature.com/doifinder/10.1038/ncomms15143
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http://dx.doi.org/10.1038/ncomms15143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436136PMC
May 2017

Rationale of cerebral protection devices in left atrial appendage occlusion.

Catheter Cardiovasc Interv 2017 Jan 20;89(1):154-158. Epub 2016 Oct 20.

Department for Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany.

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http://doi.wiley.com/10.1002/ccd.26677
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http://dx.doi.org/10.1002/ccd.26677DOI Listing
January 2017

Coronary Artery Aneurysm After Bioresorbable Vascular Scaffold Implantation With Post-Dilation: Is Less More?

JACC Cardiovasc Interv 2017 01 21;10(1):96-97. Epub 2016 Dec 21.

Asklepios Klinik St. Georg, Department for Cardiology, Hamburg, Germany; Medizinische Klinik II, Universitaetsklinikum Bonn, Bonn, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S19368798163165
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http://dx.doi.org/10.1016/j.jcin.2016.09.047DOI Listing
January 2017

Mechanisms And Prevention Of TAVI-Related Cerebrovascular Events.

Curr Pharm Des 2016 ;22(13):1879-87

Asklepios Klinik St. Georg Department of Cardiology Lohmuhlenstraße 5 D-20099 Hamburg.

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http://dx.doi.org/10.2174/1381612822666151217122610DOI Listing
December 2016

"Shock and Go?" extracorporeal cardio-pulmonary resuscitation in the golden-hour of ROSC.

Catheter Cardiovasc Interv 2016 Nov 17;88(5):691-696. Epub 2016 Jun 17.

Department of Medicine/Cardiology, University of Bonn.

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http://dx.doi.org/10.1002/ccd.26616DOI Listing
November 2016

G gene-deficient single-round rabies viruses for neuronal circuit analysis.

Virus Res 2016 May 8;216:41-54. Epub 2015 Jun 8.

Max von Pettenkofer-Institute & Gene Center, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str. 25 D-81377 München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2015.05.023DOI Listing
May 2016

Very Late Scaffold Thrombosis Due to Insufficient Strut Apposition.

JACC Cardiovasc Interv 2015 Nov 14;8(13):1768-9. Epub 2015 Oct 14.

Asklepios Klinik St. Georg, Department of Cardiology, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.jcin.2015.06.026DOI Listing
November 2015

PRESYNAPTIC NETWORKS. Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules.

Science 2015 Jul;349(6243):70-4

Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. Department of Ophthalmology, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1126/science.aab1687DOI Listing
July 2015

Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch.

Neuron 2015 Mar;85(6):1289-304

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zürich, Vladimir Prelog Weg 4, 8093 Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.02.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372258PMC
March 2015

Acute changes of mitral valve geometry during interventional edge-to-edge repair with the MitraClip system are associated with midterm outcomes in patients with functional valve disease: preliminary results from a prospective single-center study.

Circ Cardiovasc Interv 2014 Jun 3;7(3):390-9. Epub 2014 Jun 3.

From the Departments of Medicine II (R.S., D.M., M.W., N.W., C.M., A.G., G.N., C.H.) and Cardiovascular Surgery (A.W.), Heart Centre Bonn, University Hospital Bonn, Bonn, Germany.

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.113.001098DOI Listing
June 2014

Cardiomyocyte specific peroxisome proliferator-activated receptor-α overexpression leads to irreversible damage in ischemic murine heart.

Life Sci 2014 May 21;102(2):88-97. Epub 2014 Mar 21.

Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.lfs.2014.03.019DOI Listing
May 2014

Cognitive trajectory after transcatheter aortic valve implantation.

Circ Cardiovasc Interv 2013 Dec 15;6(6):615-24. Epub 2013 Oct 15.

From the Department of Medicine/Cardiology (A.G., J.K., J.-M.S., B.V.B., M.V., T.S., M.V.-N., C.H., J.O.S., N.W., E.G., G.N.), Department of Psychiatry and Psychotherapy (M.W., S.W.), and Department of Radiology (D.T., A.M.), University of Bonn, Bonn, Germany; and German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany (M.W., S.W.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.112.000429DOI Listing
December 2013

Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance.

Cell Metab 2013 Dec;18(6):844-59

Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy; Adolf Butenandt Institute, Neurobiochemistry, Ludwig Maximilians University Munich, Schillerstrasse 44, 80336 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.11.005DOI Listing
December 2013

The revised EuroSCORE II for the prediction of mortality in patients undergoing transcatheter aortic valve implantation.

Clin Res Cardiol 2013 Nov 23;102(11):821-9. Epub 2013 Jul 23.

Universitätsklinikum Bonn, Med. Klinik und Poliklinik II, Rheinische Friedrich-Wilhelms-Universität Bonn, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00392-013-0596-8DOI Listing
November 2013

The first stage of cardinal direction selectivity is localized to the dendrites of retinal ganglion cells.

Neuron 2013 Sep 22;79(6):1078-85. Epub 2013 Aug 22.

Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.neuron.2013.08.005DOI Listing
September 2013

Evaluation and management of paravalvular aortic regurgitation after transcatheter aortic valve replacement.

J Am Coll Cardiol 2013 Jul 1;62(1):11-20. Epub 2013 May 1.

Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.jacc.2013.02.088DOI Listing
July 2013

Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb.

Proc Natl Acad Sci U S A 2013 Mar 4;110(12):E1152-61. Epub 2013 Mar 4.

Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, D-80336 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.1218991110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607028PMC
March 2013

An exceptional case of frame underexpansion with a self-expandable transcatheter heart valve despite predilation.

JACC Cardiovasc Interv 2012 Dec;5(12):1288-9

Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S19368798120092
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http://dx.doi.org/10.1016/j.jcin.2012.07.014DOI Listing
December 2012

Catch me, if you can!

Eur Heart J 2012 Nov 3;33(22):2763. Epub 2012 May 3.

Department of Medicine/Cardiology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehs088DOI Listing
November 2012

Transcatheter aortic valve implantation and closure of the left atrial appendage under cerebral protection.

EuroIntervention 2012 Sep;8(5):640-1

Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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http://dx.doi.org/10.4244/EIJV8I5A98DOI Listing
September 2012

Three-dimensional speckle-tracking analysis of left ventricular function after transcatheter aortic valve implantation.

J Am Soc Echocardiogr 2012 Aug 2;25(8):827-834.e1. Epub 2012 Jun 2.

Department of Internal Medicine, Cardiology, Pulmonology and Angiology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.echo.2012.04.023DOI Listing
August 2012

Systemic inflammatory response syndrome predicts increased mortality in patients after transcatheter aortic valve implantation.

Eur Heart J 2012 Jun 26;33(12):1459-68. Epub 2012 Jan 26.

Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehs002DOI Listing
June 2012

A radial glia-specific role of RhoA in double cortex formation.

Neuron 2012 Mar;73(5):911-24

Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.neuron.2011.12.030DOI Listing
March 2012

Significantly improved rescue of rabies virus from cDNA plasmids.

Eur J Cell Biol 2012 Jan 12;91(1):10-6. Epub 2011 Mar 12.

Max von Pettenkofer-Institute & Gene Center, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 25, Munich, Germany.

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http://dx.doi.org/10.1016/j.ejcb.2011.01.008DOI Listing
January 2012

Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair.

Biochem Biophys Res Commun 2011 Aug 13;411(3):627-31. Epub 2011 Jul 13.

Department of Medicine/Cardiology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2011.07.006DOI Listing
August 2011

Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury.

J Mol Cell Cardiol 2011 Mar 26;50(3):570-7. Epub 2010 Nov 26.

Medizinische Klinik und Poliklinik II, Innere Medizin, Universitätsklinikum Bonn, Sigmund Freud Str. 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2010.11.013DOI Listing
March 2011

Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation.

JACC Cardiovasc Interv 2010 Nov;3(11):1141-9

Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S193687981000638
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http://dx.doi.org/10.1016/j.jcin.2010.09.009DOI Listing
November 2010

Targeted ultrasound-mediated delivery of nanoparticles: on the development of a new HIFU-based therapy and imaging device.

IEEE Trans Biomed Eng 2010 Jan 18;57(1):61-70. Epub 2009 Aug 18.

Philips Research NorthAmerica, BriarcliffManor, NY10510, USA.

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http://dx.doi.org/10.1109/TBME.2009.2028874DOI Listing
January 2010

Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart.

J Interv Card Electrophysiol 2009 Oct 8;26(1):3-10. Epub 2009 Aug 8.

Department of Medicine-Cardiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s10840-009-9425-4DOI Listing
October 2009

An unusual cause for recurrent syncope in a female adult with LEOPARD syndrome.

Echocardiography 2009 May 2;26(5):596-7. Epub 2008 Dec 2.

Medizinische Klinik II, Universitätsklinikum Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/j.1540-8175.2008.00828.xDOI Listing
May 2009

Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice.

J Mol Cell Cardiol 2009 May 24;46(5):644-52. Epub 2009 Feb 24.

Department of Medicine Cardiology, University of Bonn, Sigmund-Freud Strasse 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2009.02.012DOI Listing
May 2009

Gone with the flow: percutanous retrieval of a migrated wallstent trapped in the right ventricle.

Eur Heart J 2009 Mar 5;30(6):717. Epub 2008 Dec 5.

Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, Bonn 53105, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehn547DOI Listing
March 2009

Peptide-mediated interference with influenza A virus polymerase.

J Virol 2007 Jul 9;81(14):7801-4. Epub 2007 May 9.

Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.00724-07
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http://dx.doi.org/10.1128/JVI.00724-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933368PMC
July 2007

Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45.

J Mol Cell Cardiol 2006 Nov 17;41(5):787-97. Epub 2006 Aug 17.

Institute of Genetics, Division of Molecular Genetics, University of Bonn, Roemerstr. 164, 53117 Bonn, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2006.07.005DOI Listing
November 2006

Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node.

Proc Natl Acad Sci U S A 2006 Apr 29;103(15):5959-64. Epub 2006 Mar 29.

Institut für Genetik, Abteilung Molekulargenetik, Universität Bonn, Römerstrasse 164, 53117 Bonn, Germany.

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http://dx.doi.org/10.1073/pnas.0508512103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458680PMC
April 2006

Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice.

J Cell Sci 2006 Feb 31;119(Pt 4):693-701. Epub 2006 Jan 31.

Institut für Genetik, Universität Bonn, 53117 Bonn, Germany.

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http://dx.doi.org/10.1242/jcs.02800DOI Listing
February 2006

Increasing myocardial contraction and blood pressure in C57BL/6 mice during early postnatal development.

Am J Physiol Heart Circ Physiol 2003 Feb 31;284(2):H464-74. Epub 2002 Oct 31.

Department of Pharmacology, Universitätsklinik Bonn, Germany.

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http://dx.doi.org/10.1152/ajpheart.00540.2002DOI Listing
February 2003