Publications by authors named "Alexander F Markham"

67Publications

CD105 is a prognostic marker and valid endothelial target for microbubble platforms in cholangiocarcinoma.

Cell Oncol (Dordr) 2020 Oct 28;43(5):835-845. Epub 2020 May 28.

Leeds Institute of Medical Research, St James's University Hospital, Leeds, LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13402-020-00530-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581571PMC
October 2020

Increased Sensitivity of Diagnostic Mutation Detection by Re-analysis Incorporating Local Reassembly of Sequence Reads.

Mol Diagn Ther 2017 12;21(6):685-692

Yorkshire Regional Genetics Service, St. James's University Hospital, 6.2 Clinical Sciences Building, Leeds, LS9 7TF, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40291-017-0304-xDOI Listing
December 2017

Characterization and Genomic Localization of a SMAD4 Processed Pseudogene.

J Mol Diagn 2017 11 1;19(6):933-940. Epub 2017 Sep 1.

Yorkshire Regional Genetics Service, St. James's University Hospital, Leeds, United Kingdom; MRC Medical Bioinformatics Centre, Leeds Institute for Data Analytics, St. James's University Hospital, Leeds, United Kingdom; MRC Single Cell Functional Genomics Centre, University of Leeds, St. James's University Hospital, Leeds, United Kingdom.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15251578173031
Publisher Site
http://dx.doi.org/10.1016/j.jmoldx.2017.08.002DOI Listing
November 2017

m6aViewer: software for the detection, analysis, and visualization of -methyladenosine peaks from mA-seq/ME-RIP sequencing data.

RNA 2017 10 19;23(10):1493-1501. Epub 2017 Jul 19.

Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital, Leeds LS9 7TF, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.058206.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602108PMC
October 2017

Evaluation of lipid-stabilised tripropionin nanodroplets as a delivery route for combretastatin A4.

Int J Pharm 2017 Jun 8;526(1-2):547-555. Epub 2017 May 8.

School of Physics and Astronomy, University of Leeds, LS2 9JT, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2017.05.009DOI Listing
June 2017

The influence of intercalating perfluorohexane into lipid shells on nano and microbubble stability.

Soft Matter 2016 Sep 8;12(34):7223-30. Epub 2016 Aug 8.

Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, LS2 9JT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c6sm00956eDOI Listing
September 2016

On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging.

Lab Chip 2016 Feb 22;16(4):679-87. Epub 2015 Dec 22.

School of Physics and Astronomy, University of Leeds, LS2 9JT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c5lc01394aDOI Listing
February 2016

GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles.

Bioinformatics 2015 Aug 9;31(16):2728-35. Epub 2015 Apr 9.

Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btv196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528628PMC
August 2015

Detection of somatic mutations in tumors using unaligned clonal sequencing data.

Lab Invest 2014 Oct 28;94(10):1173-83. Epub 2014 Jul 28.

Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital, Leeds, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/labinvest.2014.96DOI Listing
October 2014

An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomas.

BMC Clin Pathol 2013 Dec 13;13(1):32. Epub 2013 Dec 13.

School of Medicine, University of Leeds, Wellcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1472-6890-13-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028812PMC
December 2013

The use of high-frequency ultrasound imaging and biofluorescence for in vivo evaluation of gene therapy vectors.

BMC Med Imaging 2013 Nov 12;13:35. Epub 2013 Nov 12.

School of Medicine, University of Leeds Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2342-13-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831818PMC
November 2013

Autozygosity mapping with exome sequence data.

Hum Mutat 2013 Jan 22;34(1):50-6. Epub 2012 Oct 22.

School of Medicine, University of Leeds, Leeds, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.22220DOI Listing
January 2013

High-frequency ultrasound for in vivo measurement of colon wall thickness in mice.

Ultrasound Med Biol 2012 Mar 21;38(3):432-42. Epub 2012 Jan 21.

Leeds Institute of Molecular Medicine, University of Leeds, St. James's University Hospital, Leeds United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ultrasmedbio.2011.12.011DOI Listing
March 2012

Identification of autosomal recessive disease loci using out-bred nuclear families.

Hum Mutat 2012 Feb 28;33(2):338-42. Epub 2011 Nov 28.

School of Medicine, University of Leeds, Leeds, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.21645DOI Listing
February 2012

Illuminator, a desktop program for mutation detection using short-read clonal sequencing.

Genomics 2011 Oct 19;98(4):302-9. Epub 2011 May 19.

Leeds Institute of Molecular Medicine, University of Leeds, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygeno.2011.05.004DOI Listing
October 2011

Genetic predisposition to fracture non-union: a case control study of a preliminary single nucleotide polymorphisms analysis of the BMP pathway.

BMC Musculoskelet Disord 2011 Feb 10;12:44. Epub 2011 Feb 10.

Academic Unit of Trauma and Orthopaedic Surgery, LIMM Section Musculoskeletal Disease, Clarendon Wing, Leeds Teaching Hospitals NHS Trust, Great George Street, Leeds LS1 3EX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2474-12-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053586PMC
February 2011

GeneScreen: a program for high-throughput mutation detection in DNA sequence electropherograms.

J Med Genet 2011 Feb 30;48(2):123-30. Epub 2010 Oct 30.

Division of Molecular & Translational Medicine, Leeds Institute for Molecular Medicine, University of Leeds, St James's University Hospital, Leeds, UK.

View Article

Download full-text PDF

Source
http://www.tara.tcd.ie/bitstream/handle/2262/53909/PEER_stag
Web Search
http://jmg.bmj.com/cgi/doi/10.1136/jmg.2010.082081
Publisher Site
http://dx.doi.org/10.1136/jmg.2010.082081DOI Listing
February 2011

MethylViewer: computational analysis and editing for bisulfite sequencing and methyltransferase accessibility protocol for individual templates (MAPit) projects.

Nucleic Acids Res 2011 Jan 19;39(1):e5. Epub 2010 Oct 19.

Department of Biochemistry and Molecular Biology, University of Florida Shands Cancer Center Program in Cancer Genetics, Epigenetics and Tumor Virology, Gainesville, FL 32610-3633, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkq716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017589PMC
January 2011

Common and recurrent HPGD mutations in Caucasian individuals with primary hypertrophic osteoarthropathy.

Rheumatology (Oxford) 2010 Jun 18;49(6):1056-62. Epub 2010 Mar 18.

Leeds Institute of Molecular Medicine, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/keq048DOI Listing
June 2010

Genetic diagnosis of familial breast cancer using clonal sequencing.

Hum Mutat 2010 Apr;31(4):484-91

University of Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Beckett Street, Leeds, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.21216DOI Listing
April 2010

Shadow autozygosity mapping by linkage exclusion (SAMPLE): a simple strategy to identify the genetic basis of lethal autosomal recessive disorders.

Hum Mutat 2009 Dec;30(12):1642-9

Division of Molecular & Translational Medicine, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.21105DOI Listing
December 2009

IBDfinder and SNPsetter: tools for pedigree-independent identification of autozygous regions in individuals with recessive inherited disease.

Hum Mutat 2009 Jun;30(6):960-7

Centre for Autozygosity Mapping and Section of Genetics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.20974DOI Listing
June 2009

Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.

Nat Genet 2008 Jun 25;40(6):789-93. Epub 2008 May 25.

Leeds Institute of Molecular Medicine, University of Leeds, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.153DOI Listing
June 2008

Sequence analysis and editing for bisulphite genomic sequencing projects.

Nucleic Acids Res 2007 21;35(10):e79. Epub 2007 May 21.

Leeds Institute for Molecular Medicine, University of Leeds, Leeds, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gkm330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904293PMC
June 2007

Interactive visual analysis of SNP data for rapid autozygosity mapping in consanguineous families.

Hum Mutat 2006 Oct;27(10):1041-6

Leeds Institute for Molecular Medicine, St James's University Hospital, University of Leeds, Leeds, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.20383DOI Listing
October 2006

A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity.

Blood 2006 May 12;107(9):3665-8. Epub 2006 Jan 12.

Leeds Institute of Molecular Medicine, University of Leeds, St James's University Hospital, Leeds LS9 7TF, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-03-1140DOI Listing
May 2006

Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP.

FEBS Lett 2003 Nov;554(3):501-4

Molecular Medicine Unit, Level 6, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0014-5793(03)01235-3DOI Listing
November 2003

Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis.

Blood 2004 Feb 2;103(3):1050-8. Epub 2003 Oct 2.

Molecular Medicine Unit, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-03-0707DOI Listing
February 2004

Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development.

Mech Dev 2002 Dec;119 Suppl 1:S43-7

Molecular Medicine Unit, Clinical Sciences Building, St. James's University Hospital, The University of Leeds, Leeds, LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0925-4773(03)00090-xDOI Listing
December 2002

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin.

Mol Biol Cell 2003 Nov 22;14(11):4541-56. Epub 2003 Aug 22.

Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Leeds LS9 7TF, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e03-02-0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC266771PMC
November 2003

Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development.

Gene Expr Patterns 2002 Nov;2(1-2):39-43

Molecular Medicine Unit, Clinical Sciences Building, St. James's University Hospital, The University of Leeds, Leeds, LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0925-4773(02)00354-4DOI Listing
November 2002

Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells.

Oncogene 2002 Oct;21(47):7175-86

Molecular Medicine Unit, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1205869DOI Listing
October 2002

ASPM is a major determinant of cerebral cortical size.

Nat Genet 2002 Oct 23;32(2):316-20. Epub 2002 Sep 23.

Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng995DOI Listing
October 2002

Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management.

Pediatrics 2002 Feb;109(2):E32

Molecular Medicine Unit, University of Leeds, St James's University Hospital, Leeds, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.109.2.e32DOI Listing
February 2002

Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.

Carcinogenesis 2002 Jan;23(1):107-14

Molecular Medicine Unit, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/23.1.107DOI Listing
January 2002

Characterization of the herpesvirus saimiri ORF73 gene product.

J Gen Virol 2000 Nov;81(Pt 11):2653-2658

Molecular Medicine Unit, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/0022-1317-81-11-2653DOI Listing
November 2000