Alexander Gerhard

Alexander Gerhard

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Alexander Gerhard

Alexander Gerhard

Publications by authors named "Alexander Gerhard"

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Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2019 Dec 8;46(13):2831-2847. Epub 2019 Aug 8.

Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00259-019-04462-wDOI Listing
December 2019

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.

Authors:
Katrina M Moore Jennifer Nicholas Murray Grossman Corey T McMillan David J Irwin Lauren Massimo Vivianna M Van Deerlin Jason D Warren Nick C Fox Martin N Rossor Simon Mead Martina Bocchetta Bradley F Boeve David S Knopman Neill R Graff-Radford Leah K Forsberg Rosa Rademakers Zbigniew K Wszolek John C van Swieten Lize C Jiskoot Lieke H Meeter Elise Gp Dopper Janne M Papma Julie S Snowden Jennifer Saxon Matthew Jones Stuart Pickering-Brown Isabelle Le Ber Agnès Camuzat Alexis Brice Paola Caroppo Roberta Ghidoni Michela Pievani Luisa Benussi Giuliano Binetti Bradford C Dickerson Diane Lucente Samantha Krivensky Caroline Graff Linn Öijerstedt Marie Fallström Håkan Thonberg Nupur Ghoshal John C Morris Barbara Borroni Alberto Benussi Alessandro Padovani Daniela Galimberti Elio Scarpini Giorgio G Fumagalli Ian R Mackenzie Ging-Yuek R Hsiung Pheth Sengdy Adam L Boxer Howie Rosen Joanne B Taylor Matthis Synofzik Carlo Wilke Patricia Sulzer John R Hodges Glenda Halliday John Kwok Raquel Sanchez-Valle Albert Lladó Sergi Borrego-Ecija Isabel Santana Maria Rosário Almeida Miguel Tábuas-Pereira Fermin Moreno Myriam Barandiaran Begoña Indakoetxea Johannes Levin Adrian Danek James B Rowe Thomas E Cope Markus Otto Sarah Anderl-Straub Alexandre de Mendonça Carolina Maruta Mario Masellis Sandra E Black Philippe Couratier Geraldine Lautrette Edward D Huey Sandro Sorbi Benedetta Nacmias Robert Laforce Marie-Pier L Tremblay Rik Vandenberghe Philip Van Damme Emily J Rogalski Sandra Weintraub Alexander Gerhard Chiadi U Onyike Simon Ducharme Sokratis G Papageorgiou Adeline Su Lyn Amy Brodtmann Elizabeth Finger Rita Guerreiro Jose Bras Jonathan D Rohrer

Lancet Neurol 2019 Dec 3. Epub 2019 Dec 3.

Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30394-1DOI Listing
December 2019

Widespread microglial activation in multiple system atrophy.

Mov Disord 2019 04 6;34(4):564-568. Epub 2019 Feb 6.

Departments of Nulcear Medicine and Geriatric Medicine, University Hospital Essen, Germany.

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http://dx.doi.org/10.1002/mds.27620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659386PMC
April 2019

Microglial activation, white matter tract damage, and disability in MS.

Neurol Neuroimmunol Neuroinflamm 2018 May 6;5(3):e443. Epub 2018 Mar 6.

Turku PET Centre (E.R., J.T., M.S., J.R., J.O.R.), Division of Clinical Neurosciences (E.R., M.S., J.O.R., L.A.), Department of Biostatistics (T.V.), and Medical Imaging Centre of Southwest Finland (T.P., R.P.), Turku University Hospital and University of Turku, Finland; Division of Neuroscience and Experimental Psychology (A.G.), University of Manchester, United Kingdom; Department of Nuclear Medicine and Geriatric Medicine (A.G.), University Hospital Essen, Germany; and Wolfson Molecular Imaging Centre (R.H., P.S.T.), University of Manchester, United Kingdom.

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http://dx.doi.org/10.1212/NXI.0000000000000443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840890PMC
May 2018

Functional neuroanatomical associations of working memory in early-onset Alzheimer's disease.

Int J Geriatr Psychiatry 2018 Jan 16;33(1):176-184. Epub 2017 Mar 16.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/gps.4703DOI Listing
January 2018

Microglial activation, white matter tract damage, and disability in MS.

Neurol Neuroimmunol Neuroinflamm 2018 May 6;5(3):e443. Epub 2018 Mar 6.

Turku PET Centre (E.R., J.T., M.S., J.R., J.O.R.), Division of Clinical Neurosciences (E.R., M.S., J.O.R., L.A.), Department of Biostatistics (T.V.), and Medical Imaging Centre of Southwest Finland (T.P., R.P.), Turku University Hospital and University of Turku, Finland; Division of Neuroscience and Experimental Psychology (A.G.), University of Manchester, United Kingdom; Department of Nuclear Medicine and Geriatric Medicine (A.G.), University Hospital Essen, Germany; and Wolfson Molecular Imaging Centre (R.H., P.S.T.), University of Manchester, United Kingdom.

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http://dx.doi.org/10.1212/NXI.0000000000000443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840890PMC
May 2018

TSPO imaging in parkinsonian disorders.

Clin Transl Imaging 2016;4:183-190. Epub 2016 Apr 11.

Wolfson Molecular Imaging Centre, Institute of Brain, Behaviour and Mental Health, The University of Manchester, 27 Palatine Road, Withington, Manchester, M20 3LJ UK.

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http://dx.doi.org/10.1007/s40336-016-0171-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870295PMC
April 2016

TSPO expression in brain tumours: is TSPO a target for brain tumour imaging?

Clin Transl Imaging 2016;4:145-156. Epub 2016 Mar 22.

Department of Neuroimaging, IoPPN, King's College London, London, UK.

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http://dx.doi.org/10.1007/s40336-016-0168-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820497PMC
March 2016

Cognitive-behavioural features of progressive supranuclear palsy syndrome overlap with frontotemporal dementia.

J Neurol 2015 7;262(4):916-22. Epub 2015 Feb 7.

Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK,

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http://dx.doi.org/10.1007/s00415-015-7657-zDOI Listing
January 2016

Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.

Neurobiol Dis 2015 Aug 15;80:29-41. Epub 2015 May 15.

Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.05.004DOI Listing
August 2015

The 18-kDa mitochondrial translocator protein in gliomas: from the bench to bedside.

Biochem Soc Trans 2015 Aug 3;43(4):579-85. Epub 2015 Aug 3.

Division of Brain Science, Wolfson Neuroscience Laboratories, Imperial College London, Du Cane Road, London W12 0NN, U.K.

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http://dx.doi.org/10.1042/BST20150064DOI Listing
August 2015

Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson's disease.

Brain Behav 2015 May 25;5(5):e00320. Epub 2015 Mar 25.

Department of Neurology, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust Stott Lane, M6 8HD, Salford, U.K ; Centre for Clinical and Cognitive Neurosciences, Institute of Brain Behaviour and Mental Health, University of Manchester Manchester, U.K.

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http://dx.doi.org/10.1002/brb3.320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389053PMC
May 2015

18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke.

Eur J Nucl Med Mol Imaging 2015 Mar 29;42(3):503-11. Epub 2014 Oct 29.

Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK,

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http://dx.doi.org/10.1007/s00259-014-2939-8DOI Listing
March 2015

Patterns of microglial cell activation in frontotemporal lobar degeneration.

Neuropathol Appl Neurobiol 2014 Oct;40(6):686-96

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, UK.

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http://dx.doi.org/10.1111/nan.12092DOI Listing
October 2014

Frontotemporal dementia and its subtypes: a genome-wide association study.

Authors:
Raffaele Ferrari Dena G Hernandez Michael A Nalls Jonathan D Rohrer Adaikalavan Ramasamy John B J Kwok Carol Dobson-Stone William S Brooks Peter R Schofield Glenda M Halliday John R Hodges Olivier Piguet Lauren Bartley Elizabeth Thompson Eric Haan Isabel Hernández Agustín Ruiz Mercè Boada Barbara Borroni Alessandro Padovani Carlos Cruchaga Nigel J Cairns Luisa Benussi Giuliano Binetti Roberta Ghidoni Gianluigi Forloni Daniela Galimberti Chiara Fenoglio Maria Serpente Elio Scarpini Jordi Clarimón Alberto Lleó Rafael Blesa Maria Landqvist Waldö Karin Nilsson Christer Nilsson Ian R A Mackenzie Ging-Yuek R Hsiung David M A Mann Jordan Grafman Christopher M Morris Johannes Attems Timothy D Griffiths Ian G McKeith Alan J Thomas P Pietrini Edward D Huey Eric M Wassermann Atik Baborie Evelyn Jaros Michael C Tierney Pau Pastor Cristina Razquin Sara Ortega-Cubero Elena Alonso Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Alexander Kurz Innocenzo Rainero Elisa Rubino Lorenzo Pinessi Ekaterina Rogaeva Peter St George-Hyslop Giacomina Rossi Fabrizio Tagliavini Giorgio Giaccone James B Rowe Johannes C M Schlachetzki James Uphill John Collinge Simon Mead Adrian Danek Vivianna M Van Deerlin Murray Grossman John Q Trojanowski Julie van der Zee William Deschamps Tim Van Langenhove Marc Cruts Christine Van Broeckhoven Stefano F Cappa Isabelle Le Ber Didier Hannequin Véronique Golfier Martine Vercelletto Alexis Brice Benedetta Nacmias Sandro Sorbi Silvia Bagnoli Irene Piaceri Jørgen E Nielsen Lena E Hjermind Matthias Riemenschneider Manuel Mayhaus Bernd Ibach Gilles Gasparoni Sabrina Pichler Wei Gu Martin N Rossor Nick C Fox Jason D Warren Maria Grazia Spillantini Huw R Morris Patrizia Rizzu Peter Heutink Julie S Snowden Sara Rollinson Anna Richardson Alexander Gerhard Amalia C Bruni Raffaele Maletta Francesca Frangipane Chiara Cupidi Livia Bernardi Maria Anfossi Maura Gallo Maria Elena Conidi Nicoletta Smirne Rosa Rademakers Matt Baker Dennis W Dickson Neill R Graff-Radford Ronald C Petersen David Knopman Keith A Josephs Bradley F Boeve Joseph E Parisi William W Seeley Bruce L Miller Anna M Karydas Howard Rosen John C van Swieten Elise G P Dopper Harro Seelaar Yolande A L Pijnenburg Philip Scheltens Giancarlo Logroscino Rosa Capozzo Valeria Novelli Annibale A Puca Massimo Franceschi Alfredo Postiglione Graziella Milan Paolo Sorrentino Mark Kristiansen Huei-Hsin Chiang Caroline Graff Florence Pasquier Adeline Rollin Vincent Deramecourt Florence Lebert Dimitrios Kapogiannis Luigi Ferrucci Stuart Pickering-Brown Andrew B Singleton John Hardy Parastoo Momeni

Lancet Neurol 2014 Jul;13(7):686-99

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70065-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112126PMC
July 2014

Imaging of neuroinflammation in parkinsonian syndromes with positron emission tomography.

Curr Neurol Neurosci Rep 2013 Dec;13(12):405

Wolfson Molecular Imaging Center, Institute of Brain, Behaviour and Mental Health, The University of Manchester, 27 Palatine Road, Withington, Manchester, M20 3LJ, UK,

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http://dx.doi.org/10.1007/s11910-013-0405-9DOI Listing
December 2013

[¹¹C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches.

Eur J Nucl Med Mol Imaging 2013 Sep 29;40(9):1406-19. Epub 2013 May 29.

Wolfson Molecular Imaging Centre, University of Manchester, 27 Palatine Road, Manchester, UK.

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http://dx.doi.org/10.1007/s00259-013-2447-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738844PMC
September 2013

Diffusion-weighted imaging and its relationship to microglial activation in parkinsonian syndromes.

Parkinsonism Relat Disord 2013 May 18;19(5):527-32. Epub 2013 Feb 18.

Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/j.parkreldis.2013.01.017DOI Listing
May 2013

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study.

Neurobiol Dis 2008 Dec 15;32(3):412-9. Epub 2008 Aug 15.

MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK.

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http://dx.doi.org/10.1016/j.nbd.2008.08.001DOI Listing
December 2008

Functional relevant loss of long association fibre tracts integrity in early Alzheimer's disease.

Neuropsychologia 2008 23;46(6):1698-706. Epub 2007 Dec 23.

Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.neuropsychologia.2007.12.010DOI Listing
September 2008

Microglial activation in presymptomatic Huntington's disease gene carriers.

Brain 2007 Jul 30;130(Pt 7):1759-66. Epub 2007 Mar 30.

MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1093/brain/awm044DOI Listing
July 2007

A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195.

Neuroimage 2007 May 21;36(1):28-37. Epub 2007 Feb 21.

Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2007.02.017DOI Listing
May 2007

Imaging microglial activation in Huntington's disease.

Brain Res Bull 2007 Apr 27;72(2-3):148-51. Epub 2006 Nov 27.

Division of Neuroscience and Psychological Medicine, Hammersmith Hospital, Imperial College London, UK.

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http://dx.doi.org/10.1016/j.brainresbull.2006.10.029DOI Listing
April 2007

Reference and target region modeling of [11C]-(R)-PK11195 brain studies.

J Nucl Med 2007 Jan;48(1):158-67

Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom.

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January 2007

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease.

Neurobiol Dis 2006 Feb 21;21(2):404-12. Epub 2005 Sep 21.

MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.nbd.2005.08.002DOI Listing
February 2006

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.

Mov Disord 2006 Jan;21(1):89-93

MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, and National Hospital for Neurology and Neurosurgery, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.20668DOI Listing
January 2006

Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study.

Neuroimage 2005 Jan 18;24(2):591-5. Epub 2004 Nov 18.

MRC Clinical Sciences Centre and Department of Neuropathology, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2004.09.034DOI Listing
January 2005

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration.

Mov Disord 2004 Oct;19(10):1221-6

MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.20162DOI Listing
October 2004

Cardiovascular effects of methamphetamine in Parkinson's disease patients.

Mov Disord 2004 Mar;19(3):298-303

MRC Clinical Science Center and Division of Neurosciences, Faculty of Medicine, Imperial College. Hammersmith Hospital Campus, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.10651DOI Listing
March 2004

In vivo imaging of neuroinflammation.

Eur Neuropsychopharmacol 2002 Dec;12(6):581-6

Clinical Sciences Centre, PET-Neurology, Cyclotron Building, Hammersmith Hospital, DuCane Road, W12 ONN, London, UK.

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http://dx.doi.org/10.1016/s0924-977x(02)00107-4DOI Listing
December 2002