Publications by authors named "Alexander Aleshin"

29Publications

Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.

Chem Biol 2014 May 3;21(5):596-607. Epub 2014 Apr 3.

School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China; Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035439PMC
May 2014

Crystal structure of a glucose/H+ symporter and its mechanism of action.

Proc Natl Acad Sci U S A 2013 Oct 14;110(44):17862-7. Epub 2013 Oct 14.

Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL 60064.

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http://dx.doi.org/10.1073/pnas.1311485110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816430PMC
October 2013

Activity, specificity, and probe design for the smallpox virus protease K7L.

J Biol Chem 2012 Nov 25;287(47):39470-9. Epub 2012 Sep 25.

Program in Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.388678
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http://dx.doi.org/10.1074/jbc.M112.388678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501048PMC
November 2012

Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

J Biol Chem 2012 Jun 12;287(23):19642-52. Epub 2012 Apr 12.

Program on Infectious Diseases, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M112.361121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365999PMC
June 2012

Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).

J Biol Chem 2012 Mar 20;287(13):10210-22. Epub 2012 Jan 20.

Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M111.327809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323040PMC
March 2012

Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.

J Biol Chem 2011 Jun 25;286(23):20970-6. Epub 2011 Apr 25.

Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M111.237669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121525PMC
June 2011

The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.

Arch Virol 2011 Feb 27;156(2):313-8. Epub 2010 Oct 27.

Inflammatory and Infectious Disease Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s00705-010-0838-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918179PMC
February 2011

Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.

J Gen Virol 2008 Mar;89(Pt 3):636-641

Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1099/vir.0.83359-0DOI Listing
March 2008

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold.

Protein Sci 2007 May 30;16(5):795-806. Epub 2007 Mar 30.

Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1110/ps.072753207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206648PMC
May 2007

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.

Protein Expr Purif 2007 Apr 1;52(2):334-9. Epub 2006 Dec 1.

Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.pep.2006.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857357PMC
April 2007

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.

Protein Sci 2007 Jan 22;16(1):118-24. Epub 2006 Nov 22.

Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1110/ps.062454707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222835PMC
January 2007

Crystal structure and evolution of a prokaryotic glucoamylase.

J Mol Biol 2003 Mar;327(1):61-73

Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA.

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http://dx.doi.org/10.1016/s0022-2836(03)00084-6DOI Listing
March 2003