Publications by authors named "Alexander D Crawford"

40Publications

Phenotypic assays in yeast and zebrafish reveal drugs that rescue deficiency.

Brain Commun 2019 27;1(1):fcz019. Epub 2019 Sep 27.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Belvaux, Luxembourg.

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http://dx.doi.org/10.1093/braincomms/fcz019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425419PMC
September 2019

Seizing the moment: Zebrafish epilepsy models.

Neurosci Biobehav Rev 2020 09 13;116:1-20. Epub 2020 Jun 13.

Chemical Neuroscience Group, Centre for Molecular Medicine Norway (NCMM), University of Oslo, Gaustadalléen 21, Forskningsparken, 0349, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2020.06.010DOI Listing
September 2020

Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles.

J Ethnopharmacol 2020 Sep 21;259:112954. Epub 2020 May 21.

School of Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU - Rue Michel Servet 1, CH-1211, Geneva 4, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2020.112954DOI Listing
September 2020

Zebrafish bioassay-guided isolation of antiseizure compounds from the Cameroonian medicinal plant Cyperus articulatus L.

Phytomedicine 2020 Jan 23;70:153175. Epub 2020 Jan 23.

Institute of Pharmaceutical Sciences of Western Switzerland, CMU - Rue Michel-Servet 1, Geneva 4 CH-1211, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2020.153175DOI Listing
January 2020

Fishing for a deeper understanding of nicotine effects using zebrafish behavioural models.

Prog Neuropsychopharmacol Biol Psychiatry 2020 03 26;98:109826. Epub 2019 Nov 26.

Independent Laboratory of Behavioral Studies, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2019.109826DOI Listing
March 2020

Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B.

Mar Drugs 2019 Oct 25;17(11). Epub 2019 Oct 25.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49 box 824, 3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/md17110607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891649PMC
October 2019

High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae).

Phytomedicine 2019 Feb 26;54:259-264. Epub 2018 Oct 26.

Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.10.030DOI Listing
February 2019

Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy.

ACS Chem Neurosci 2019 04 6;10(4):1992-2003. Epub 2018 Nov 6.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences , University of Leuven , Leuven 3000 , Belgium.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00281
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http://dx.doi.org/10.1021/acschemneuro.8b00281DOI Listing
April 2019

Fishing Anti-Inflammatories from Known Drugs: In Silico Repurposing, Design, Synthesis and Biological Evaluation of Bisacodyl Analogues.

Curr Top Med Chem 2017 Aug 17. Epub 2017 Aug 17.

Grupo de Investigación Ambiental (GIA), Fundación Universitaria Tecnológico de Comfenalco, Facultad de Ingenierías, Programa de Ingeniería de Procesos, Cartagena de Indias, Bolívar 130001. Colombia.

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http://dx.doi.org/10.2174/1568026617666170817161953DOI Listing
August 2017

Marine Biodiscovery Goes Deeper: Using In Vivo Bioassays Based on Model Organisms to Identify Biomedically Relevant Marine Metabolites.

Planta Med 2016 Jun 18;82(9-10):754-60. Epub 2016 May 18.

Chemical Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.

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http://dx.doi.org/10.1055/s-0042-106391DOI Listing
June 2016

Potential of zebrafish as a model for exploring the role of the amygdala in emotional memory and motivational behavior.

J Neurosci Res 2016 Jun 2;94(6):445-62. Epub 2016 Feb 2.

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.

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http://dx.doi.org/10.1002/jnr.23712DOI Listing
June 2016

Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

J Appl Toxicol 2015 Sep 6;35(9):1017-29. Epub 2015 Feb 6.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven Campus Gasthuisberg, O&N 2, 08.4226 Herestraat 49, PB 824, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1002/jat.3091DOI Listing
September 2015

Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum.

ACS Chem Neurosci 2014 Oct 8;5(10):993-1004. Epub 2014 Sep 8.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , 30, quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1021/cn5001342DOI Listing
October 2014

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes.

Bioorg Med Chem Lett 2014 Sep 24;24(17):4151-7. Epub 2014 Jul 24.

Department of Biological and Pharmaceutical Chemistry, University of London, School of Pharmacy, London WC1N 1AX, UK; School of Chemistry, National University of Ireland, Galway, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.07.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146677PMC
September 2014

Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolites.

PLoS One 2013 4;8(10):e75404. Epub 2013 Oct 4.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium ; Faculty of Chemical Sciences, School of Biochemistry and Pharmacy, University of Cuenca, Cuenca, Ecuador ; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075404PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790782PMC
July 2014

Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.

ACS Chem Neurosci 2013 Nov 6;4(11):1479-87. Epub 2013 Sep 6.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical & Pharmacological Sciences, KU Leuven - University of Leuven , 3000 Leuven, Belgium.

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http://dx.doi.org/10.1021/cn400140eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837379PMC
November 2013

Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae.

PLoS One 2012 17;7(10):e43850. Epub 2012 Oct 17.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043850PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474771PMC
April 2013

Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models.

Epilepsy Behav 2012 May 5;24(1):14-22. Epub 2012 Apr 5.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical & Pharmacological Sciences, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.yebeh.2012.02.020DOI Listing
May 2012

Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: the nitroindazolinone chemotype.

Eur J Med Chem 2011 Dec 17;46(12):5736-53. Epub 2011 Aug 17.

Institut Universitari de Ciència Molecular, Universitat de València, Edifici d'Instituts de Paterna, P O Box 22085, 46071 València, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2011.07.053DOI Listing
December 2011

Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.

Epilepsy Behav 2011 Nov 1;22(3):450-60. Epub 2011 Oct 1.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Brussels, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S152550501100480
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http://dx.doi.org/10.1016/j.yebeh.2011.08.016DOI Listing
November 2011

Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio).

Gen Comp Endocrinol 2010 Mar 1;166(1):134-41. Epub 2009 Oct 1.

Laboratory of Comparative Endocrinology, Division of Animal Physiology and Neurobiology, Katholieke Universiteit Leuven, BE-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ygcen.2009.09.011DOI Listing
March 2010

Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish.

Endocrinology 2009 Jan 18;150(1):530-9. Epub 2008 Sep 18.

Laboratory of Comparative Endocrinology, Division of Animal Physiology and Neurobiology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1210/en.2008-0457DOI Listing
January 2009