Alexander C J Van Akkooi

Alexander C J Van Akkooi

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Alexander C J Van Akkooi

Publications by authors named "Alexander C J Van Akkooi"

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Time dependent dynamics of wound complications after preoperative radiotherapy in Extremity Soft Tissue Sarcomas.

Eur J Surg Oncol 2019 04 6;45(4):684-690. Epub 2018 Oct 6.

Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Radiation Oncology, LUMC, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejso.2018.09.001DOI Listing
April 2019

The extent of surgery for stage III melanoma: how much is appropriate?

Lancet Oncol 2019 Mar;20(3):e167-e174

Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30099-3DOI Listing
March 2019

Adjuvant systemic therapy in high-risk melanoma.

Melanoma Res 2019 Mar 20. Epub 2019 Mar 20.

Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CMR.0000000000000604DOI Listing
March 2019

Validation of a Nomogram for Non-sentinel Node Positivity in Melanoma Patients, and Its Clinical Implications: A Brazilian-Dutch Study.

Ann Surg Oncol 2019 Feb 19;26(2):395-405. Epub 2018 Nov 19.

Department of Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1245/s10434-018-7038-9DOI Listing
February 2019

Parotidectomy in patients with head and neck cutaneous melanoma with cervical lymph node involvement.

Head Neck 2019 Feb 14. Epub 2019 Feb 14.

Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hed.25670DOI Listing
February 2019

Reply to: Letter re: Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma: A multicenter experience.

Eur J Surg Oncol 2019 Feb 16. Epub 2019 Feb 16.

Department of Surgical Oncology, Netherlands Cancer Institute, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejso.2019.02.020DOI Listing
February 2019

High response rates for T-VEC in early metastatic melanoma (stage IIIB/C-IVM1a).

Int J Cancer 2019 Jan 29. Epub 2019 Jan 29.

Department of Surgical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.32172DOI Listing
January 2019

Treatment and survival of Merkel cell carcinoma since 1993: a population-based cohort study in the Netherlands.

J Am Acad Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Dermatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jaad.2019.01.042DOI Listing
January 2019

Melanoma.

Lancet 2018 09;392(10151):971-984

Department of Dermatology, University Hospital Essen, Essen, Germany; German Cancer Consortium, Heidelberg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183155
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http://dx.doi.org/10.1016/S0140-6736(18)31559-9DOI Listing
September 2018

Merkel cell carcinoma: Clinical outcome and prognostic factors in 351 patients.

J Surg Oncol 2018 Jun 22;117(8):1768-1775. Epub 2018 May 22.

Departement of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/jso.25090DOI Listing
June 2018

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma.

N Engl J Med 2018 May 15;378(19):1789-1801. Epub 2018 Apr 15.

From the Gustave Roussy Cancer Campus Grand Paris and University Paris-Saclay, Villejuif (A.M.M.E., C.R.), Hospices Civils de Lyon Cancer Institute, Cancer Research Center of Lyon, Lyon University, Lyon (S.D.), and Aix-Marseille University, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille (J.-J.G.) - all in France; Netherlands Cancer Institute-Antoni van Leeuwenhoek (C.U.B., A.C.J.A.) and VU University Medical Center (A.J.M.E.), Amsterdam, and Radboud University Medical Center Nijmegen, Nijmegen (R.K.) - all in the Netherlands; Azienda Ospedaliera Papa Giovanni XXIII, Bergamo (M. Mandala), Istituto Nazionale Tumori Istituto di Ricovero e Cura a Carattere Scientifico Fondazione G. Pascale, Naples (P.A.A.), and Universita Degli Studi Di Siena-Policlinico le Scotte, Siena (M. Maio) - all in Italy; Melanoma Institute Australia, the University of Sydney, and Mater and Royal North Shore Hospitals (G.V.L.) and Westmead and Blacktown Hospitals, Melanoma Institute Australia and the University of Sydney (M.S.C.), Sydney, Princess Alexandra Hospital, University of Queensland, Brisbane (V.A.), Alfred Hospital (A.H.) and Peter MacCallum Cancer Centre (S. Sandhu), Melbourne, VIC, and Fiona Stanley Hospital-University of Western Australia-Edith Cowan University Perth, Perth (A.K.) - all in Australia; Cancer Research Center, Moscow (M.L.); Royal Marsden Hospital, London (J.L.); Hospital Clinic Universitari de Barcelona, Barcelona (S.P.); Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland (P.R.); University Hospital Essen, Essen and German Cancer Consortium, Heidelberg (D.S.), and the Skin Cancer Center, Department of Dermatology, Hannover Medical School, Hannover (R.G.) - all in Germany; Washington University School of Medicine, St. Louis (L.H.-A.); Centre Hospitalier de l'Université de Montréal (CHUM), Centre de Recherche du CHUM, Montreal (R.J.); Christie NHS Foundation Trust, Manchester, United Kingdom (P.L.); Merck, Kenilworth, NJ (N.I.); and the European Organization for the Research and Treatment of Cancer Headquarters, Brussels (S.M., S. Suciu).

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http://dx.doi.org/10.1056/NEJMoa1802357DOI Listing
May 2018

Practice-Changing Developments in Stage III Melanoma: Surgery, Adjuvant Targeted Therapy, and Immunotherapy.

Am Soc Clin Oncol Educ Book 2018 May;38:759-762

From the Department of Hematology/Oncology, Winship Cancer Institute, Emory University, Atlanta, GA; Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland; Department of Surgical Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.

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http://dx.doi.org/10.1200/EDBK_200241DOI Listing
May 2018

Positron emission tomography/computed tomography evaluation of oncolytic virus therapy efficacy in melanoma.

Eur J Cancer 2018 02 8;90:149-152. Epub 2017 Dec 8.

Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, NL-1066 CX Amsterdam, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049173140
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http://dx.doi.org/10.1016/j.ejca.2017.11.007DOI Listing
February 2018

Unknown Primary Melanoma: Worldwide Survey on Clinical Management.

Dermatology 2016 5;232(6):704-707. Epub 2017 Jan 5.

Section of Dermatology, Medical Sciences Department, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1159/000453592DOI Listing
December 2017

Pre-SN Ultrasound-FNAC can be Sensitive for Lymph Node Metastases in Melanoma Patients if Performed with the Use of the Berlin Criteria.

Ann Surg Oncol 2017 Dec 20;24(Suppl 3):661-662. Epub 2017 Nov 20.

Institut de Cancérologie, Gustav Roussy, Villejuif, France.

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http://dx.doi.org/10.1245/s10434-017-6230-7DOI Listing
December 2017

Clinical prognostic markers in stage IIIC melanoma.

J Surg Oncol 2017 Aug 15;116(2):244-251. Epub 2017 Apr 15.

Department of Surgical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/jso.24635DOI Listing
August 2017

Isolated Limb Perfusion for Melanoma is Safe and Effective in Elderly Patients.

Ann Surg Oncol 2017 Jul 10;24(7):1997-2005. Epub 2017 Feb 10.

Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1245/s10434-017-5803-9DOI Listing
July 2017

PET/CT surveillance detects asymptomatic recurrences in stage IIIB and IIIC melanoma patients: a prospective cohort study.

Melanoma Res 2017 06;27(3):251-257

Departments of aSurgical Oncology bNuclear Medicine, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CMR.0000000000000347DOI Listing
June 2017

Implementation of the 7th edition AJCC staging system: Effects on staging and survival for pT1 melanoma. A Dutch population based study.

Int J Cancer 2017 04 7;140(8):1802-1808. Epub 2017 Feb 7.

Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.30607DOI Listing
April 2017

Surgical Management and Adjuvant Therapy for High-Risk and Metastatic Melanoma.

Am Soc Clin Oncol Educ Book 2016 ;35:e505-14

From the Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands; Georgetown Lombardi Comprehensive Cancer Center, Washington, DC; St. Luke's University Hospital, Temple University, Allentown, PA; University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1200/EDBK_159087DOI Listing
January 2017

Clinical Prognostic Markers in Stage IIIB Melanoma.

Ann Surg Oncol 2016 12 5;23(13):4195-4202. Epub 2016 Jul 5.

Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1245/s10434-016-5396-8DOI Listing
December 2016

The Diagnostic Value of PET/CT Imaging in Melanoma Groin Metastases.

Ann Surg Oncol 2016 07 26;23(7):2323-9. Epub 2016 Feb 26.

Department of Surgical Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1245/s10434-016-5142-2DOI Listing
July 2016

Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity.

Melanoma Res 2016 06;26(3):267-71

aDepartment of Dermatology, Venerology and Allergology, Charité - University of Medicine Berlin, Berlin bDepartment of Dermatology, Harz Skin Cancer Center, Quedlinburg, Germany cDepartment of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam dDepartment of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands eGustav Roussy, Institute of Oncology, Villejuif/Paris-Sud, France.

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http://dx.doi.org/10.1097/CMR.0000000000000223DOI Listing
June 2016

Making Peace With Cancer.

J Clin Oncol 2015 Dec 12;33(35):4227-8. Epub 2015 Oct 12.

Christiane A. Voit, Charité-Universitätsmedizin, Berlin, Germany; and Alexander C.J. van Akkooi, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2015.63.1333DOI Listing
December 2015

[Sentinel lymph node procedure in melanoma patients: a staging procedure, not a therapy].

Ned Tijdschr Geneeskd 2014 ;158:A8113

Nederlands Kanker Instituut-Antoni van Leeuwenhoek (NKI-AVL), afd. Chirurgische-Oncologie, Amsterdam.

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April 2015

SLNB in melanoma-DFS a true and cost-effective benefit?

Nat Rev Clin Oncol 2014 Nov 14;11(11). Epub 2014 Oct 14.

Cancer Institute, Gustave Roussy Cancer Campus, Grand Paris, 114 rue Édouard Vaillant, 94805 Villejuif, France.

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http://dx.doi.org/10.1038/nrclinonc.2014.65-c3DOI Listing
November 2014

Ultrasound diagnosis of an atypical axillary lesion.

Melanoma Res 2014 Oct;24(5):517-21

aDepartment of Dermatology, Charité, Humboldt University of Berlin, Berlin bDepartment of Dermatology, University of Mainz, Mainz, Germany cDepartment of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands dInstitute Gustave Roussy Cancer Center, Villejuif, Paris Sud, France.

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http://dx.doi.org/10.1097/CMR.0000000000000105DOI Listing
October 2014

Ultrasound-guided fine needle aspiration cytology as an addendum to sentinel lymph node biopsy can perfect the staging strategy in melanoma patients.

Eur J Cancer 2014 Sep 3;50(13):2280-8. Epub 2014 Jul 3.

Institut de Cancérologie Gustav Roussy, Paris-Sud/Villejuif, France; European Organization for Research and Treatment of Cancer (EORTC) Melanoma Group (MG), Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2014.05.027DOI Listing
September 2014

Sentinel node followed by completion lymph node dissection versus nodal observation: staging or therapeutic? Controversy continues despite final results of MSLT-1.

Melanoma Res 2014 Aug;24(4):291-4

Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CMR.0000000000000073DOI Listing
August 2014

Pigmentation in the sentinel node correlates with increased sentinel node tumor burden in melanoma patients.

Melanoma Res 2014 Jun;24(3):261-6

aDepartment of Surgical Oncology, Erasmus University Medical Center - Daniel den Hoed Cancer Center bDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/CMR.0000000000000061DOI Listing
June 2014

Melanoma: MSLT-1--SNB is a biomarker, not a therapeutic intervention.

Nat Rev Clin Oncol 2014 May 8;11(5):248-9. Epub 2014 Apr 8.

Cancer Institute, Gustave Roussy Cancer Campus, Grand Paris, 114 rue Édouard Vaillant, 94805 Villejuif, France.

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http://dx.doi.org/10.1038/nrclinonc.2014.64DOI Listing
May 2014

Conditional survival of malignant melanoma in The Netherlands: 1994-2008.

Eur J Cancer 2014 Feb 18;50(3):602-10. Epub 2013 Nov 18.

Eindhoven Cancer Registry, Comprehensive Cancer Centre South, Eindhoven, The Netherlands; Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2013.10.019DOI Listing
February 2014

[Hypothenar hammer syndrome; rare arterial disorder of the hand due to blunt trauma].

Ned Tijdschr Geneeskd 2013 ;157(21):A6077

Maasstad Ziekenhuis, Afd. Plastische, Reconstructieve en Handchirurgie, Rotterdam, the Netherlands.

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July 2013

Completion lymph node dissection after a positive sentinel node: no longer a must?

Curr Opin Oncol 2013 Mar;25(2):152-9

Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1097/CCO.0b013e32835dafb4DOI Listing
March 2013

Fine needle aspiration cytology of palpable and nonpalpable lymph nodes to detect metastatic melanoma.

J Natl Cancer Inst 2011 Dec 21;103(23):1771-7. Epub 2011 Sep 21.

Department of Dermatology, Charité University Medicine, Charitéplatz 1, Berlin 10117, Germany.

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http://dx.doi.org/10.1093/jnci/djr381DOI Listing
December 2011

Multimarker reverse transcriptase-polymerase chain reaction assay in lymphatic drainage and sentinel node tumor burden.

Ann Surg Oncol 2010 Dec 7;17(12):3314-23. Epub 2010 Jul 7.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

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http://dx.doi.org/10.1245/s10434-010-1142-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995879PMC
December 2010

Role of ultrasound in the assessment of the sentinel node of melanoma patients.

AJR Am J Roentgenol 2010 Dec;195(6):W474-5; author reply W476

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http://dx.doi.org/10.2214/AJR.10.4833DOI Listing
December 2010

Unusual first presentation of metastatic pancreatic cancer as skin metastases in a burn patient.

Burns 2010 Sep 13;36(6):e111-4. Epub 2010 Apr 13.

Department of Surgery, Rotterdam Burn Centre, Maasstad Ziekenhuis, Groene Hilledijk 315, 3075 EA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.burns.2009.12.004DOI Listing
September 2010

Importance of tumor load in the sentinel node in melanoma: clinical dilemmas.

Nat Rev Clin Oncol 2010 Aug 22;7(8):446-54. Epub 2010 Jun 22.

Department of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, Kamer A1-41, 3075 EA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrclinonc.2010.100DOI Listing
August 2010

Epidemiology of extracutaneous melanoma in the Netherlands.

Cancer Epidemiol Biomarkers Prev 2010 Jun 25;19(6):1453-9. Epub 2010 May 25.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-1267DOI Listing
June 2010

Surgery of primary melanomas.

Cancers (Basel) 2010 May 11;2(2):824-41. Epub 2010 May 11.

Soft Tissue/Bone Sarcoma and Melanoma Department, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

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http://dx.doi.org/10.3390/cancers2020824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835107PMC
May 2010

New developments in sentinel node staging in melanoma: controversies and alternatives.

Curr Opin Oncol 2010 May;22(3):169-77

Department of Surgical Oncology, Erasmus University Medical Center - Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCO.0b013e328337aa78DOI Listing
May 2010

Ultrasound morphology criteria predict metastatic disease of the sentinel nodes in patients with melanoma.

J Clin Oncol 2010 Feb 11;28(5):847-52. Epub 2010 Jan 11.

Department of Dermatology, Charité, University Medicine Berlin, Berlin, 10117, Germany.

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http://dx.doi.org/10.1200/JCO.2009.25.7428DOI Listing
February 2010

Expert opinion in melanoma: the sentinel node; EORTC Melanoma Group recommendations on practical methodology of the measurement of the microanatomic location of metastases and metastatic tumour burden.

Eur J Cancer 2009 Nov 18;45(16):2736-42. Epub 2009 Sep 18.

Erasmus University Medical Centre - Daniel den Hoed Cancer Centre, Department of Surgical Oncology, Groene Hilledijk 301 - Kamer A1-41, 3075 EA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2009.08.015DOI Listing
November 2009

Detection of melanoma micrometastases in sentinel nodes - the cons.

Surg Oncol 2008 Sep 9;17(3):175-81. Epub 2008 Jul 9.

Department of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, P.O. Box 5201, 301 Groene Hilledijk, 3008 AE, Rotterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S096074040800054
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http://dx.doi.org/10.1016/j.suronc.2008.06.004DOI Listing
September 2008

Sentinel lymph-node false positivity in melanoma.

Nat Clin Pract Oncol 2008 Apr;5(4):E2

Department of Surgical Oncology, Erasmus University MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1038/ncponc1111DOI Listing
April 2008

Isolated limb perfusion for an irresectable melanoma recurrence in a Jehovah's witness.

Eur J Cardiothorac Surg 2006 Aug 7;30(2):408-10. Epub 2006 Jul 7.

Erasmus University Medical Center-Daniel den Hoed Cancer Center, Department of Surgical Oncology, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejcts.2006.04.020DOI Listing
August 2006