Alexander Arlt

Alexander Arlt

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Alexander Arlt

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Do We Really Need Another Special Issue on NF-κB in Cancer and Inflammation?

Cancers (Basel) 2019 Dec 9;11(12). Epub 2019 Dec 9.

Laboratory of Molecular Gastroenterology & Hepatology, Department of Internal Medicine I, UKSH-Campus Kiel, 24105 Kiel, Germany.

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http://dx.doi.org/10.3390/cancers11121978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966584PMC
December 2019

Diagnostic and interventional digital pancreatoscopy as an "all-in-one" approach in chronic pancreatitis: a case report.

Endoscopy 2019 10 23;51(10):E288-E289. Epub 2019 May 23.

Interdisciplinary Endoscopy, Medical Department 1, University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1055/a-0896-2405DOI Listing
October 2019

NF-κB Dependent Chemokine Signaling in Pancreatic Cancer.

Cancers (Basel) 2019 Sep 26;11(10). Epub 2019 Sep 26.

Laboratory of Molecular Gastroenterology & Hepatology, Department of Internal Medicine I, UKSH-Campus Kiel, 24105 Kiel, Germany.

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http://dx.doi.org/10.3390/cancers11101445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826905PMC
September 2019

Severe bleeding is a rare event in patients receiving lumen-apposing metal stents for the drainage of pancreatic fluid collections.

Gut 2019 05 20;68(5):945-946. Epub 2018 Apr 20.

Department of Medicine I, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden (TU Dresden), Dresden, Germany.

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http://dx.doi.org/10.1136/gutjnl-2018-316581DOI Listing
May 2019

The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2.

Oncogene 2019 02 9;38(9):1461-1476. Epub 2018 Oct 9.

Laboratory of Molecular Gastroenterology & Tumor Biology, Institute for Experimental Cancer Research, Christian-Albrechts-University & UKSH Campus Kiel, Bldg. 17, Arnold-Heller-Straße 3, 24105, Kiel, Germany.

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http://dx.doi.org/10.1038/s41388-018-0518-3DOI Listing
February 2019

TRAIL/NF-κB/CX3CL1 Mediated Onco-Immuno Crosstalk Leading to TRAIL Resistance of Pancreatic Cancer Cell Lines.

Int J Mol Sci 2018 Jun 4;19(6). Epub 2018 Jun 4.

Laboratory of Molecular Gastroenterology & Hepatology, Department of Internal Medicine I, UKSH-Campus Kiel, 24105 Kiel, Germany.

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http://dx.doi.org/10.3390/ijms19061661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032098PMC
June 2018

[Hyponatremia: Differential Diagnosis and Treatment].

Dtsch Med Wochenschr 2017 Aug 15;142(16):1231-1247. Epub 2017 Aug 15.

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http://dx.doi.org/10.1055/s-0043-108953DOI Listing
August 2017

Role of CCL20 mediated immune cell recruitment in NF-κB mediated TRAIL resistance of pancreatic cancer.

Biochim Biophys Acta Mol Cell Res 2017 May 8;1864(5):782-796. Epub 2017 Feb 8.

Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH-Campus Kiel, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2017.02.005DOI Listing
May 2017

Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study.

Eur Surg Res 2016 20;57(3-4):155-170. Epub 2016 Jul 20.

Department of General, Visceral, Thoracic, Transplantation and Pediatric Surgery University Medical Center Schleswig-Holstein (UKSH), Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1159/000447511DOI Listing
April 2017

Phase-transfer catalyzed asymmetric synthesis of α,β-unsaturated γ,γ-disubstituted γ-lactams.

Chem Commun (Camb) 2017 Apr;53(35):4779-4782

Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1039/c7cc01058cDOI Listing
April 2017

Investigational histone deacetylase inhibitors for treating pancreatic adenocarcinoma.

Expert Opin Investig Drugs 2016 Nov 5;25(11):1251-1254. Epub 2016 Oct 5.

b Institute for Experimental Cancer Research , Laboratory of Molecular Gastroenterology, - Christian-Albrechts-University & UKSH Campus Kiel , Kiel , Germany.

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http://dx.doi.org/10.1080/13543784.2016.1240167DOI Listing
November 2016

Colonic Lamina Propria Inflammatory Cells from Patients with IBD Induce the Nuclear Factor-E2 Related Factor-2 Thereby Leading to Greater Proteasome Activity and Apoptosis Protection in Human Colonocytes.

Inflamm Bowel Dis 2016 11;22(11):2593-2606

*Laboratory of Molecular Gastroenterology, Department of Internal Medicine I, UKSH Campus, Kiel, Germany; †Institute of Pathology, Christian-Albrechts-University and UKSH Campus, Kiel, Germany; ‡Department of General-, Thoracic and Visceral Surgery, UKSH Campus, Kiel, Germany; and §Institute for Experimental Cancer Research, Christian-Albrechts-University and UKSH Campus, Kiel, Germany.

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http://dx.doi.org/10.1097/MIB.0000000000000925DOI Listing
November 2016

Discovery of Rigidified α,β-Unsaturated Imines as New Resistance-breaking Insecticides for Malaria Vector Control.

Chimia (Aarau) 2016 Oct;70(10):694-697

Bayer CropScience AG Pest Control Chemistry Alfred-Nobel-Str. 50 D-40789 Monheim, Germany.

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http://dx.doi.org/10.2533/chimia.2016.694DOI Listing
October 2016

Abdominal malrotation overlooked at extensive cross-sectional imaging and leading to life-threatening gastrointestinal bleeding.

Endoscopy 2015 29;47 Suppl 1:E639-40. Epub 2015 Dec 29.

Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1055/s-0034-1393651DOI Listing
September 2016

Endoscopic ultrasound-guided biliary drainage using a lumen-apposing self-expanding metal stent: a case series.

Endoscopy 2015 Sep 28;47(9):858-61. Epub 2015 May 28.

Medical Department 1, University Hospital Dresden, Technical University Dresden (TUD), Dresden, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1392104
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http://dx.doi.org/10.1055/s-0034-1392104DOI Listing
September 2015

Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis.

Innate Immun 2015 Jan 11;21(1):30-41. Epub 2013 Dec 11.

Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany Department of Surgery and Psychiatry, University Hospital of Kuopio, Kuopio, Finland Institute of Biomedicine, Department of Physiology and Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1177/1753425913515033DOI Listing
January 2015

Antibiosis of Necrotizing Pancreatitis.

Viszeralmedizin 2014 Oct;30(5):318-24

Department of Internal Medicine I, University Hospital Dresden, Dresden University of Technology, Dresden, Germany.

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http://dx.doi.org/10.1159/000367948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513830PMC
October 2014

Cytoprotection "gone astray": Nrf2 and its role in cancer.

Onco Targets Ther 2014 26;7:1497-518. Epub 2014 Aug 26.

Laboratory of Molecular Gastroenterology, Department of Internal Medicine I, Universitätsklinikum Schleswig-Holstein Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.2147/OTT.S36624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155833PMC
September 2014

Endoscopic endoluminal vacuum therapy is superior to other regimens in managing anastomotic leakage after esophagectomy: a comparative retrospective study.

Surg Endosc 2013 Oct 25;27(10):3883-90. Epub 2013 May 25.

Department of General and Thoracic Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3 (Haus 18), 24105, Kiel, Germany,

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http://dx.doi.org/10.1007/s00464-013-2998-0DOI Listing
October 2013

Total synthesis of nominal gobienine A.

Chemistry 2013 Jun 15;19(24):7731-8. Epub 2013 Apr 15.

Max-Planck-Institut für Kohlenforschung, 45470 Mülheim/Ruhr, Germany.

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http://dx.doi.org/10.1002/chem.201300827DOI Listing
June 2013

Targeting apoptosis pathways in pancreatic cancer.

Cancer Lett 2013 May 13;332(2):346-58. Epub 2010 Nov 13.

Laboratory of Molecular Gastroenterology and Hepatology, Dept. of Internal Medicine 1, UKSH-Campus Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.canlet.2010.10.015DOI Listing
May 2013

Oral glutamine supplementation improves intestinal permeability dysfunction in a murine acute graft-vs.-host disease model.

Am J Physiol Gastrointest Liver Physiol 2013 Apr 31;304(7):G646-54. Epub 2013 Jan 31.

Department of Internal Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1152/ajpgi.00246.2012DOI Listing
April 2013

A total synthesis of spirastrellolide A methyl ester.

Chemistry 2013 Mar 18;19(11):3596-608. Epub 2013 Feb 18.

Max-Planck-Institut für Kohlenforschung, 45470 Mülheim/Ruhr, Germany.

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http://doi.wiley.com/10.1002/chem.201203965
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http://dx.doi.org/10.1002/chem.201203965DOI Listing
March 2013

Expression pattern and localization of alpha-synuclein in the human enteric nervous system.

Neurobiol Dis 2012 Dec 28;48(3):474-80. Epub 2012 Jul 28.

Department of Anatomy, Christian Albrecht's University, and Department of Neurology, University Hospital Schleswig-Holstein, Otto-Hahn-Platz 8, 24118 Kiel, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961120026
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http://dx.doi.org/10.1016/j.nbd.2012.07.018DOI Listing
December 2012

Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease.

J Crohns Colitis 2012 May 11;6(4):464-9. Epub 2011 Nov 11.

Department of Internal Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

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http://dx.doi.org/10.1016/j.crohns.2011.10.004DOI Listing
May 2012

Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis.

BMC Gastroenterol 2012 May 14;12:48. Epub 2012 May 14.

Department of Gastroenterology, Charité University Campus Mitte, Berlin, Germany.

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http://dx.doi.org/10.1186/1471-230X-12-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404947PMC
May 2012

Characterisation of FAP-1 expression and CD95 mediated apoptosis in the A818-6 pancreatic adenocarcinoma differentiation system.

Differentiation 2012 Mar 21;83(3):148-57. Epub 2011 Dec 21.

Institute for Experimental Cancer Research, Division Molecular Oncology, University Hospital Schleswig-Holstein Campus Kiel, Germany.

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http://dx.doi.org/10.1016/j.diff.2011.11.013DOI Listing
March 2012

Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection.

J Biol Chem 2011 Nov 11;286(47):40911-21. Epub 2011 Oct 11.

Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, Universitätsklinikum Schleswig Holstein-Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1074/jbc.M111.274902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220482PMC
November 2011

Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis.

Eur J Cell Biol 2011 Jun-Jul;90(6-7):545-52. Epub 2010 Nov 26.

Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH-Campus Kiel, Arnold-Heller-Straße 3, Bldg. 6, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.ejcb.2010.10.002DOI Listing
September 2011

Second-generation total synthesis of spirastrellolide F methyl ester: the alkyne route.

Angew Chem Int Ed Engl 2011 Sep 26;50(37):8739-44. Epub 2011 Jul 26.

Max-Planck-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany.

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http://dx.doi.org/10.1002/anie.201103270DOI Listing
September 2011

IL-1β and ADAM17 are central regulators of β-defensin expression in Candida esophagitis.

Am J Physiol Gastrointest Liver Physiol 2011 Apr 13;300(4):G547-53. Epub 2011 Jan 13.

Department of Internal Medicine I, University of Kiel, Germany University Hospital Schleswig-Holstein, Germany.

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http://dx.doi.org/10.1152/ajpgi.00251.2010DOI Listing
April 2011

Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming growth factor-β1 (TGF-β)-induced L1CAM expression in human pancreatic ductal adenocarcinoma cells.

Int J Oncol 2011 Jan;38(1):257-66

Department of Internal Medicine 1, Laboratory of Molecular Gastroenterology & Hepatology, UKSH-Campus Kiel, Arnold-Heller-Strasse 3, Bldg. 6, 24105 Kiel, Germany.

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January 2011

Chronic portal vein thrombosis: transcapsular hepatic collateral vessels and communicating ectopic varices.

Radiology 2010 Nov 9;257(2):568-78. Epub 2010 Sep 9.

Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.

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http://dx.doi.org/10.1148/radiol.10100157DOI Listing
November 2010

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells.

Mol Cancer 2010 Apr 16;9:80. Epub 2010 Apr 16.

Technische Universität München, Klinikum rechts der Isar, II, Medizinische Klinik, Ismaninger Str, 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1186/1476-4598-9-80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867820PMC
April 2010

A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis.

Hum Mol Genet 2010 Feb 6;19(3):553-62. Epub 2009 Nov 6.

Institute for Clinical Molecular Biology, Christian-Albrechts-University Kiel, Schittenhelmstrasse 12, Kiel, Germany.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddp508DOI Listing
February 2010

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.

J Cell Sci 2009 Oct;122(Pt 19):3522-30

Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany.

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http://dx.doi.org/10.1242/jcs.050690DOI Listing
October 2009

IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis.

Biochim Biophys Acta 2008 May 23;1783(5):941-52. Epub 2007 Dec 23.

Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2007.12.010DOI Listing
May 2008

Immediate early gene-X1 interferes with 26 S proteasome activity by attenuating expression of the 19 S proteasomal components S5a/Rpn10 and S1/Rpn2.

Biochem J 2007 Mar;402(2):367-75

Laboratory of Molecular Gastroenterology and Hepatology, First Department of Medicine, UKSH (Universitätsklinikum Schleswig-Holstein), Kiel Campus, D-24105 Kiel, Federal Republic of Germany.

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http://dx.doi.org/10.1042/BJ20061072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1798431PMC
March 2007

A modified random oligonucleotide-based combination therapy for adjuvant treatment of pancreatic ductal adenocarcinoma.

Int J Oncol 2006 May;28(5):1105-12

Department of General Surgery and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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May 2006

Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo.

Gastroenterology 2005 Sep;129(3):952-68

Division of Molecular Gastroenterology and Hepatology, First Department of Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1053/j.gastro.2005.06.059DOI Listing
September 2005

Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells.

J Biol Chem 2005 Jul 26;280(26):24849-56. Epub 2005 Apr 26.

Laboratory of Molecular Gastroenterology and Hepatology, First Department of Medicine, Christian-Albrechts-University of Kiel, Schittenhelmstrasse 12, D-24105 Kiel, Germany.

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http://www.jbc.org/content/early/2005/04/26/jbc.M501571200.f
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http://www.jbc.org/cgi/doi/10.1074/jbc.M501571200
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http://dx.doi.org/10.1074/jbc.M501571200DOI Listing
July 2005

CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.

FASEB J 2005 Apr 24;19(6):620-2. Epub 2005 Jan 24.

Molecular Oncology Unit, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1096/fj.04-2984fjeDOI Listing
April 2005

Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1.

FASEB J 2005 Jan 28;19(1):91-3. Epub 2004 Oct 28.

Institute of Clinical Molecular Biology, Schleswig-Holstein University Medical Center, Kiel, Germany.

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http://dx.doi.org/10.1096/fj.04-2073fjeDOI Listing
January 2005

[Autocrine IL-1beta secretion leads to NF-kappabeta-mediated chemoresistance in pancreatic carcinoma cells in vivo].

Med Klin (Munich) 2004 Apr;99(4):185-90

Labor für Molekulare Gastroenterologie und Hepatologie, Klinik für Allgemeine Innere Medizin, UKSH-Campus Kiel, Kiel.

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http://dx.doi.org/10.1007/s00063-004-1027-4DOI Listing
April 2004

PKCmu prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells.

Oncogene 2003 Dec;22(55):8939-47

Molecular Oncology, Clinic for General Surgery and Thoracic Surgery, Christian-Albrechts-University, Arnold-Heller-Str7, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1038/sj.onc.1207001DOI Listing
December 2003

Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death.

Oncogene 2003 May;22(21):3243-51

1Laboratory of Molecular Gastroenterology & Hepatology, 1st Department of Medicine, University of Kiel, Germany.

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http://dx.doi.org/10.1038/sj.onc.1206390DOI Listing
May 2003

The early response gene IEX-1 attenuates NF-kappaB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death.

Oncogene 2003 May;22(21):3343-51

Laboratory of Molecular Gastroenterology & Hepatology, 1st Department of Medicine, Christian-Albrechts University of Kiel, Schittenhelmstr. 12, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1038/sj.onc.1206524DOI Listing
May 2003

Usage of the NF-kappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer.

Int J Cancer 2003 Apr;104(4):469-76

Laboratory of Molecular Gastroenterology & Hepatology, 1st Dept. of Medicine, Christian-Albrechts University, Kiel, Germany.

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http://dx.doi.org/10.1002/ijc.10963DOI Listing
April 2003

Angiotensin AT2 receptor ligands: do they have potential as future treatments for neurological disease?

CNS Drugs 2002 ;16(3):145-53

Institute of Anatomy, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.2165/00023210-200216030-00001DOI Listing
May 2002

Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines.

Cancer Res 2002 Feb;62(3):910-6

Laboratory of Molecular Gastroenterology, Department of Medicine, University of Kiel, Schittenhelmstrasse 12, D-24105 Kiel, Germany.

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February 2002