Alexander Eggermont

Alexander Eggermont

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Alexander Eggermont

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The great debate at "Melanoma Bridge 2018", Naples, December 1st, 2018.

J Transl Med 2019 May 10;17(1):148. Epub 2019 May 10.

Clinical Trials Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale", Naples, Italy.

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http://dx.doi.org/10.1186/s12967-019-1892-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509811PMC
May 2019

Estimation of Distant Metastasis-free Survival in Trials of Adjuvant Therapy for Melanoma.

N Engl J Med 2019 04;380(14):1374-1376

EORTC Headquarters, Brussels, Belgium.

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http://dx.doi.org/10.1056/NEJMc1902228DOI Listing
April 2019

Boosting the social impact of innovative cancer research - towards a mission-oriented approach to cancer.

Mol Oncol 2019 03 27;13(3):497-501. Epub 2019 Feb 27.

Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/1878-0261.12464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396369PMC
March 2019

PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade.

Br J Cancer 2019 01 9;120(1):3-5. Epub 2018 Nov 9.

Département d'Innovation Thérapeutique et d'Essais Précoces, Gustave Roussy, Université Paris-Saclay, Villejuif, F-94805, France.

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http://www.nature.com/articles/s41416-018-0294-4
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http://dx.doi.org/10.1038/s41416-018-0294-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325162PMC
January 2019

The new era of adjuvant therapies for melanoma.

Nat Rev Clin Oncol 2018 09;15(9):535-536

Department of Medicine, Division of Hematology and Oncology, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.

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http://www.nature.com/articles/s41571-018-0048-5
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http://dx.doi.org/10.1038/s41571-018-0048-5DOI Listing
September 2018

Adjuvant Pembrolizumab in Resected Stage III Melanoma.

N Engl J Med 2018 08;379(6):593-595

European Organization for the Research and Treatment of Cancer Headquarters, Brussels, Belgium

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http://dx.doi.org/10.1056/NEJMc1807505DOI Listing
August 2018

A roadmap for restoring trust in Big Data.

Lancet Oncol 2018 08;19(8):1014-1015

European Alliance for Personalised Medicine, Brussels, Belgium; Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.

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http://dx.doi.org/10.1016/S1470-2045(18)30425-XDOI Listing
August 2018

Reply to 'Challenging PD-L1 expressing cytotoxic T cells as a predictor for response to immunotherapy in melanoma'.

Nat Commun 2018 07 26;9(1):2922. Epub 2018 Jul 26.

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805, Villejuif, France.

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http://dx.doi.org/10.1038/s41467-018-05048-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062500PMC
July 2018

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma.

N Engl J Med 2018 May 15;378(19):1789-1801. Epub 2018 Apr 15.

From the Gustave Roussy Cancer Campus Grand Paris and University Paris-Saclay, Villejuif (A.M.M.E., C.R.), Hospices Civils de Lyon Cancer Institute, Cancer Research Center of Lyon, Lyon University, Lyon (S.D.), and Aix-Marseille University, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille (J.-J.G.) - all in France; Netherlands Cancer Institute-Antoni van Leeuwenhoek (C.U.B., A.C.J.A.) and VU University Medical Center (A.J.M.E.), Amsterdam, and Radboud University Medical Center Nijmegen, Nijmegen (R.K.) - all in the Netherlands; Azienda Ospedaliera Papa Giovanni XXIII, Bergamo (M. Mandala), Istituto Nazionale Tumori Istituto di Ricovero e Cura a Carattere Scientifico Fondazione G. Pascale, Naples (P.A.A.), and Universita Degli Studi Di Siena-Policlinico le Scotte, Siena (M. Maio) - all in Italy; Melanoma Institute Australia, the University of Sydney, and Mater and Royal North Shore Hospitals (G.V.L.) and Westmead and Blacktown Hospitals, Melanoma Institute Australia and the University of Sydney (M.S.C.), Sydney, Princess Alexandra Hospital, University of Queensland, Brisbane (V.A.), Alfred Hospital (A.H.) and Peter MacCallum Cancer Centre (S. Sandhu), Melbourne, VIC, and Fiona Stanley Hospital-University of Western Australia-Edith Cowan University Perth, Perth (A.K.) - all in Australia; Cancer Research Center, Moscow (M.L.); Royal Marsden Hospital, London (J.L.); Hospital Clinic Universitari de Barcelona, Barcelona (S.P.); Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland (P.R.); University Hospital Essen, Essen and German Cancer Consortium, Heidelberg (D.S.), and the Skin Cancer Center, Department of Dermatology, Hannover Medical School, Hannover (R.G.) - all in Germany; Washington University School of Medicine, St. Louis (L.H.-A.); Centre Hospitalier de l'Université de Montréal (CHUM), Centre de Recherche du CHUM, Montreal (R.J.); Christie NHS Foundation Trust, Manchester, United Kingdom (P.L.); Merck, Kenilworth, NJ (N.I.); and the European Organization for the Research and Treatment of Cancer Headquarters, Brussels (S.M., S. Suciu).

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http://dx.doi.org/10.1056/NEJMoa1802357DOI Listing
May 2018

Combination Immunotherapy Development in Melanoma.

Am Soc Clin Oncol Educ Book 2018 May;38:197-207

From the Gustave Roussy Cancer Institute and University Paris-Saclay, Villejuif, France; Earle A. Chiles Research Institute, Portland, OR; The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/EDBK_201131DOI Listing
May 2018

European Academy of Cancer Sciences-Designation of Comprehensive Cancer Centres of Excellence.

Eur J Cancer 2018 04 14;93:138-139. Epub 2018 Feb 14.

The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2018.01.003DOI Listing
April 2018

Neoadjuvant therapy in melanoma: the next step?

Lancet Oncol 2018 02 18;19(2):151-153. Epub 2018 Jan 18.

Cancer Institute Gustave Roussy, University Paris-Sud, 98400 Villejuif/Paris-Sud, France.

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http://dx.doi.org/10.1016/S1470-2045(18)30016-0DOI Listing
February 2018

Relapse-Free Survival as a Surrogate for Overall Survival in the Evaluation of Stage II-III Melanoma Adjuvant Therapy.

J Natl Cancer Inst 2018 01;110(1)

European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium; Gustave Roussy Cancer Campus Grand Paris, Villejuif, France; The Christie NHS Foundation Trust, Manchester, UK; University of Pittsburgh Cancer Institute and School of Medicine, Pittsburgh, PA; Mayo Clinic Rochester, Rochester, MN; University of Tubingen, Tubingen, Germany; University of Edinburgh, Western General Hospital, Edinburgh, UK; Bristol-Myers Squibb, Wallingford, CT; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK; Universitas Brawijaya, Malang, Indonesia; IDDI, Louvain-la-Neuve, Belgium.

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http://dx.doi.org/10.1093/jnci/djx133DOI Listing
January 2018

Development and evaluation of an isolated limb infusion model for investigation of drug delivery kinetics to solid tumors by thermosensitive liposomes and hyperthermia.

J Control Release 2018 01 18;270:282-289. Epub 2017 Dec 18.

Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jconrel.2017.12.012DOI Listing
January 2018

Pre-SN Ultrasound-FNAC can be Sensitive for Lymph Node Metastases in Melanoma Patients if Performed with the Use of the Berlin Criteria.

Ann Surg Oncol 2017 12 20;24(Suppl 3):661-662. Epub 2017 Nov 20.

Institut de Cancérologie, Gustav Roussy, Villejuif, France.

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http://dx.doi.org/10.1245/s10434-017-6230-7DOI Listing
December 2017

Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3.

Oncotarget 2017 Dec 30;8(65):108786-108801. Epub 2017 Oct 30.

INSERM UMR1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Equipe Labellisée par La Ligue Contre Le Cancer, EPHE, Faculté de Médecine, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.18632/oncotarget.22150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752481PMC
December 2017

The 2017 complete overhaul of adjuvant therapies for high-risk melanoma and its consequences for staging and management of melanoma patients.

Eur J Cancer 2017 11 29;86:101-105. Epub 2017 Sep 29.

University Hospital Zürich, Department of Dermatology, Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.ejca.2017.09.014DOI Listing
November 2017

Investigation of Particle Accumulation, Chemosensitivity and Thermosensitivity for Effective Solid Tumor Therapy Using Thermosensitive Liposomes and Hyperthermia.

Theranostics 2016 24;6(10):1717-31. Epub 2016 Jun 24.

1. Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.7150/thno.14960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955068PMC
October 2017

Adjuvant interferon-α for the treatment of high-risk melanoma: An individual patient data meta-analysis.

Eur J Cancer 2017 09 7;82:171-183. Epub 2017 Jul 7.

Cancer Research UK Clinical Trials Unit, College of Medical and Dental Sciences, Robert Aitken Institute, University of Birmingham, Birmingham, B15 2TT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.06.006DOI Listing
September 2017

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape.

Eur J Cancer 2017 08 15;81:116-129. Epub 2017 Jun 15.

Research Branch, Sidra Medical and Research Centre, Doha, Qatar. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.01.035DOI Listing
August 2017

Comparing the therapeutic potential of thermosensitive liposomes and hyperthermia in two distinct subtypes of breast cancer.

J Control Release 2017 07 4;258:34-42. Epub 2017 May 4.

Department of Surgery, Erasmus MC, 's-Gravendijkwal 230, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jconrel.2017.05.005DOI Listing
July 2017

Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1.

Clin Cancer Res 2017 04 8;23(8):1920-1928. Epub 2016 Nov 8.

Département d'Innovation Thérapeutique et des Essais Précoces (DITEP), Gustave Roussy, Université Paris Saclay, Villejuif, France.

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http://clincancerres.aacrjournals.org/content/early/2016/11/
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http://dx.doi.org/10.1158/1078-0432.CCR-16-1741DOI Listing
April 2017

Ipilimumab Adjuvant Therapy in Melanoma.

N Engl J Med 2017 01;376(4):399

European Institute of Oncology, Milan, Italy

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http://dx.doi.org/10.1056/NEJMc1615564DOI Listing
January 2017

Adjuvant ipilimumab in stage III melanoma: New landscape, new questions.

Eur J Cancer 2016 12 4;69:39-42. Epub 2016 Nov 4.

Gustave Roussy Cancer Campus Grand Paris, Villejuif, France; Universite Paris-Sud, Kremlin-Bicêtre, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.10.009DOI Listing
December 2016

A systematic review examining factors influencing health related quality of life among melanoma cancer survivors.

Eur J Cancer 2016 12 11;69:189-198. Epub 2016 Nov 11.

European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2016.10.008DOI Listing
December 2016

Cost-effectiveness analysis in melanoma detection: A transition model applied to dermoscopy.

Eur J Cancer 2016 11 2;67:38-45. Epub 2016 Sep 2.

Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2016.07.020DOI Listing
November 2016

Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy.

N Engl J Med 2016 11 7;375(19):1845-1855. Epub 2016 Oct 7.

From Gustave Roussy Cancer Campus Grand Paris, Villejuif (A.M.M.E., C.R.), Aix-Marseille University, Hôpital de La Timone, Marseille (J.-J.G.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Paris (C.L.), University Lille, INSERM Unité-1189, Centre Hospitalier Universitaire (CHU) Lille, Service de Dermatologie, Lille (L.M.), and CHU Lyon, Lyon (L.T.) - all in France; the Oncology Institute of Veneto-Istituto di Ricovero e Cura a Carattere Scientifico, Padua (V.C.-S.), Istituto Nazionale Tumori Fondazione G. Pascale, Naples (P.A.A.), Istituti Fisioterapici Ospitalieri, Rome (V.F.), University Hospital of Siena, Istituto Toscano Tumori, Siena (M.M.), and the European Institute of Oncology, Milan (A.T.) - all in Italy; University of Zurich Hospital, Zurich, Switzerland (R.D.); Memorial Sloan Kettering Cancer Center, New York (J.D.W.); Aarhus University Hospital, Aarhus (H.S.), and Odense University Hospital, Odense (L.B.) - both in Denmark; the Angeles Clinic and Research Institute, Los Angeles (O.H.); Oncology Specialists, Park Ridge, IL (J.M.R.); Cross Cancer Institute, Edmonton, AB, Canada (M.S.); H. Lee Moffitt Cancer Center, Tampa, FL (J.S.W.); Broomfield Hospital, Chelmsford, United Kingdom (S.T.); Universitätsklinikum Schleswig-Holstein, Kiel (A.H.), and University Hospital Heidelberg, Heidelberg (J.C.H.) - both in Germany; Dana-Farber Cancer Institute, Boston (F.S.H.); Bristol-Myers Squibb, Princeton, NJ (C.T., V.P.); and the European Organization for Research and Treatment of Cancer, Brussels (G.S., S.S.).

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http://dx.doi.org/10.1056/NEJMoa1611299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648545PMC
November 2016

Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status.

Eur Urol 2016 10 23;70(4):623-632. Epub 2015 Dec 23.

INSERM (Institut National de la Santé et de la Recherche Médicale) UMR1186, Laboratory Integrative Tumor Immunology and Genetic Oncology, Villejuif, France; INSERM, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif, F-94805, France. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.11.029DOI Listing
October 2016

Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration.

Eur J Cancer 2016 10 11;66:34-46. Epub 2016 Aug 11.

Department of Surgical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands; Gustave Roussy Cancer Campus Grand Paris, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.020DOI Listing
October 2016

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects.

Immunity 2016 10 4;45(4):931-943. Epub 2016 Oct 4.

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, Villejuif, 94805, France; Institut National de la Santé Et de la Recherche Medicale (INSERM), U1015, GRCC, Villejuif, 94805, France; University of Paris-Saclay, Kremlin Bicêtre, 94270, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, 94805, France. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.09.009DOI Listing
October 2016

Prognostic and predictive value of YKL-40 in stage IIB-III melanoma.

Melanoma Res 2016 08;26(4):367-76

aDepartment of Oncology, Odense University Hospital, Odense C bThe Finsen Laboratory, Rigshospitalet, and Biotech Research and Innovation Centre, University of Copenhagen, København Departments of cOncology dMedicine ePathology, Herlev University Hospital, Herlev fAarhus University Hospital, Aarhus, Denmark gDepartment of Surgical Oncology, Erasmus University Medical Center-Daniel Den Hoed Cancer Center, Rotterdam, The Netherlands hKarolinska Institute, Stockholm, Sweden iEORTC Headquarters, Brussels, Belgium jGustave Roussy Cancer Institute, Villejuif, France.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/CMR.0000000000000237DOI Listing
August 2016

Melanomas prevent endothelial cell death under restrictive culture conditions by signaling through AKT and p38 MAPK/ ERK-1/2 cascades.

Oncoimmunology 2016 12;5(10):e1219826. Epub 2016 Aug 12.

Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus Medical Center , Rotterdam, the Netherlands.

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http://dx.doi.org/10.1080/2162402X.2016.1219826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087299PMC
August 2016

Trial Watch: Immunotherapy plus radiation therapy for oncological indications.

Oncoimmunology 2016 25;5(9):e1214790. Epub 2016 Jul 25.

INSERM, U1138, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie/Paris VI, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France; Gustave Roussy Cancer Campus, Villejuif, France; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1080/2162402X.2016.1214790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048768PMC
July 2016

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial.

Clin Cancer Res 2016 06 12;22(12):2960-8. Epub 2016 Jan 12.

Laboratoire de Recherche Translationnelle et Centre de RessourcesBiologiques, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France. INSERM U981, Gustave Roussy, Villejuif, France. Département de Biologie et Pathologie Médicales, Gustave Roussy, Villejuif, France. Faculté de Pharmacie, Université Paris Sud, Châtenay-Malabry, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2470DOI Listing
June 2016

Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity.

Melanoma Res 2016 06;26(3):267-71

aDepartment of Dermatology, Venerology and Allergology, Charité - University of Medicine Berlin, Berlin bDepartment of Dermatology, Harz Skin Cancer Center, Quedlinburg, Germany cDepartment of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam dDepartment of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands eGustav Roussy, Institute of Oncology, Villejuif/Paris-Sud, France.

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http://dx.doi.org/10.1097/CMR.0000000000000223DOI Listing
June 2016

Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy.

Oncoimmunology 2016 Jun 10;5(6):e1149674. Epub 2016 Mar 10.

INSERM, U1138, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie/Paris VI, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2016.1149674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938376PMC
June 2016

Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis.

J Invest Dermatol 2016 05 29;136(5):994-1001. Epub 2016 Jan 29.

INSERM U1015, Gustave Roussy Cancer Center, Villejuif, France; University Paris Saclay, Kremlin Bicêtre, France; Gustave Roussy Cancer Center, Villejuif, France; CIC Biothérapie IGR Curie CIC1428, Gustave Roussy Cancer Center, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2015.12.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156792PMC
May 2016

Prognostic impact of the expression of NCR1 and NCR3 NK cell receptors and PD-L1 on advanced non-small cell lung cancer.

Oncoimmunology 2017 13;6(1):e1163456. Epub 2016 May 13.

Gustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM, GRCC, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT), GRCC, Villejuif, France; University of Paris Sud XI, Kremlin Bicêtre, France; Department of Immuno-Oncology, GRCC, Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2016.1163456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283624PMC
May 2016

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC.

Oncoimmunology 2016 Apr 12;5(4):e1071008. Epub 2015 Aug 12.

Gustave Roussy Cancer Campus, Villejuif, France; Laboratoire d'Immunomonitoring en Oncologie, UMS 3655 CNRS / US 23 INSERM Gustave Roussy Cancer Campus, Villejuif, France; Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France; Laboratoire de Thérapie Cellulaire, Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2015.1071008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839329PMC
April 2016

Pharmacokinetics, Tissue Distribution and Therapeutic Effect of Cationic Thermosensitive Liposomal Doxorubicin Upon Mild Hyperthermia.

Pharm Res 2016 Mar 30;33(3):627-38. Epub 2015 Oct 30.

Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus Medical Center, POBox 1738, 3000, DR, Rotterdam, The Netherlands.

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http://link.springer.com/10.1007/s11095-015-1815-y
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http://dx.doi.org/10.1007/s11095-015-1815-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744262PMC
March 2016

In depth study on thermosensitive liposomes: Optimizing formulations for tumor specific therapy and in vitro to in vivo relations.

Biomaterials 2016 Mar 22;82:138-50. Epub 2015 Dec 22.

Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.biomaterials.2015.12.023DOI Listing
March 2016

Secondary Tumors Arising in Patients Undergoing BRAF Inhibitor Therapy Exhibit Increased BRAF-CRAF Heterodimerization.

Cancer Res 2016 Mar 29;76(6):1476-84. Epub 2016 Jan 29.

Département de médecine oncologique, Gustave Roussy, Villejuif, France. INSERM, U981, Villejuif, France. Faculté de Médecine, Université Paris-Sud, Le Kremlin Bicetre, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2900-TDOI Listing
March 2016

Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy.

Oncoimmunology 2016 Mar 2;5(3):e1088631. Epub 2015 Sep 2.

INSERM, U1138, Paris, France; Université Pierre et Marie Curie/Paris VI, Paris, France; Gustave Roussy Cancer Campus, Villejuif, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1080/2162402X.2015.1088631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839356PMC
March 2016

Trial Watch-Immunostimulation with cytokines in cancer therapy.

Oncoimmunology 2016 Feb 8;5(2):e1115942. Epub 2015 Dec 8.

INSERM, U1138, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie/Paris VI, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France; Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2015.1115942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801437PMC
February 2016

Trial Watch-Oncolytic viruses and cancer therapy.

Oncoimmunology 2016 Feb 8;5(2):e1117740. Epub 2015 Dec 8.

INSERM, U1138, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie/Paris VI, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France; Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2015.1117740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801444PMC
February 2016

Enhanced Specificity and Drug Delivery in Tumors by cRGD-Anchoring Thermosensitive Liposomes.

Pharm Res 2015 Dec 23;32(12):3862-76. Epub 2015 Jul 23.

Laboratory Experimental Surgical Oncology, Section Surgical Oncology Department of Surgery, Erasmus MC Cancer Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s11095-015-1746-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628091PMC
December 2015

Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials.

J Clin Oncol 2015 Nov 24;33(32):3817-25. Epub 2015 Aug 24.

Maria Schwaederle, Melissa Zhao, and Razelle Kurzrock, Center for Personalized Cancer Therapy, University of California, San Diego, Moores Cancer Center, La Jolla, CA; J. Jack Lee and John Mendelsohn, The University of Texas MD Anderson Cancer Center, Houston, TX; Richard L. Schilsky, American Society of Clinical Oncology, Alexandria, VA; Alexander M. Eggermont and Vladimir Lazar, Institut Gustave Roussy, University Paris-Sud; and Alexander M. Eggermont, Richard L. Schilsky, John Mendelsohn, Vladimir Lazar, and Razelle Kurzrock, Worldwide Innovative Network in Personalized Cancer Medicine, Villejuif, France.

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http://jco.ascopubs.org/content/33/32/3817.full.pdf
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.61.5997
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http://dx.doi.org/10.1200/JCO.2015.61.5997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737863PMC
November 2015

Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA Approval.

J Natl Cancer Inst 2015 Nov 15;107(11). Epub 2015 Sep 15.

Department of Clinical Medicine, Hemocentro da Unicamp, University of Campinas, Sao Paulo, Brazil (DLFJ); Department of Clinical Oncology, Hospital Sirio Libanes, Sao Paulo, Brazil (DLFJ); Center for Personalized Cancer Therapy and Division of Hematology and Oncology, University of California, San Diego, CA (MS, RK); Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX (CW, JJL); Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, TX (DSH); Department of Functional Genomics, Institut Gustave Roussy, University Paris-Sud, Villejuif, France (AME, VL); Worldwide Innovative Network in Personalized Cancer Medicine, Villejuif, France (AME, RLS, JM, VL, RK); American Society of Clinical Oncology, Alexandria, VA (RLS); The University of Texas MD Anderson Cancer Center, Houston, TX (JM).

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http://jnci.oxfordjournals.org/content/107/11/djv253.full.pd
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http://jnci.oxfordjournals.org/content/108/3/djv430.full.pdf
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv25
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http://dx.doi.org/10.1093/jnci/djv253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857149PMC
November 2015

Trial Watch: Adoptive cell transfer for oncological indications.

Oncoimmunology 2015 Nov 5;4(11):e1046673. Epub 2015 May 5.

Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM; U1138 ; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers ; Paris, France ; Université Pierre et Marie Curie/Paris VI ; Paris, France ; Université Paris Descartes/Paris V , Sorbonne Paris Cité , Paris, France.

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http://dx.doi.org/10.1080/2162402X.2015.1046673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590013PMC
November 2015

How should we use anti-CTLA-4 antibodies?

Eur J Cancer 2015 Nov;51(17):2686-8

Gustave Roussy Cancer Campus Grand Paris, 114 rue Edouard Vaillant, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.ejca.2015.09.002DOI Listing
November 2015

Repeated isolated limb perfusion in melanoma patients with recurrent in-transit metastases.

Melanoma Res 2015 Oct;25(5):427-31

aDepartment of Surgical Oncology, Erasmus MC-Cancer Institute, Rotterdam, The Netherlands bGustave Roussy Cancer Campus Grand Paris, Villejuif, France.

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http://dx.doi.org/10.1097/CMR.0000000000000177DOI Listing
October 2015

Doubling the blockade for melanoma immunotherapy.

Oncoimmunology 2016;5(1):e1106127. Epub 2015 Oct 29.

Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM, U1138, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie/Paris VI, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1080/2162402X.2015.1106127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760293PMC
October 2015

Plasma membrane targeting by short chain sphingolipids inserted in liposomes improves anti-tumor activity of mitoxantrone in an orthotopic breast carcinoma xenograft model.

Eur J Pharm Biopharm 2015 Aug 14;94:207-19. Epub 2015 May 14.

Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus MC Cancer Institute, Rotterdam 3000 CA, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2015.05.003DOI Listing
August 2015

Immune checkpoint inhibitors in melanoma provide the cornerstones for curative therapies.

Semin Oncol 2015 Jun 14;42(3):429-35. Epub 2015 Feb 14.

Gustave Roussy Cancer Campus Grand Paris and University Paris-Sud, Paris, France.

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http://dx.doi.org/10.1053/j.seminoncol.2015.02.010DOI Listing
June 2015

A ring barrier-based migration assay to assess cell migration in vitro.

Nat Protoc 2015 Jun 21;10(6):904-15. Epub 2015 May 21.

Laboratory of Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1038/nprot.2015.056DOI Listing
June 2015

Trial watch: Naked and vectored DNA-based anticancer vaccines.

Oncoimmunology 2015 May 2;4(5):e1026531. Epub 2015 Apr 2.

Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM , U1138; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers ; Paris, France ; Université Pierre et Marie Curie/Paris VI ; Paris, France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris, France.

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http://dx.doi.org/10.1080/2162402X.2015.1026531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485755PMC
May 2015

Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications.

Oncoimmunology 2015 Apr 2;4(4):e1008814. Epub 2015 Mar 2.

Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM , U1138; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris, France.

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http://www.tandfonline.com/doi/full/10.1080/2162402X.2015.10
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http://dx.doi.org/10.1080/2162402X.2015.1008814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485728PMC
April 2015

Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy.

Oncoimmunology 2015 Apr 2;4(4):e1008866. Epub 2015 Mar 2.

Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM, U1138 ; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris, France.

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http://dx.doi.org/10.1080/2162402X.2015.1008866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485780PMC
April 2015

Trial Watch: Peptide-based anticancer vaccines.

Oncoimmunology 2015 Apr 9;4(4):e974411. Epub 2015 Jan 9.

Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM, U1138 ; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris, France.

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http://dx.doi.org/10.4161/2162402X.2014.974411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485775PMC
April 2015