Publications by authors named "Alexander Federation"

18Publications

Highly Parallel Quantification and Compartment Localization of Transcription Factors and Nuclear Proteins.

Cell Rep 2020 02;30(8):2463-2471.e5

Altius Institute for Biomedical Sciences, Seattle, WA 98121, USA; University of Washington, Department of Genome Sciences, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.096DOI Listing
February 2020

Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia.

Cancer Cell 2018 12 29;34(6):982-995.e7. Epub 2018 Nov 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183048
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http://dx.doi.org/10.1016/j.ccell.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298230PMC
December 2018

Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity.

J Clin Invest 2018 11 2;128(11):4898-4911. Epub 2018 Oct 2.

Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI98353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205397PMC
November 2018

BET bromodomain proteins regulate enhancer function during adipogenesis.

Proc Natl Acad Sci U S A 2018 02 14;115(9):2144-2149. Epub 2018 Feb 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1711155115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834672PMC
February 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

Models of human core transcriptional regulatory circuitries.

Genome Res 2016 Mar 3;26(3):385-96. Epub 2016 Feb 3.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

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http://dx.doi.org/10.1101/gr.197590.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772020PMC
March 2016

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.

Cell 2014 Dec 4;159(7):1538-48. Epub 2014 Dec 4.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322776PMC
December 2014

The use of small molecules in somatic-cell reprogramming.

Trends Cell Biol 2014 Mar 31;24(3):179-87. Epub 2013 Oct 31.

Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2013.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943685PMC
March 2014

Tuning β-sheet peptide self-assembly and hydrogelation behavior by modification of sequence hydrophobicity and aromaticity.

Biomacromolecules 2011 Jul 24;12(7):2735-45. Epub 2011 May 24.

Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, USA.

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http://dx.doi.org/10.1021/bm200510kDOI Listing
July 2011