Publications by authors named "Alexander Drilon"

100Publications

CNS Metastases in Patients With Exon 14-Altered Lung Cancers and Outcomes With Crizotinib.

JCO Precis Oncol 2020 27;4. Epub 2020 Jul 27.

Thoracic Oncology and Early Drug Development Services, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center; and Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/PO.20.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446485PMC
July 2020

The METeoric rise of MET in lung cancer.

Cancer 2020 Sep 5. Epub 2020 Sep 5.

Department of Oncology, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1002/cncr.33159DOI Listing
September 2020

Efficacy of Selpercatinib in -Altered Thyroid Cancers.

N Engl J Med 2020 08;383(9):825-835

From Massachusetts General Hospital (L.J.W.) and Dana-Farber Cancer Institute (J. Lorch), Boston; Memorial Sloan Kettering Cancer Center, New York (E.S., A.D.); Royal North Shore Hospital, St. Leonards, NSW (B.R.), and Peter MacCallum Cancer Institute, Melbourne, VIC (B.S.) - both in Australia; University of California, San Francisco-Helen Diller Family Comprehensive Cancer Center, San Francisco (H.K.), David Geffen School of Medicine at UCLA, Los Angeles (J.W.G.), and Chao Family Comprehensive Cancer Center, University of California Irvine, Orange (V.W.Z.) - all in California; University of Michigan, Ann Arbor (F.W.), and START Midwest, Grand Rapids (N.L.) - both in Michigan; University of Pennsylvania, Philadelphia (M.B.); University of Chicago, Chicago (J.P.); Gustave Roussy, Villejuif (S.L.), Institut Bergonié, Bordeaux (Y.G.), Aix Marseille University, Centre National de la Recherche Scientifique, INSERM, Centre de Recherche en Cancérologie de Marseille, Assistance Publique-Hôpitaux de Marseille, Early Phase Cancer Trial Center CLIP2, Hospital La Timone, Marseille (F.B.), Centre Léon Bérard, Lyon (C.D.L.F.), and Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris-Descartes, Paris (J.M.) - all in France; Mayo Clinic-Rochester, Rochester, MN (J.C.M.); Winship Cancer Institute of Emory University, Atlanta (T.K.O.); National Cancer Center Singapore, Singapore (D.S.W.T.); University of Bern, Bern, and Cantonal Hospital of Lucerne, Lucerne - both in Switzerland (O.G.); University of North Carolina-Chapel Hill, Chapel Hill (J.W.); University of Wisconsin-Carbone Cancer Center, Madison (M.E.B.); British Columbia Cancer Agency, Vancouver, Canada (J. Laskin); Oregon Health and Science University, Portland (M.H.T.); Universitätsklinikum Würzburg, Department of Internal Medicine I, Division of Endocrinology and Diabetology, Würzburg, Germany (M.K.); Sarah Cannon Research Institute-Tennessee Oncology, Nashville (T.M.B.); Johns Hopkins Kimmel Cancer Center, Washington, DC (B.L.); Fundación Jimenez Diaz, START-Madrid, Madrid (V.M.); Loxo Oncology, Stamford, CT (K.E., M.N., D.H., E.Y.Z., X.H., L.Y., J.K., S.M.R.); University of Texas M.D. Anderson Cancer Center, Houston (V.S., M.E.C.); and Ohio State University Comprehensive Cancer Center, Columbus (M.H.S.).

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http://dx.doi.org/10.1056/NEJMoa2005651DOI Listing
August 2020

Efficacy of Selpercatinib in Fusion-Positive Non-Small-Cell Lung Cancer.

N Engl J Med 2020 08;383(9):813-824

From Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College (A.D., E.R.) and New York University Langone Medical Center (V.V.), New York, and Roswell Park Comprehensive Cancer Center, Buffalo (G.K.D.) - all in New York; Dana-Farber Cancer Institute (G.R.O.) and Massachusetts General Hospital (J.G.), Boston; National Cancer Centre Singapore, Singapore (D.S.W.T.); the Chinese University of Hong Kong, Hong Kong, China (H.H.F.L.); Sarah Cannon Research Institute, Nashville (M.J.); University of California, San Francisco-Helen Diller Family Comprehensive Cancer Center, San Francisco (C.E.M.), University of California, San Diego, Moores Cancer Center, La Jolla (L.B.), and City of Hope Comprehensive Cancer Center, Duarte (K.L.R.) - all in California; University of Bern, Bern, and Cantonal Hospital of Lucerne, Lucerne - both in Switzerland (O.G.); Institut Gustave Roussy, Villejuif (B.B.), Hospital La Timone, Marseille (F.B.), and Centre Léon Bérard, Lyon (P.A.C.) - all in France; Severance Hospital, Yonsei University Health System (B.C.C.), and Samsung Medical Center, Sungkyunkwan University School of Medicine (K.P.), Seoul, and Seoul National University Bundang Hospital, Seongnam (Y.J.K.) - all in South Korea; Soroka University Medical Center, Beer-Sheva, Israel (N.P.); University of North Carolina-Chapel Hill, Chapel Hill (J. Weiss); National Cancer Center Hospital (Y.O.) and Cancer Institute Hospital of the Japanese Foundation for Cancer Research (M. Nishio), Tokyo, National Hospital Organization Kyushu Cancer Center, Fukuoka (T. Seto), Tottori University Hospital, Tottori (T. Sakamoto), Hyogo Cancer Center, Akashi (M.S.), Okayama University Hospital, Okayama (K.O.), and National Cancer Center Hospital East, Chiba (K.G.) - all in Japan; University of Chicago, Chicago (J.P.); the Ohio State University Comprehensive Cancer Center, Columbus (M.H.S.), and Cleveland Clinic, Cleveland (N.A.P.); Istituto Nazionale Tumori-National Cancer Institute, Università degli Studi di Milano, Milan (F.D.B.); Vall d'Hebron Institute of Oncology, Hospital Universitario Vall d'Hebron, Barcelona (E.G.); Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany (J. Wolf); Peter MacCallum Cancer Institute, Melbourne, VIC, Australia (B.S.); Sarah Cannon Research Institute at HealthONE, Denver (G.F.); Loxo Oncology, Stamford, CT (K.E., M. Nguyen, B.N., E.Y.Z., L.Y., X.H., E.O., S.M.R.); and the University of Texas M.D. Anderson Cancer Center, Houston (V.S.).

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http://dx.doi.org/10.1056/NEJMoa2005653DOI Listing
August 2020

ROS1-dependent cancers - biology, diagnostics and therapeutics.

Nat Rev Clin Oncol 2020 Aug 5. Epub 2020 Aug 5.

Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.

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http://dx.doi.org/10.1038/s41571-020-0408-9DOI Listing
August 2020

An umbrella approach to test lung cancer therapies.

Nature 2020 Jul;583(7818):688-689

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http://dx.doi.org/10.1038/d41586-020-02062-5DOI Listing
July 2020

Progresses Toward Precision Medicine in -altered Solid Tumors.

Clin Cancer Res 2020 Jul 14. Epub 2020 Jul 14.

Division of Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-20-1587DOI Listing
July 2020

MET-dependent solid tumours - molecular diagnosis and targeted therapy.

Nat Rev Clin Oncol 2020 Sep 8;17(9):569-587. Epub 2020 Jun 8.

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41571-020-0377-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478851PMC
September 2020

State-of-the-Art Strategies for Targeting -Dependent Cancers.

J Clin Oncol 2020 Apr 21;38(11):1209-1221. Epub 2020 Feb 21.

Department of Investigational Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.19.02551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145587PMC
April 2020

KRAS as a druggable target in NSCLC: Rising like a phoenix after decades of development failures.

Cancer Treat Rev 2020 Apr 7;85:101978. Epub 2020 Feb 7.

Oncology Department, University Hospital of Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2020.101978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448574PMC
April 2020

Complete Pathological Response to Crizotinib in a Patient with ALK-rearranged Lung Adenocarcinoma.

Clin Lung Cancer 2020 01 13;21(1):e25-e29. Epub 2019 Oct 13.

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1016/j.cllc.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996866PMC
January 2020

MET IHC Is a Poor Screen for MET Amplification or MET Exon 14 Mutations in Lung Adenocarcinomas: Data from a Tri-Institutional Cohort of the Lung Cancer Mutation Consortium.

J Thorac Oncol 2019 09 20;14(9):1666-1671. Epub 2019 Jun 20.

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1016/j.jtho.2019.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708730PMC
September 2019

The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.

Hum Pathol 2019 06 1;88:66-77. Epub 2019 Apr 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.humpath.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388159PMC
June 2019

NTRK fusion-positive cancers and TRK inhibitor therapy.

Nat Rev Clin Oncol 2018 12;15(12):731-747

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41571-018-0113-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419506PMC
December 2018

Tumor-Agnostic Drug Development.

Am Soc Clin Oncol Educ Book 2018 May;38:184-187

From the Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY; Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/EDBK_200831DOI Listing
May 2018

Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of , , and fusion-positive solid tumors.

Ther Clin Risk Manag 2018 20;14:1247-1252. Epub 2018 Jul 20.

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA,

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http://dx.doi.org/10.2147/TCRM.S147381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055893PMC
July 2018

Tumor Mutation Burden and Efficacy of EGFR-Tyrosine Kinase Inhibitors in Patients with -Mutant Lung Cancers.

Clin Cancer Res 2019 02 25;25(3):1063-1069. Epub 2018 Jul 25.

Department of Medicine, Division of Solid Tumor Oncology, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347551PMC
February 2019

Ado-Trastuzumab Emtansine for Patients With HER2-Mutant Lung Cancers: Results From a Phase II Basket Trial.

J Clin Oncol 2018 08 10;36(24):2532-2537. Epub 2018 Jul 10.

Bob T. Li, Ronglai Shen, Darren Buonocore, Zachary T. Olah, Ai Ni, Michelle S. Ginsberg, Gary A. Ulaner, Michael Offin, Daniel Feldman, Helen H. Won, Edyta B. Brzostowski, Gregory J. Riely, David B. Solit, David M. Hyman, Alexander Drilon, Charles M. Rudin, Michael F. Berger, Jose Baselga, Maurizio Scaltriti, Maria E. Arcila, and Mark G. Kris, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, New York, NY; Bob T. Li, Nick Pavlakis, and Stephen Clarke, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; and Todd Hembrough, Fabiola Cecchi, and Sarit Schwartz, NantOmics, Rockville, MD.

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http://ascopubs.org/doi/10.1200/JCO.2018.77.9777
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http://dx.doi.org/10.1200/JCO.2018.77.9777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366814PMC
August 2018

CT features of HER2-mutant lung adenocarcinomas.

Clin Imaging 2018 Sep - Oct;51:279-283. Epub 2018 Jun 7.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinimag.2018.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382989PMC
November 2018

Learning All That We Can From MyPathway.

J Clin Oncol 2018 08 1;36(23):2450-2451. Epub 2018 Jun 1.

Jessica J. Tao, Alison M. Schram, Memorial Sloan Kettering Cancer Center, New York, NY; and James J. Harding, Alexander Drilon, and David M. Hyman, Memorial Sloan Kettering Cancer Center; Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/JCO.2018.78.4728DOI Listing
August 2018

Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.

N Engl J Med 2018 02;378(8):731-739

From Memorial Sloan Kettering Cancer Center (A. Drilon, J.F.H., R.B., M.L., D.M.H.) and Weill Cornell Medical College (A. Drilon, D.M.H.), New York; University of Texas Southwestern Medical Center-Children's Health, Dallas (T.W.L.); Stanford Cancer Center, Stanford University, Palo Alto (S.K.), Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California (L.M.), and UCLA David Geffen School of Medicine (N.F.), Los Angeles, and Loxo Oncology, South San Francisco (B.B.T., K.E., S.C., N.C.K., M.C.C.) - all in California; Dana-Farber-Boston Children's Cancer and Blood Disorders Center (S.G.D.), Dana-Farber Cancer Institute (G.D.D., M.N.), Ludwig Center at Harvard (G.D.D.), and Massachusetts General Hospital (A.F.F.) - all in Boston; the Finsen Center, Rigshospitalet, Copenhagen (U.N.L.); University of Colorado, Aurora (R.C.D.); St. Jude Children's Research Hospital, Memphis (A.S.P.), and Vanderbilt University, Nashville (J.B.) - both in Tennessee; Cincinnati Children's Hospital Medical Center, Cincinnati (B.T.); University Hospitals of Cleveland Medical Center (A. Dowlati) and Taussig Cancer Institute, Cleveland Clinic (D.P.S.S.), Cleveland; University of Pennsylvania Perelman School of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery, and the Abramson Cancer Center (M.S.B.), and Fox Chase Cancer Center (W.S.E.-D.), Philadelphia; University of Washington-Seattle Cancer Care Alliance (C.B.), Seattle Children's Hospital (E.R.R.), and Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center (D.S. Hawkins), Seattle; University of Texas M.D. Anderson Cancer Center, Houston (F.M.-B., D.S. Hong); Inova Schar Cancer Institute, Falls Church, VA (J.D.); START Madrid, Centro Integral Oncológico Clara Campal, Madrid (V.B.); Nemours Children's Hospital, Orlando (R.N.), and Memorial Cancer Institute-Florida International University, Miami (L.E.R.) - both in Florida; Oregon Health and Science University, Portland (M.T.); and WVU Cancer Institute, West Virginia University, Morgantown (P.C.M.).

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http://dx.doi.org/10.1056/NEJMoa1714448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857389PMC
February 2018

Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes.

Nat Rev Clin Oncol 2018 03 14;15(3):151-167. Epub 2017 Nov 14.

National Cancer Center, 11 Hospital Drive, Singapore 169610, Singapore.

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http://dx.doi.org/10.1038/nrclinonc.2017.175DOI Listing
March 2018

Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance.

Nat Rev Clin Oncol 2017 Dec 31;14(12):735-748. Epub 2017 Aug 31.

Department of Medicine 1275 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nrclinonc.2017.127DOI Listing
December 2017

Combination MET- and EGFR-directed therapy in MET-overexpressing non-small cell lung cancers: time to move on to better biomarkers?

Transl Lung Cancer Res 2017 Jun;6(3):393-395

Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.21037/tlcr.2017.04.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504114PMC
June 2017

Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.

Nat Commun 2017 07 11;8:15987. Epub 2017 Jul 11.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms15987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508201PMC
July 2017

Targeting RET-rearranged lung cancers with multikinase inhibitors.

Oncoscience 2017 Mar 14;4(3-4):23-24. Epub 2017 Apr 14.

Developmetal Therapeutics, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, 10065, USA.

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http://dx.doi.org/10.18632/oncoscience.345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441470PMC
March 2017

Targeting RET in Patients With RET-Rearranged Lung Cancers: Results From the Global, Multicenter RET Registry.

J Clin Oncol 2017 May 13;35(13):1403-1410. Epub 2017 Mar 13.

Oliver Gautschi, Kristin Zeidler, and Joachim Diebold, Lucerne Cantonal Hospital, Luzern; Patrizia Froesch, Ente Ospedaliero Cantonale, Bellinzona; Martin Früh, Kantonsspital St Gallen, St Gallen; Sacha I. Rothschild, University Hospital Basel, Basel, Switzerland; Julie Milia and Julien Mazières, Hôpital Larrey; Thomas Filleron, Institut Universitaire du Cancer, Claudius Regaud, Toulouse; Benjamin Besse and Jordi Remon-Masip, Institute Gustave Roussy, Villejuif; Gérard Zalcman, University Hospital Bichat, Paris; Isabelle Monnet, Centre Hospitalier Intercommunal de Creteil, Creteil; Florian Cabillic, Université de Rennes 1, Rennes, France; Juergen Wolf and Sebastian Michels, Center for Integrated Oncology, Cologne; Georg Pall, Fachkliniken Wangen, Wangen Im Allgäu; Arne Warth, Heidelberg University Hospital; Thomas Muley, Thoraxklinik at University of Heidelberg and Translational Lung Research Center, Heidelberg, Germany; David P. Carbone and Dwight Owen, Ohio State University Comprehensive Cancer Center, Columbus; Vamsidhar Velcheti, Cleveland Clinic, Pepper Pike, OH; Ross Camidge and Vignhesh Narayanan, University of Colorado, Denver; Robert C. Doebele, University of Colorado, Aurora, CO; Pasi A. Janne and Mark M. Awad, Dana-Farber Cancer Institute, Boston, MA; Daniel D. Karp, The University of Texas MD Anderson Cancer Center, Houston, TX; Heather A. Wakelee and Joel W. Neal, Stanford University, Stanford; Sai-Hong Ignatius Ou, University of California, Irvine, Orange; David R. Gandara and Jonathan W. Riess, University of California, Davis Cancer Center, Sacramento, CA; Alexander Drilon, Memorial Sloan Kettering Cancer Center, New York, NY; Nir Peled, Davidoff Cancer Center, Petach Tiqwa, Israël; Chul-Cho Byoung, Yonseï Cancer Center, Seoul, Republic of Korea; Michael Van Den Heuvel, Netherlands Cancer Institute, Amsterdam, the Netherlands; Tony S.K. Mok, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China; James C.H. Yang and Jin-Yuan Shih, National Taiwan University Hospital, Taipei, Republic of China; Sanjay Popat, Royal Marsden Hospital, London, United Kingdom; and Rafael Rosell and Niki Karachaliou, Catalan Institute of Oncology, Barcelona, Spain.

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http://dx.doi.org/10.1200/JCO.2016.70.9352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559893PMC
May 2017

The activity, safety, and evolving role of brigatinib in patients with -rearranged non-small cell lung cancers.

Onco Targets Ther 2017 6;10:1983-1992. Epub 2017 Apr 6.

Developmetal Therapeutics, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center.

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http://dx.doi.org/10.2147/OTT.S109295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388194PMC
April 2017

Changing the Therapeutic Landscape in Non-small Cell Lung Cancers: the Evolution of Comprehensive Molecular Profiling Improves Access to Therapy.

Curr Oncol Rep 2017 Apr;19(4):24

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, 300 East 66th Street, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s11912-017-0587-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428198PMC
April 2017

The addition of anti-angiogenic tyrosine kinase inhibitors to chemotherapy for patients with advanced non-small-cell lung cancers: A meta-analysis of randomized trials.

Lung Cancer 2016 12 17;102:21-27. Epub 2016 Oct 17.

Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia; Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441998PMC
December 2016

Targeted therapy outcomes in RET-rearranged lung cancers: drug or driver?

Authors:
Alexander Drilon

Lancet Respir Med 2017 01 4;5(1):5-6. Epub 2016 Nov 4.

Thoracic Oncology Service and Developmental Therapeutics Clinic, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(16)30369-1DOI Listing
January 2017

Targeting MET in Lung Cancer: Will Expectations Finally Be MET?

J Thorac Oncol 2017 01 26;12(1):15-26. Epub 2016 Oct 26.

University of Colorado Cancer Center, Aurora, Colorado.

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http://dx.doi.org/10.1016/j.jtho.2016.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603268PMC
January 2017

MET Exon 14 Alterations in Lung Cancer: Exon Skipping Extends Half-Life.

Authors:
Alexander Drilon

Clin Cancer Res 2016 06 23;22(12):2832-4. Epub 2016 Mar 23.

Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911276PMC
June 2016

KRAS-Mutant Lung Cancers in the Era of Targeted Therapy.

Adv Exp Med Biol 2016 ;893:155-178

Department of Medicine, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/978-3-319-24223-1_8DOI Listing
May 2016

Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer.

J Thorac Oncol 2015 Dec;10(12):1670-4

*Department of Medicine, Massachusetts General Hospital, Boston, MA; †Department of Pathology, Massachusetts General Hospital, Boston, MA; ‡Memorial Sloan Kettering Cancer Center, New York, NY; ‖Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, FL; §Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN; ¶Department of Medicine, Georgetown University Medical Center, Washington, DC; #University of California Irving Health, Orange, CA; **Dana-Farber Cancer Institute, Boston, MA; ††Beth Israel Deaconess Medical Center, Boston, MA; and ‡‡Ignyta, Inc., San Diego, CA.

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http://ignyta.com/wp-content/uploads/2016/01/Durable-Clinica
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http://linkinghub.elsevier.com/retrieve/pii/S155608641535087
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http://dx.doi.org/10.1097/01.JTO.0000473485.38553.f0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643748PMC
December 2015

Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.

Proc Natl Acad Sci U S A 2015 Sep 8;112(39):E5381-90. Epub 2015 Sep 8.

Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239; Howard Hughes Medical Institute, Portland, OR 97239;

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http://dx.doi.org/10.1073/pnas.1515281112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593101PMC
September 2015

Impact of Concurrent PIK3CA Mutations on Response to EGFR Tyrosine Kinase Inhibition in EGFR-Mutant Lung Cancers and on Prognosis in Oncogene-Driven Lung Adenocarcinomas.

J Thorac Oncol 2015 Dec;10(12):1713-9

*Thoracic Oncology Service, Department of Medicine, †Department of Epidemiology and Biostatistics, ‡Department of Radiology, and §Department of Pathology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153509
Publisher Site
http://dx.doi.org/10.1097/JTO.0000000000000671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760768PMC
December 2015

Toxicity Attribution in Phase I Trials: Evaluating the Effect of Dose on the Frequency of Related and Unrelated Toxicities.

Clin Cancer Res 2016 Feb 31;22(3):553-9. Epub 2015 Aug 31.

Weill Cornell Medical College, New York, New York. Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819316PMC
February 2016

Acquired Resistance of EGFR-Mutant Lung Cancer to a T790M-Specific EGFR Inhibitor: Emergence of a Third Mutation (C797S) in the EGFR Tyrosine Kinase Domain.

JAMA Oncol 2015 Oct;1(7):982-4

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1001/jamaoncol.2015.1066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665629PMC
October 2015

Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping.

Cancer Discov 2015 Aug 13;5(8):842-9. Epub 2015 May 13.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658654PMC
August 2015

MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking.

Clin Cancer Res 2015 Apr 28;21(8):1935-43. Epub 2014 Oct 28.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401580PMC
April 2015

A prospective study of tumor suppressor gene methylation as a prognostic biomarker in surgically resected stage I to IIIA non-small-cell lung cancers.

J Thorac Oncol 2014 Sep;9(9):1272-7

*Memorial Sloan Kettering Cancer Center, New York, NY; †Tokyo Medical and Dental University, Tokyo, Japan; and ‡Massachusetts General Hospital Cancer Center, Boston, MA.

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http://dx.doi.org/10.1097/JTO.0000000000000256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133740PMC
September 2014