Alexander Dobrovic

Alexander Dobrovic

UNVERIFIED PROFILE

Are you Alexander Dobrovic?   Register this Author

Register author
Alexander Dobrovic

Alexander Dobrovic

Publications by authors named "Alexander Dobrovic"

Are you Alexander Dobrovic?   Register this Author

100Publications

2490Reads

17Profile Views

Publisher Correction: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.

Authors:
Brett W Stringer Bryan W Day Rochelle C J D'Souza Paul R Jamieson Kathleen S Ensbey Zara C Bruce Yi Chieh Lim Kate Goasdoué Carolin Offenhäuser Seçkin Akgül Suzanne Allan Thomas Robertson Peter Lucas Gert Tollesson Scott Campbell Craig Winter Hongdo Do Alexander Dobrovic Po-Ling Inglis Rosalind L Jeffree Terrance G Johns Andrew W Boyd

Sci Rep 2020 Jan 21;10(1):1185. Epub 2020 Jan 21.

QiMR Berghofer Medical Research institute, Brisbane, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-020-57850-wDOI Listing
January 2020

Letter to the editor: Elevated Plasma Levels of Cell-Free DNA During Liver Transplantation Are Associated With Activation of Coagulation.

Authors:
Osamu Yoshino Vijayaragavan Muralidharan Alexander Dobrovic Su Kah Goh

Liver Transpl 2019 Nov 29. Epub 2019 Nov 29.

Department of Surgery, University of Melbourne.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/lt.25695DOI Listing
November 2019

Molecular Genomic Profiling of Melanocytic Nevi.

Authors:
Andrew J Colebatch Peter Ferguson Felicity Newell Stephen H Kazakoff Tom Witkowski Alexander Dobrovic Peter A Johansson Robyn P M Saw Jonathan R Stretch Grant A McArthur Georgina V Long John F Thompson John V Pearson Graham J Mann Nicholas K Hayward Nicola Waddell Richard A Scolyer James S Wilmott

J Invest Dermatol 2019 Aug 14;139(8):1762-1768. Epub 2019 Feb 14.

Melanoma Institute Australia, The University of Sydney, New South Wales, Australia; Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S0022202X193011
Publisher Site
http://dx.doi.org/10.1016/j.jid.2018.12.033DOI Listing
August 2019

A new normalization for Nanostring nCounter gene expression data.

Authors:
Ramyar Molania Johann A Gagnon-Bartsch Alexander Dobrovic Terence P Speed

Nucleic Acids Res 2019 07;47(12):6073-6083

Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/nar/gkz433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614807PMC
July 2019

The Measurement of Donor-Specific Cell-Free DNA Identifies Recipients With Biopsy-Proven Acute Rejection Requiring Treatment After Liver Transplantation.

Authors:
Su Kah Goh Hongdo Do Adam Testro Julie Pavlovic Angela Vago Julie Lokan Robert M Jones Christopher Christophi Alexander Dobrovic Vijayaragavan Muralidharan

Transplant Direct 2019 Jul 21;5(7):e462. Epub 2019 Jun 21.

Department of Surgery, The University of Melbourne, Austin Health, Heidelberg, VIC, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/TXD.0000000000000902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616138PMC
July 2019

Genomic Analysis of Circulating Tumor DNA Using a Melanoma-Specific UltraSEEK Oncogene Panel.

Authors:
Elin S Gray Tom Witkowski Michelle Pereira Leslie Calapre Karl Herron Darryl Irwin Brett Chapman Muhammad A Khattak Jeanette Raleigh Athena Hatzimihalis Jonathan Cebon Shahneen Sandhu Grant A McArthur Michael Millward Melanie Ziman Alexander Dobrovic Stephen Q Wong

J Mol Diagn 2019 May 5;21(3):418-426. Epub 2019 Feb 5.

Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S15251578183023
Publisher Site
http://dx.doi.org/10.1016/j.jmoldx.2018.12.001DOI Listing
May 2019

Standard dose osimertinib for erlotinib refractory T790M-negative -mutant non-small cell lung cancer with leptomeningeal disease.

Authors:
Surein Arulananda Hongdo Do Gareth Rivalland Zoe Loh Ashan Musafer Eddie Lau Paul Mitchell Alexander Dobrovic Thomas John

J Thorac Dis 2019 May;11(5):1756-1764

Cancer Immunobiology Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.21037/jtd.2019.05.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588760PMC
May 2019

gene: its function and dysregulation in cancer.

Authors:
Andrew J Colebatch Alexander Dobrovic Wendy A Cooper

J Clin Pathol 2019 Apr 29;72(4):281-284. Epub 2019 Jan 29.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

View Article

Download full-text PDF

 Source
http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2018-205653
Publisher Site
http://dx.doi.org/10.1136/jclinpath-2018-205653DOI Listing
April 2019

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival.

Authors:
Erinna F Lee Tiffany J Harris Sharon Tran Marco Evangelista Surein Arulananda Thomas John Celeste Ramnac Chloe Hobbs Haoran Zhu Gency Gunasingh David Segal Andreas Behren Jonathan Cebon Alexander Dobrovic John M Mariadason Andreas Strasser Leona Rohrbeck Nikolas K Haass Marco J Herold W Douglas Fairlie

Cell Death Dis 2019 04 24;10(5):342. Epub 2019 Apr 24.

La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41419-019-1568-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482196PMC
April 2019

A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.

Authors:
Brett W Stringer Bryan W Day Rochelle C J D'Souza Paul R Jamieson Kathleen S Ensbey Zara C Bruce Yi Chieh Lim Kate Goasdoué Carolin Offenhäuser Seçkin Akgül Suzanne Allan Thomas Robertson Peter Lucas Gert Tollesson Scott Campbell Craig Winter Hongdo Do Alexander Dobrovic Po-Ling Inglis Rosalind L Jeffree Terrance G Johns Andrew W Boyd

Sci Rep 2019 Mar 20;9(1):4902. Epub 2019 Mar 20.

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-019-41277-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427001PMC
March 2019

Fc-gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer.

Authors:
Daniel Shepshelovich Amanda R Townsend Osvaldo Espin-Garcia Lidija Latifovic Chris J O'Callaghan Derek J Jonker Dongsheng Tu Eric Chen Eric Morgen Timothy J Price Jeremy Shapiro Lillian L Siu Michiaki Kubo Alexander Dobrovic Mark J Ratain Wei Xu Taisei Mushiroda Geoffrey Liu

Cancer Med 2018 11 14;7(11):5478-5487. Epub 2018 Oct 14.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/cam4.1819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246957PMC
November 2018

Mismatch Repair Protein Defects and Microsatellite Instability in Malignant Pleural Mesothelioma.

Authors:
Surein Arulananda Bibhusal Thapa Marzena Walkiewicz Giada V Zapparoli David S Williams Alexander Dobrovic Thomas John

J Thorac Oncol 2018 10 26;13(10):1588-1594. Epub 2018 Jul 26.

Cancer Immuno-Biology Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, Australia; Department of Medical Oncology, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, Victoria, Australia. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S15560864183081
Publisher Site
http://dx.doi.org/10.1016/j.jtho.2018.07.015DOI Listing
October 2018

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.

Authors:
Olga Kondrashova Monique Topp Ksenija Nesic Elizabeth Lieschke Gwo-Yaw Ho Maria I Harrell Giada V Zapparoli Alison Hadley Robert Holian Emma Boehm Valerie Heong Elaine Sanij Richard B Pearson John J Krais Neil Johnson Orla McNally Sumitra Ananda Kathryn Alsop Karla J Hutt Scott H Kaufmann Kevin K Lin Thomas C Harding Nadia Traficante Anna deFazio Iain A McNeish David D Bowtell Elizabeth M Swisher Alexander Dobrovic Matthew J Wakefield Clare L Scott

Nat Commun 2018 09 28;9(1):3970. Epub 2018 Sep 28.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

View Article

Download full-text PDF

 Source
http://www.nature.com/articles/s41467-018-05564-z
Publisher Site
http://dx.doi.org/10.1038/s41467-018-05564-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162272PMC
September 2018

Adapting an Established Clinical Chemistry Quality Control Measure for Droplet Generation Performance in Digital PCR.

Authors:
Su Kah Goh Boris Ka Leong Wong Vijayaragavan Muralidharan Christopher Christophi Hongdo Do Alexander Dobrovic

Clin Chem 2018 08 11;64(8):1255-1257. Epub 2018 Jun 11.

Translational Genomics and Epigenomics Laboratory Olivia Newton-John Cancer Research Institute Heidelberg, Victoria, Australia

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2018.291120DOI Listing
August 2018

DNA Methylation Profiling of Breast Cancer Cell Lines along the Epithelial Mesenchymal Spectrum-Implications for the Choice of Circulating Tumour DNA Methylation Markers.

Authors:
Anh Viet-Phuong Le Marcin Szaumkessel Tuan Zea Tan Jean-Paul Thiery Erik W Thompson Alexander Dobrovic

Int J Mol Sci 2018 Aug 28;19(9). Epub 2018 Aug 28.

Olivia Newton John Cancer Research Institute, Heidelberg, VIC 3084, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3390/ijms19092553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164039PMC
August 2018

Somatic mutation in the of Sturge-Weber syndrome.

Authors:
Michael S Hildebrand A Simon Harvey Stephen Malone John A Damiano Hongdo Do Zimeng Ye Lara McQuillan Wirginia Maixner Renate Kalnins Bernadette Nolan Martin Wood Ezgi Ozturk Nigel C Jones Greta Gillies Kate Pope Paul J Lockhart Alexander Dobrovic Richard J Leventer Ingrid E Scheffer Samuel F Berkovic

Neurol Genet 2018 Jun 1;4(3):e236. Epub 2018 May 1.

Department of Medicine (Austin Hospital) (M.S.H., J.A.D., Z.Y., L.M., I.E.S., S.F.B.), University of Melbourne, Heidelberg, Victoria, Australia; Murdoch Childrens Research Institute (M.S.H., A.S.H., G.G., K.P., P.J.L., R.J.L.), Parkville, Victoria, Australia; Department of Paediatrics (Royal Children's Hospital) (A.S.H., G.G., K.P., P.J.L., R.J.L., I.E.S.), Department of Pathology (H.D., R.K., A.D), and Department of Medicine (Royal Melbourne Hospital) (E.O., N.C.J.), University of Melbourne, Parkville, Victoria, Australia; Department of Neurology (A.S.H., R.J.L., I.E.S.) and Department of Neurosurgery (W.M.), Royal Children's Hospital, Parkville, Victoria, Australia; Department of Neurosciences (S.M., B.N.) and Neurosurgical Department (M.W.), Lady Cilento Children's Hospital, Brisbane, Queensland, Australia; Translational Genomics and Epigenomics Laboratory (H.D., A.D.), Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine (H.D., A.D.), La Trobe University, Bundoora, Victoria, Australia; Anatomical Pathology (R.K.), Austin Health, Heidelberg, Victoria, Australia; Department of Neuroscience (N.C.J.), Central Clinical School, Monash University, Victoria, Australia; and Department of Neurology (N.C.J.), The Alfred Hospital, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1212/NXG.0000000000000236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931068PMC
June 2018

Optimizing Amplification of the GC-Rich Promoter Region Using 7-Deaza-dGTP for Droplet Digital PCR Quantification of Promoter Mutations.

Authors:
Andrew J Colebatch Tom Witkowski Paul M Waring Grant A McArthur Stephen Q Wong Alexander Dobrovic

Clin Chem 2018 04 30;64(4):745-747. Epub 2018 Jan 30.

Department of Pathology, University of Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2017.284257DOI Listing
April 2018

Fresh Frozen Plasma Transfusion Can Confound the Analysis of Circulating Cell-Free DNA.

Authors:
Su Kah Goh Vijayaragavan Muralidharan Christopher Christophi Alexander Dobrovic

Clin Chem 2018 04 13;64(4):749-751. Epub 2018 Feb 13.

Translational Genomics and Epigenomics Laboratory Olivia Newton-John Cancer Research Institute Victoria, Australia

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2017.285684DOI Listing
April 2018

White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk: A Perspective.

Authors:
Alexander Dobrovic

Ann Intern Med 2018 03 16;168(5):365-366. Epub 2018 Jan 16.

Olivia Newton-John Cancer Research Institute, Heidelberg, La Trobe University, Bundoora, and University of Melbourne, Parkville, Victoria, Australia (A.D.).

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.7326/M17-3340DOI Listing
March 2018

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer.

Authors:
Dale W Garsed Kathryn Alsop Sian Fereday Catherine Emmanuel Catherine J Kennedy Dariush Etemadmoghadam Bo Gao Val Gebski Valérie Garès Elizabeth L Christie Maartje C A Wouters Katy Milne Joshy George Ann-Marie Patch Jason Li Gisela Mir Arnau Timothy Semple Sreeja R Gadipally Yoke-Eng Chiew Joy Hendley Thomas Mikeska Giada V Zapparoli Kaushalya Amarasinghe Sean M Grimmond John V Pearson Nicola Waddell Jillian Hung Colin J R Stewart Raghwa Sharma Prue E Allan Peter F Rambau Orla McNally Linda Mileshkin Anne Hamilton Sumitra Ananda Marisa Grossi Paul A Cohen Yee C Leung Robert M Rome Philip Beale Penny Blomfield Michael Friedlander Alison Brand Alexander Dobrovic Martin Köbel Paul Harnett Brad H Nelson David D L Bowtell Anna deFazio

Clin Cancer Res 2018 02 23;24(3):569-580. Epub 2017 Oct 23.

Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1078-0432.CCR-17-1621DOI Listing
February 2018

In Reply to Leone.

Authors:
Hongdo Do Surein Arulananda Thomas John Alexander Dobrovic

J Thorac Oncol 2018 02;13(2):e22-e23

Olivia Newton-John Cancer and Wellness Center, Heidelberg, Melbourne, Australia; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jtho.2017.11.119DOI Listing
February 2018

structural rearrangements in metastatic pheochromocytomas.

Authors:
Trisha Dwight Aidan Flynn Kaushalya Amarasinghe Diana E Benn Richard Lupat Jason Li Daniel L Cameron Annette Hogg Shiva Balachander Ida L M Candiloro Stephen Q Wong Bruce G Robinson Anthony T Papenfuss Anthony J Gill Alexander Dobrovic Rodney J Hicks Roderick J Clifton-Bligh Richard W Tothill

Endocr Relat Cancer 2018 01 3;25(1):1-9. Epub 2017 Oct 3.

The Peter MacCallum Cancer CentreEast Melbourne, Victoria, Australia

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1530/ERC-17-0306DOI Listing
January 2018

Assessing alternative base substitutions at primer CpG sites to optimise unbiased PCR amplification of methylated sequences.

Authors:
Ida L M Candiloro Thomas Mikeska Alexander Dobrovic

Clin Epigenetics 2017 4;9:31. Epub 2017 Apr 4.

Department of Pathology, The University of Melbourne, Parkville, Victoria 3010 Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13148-017-0328-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379501PMC
December 2017

GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly.

Authors:
Daniel L Cameron Jan Schröder Jocelyn Sietsma Penington Hongdo Do Ramyar Molania Alexander Dobrovic Terence P Speed Anthony T Papenfuss

Genome Res 2017 12 2;27(12):2050-2060. Epub 2017 Nov 2.

Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1101/gr.222109.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741059PMC
December 2017

Sensitive quantitative detection of somatic mosaic mutation in "double cortex" syndrome.

Authors:
John A Damiano Hongdo Do Ezgi Ozturk Rosemary Burgess Renate Kalnins Nigel C Jones Alexander Dobrovic Samuel F Berkovic Michael S Hildebrand

Epileptic Disord 2017 Dec;19(4):450-455

Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1684/epd.2017.0944DOI Listing
December 2017

Combination Osimertinib and Gefitinib in C797S and T790M EGFR-Mutated Non-Small Cell Lung Cancer.

Authors:
Surein Arulananda Hongdo Do Ashan Musafer Paul Mitchell Alexander Dobrovic Thomas John

J Thorac Oncol 2017 11 24;12(11):1728-1732. Epub 2017 Aug 24.

Cancer Immunobiology Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia; Department of Medical Oncology, Olivia Newton-John Cancer and Wellness Centre, Austin Health, Heidelberg, Victoria, Australia. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S15560864173068
Publisher Site
http://dx.doi.org/10.1016/j.jtho.2017.08.006DOI Listing
November 2017

DNA Breathing Enables Closed-Tube Mutant Allele Enrichment for Circulating Tumor DNA Analysis.

Authors:
Alexander Dobrovic

Clin Chem 2017 10 13;63(10):e1-e3. Epub 2017 Sep 13.

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2017.276493DOI Listing
October 2017

LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.

Authors:
Jia-Min B Pang Ramyar Molania Ashwini Chand Kevin Knower Elena A Takano David J Byrne Thomas Mikeska Ewan K A Millar Cheok Soon Lee Sandra A O'Toole Colin Clyne Kylie L Gorringe Alexander Dobrovic Stephen B Fox

Oncotarget 2017 Oct 28;8(48):83626-83636. Epub 2017 Jul 28.

Department of Pathology, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC 3000, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.18886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663541PMC
October 2017

Digital PCR of Genomic Rearrangements for Monitoring Circulating Tumour DNA.

Authors:
Hongdo Do Daniel Cameron Ramyar Molania Bibhusal Thapa Gareth Rivalland Paul L Mitchell Carmel Murone Thomas John Anthony Papenfuss Alexander Dobrovic

Adv Exp Med Biol 2016 ;924:139-146

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, 3084, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/978-3-319-42044-8_27DOI Listing
September 2017

Reducing Artifactual T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase.

Authors:
Hongdo Do Ramyar Molania Paul L Mitchell Rita Vaiskunaite John D Murdoch Alexander Dobrovic

Clin Chem 2017 Sep 18;63(9):1506-1514. Epub 2017 Jul 18.

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2017.271932DOI Listing
September 2017

EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma.

Authors:
Timothy D Clay Prudence A Russell Hongdo Do Vijaya Sundararajan Matthew Conron Gavin M Wright Benjamin Solomon Alexander Dobrovic Sue-Anne McLachlan Melissa M Moore

Med Oncol 2017 Sep 6;34(10):175. Epub 2017 Sep 6.

Department of Medicine, St Vincent's Hospital, Melbourne Medical School, University of Melbourne, Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s12032-017-1031-1DOI Listing
September 2017

BRCA2 carriers with male breast cancer show elevated tumour methylation.

Authors:
Siddhartha Deb Kylie L Gorringe Jia-Min B Pang David J Byrne Elena A Takano Alexander Dobrovic Stephen B Fox

BMC Cancer 2017 09 11;17(1):641. Epub 2017 Sep 11.

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12885-017-3632-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594583PMC
September 2017

Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer.

Authors:
Jia-Min B Pang Peter Savas Andrew P Fellowes Gisela Mir Arnau Tanjina Kader Ravikiran Vedururu Chelsee Hewitt Elena A Takano David J Byrne David Yh Choong Ewan Ka Millar C Soon Lee Sandra A O'Toole Sunil R Lakhani Margaret C Cummings G Bruce Mann Ian G Campbell Alexander Dobrovic Sherene Loi Kylie L Gorringe Stephen B Fox

Mod Pathol 2017 07 24;30(7):952-963. Epub 2017 Mar 24.

Department of Pathology, Peter MacCallum Cancer Centre, Grattan Street, Melbourne, VIC, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/modpathol.2017.21DOI Listing
July 2017

Probe-Free Digital PCR Quantitative Methodology to Measure Donor-Specific Cell-Free DNA after Solid-Organ Transplantation.

Authors:
Su Kah Goh Vijayaragavan Muralidharan Christopher Christophi Hongdo Do Alexander Dobrovic

Clin Chem 2017 03 18;63(3):742-750. Epub 2017 Jan 18.

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2016.264838DOI Listing
March 2017

Erratum: An optimised direct lysis method for gene expression studies on low cell numbers.

Authors:
Anh Viet-Phuong Le Dexing Huang Tony Blick Erik W Thompson Alexander Dobrovic

Sci Rep 2017 03 9;7:43075. Epub 2017 Mar 9.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep43075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343436PMC
March 2017

Evaluation of Different Oligonucleotide Base Substitutions at CpG Binding sites in Multiplex Bisulfite-PCR sequencing.

Authors:
Jennifer Lu Kelin Ru Ida Candiloro Alexander Dobrovic Darren Korbie Matt Trau

Sci Rep 2017 03 22;7:45096. Epub 2017 Mar 22.

Centre for Personalised Nanomedicine, Australian Institute for Nanoengineering and Biotechnology, University of Queensland, Brisbane, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep45096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361148PMC
March 2017

Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas.

Authors:
Annette M Lim Nicholas C Wong Ruth Pidsley Elena Zotenko June Corry Alexander Dobrovic Susan J Clark Danny Rischin Benjamin Solomon

Clin Epigenetics 2016 18;8:74. Epub 2016 Jul 18.

Department of Medical Oncology, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre Building, 305 Grattan St, Melbourne, Victoria 3000 Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13148-016-0235-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948090PMC
December 2016

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies.

Authors:
Andrew J Colebatch Leon Di Stefano Stephen Q Wong Ross D Hannan Paul M Waring Alexander Dobrovic Grant A McArthur Anthony T Papenfuss

Oncotarget 2016 Oct;7(41):66569-66585

Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.11892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341821PMC
October 2016

Temporal changes of EGFR mutations and T790M levels in tumour and plasma DNA following AZD9291 treatment.

Authors:
Puey Ling Chia Hongdo Do Adrienne Morey Paul Mitchell Alexander Dobrovic Thomas John

Lung Cancer 2016 08 11;98:29-32. Epub 2016 May 11.

Department of Medical Oncology, Austin Health, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.lungcan.2016.05.003DOI Listing
August 2016

Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat.

Authors:
Nicholas C Wong Bernard J Pope Ida Candiloro Darren Korbie Matt Trau Stephen Q Wong Thomas Mikeska Bryce J W van Denderen Erik W Thompson Stefanie Eggers Stephen R Doyle Alexander Dobrovic

Gigascience 2015 26;4:55. Epub 2015 Nov 26.

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084 Australia ; Department of Pathology, The University of Melbourne, Parkville, VIC 3052 Australia ; Division of Cancer Medicine, La Trobe University, Bundoora, VIC 3086 Australia ; School of Cancer Medicine, La Trobe University, Bundoora, VIC 3084 Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13742-015-0098-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660811PMC
July 2016

Comparison of 3 Methodologies for Genotyping of Small Deletion and Insertion Polymorphisms.

Authors:
Su Kah Goh Ashan Musafer Tom Witkowski Vijayaragavan Muralidharan Christopher Christophi Hongdo Do Alexander Dobrovic

Clin Chem 2016 Jul;62(7):1012-9

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Victoria, Australia; Department of Pathology, University of Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2016.256388DOI Listing
July 2016

Fc-γ Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer.

Authors:
Geoffrey Liu Dongsheng Tu Marcia Lewis Dangxiao Cheng Leslie A Sullivan Zhuo Chen Eric Morgen John Simes Timothy J Price Niall C Tebbutt Jeremy D Shapiro G Mark Jeffery J Daniel Mellor Thomas Mikeska Shakeel Virk Lois E Shepherd Derek J Jonker Christopher J O'Callaghan John R Zalcberg Christos S Karapetis Alexander Dobrovic

Clin Cancer Res 2016 05;22(10):2435-44

Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Australia. Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia. School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1078-0432.CCR-15-0414DOI Listing
May 2016

MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing.

Authors:
Nicholas C Wong Bernard J Pope Ida L Candiloro Darren Korbie Matt Trau Stephen Q Wong Thomas Mikeska Xinmin Zhang Mark Pitman Stefanie Eggers Stephen R Doyle Alexander Dobrovic

BMC Bioinformatics 2016 Feb 24;17:98. Epub 2016 Feb 24.

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, 3084, Australia.

View Article

Download full-text PDF

 Source
http://www.biomedcentral.com/1471-2105/17/98
Publisher Site
http://dx.doi.org/10.1186/s12859-016-0950-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765133PMC
February 2016

Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour.

Authors:
Katie T Huang Thomas Mikeska Jason Li Elena A Takano Ewan K A Millar Peter H Graham Samantha E Boyle Ian G Campbell Terence P Speed Alexander Dobrovic Stephen B Fox

BMC Cancer 2015 Oct 9;15:669. Epub 2015 Oct 9.

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, VIC, 3002, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12885-015-1676-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600279PMC
October 2015

"Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic.

Authors:
John P Parisot Heather Thorne Andrew Fellowes Ken Doig Mark Lucas John J McNeil Brett Doble Alexander Dobrovic Thomas John Paul A James Lara Lipton David Ashley Theresa Hayes Paul McMurrick Gary Richardson Paula Lorgelly Stephen B Fox David M Thomas

J Pers Med 2015 Oct 29;5(4):354-69. Epub 2015 Oct 29.

Division of Cancer Research, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne VIC 3002, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3390/jpm5040354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695860PMC
October 2015

Copy number analysis of ductal carcinoma in situ with and without recurrence.

Authors:
Kylie L Gorringe Sally M Hunter Jia-Min Pang Ken Opeskin Prue Hill Simone M Rowley David Y H Choong Ella R Thompson Alexander Dobrovic Stephen B Fox G Bruce Mann Ian G Campbell

Mod Pathol 2015 Sep 19;28(9):1174-84. Epub 2015 Jun 19.

Cancer Genetics Laboratory, Peter MacCullum Cancer Centre, East Melbourne, VIC, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/modpathol.2015.75DOI Listing
September 2015

An optimised direct lysis method for gene expression studies on low cell numbers.

Authors:
Anh Viet-Phuong Le Dexing Huang Tony Blick Erik W Thompson Alexander Dobrovic

Sci Rep 2015 Aug 5;5:12859. Epub 2015 Aug 5.

1] Translational Genomics &Epigenomics, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia [2] Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia [3] School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep12859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525356PMC
August 2015

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals.

Authors:
Imran G House Kevin Thia Amelia J Brennan Richard Tothill Alexander Dobrovic Wei Z Yeh Richard Saffery Zac Chatterton Joseph A Trapani Ilia Voskoboinik

Immunol Cell Biol 2015 Jul 17;93(6):575-80. Epub 2015 Mar 17.

1] Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, Parkville, Victoria, Australia [3] Department of Pathology, University of Melbourne, Parkville, Victoria, Australia [4] Department of Genetics, University of Melbourne, Parkville, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1038/icb.2015.1
Publisher Site
http://dx.doi.org/10.1038/icb.2015.1DOI Listing
July 2015

Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast.

Authors:
Jia-Min B Pang Kylie L Gorringe Stephen Q Wong Alexander Dobrovic Ian G Campbell Stephen B Fox

Breast Cancer Res 2015 Jun 16;17:80. Epub 2015 Jun 16.

Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, 3002, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13058-015-0586-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469314PMC
June 2015

Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations.

Authors:
Simon Chang-Hao Tsao Jonathan Weiss Christopher Hudson Christopher Christophi Jonathan Cebon Andreas Behren Alexander Dobrovic

Sci Rep 2015 Jun 22;5:11198. Epub 2015 Jun 22.

1] Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia [2] Department of Pathology, University of Melbourne, Parkville, Victoria, Australia [3] School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep11198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476039PMC
June 2015

High-resolution assessment of copy number variation.

Authors:
Alexander Dobrovic

Clin Chem 2015 May 3;61(5):684-5. Epub 2015 Apr 3.

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia; Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2015.239368DOI Listing
May 2015

Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome.

Authors:
Annette M Lim Ida Lm Candiloro Nicholas Wong Marnie Collins Hongdo Do Elena A Takano Christopher Angel Richard J Young June Corry David Wiesenfeld Stephen Kleid Elizabeth Sigston Bernard Lyons Danny Rischin Benjamin Solomon Alexander Dobrovic

Clin Epigenetics 2014 9;6(1):22. Epub 2014 Dec 9.

Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Cancer Research, Olivia Newton-John Cancer & Wellness Centre, Austin Health, 145-163 Studley Road, Heidelberg, Victoria 3084 Australia ; Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1 A'Beckett Street, Melbourne, Victoria 8006 Australia ; Department of Pathology, The University of Melbourne, Parkville, Victoria 3010 Australia ; School of Cancer Medicine, La Trobe University, Bundoora, Victoria 3084 Australia.

View Article

Download full-text PDF

 Source
http://europepmc.org/articles/PMC4391486
Web Search
https://www.researchgate.net/publication/305388481_Genome-sc
Web Search
http://clinicalepigeneticsjournal.biomedcentral.com/articles
Publisher Site
http://dx.doi.org/10.1186/1868-7083-6-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391486PMC
April 2015

Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC.

Authors:
Michael Michael Shane C White Ehtesham Abdi Louise Nott Phillip Clingan Allan Zimet Peter Button Daniel Gregory Benjamin Solomon Alexander Dobrovic Hongdo Do Stephen Clarke

Asia Pac J Clin Oncol 2015 Mar 27;11(1):4-14. Epub 2014 Feb 27.

Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/ajco.12178DOI Listing
March 2015

Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.

Authors:
Clare Stirzaker Elena Zotenko Jenny Z Song Wenjia Qu Shalima S Nair Warwick J Locke Andrew Stone Nicola J Armstong Mark D Robinson Alexander Dobrovic Kelly A Avery-Kiejda Kate M Peters Juliet D French Sandra Stein Darren J Korbie Matt Trau John F Forbes Rodney J Scott Melissa A Brown Glenn D Francis Susan J Clark

Nat Commun 2015 Feb 2;6:5899. Epub 2015 Feb 2.

1] Epigenetics Group, Cancer Division, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia [2] St Vincent's Clinical School, University of NSW, Sydney, New South Wales 2010, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms6899DOI Listing
February 2015

Bioinformatics pipelines for targeted resequencing and whole-exome sequencing of human and mouse genomes: a virtual appliance approach for instant deployment.

Authors:
Jason Li Maria A Doyle Isaam Saeed Stephen Q Wong Victoria Mar David L Goode Franco Caramia Ken Doig Georgina L Ryland Ella R Thompson Sally M Hunter Saman K Halgamuge Jason Ellul Alexander Dobrovic Ian G Campbell Anthony T Papenfuss Grant A McArthur Richard W Tothill

PLoS One 2014 21;9(4):e95217. Epub 2014 Apr 21.

Translational Research Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia; Department of Pathology, University of Melbourne, Parkville, VIC, Australia.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095217PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994043PMC
January 2015

DNA ligase-based strategy for quantifying heterogeneous DNA methylation without sequencing.

Authors:
Eugene J H Wee Sakandar Rauf Muhammad J A Shiddiky Alexander Dobrovic Matt Trau

Clin Chem 2015 Jan 1;61(1):163-71. Epub 2014 Oct 1.

Centre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), and School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2014.227546DOI Listing
January 2015

Sequence artifacts in DNA from formalin-fixed tissues: causes and strategies for minimization.

Authors:
Hongdo Do Alexander Dobrovic

Clin Chem 2015 Jan 24;61(1):64-71. Epub 2014 Nov 24.

Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; Department of Pathology, University of Melbourne, Parkville, Victoria, Australia; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2014.223040DOI Listing
January 2015

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma.

Authors:
Stephen Q Wong Andreas Behren Victoria J Mar Katherine Woods Jason Li Claire Martin Karen E Sheppard Rory Wolfe John Kelly Jonathan Cebon Alexander Dobrovic Grant A McArthur

Oncotarget 2015 Jan;6(2):1115-27

Division of Cancer Research, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359221PMC
http://dx.doi.org/10.18632/oncotarget.2747DOI Listing
January 2015

PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer.

Authors:
Siddhartha Deb Hongdo Do David Byrne Nicholas Jene Alexander Dobrovic Stephen B Fox

Breast Cancer Res 2013 ;15(4):R69

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/bcr3463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978692PMC
December 2014

Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver.

Authors:
Catherine Emmanuel Yoke-Eng Chiew Joshy George Dariush Etemadmoghadam Michael S Anglesio Raghwa Sharma Peter Russell Catherine Kennedy Sian Fereday Jillian Hung Laura Galletta Russell Hogg Gerard V Wain Alison Brand Rosemary Balleine Laura MacConaill Emanuele Palescandolo Sally M Hunter Ian Campbell Alexander Dobrovic Stephen Q Wong Hongdo Do Christine L Clarke Paul R Harnett David D L Bowtell Anna deFazio

Clin Cancer Res 2014 Dec 14;20(24):6618-30. Epub 2014 Oct 14.

Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia. Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, New South Wales, Australia. University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia. Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital, Sydney, New South Wales, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1078-0432.CCR-14-1292DOI Listing
December 2014

Role of p53 in the progression of gastric cancer.

Authors:
Rita A Busuttil Giada V Zapparoli Sue Haupt Christina Fennell Stephen Q Wong Jia-Min B Pang Elena A Takeno Catherine Mitchell Natasha Di Costanzo Stephen Fox Ygal Haupt Alexander Dobrovic Alex Boussioutas

Oncotarget 2014 Dec;5(23):12016-26

Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia. Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia. Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC, Australia.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322971PMC
http://dx.doi.org/10.18632/oncotarget.2434DOI Listing
December 2014

Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma.

Authors:
Victoria J Mar Stephen Q Wong Aleksandra Logan Trung Nguyen Jonathan Cebon John W Kelly Rory Wolfe Alexander Dobrovic Catriona McLean Grant A McArthur

Pigment Cell Melanoma Res 2014 Nov 4;27(6):1117-25. Epub 2014 Aug 4.

Victorian Melanoma Service, Alfred Hospital, Melbourne, Vic., Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic., Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/pcmr.12295DOI Listing
November 2014

Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors.

Authors:
Puey Ling Chia Paul Mitchell Alexander Dobrovic Thomas John

Clin Epidemiol 2014 20;6:423-32. Epub 2014 Nov 20.

Department of Medical Oncology, Olivia-Newton John Cancer and Wellness Centre, Victoria, Australia ; Ludwig Institute for Cancer Research, Austin Health, Victoria, Australia ; School of Cancer Medicine, La Trobe University, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://www.dovepress.com/prevalence-and-natural-history-of-a
Publisher Site
http://dx.doi.org/10.2147/CLEP.S69718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242069PMC
November 2014

Methylation profiling of ductal carcinoma in situ and its relationship to histopathological features.

Authors:
Jia-Min B Pang Siddhartha Deb Elena A Takano David J Byrne Nicholas Jene Alice Boulghourjian Anne Holliday Ewan Millar C Soon Lee Sandra A O'Toole Alexander Dobrovic Stephen B Fox

Breast Cancer Res 2014 Oct 21;16(5):423. Epub 2014 Oct 21.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13058-014-0423-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303108PMC
October 2014

Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer.

Authors:
Siddhartha Deb Ida Johansson David Byrne Cecilia Nilsson Leonie Constable Marie-Louise Fjällskog Alexander Dobrovic Ingrid Hedenfalk Stephen B Fox

Mod Pathol 2014 09 24;27(9):1223-30. Epub 2014 Jan 24.

1] Department of Pathology, Peter MacCallum Cancer Center, Melbourne, Australia [2] Department of Pathology and the Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/modpathol.2013.231DOI Listing
September 2014

Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome.

Authors:
Annette M Lim Hongdo Do Richard J Young Stephen Q Wong Christopher Angel Marnie Collins Elena A Takano June Corry David Wiesenfeld Stephen Kleid Elizabeth Sigston Bernard Lyons Stephen B Fox Danny Rischin Alexander Dobrovic Benjamin Solomon

Int J Cancer 2014 Aug 30;135(4):887-95. Epub 2014 Jan 30.

Department of Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia; University of Melbourne, Australia; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/ijc.28727DOI Listing
August 2014

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.

Authors:
Richard J Young Kelly Waldeck Claire Martin Jung H Foo Donald P Cameron Laura Kirby Hongdo Do Catherine Mitchell Carleen Cullinane Wendy Liu Stephen B Fox Ken Dutton-Regester Nicholas K Hayward Nicholas Jene Alexander Dobrovic Richard B Pearson James G Christensen Sophia Randolph Grant A McArthur Karen E Sheppard

Pigment Cell Melanoma Res 2014 Jul 6;27(4):590-600. Epub 2014 Mar 6.

Research Division, Peter MacCallum Cancer Centre, East Melbourne, Vic., Australia.

View Article

Download full-text PDF

 Source
https://minerva-access.unimelb.edu.au/bitstream/handle/11343
Web Search
http://doi.wiley.com/10.1111/pcmr.12228
Publisher Site
http://dx.doi.org/10.1111/pcmr.12228DOI Listing
July 2014

The clinical relevance of pathologic subtypes in metastatic lung adenocarcinoma.

Authors:
Timothy D Clay Hongdo Do Vijaya Sundararajan Melissa M Moore Matthew Conron Gavin M Wright Sue-Anne McLachlan Alexander Dobrovic Prudence A Russell

J Thorac Oncol 2014 May;9(5):654-63

*Department of Medical Oncology, St. Vincent's Hospital, Melbourne; †Department of Medicine, University of Melbourne; ‡Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Cancer Research, Olivia Newton John Cancer and Wellness Centre, Heidelberg; §Department of Pathology, University of Melbourne; ‖Department of Medicine, Eastern Hill Academic Centre, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne; ¶Department of Respiratory Medicine, St. Vincent's Hospital; #Department of Thoracic Surgery, St. Vincent's Hospital, Melbourne; **Department of Surgery, University of Melbourne; and ††Department of Anatomical Pathology, St. Vincent's Hospital, Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/JTO.0000000000000150DOI Listing
May 2014

Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing.

Authors:
Stephen Q Wong Jason Li Angela Y-C Tan Ravikiran Vedururu Jia-Min B Pang Hongdo Do Jason Ellul Ken Doig Anthony Bell Grant A MacArthur Stephen B Fox David M Thomas Andrew Fellowes John P Parisot Alexander Dobrovic

BMC Med Genomics 2014 May 13;7:23. Epub 2014 May 13.

Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1755-8794-7-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032349PMC
May 2014

Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine.

Authors:
Gavin M Wright Hongdo Do Jonathan Weiss Naveed Z Alam Vivek Rathi Marzena Walkiewicz Thomas John Prudence A Russell Alexander Dobrovic

Oncotarget 2014 Apr;5(8):2107-15

Translational Genomics and Epigenomics Laboratory Ludwig Institute for Cancer Research Olivia Newton-John Cancer and Wellness Centre Heidelberg, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039149PMC
http://dx.doi.org/10.18632/oncotarget.1840DOI Listing
April 2014

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma.

Authors:
Hongdo Do Nicholas C Wong Carmel Murone Thomas John Benjamin Solomon Paul L Mitchell Alexander Dobrovic

Sci Rep 2014 Feb 26;4:4186. Epub 2014 Feb 26.

1] Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, 8006, Australia [2] Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Medical Research, Olivia Newton-John Cancer and Wellness Centre, Austin Hospital, Heidelberg, Victoria, 3084, Australia [3] Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, 3010, Australia [4] Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, 8006, Australia [5] Department of Pathology, University of Melbourne, Parkville, Victoria, 3010, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep04186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935198PMC
February 2014

Characterization of a novel tumorigenic esophageal adenocarcinoma cell line: OANC1.

Authors:
Nicholas J Clemons Hongdo Do Christina Fennell Siddhartha Deb Andrew Fellowes Alexander Dobrovic Wayne A Phillips

Dig Dis Sci 2014 Jan;59(1):78-88

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s10620-013-2882-8DOI Listing
January 2014

EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma.

Authors:
Prudence A Russell Yong Yu Hongdo Do Timothy D Clay Melissa M Moore Gavin M Wright Matthew Conron Zoe Wainer Alexander Dobrovic Sue-Anne McLachlan

Pathology 2014 Jan;46(1):32-6

1Department of Anatomical Pathology, St Vincent's Hospital, University of Melbourne, Fitzroy 2Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne 3Department of Medical Oncology, St Vincent's Hospital, University of Melbourne, Fitzroy 4University of Melbourne Department of Surgery, St Vincent's Hospital, Fitzroy 5Department of Respiratory and Sleep Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00313025163063
Publisher Site
http://dx.doi.org/10.1097/PAT.0000000000000027DOI Listing
January 2014

The fusion partner specifies the oncogenic potential of NUP98 fusion proteins.

Authors:
Jesslyn Saw David J Curtis Damian J Hussey Alexander Dobrovic Peter D Aplan Christopher I Slape

Leuk Res 2013 Dec 21;37(12):1668-73. Epub 2013 Sep 21.

Division of Blood Cancers, Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.leukres.2013.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883578PMC
December 2013

BRAF inhibitor-driven tumor proliferation in a KRAS-mutated colon carcinoma is not overcome by MEK1/2 inhibition.

Authors:
Miles C Andrews Andreas Behren Fiona Chionh John Mariadason Laura J Vella Hongdo Do Alexander Dobrovic Niall Tebbutt Jonathan Cebon

J Clin Oncol 2013 Dec 4;31(35):e448-51. Epub 2013 Nov 4.

Joint Ludwig-Austin Oncology Unit, Austin Health, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1200/JCO.2013.50.4118DOI Listing
December 2013

Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours.

Authors:
Stephen Q Wong Jason Li Renato Salemi Karen E Sheppard Hongdo Do Richard W Tothill Grant A McArthur Alexander Dobrovic

Sci Rep 2013 Dec 13;3:3494. Epub 2013 Dec 13.

1] Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia [2] Department of Pathology, The University of Melbourne, Parkville, Victoria, 3010, Australia [3] Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Cancer Research, The Olivia Newton-John Cancer and Wellness Centre, Heidelberg, Victoria, 3084, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep03494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861801PMC
December 2013

A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma.

Authors:
Anna Richter Fabienne Grieu Amerigo Carrello Benhur Amanuel Kateh Namdarian Aleksandra Rynska Amanda Lucas Victoria Michael Anthony Bell Stephen B Fox Chelsee A Hewitt Hongdo Do Grant A McArthur Stephen Q Wong Alexander Dobrovic Barry Iacopetta

Sci Rep 2013 ;3:1659

School of Surgery, University of Western Australia, Nedlands, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep01659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625889PMC
October 2013

Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors.

Authors:
Matthew Anaka Christopher Hudson Pu-Han Lo Hongdo Do Otavia L Caballero Ian D Davis Alexander Dobrovic Jonathan Cebon Andreas Behren

BMC Med Genomics 2013 Oct 11;6:40. Epub 2013 Oct 11.

Cancer Immuno-biology Lab, Ludwig Institute for Cancer Research Melbourne, Austin Branch, Melbourne, Victoria 3084, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1755-8794-6-40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852494PMC
October 2013

Reducing sequence artifacts in amplicon-based massively parallel sequencing of formalin-fixed paraffin-embedded DNA by enzymatic depletion of uracil-containing templates.

Authors:
Hongdo Do Stephen Q Wong Jason Li Alexander Dobrovic

Clin Chem 2013 Sep 6;59(9):1376-83. Epub 2013 May 6.

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1373/clinchem.2012.202390DOI Listing
September 2013

BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage.

Authors:
Victoria J Mar Stephen Q Wong Jason Li Richard A Scolyer Catriona McLean Anthony T Papenfuss Richard W Tothill Hojabr Kakavand Graham J Mann John F Thompson Andreas Behren Jonathan S Cebon Rory Wolfe John W Kelly Alexander Dobrovic Grant A McArthur

Clin Cancer Res 2013 Sep 5;19(17):4589-98. Epub 2013 Jul 5.

Molecular Oncology Laboratory, Oncogenic Signaling and Growth Control Program, Peter MacCallum Cancer Centre, East Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://clincancerres.aacrjournals.org/content/early/2013/08/
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-13-0398DOI Listing
September 2013

Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations.

Authors:
Joshy George Kathryn Alsop Dariush Etemadmoghadam Heather Hondow Thomas Mikeska Alexander Dobrovic Anna deFazio Gordon K Smyth Douglas A Levine Gillian Mitchell David D Bowtell

Clin Cancer Res 2013 Jul 30;19(13):3474-84. Epub 2013 Apr 30.

Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://clincancerres.aacrjournals.org/content/early/2013/06/
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-13-0066DOI Listing
July 2013

DNA methylation in ductal carcinoma in situ of the breast.

Authors:
Jia-Min B Pang Alexander Dobrovic Stephen B Fox

Breast Cancer Res 2013 Jun 28;15(3):206. Epub 2013 Jun 28.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/bcr3420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707020PMC
June 2013

No evidence for PALB2 methylation in high-grade serous ovarian cancer.

Authors:
Thomas Mikeska Kathryn Alsop Gillian Mitchell David Dl Bowtell Alexander Dobrovic

J Ovarian Res 2013 Apr 12;6(1):26. Epub 2013 Apr 12.

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.

View Article

Download full-text PDF

 Source
http://ovarianresearch.biomedcentral.com/articles/10.1186/17
Publisher Site
http://dx.doi.org/10.1186/1757-2215-6-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636006PMC
April 2013

Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2 V617F mutant allele detection.

Authors:
Giada V Zapparoli Robert N Jorissen Chelsee A Hewitt Michelle McBean David A Westerman Alexander Dobrovic

BMC Cancer 2013 Apr 24;13:206. Epub 2013 Apr 24.

Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1471-2407-13-206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658971PMC
April 2013

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.

Authors:
James D Mellor Michael P Brown Helen R Irving John R Zalcberg Alexander Dobrovic

J Hematol Oncol 2013 Jan 4;6. Epub 2013 Jan 4.

Pharmacy Department, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria, 3002, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1756-8722-6-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549734PMC
January 2013

No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia.

Authors:
Thomas Mikeska Dennis A Carney John F Seymour Alexander Dobrovic

Leuk Lymphoma 2012 Jul 31;53(7):1420-2. Epub 2012 Jan 31.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3109/10428194.2011.653640DOI Listing
July 2012

BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group.

Authors:
Kathryn Alsop Sian Fereday Cliff Meldrum Anna deFazio Catherine Emmanuel Joshy George Alexander Dobrovic Michael J Birrer Penelope M Webb Colin Stewart Michael Friedlander Stephen Fox David Bowtell Gillian Mitchell

J Clin Oncol 2012 Jul 18;30(21):2654-63. Epub 2012 Jun 18.

Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1200/JCO.2011.39.8545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413277PMC
July 2012

Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis.

Authors:
Angela Y-C Tan Stephen Q Wong Charlotte Guldborg Nyvold Dennis A Carney Andrew Wei John F Seymour Peter Hokland Westerman Alexander Dobrovic

Leuk Lymphoma 2012 Jun 13;53(6):1225-9. Epub 2012 Jan 13.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3109/10428194.2011.645817DOI Listing
June 2012

DNA methylation biomarkers in cancer: progress towards clinical implementation.

Authors:
Thomas Mikeska Christoph Bock Hongdo Do Alexander Dobrovic

Expert Rev Mol Diagn 2012 Jun;12(5):473-87

Molecular Pathology Research & Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, Victoria 8006, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1586/erm.12.45DOI Listing
June 2012

Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders.

Authors:
Piers A Blombery Stephen Q Wong Chelsee A Hewitt Alexander Dobrovic Ellen L Maxwell Surender Juneja George Grigoriadis David A Westerman

Haematologica 2012 May 1;97(5):780-3. Epub 2011 Dec 1.

Peter MacCallum Cancer Centre, Division of Cancer Medicine, East Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3324/haematol.2011.054874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342983PMC
May 2012

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer.

Authors:
Andrew J Weickhardt Tim J Price Geoff Chong Val Gebski Nick Pavlakis Terrance G Johns Arun Azad Effie Skrinos Kate Fluck Alexander Dobrovic Renato Salemi Andrew M Scott John M Mariadason Niall C Tebbutt

J Clin Oncol 2012 May 12;30(13):1505-12. Epub 2012 Mar 12.

Ludwig Institute for Cancer Research, Australia.

View Article

Download full-text PDF

 Source
http://jco.ascopubs.org/content/early/2012/03/06/JCO.2011.38
Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2011.38.6599
Publisher Site
http://dx.doi.org/10.1200/JCO.2011.38.6599DOI Listing
May 2012

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase.

Authors:
Hongdo Do Alexander Dobrovic

Oncotarget 2012 May;3(5):546-58

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388184PMC
http://dx.doi.org/10.18632/oncotarget.503DOI Listing
May 2012

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes.

Authors:
Lasse Sommer Kristensen Michael P Raynor Ida Candiloro Alexander Dobrovic

Oncotarget 2012 Apr;3(4):450-61

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380579PMC
http://dx.doi.org/10.18632/oncotarget.480DOI Listing
April 2012

Analysing DNA methylation using bisulphite pyrosequencing.

Authors:
Thomas Mikeska Jörg Felsberg Chelsee A Hewitt Alexander Dobrovic

Methods Mol Biol 2011 ;791:33-53

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/978-1-61779-316-5_4
Publisher Site
http://dx.doi.org/10.1007/978-1-61779-316-5_4DOI Listing
December 2011

Closed-tube PCR methods for locus-specific DNA methylation analysis.

Authors:
Ida L M Candiloro Thomas Mikeska Alexander Dobrovic

Methods Mol Biol 2011 ;791:55-71

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/978-1-61779-316-5_5
Publisher Site
http://dx.doi.org/10.1007/978-1-61779-316-5_5DOI Listing
December 2011

Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.

Authors:
Katie T Huang Elena A Takano Thomas Mikeska David J Byrne Alexander Dobrovic Stephen B Fox

Breast Cancer Res Treat 2011 Nov 14;130(1):319-29. Epub 2011 Jul 14.

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, 8006, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s10549-011-1657-1DOI Listing
November 2011

Sensitive quantification of somatic mutations using molecular inversion probes.

Authors:
Rena Hirani Ashley R Connolly Lisa Putral Alexander Dobrovic Matt Trau

Anal Chem 2011 Nov 13;83(21):8215-21. Epub 2011 Oct 13.

Centre for Biomarker Research and Development, Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, Australia.

View Article

Download full-text PDF

 Source
http://pubs.acs.org/doi/abs/10.1021/ac2019409
Publisher Site
http://dx.doi.org/10.1021/ac2019409DOI Listing
November 2011

Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma.

Authors:
Bianca Devitt Wendy Liu Renato Salemi Rory Wolfe John Kelly Chin-Yuan Tzen Alexander Dobrovic Grant McArthur

Pigment Cell Melanoma Res 2011 Aug 22;24(4):666-72. Epub 2011 Jun 22.

Division of Cancer Medicine and Research, Peter MacCallum Cancer Centre, East Melbourne, Vic., Australia.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1111/j.1755-148X.2011.00873.x
Publisher Site
http://dx.doi.org/10.1111/j.1755-148X.2011.00873.xDOI Listing
August 2011

A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes.

Authors:
Heather L Hondow Stephen B Fox Gillian Mitchell Rodney J Scott Victoria Beshay Stephen Q Wong Alexander Dobrovic

BMC Cancer 2011 Jun 24;11:265. Epub 2011 Jun 24.

Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, Melbourne, Victoria, 8006, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1471-2407-11-265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146935PMC
June 2011

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer.

Authors:
Genni M Newnham Matthew Conron Sueanne McLachlan Alexander Dobrovic Hongdo Do Jason Li Kenneth Opeskin Natalie Thompson Gavin M Wright David M Thomas

BMC Cancer 2011 Mar 7;11:93. Epub 2011 Mar 7.

Department of Oncology, St Vincent's Hospital, (Victoria Pde), Melbourne, (3065), Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1471-2407-11-93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058106PMC
March 2011