Alexander A Vinks

Alexander A Vinks

UNVERIFIED PROFILE

Are you Alexander A Vinks?   Register this Author

Register author
Alexander A Vinks

Alexander A Vinks

Publications by authors named "Alexander A Vinks"

Are you Alexander A Vinks?   Register this Author

100Publications

2551Reads

40Profile Views

Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus.

Am J Transplant 2019 Oct 21;19(10):2944-2948. Epub 2019 May 21.

Division of Nephrology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15398DOI Listing
October 2019

Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates.

Clin Pharmacol Ther 2019 Sep 12. Epub 2019 Sep 12.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1607DOI Listing
September 2019

Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease.

Inflamm Bowel Dis 2019 Jul 9. Epub 2019 Jul 9.

Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ibd/izz143DOI Listing
July 2019

Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different?

Biol Blood Marrow Transplant 2019 Jul 18. Epub 2019 Jul 18.

Department of Pediatrics, Bone Marrow Transplant Service, Memorial Sloan Kettering, New York, New York; Division of Pediatric Hematology-Oncology, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2019.07.014DOI Listing
July 2019

Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery.

Clin Pharmacokinet 2019 Jun;58(6):793-803

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC6018, Cincinnati, OH, 45229-3039, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40262-018-0729-3
Publisher Site
http://dx.doi.org/10.1007/s40262-018-0729-3DOI Listing
June 2019

Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values.

Am J Transplant 2019 May 26;19(5):1410-1420. Epub 2018 Dec 26.

Division of Hematology and Oncology, Children's Hospital of Richmond, Richmond, Virginia.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ajt.15199
Publisher Site
http://dx.doi.org/10.1111/ajt.15199DOI Listing
May 2019

Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib.

Pediatr Blood Cancer 2019 May 24;66(5):e27618. Epub 2019 Jan 24.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.27618DOI Listing
May 2019

A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition.

CPT Pharmacometrics Syst Pharmacol 2019 May 7;8(5):273-284. Epub 2019 Mar 7.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/psp4.12392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539708PMC
May 2019

Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients.

Pharmacotherapy 2019 May 15;39(5):564-575. Epub 2019 Apr 15.

Department of Surgery, Division of Transplantation, University of Cincinnati, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.2260DOI Listing
May 2019

Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study.

Clin Pharmacol Ther 2019 Mar 8;105(3):761-768. Epub 2018 Nov 8.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cpt.1249
Publisher Site
http://dx.doi.org/10.1002/cpt.1249DOI Listing
March 2019

From Molecule to Patient and Ways to Get the Dose Precisely Right.

Clin Pharmacol Ther 2019 Mar;105(3):534-537

Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1355DOI Listing
March 2019

Suggestions for Model-Informed Precision Dosing to Optimize Neonatal Drug Therapy.

J Clin Pharmacol 2019 Feb 11;59(2):168-176. Epub 2018 Sep 11.

Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jcph.1315
Publisher Site
http://dx.doi.org/10.1002/jcph.1315DOI Listing
February 2019

Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia.

Eur J Pharm Sci 2019 Feb 8;128:209-214. Epub 2018 Dec 8.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09280987183053
Publisher Site
http://dx.doi.org/10.1016/j.ejps.2018.12.004DOI Listing
February 2019

Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma.

Pediatr Blood Cancer 2019 01 30;66(1):e27425. Epub 2018 Aug 30.

Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.27425DOI Listing
January 2019

Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial.

Intensive Care Med 2018 Nov 25;44(11):2006-2008. Epub 2018 Sep 25.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00134-018-5374-7
Publisher Site
http://dx.doi.org/10.1007/s00134-018-5374-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235707PMC
November 2018

Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management.

Br J Clin Pharmacol 2018 07 17;84(7):1410-1412. Epub 2018 Apr 17.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/bcp.13585
Publisher Site
http://dx.doi.org/10.1111/bcp.13585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005594PMC
July 2018

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants.

CPT Pharmacometrics Syst Pharmacol 2018 07 19;7(7):464-473. Epub 2018 Jun 19.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/psp4.12306
Publisher Site
http://dx.doi.org/10.1002/psp4.12306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063742PMC
July 2018

Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study.

J Antimicrob Chemother 2018 06;73(6):1651-1658

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dky030DOI Listing
June 2018

Population Pharmacokinetics and Optimal Sampling Strategy for Model-Based Precision Dosing of Melphalan in Patients Undergoing Hematopoietic Stem Cell Transplantation.

Clin Pharmacokinet 2018 05;57(5):625-636

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH, 45229-3039, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-017-0581-xDOI Listing
May 2018

Using a Vancomycin PBPK Model in Special Populations to Elucidate Case-Based Clinical PK Observations.

CPT Pharmacometrics Syst Pharmacol 2018 04 15;7(4):237-250. Epub 2018 Feb 15.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/psp4.12279
Publisher Site
http://dx.doi.org/10.1002/psp4.12279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915605PMC
April 2018

Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies.

Pediatr Clin North Am 2017 12;64(6):1417-1438

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229-3039, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pcl.2017.08.011DOI Listing
December 2017

Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies.

Eur J Pharm Sci 2017 Nov 17;109S:S124-S131. Epub 2017 May 17.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2017.05.037DOI Listing
November 2017

Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents.

Clin Pharmacokinet 2017 10;56(10):1207-1217

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH, 45229-3039, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-017-0512-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557705PMC
October 2017

Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents.

J Clin Pharmacol 2017 10 16;57(10):1244-1257. Epub 2017 May 16.

Clinical Development, Teva Pharmaceutical Industries, Frazer, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.932DOI Listing
October 2017

Opportunities for model-based precision dosing in the treatment of sickle cell anemia.

Blood Cells Mol Dis 2017 09 9;67:143-147. Epub 2017 Aug 9.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcmd.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677562PMC
September 2017

Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies.

Pediatr Blood Cancer 2017 Aug 16;64(8). Epub 2017 Feb 16.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.26470DOI Listing
August 2017

Time in therapeutic range as a marker for thrombotic and bleeding outcomes in Fontan patients.

J Thromb Thrombolysis 2017 Jul;44(1):38-47

Adolescent and Adult Congenital Program, Children's Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11239-017-1499-8DOI Listing
July 2017

Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy.

Clin Transplant 2017 06 2;31(6). Epub 2017 May 2.

Division of Nephrology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ctr.12975DOI Listing
June 2017

Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group.

Br J Clin Pharmacol 2017 05 20;83(5):1097-1107. Epub 2016 Dec 20.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.13181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401981PMC
May 2017

OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children.

Pharmacogenomics 2017 May 4;18(7):621-629. Epub 2017 May 4.

Department of Anesthesia, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2017-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591462PMC
May 2017

Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab.

Biol Blood Marrow Transplant 2017 Apr 12;23(4):635-641. Epub 2017 Jan 12.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2017.01.071DOI Listing
April 2017

Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation.

J Pediatr Psychol 2017 Mar;42(2):232-244

Department of Psychology, University of Cincinnati, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jpepsy/jsw039DOI Listing
March 2017

Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus.

Clin Pharmacokinet 2017 02;56(2):107-125

Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, SLC, Utah 295 Chipeta Way, Salt Lake City, UT, 84108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-016-0426-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575762PMC
February 2017

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.

Drug Metab Dispos 2017 01 25;45(1):23-26. Epub 2016 Oct 25.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (D.H., C.E., A.A.V., T.F); and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio (C.E., A.A.V., T.F)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.116.072256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047210PMC
January 2017

A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2016 12 21;22(12):2220-2225. Epub 2016 Sep 21.

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2016.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683393PMC
December 2016

Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients.

Ther Drug Monit 2016 10;38(5):607-13

*Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; and †Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0000000000000314DOI Listing
October 2016

A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses.

Biol Blood Marrow Transplant 2016 10 3;22(10):1829-1835. Epub 2016 Aug 3.

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2016.08.001DOI Listing
October 2016

Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness.

JPEN J Parenter Enteral Nutr 2016 08 19;40(6):860-8. Epub 2015 Feb 19.

Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA Division of Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0148607115572193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609528PMC
August 2016

Pharmacokinetic modeling of therapies for systemic lupus erythematosus.

Expert Rev Clin Pharmacol 2015 9;8(5):587-603. Epub 2015 Jul 9.

a 1 Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/17512433.2015.1059751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575755PMC
April 2016

Development of a pharmacokinetic-guided dose individualization strategy for hydroxyurea treatment in children with sickle cell anaemia.

Br J Clin Pharmacol 2016 Apr 5;81(4):742-52. Epub 2016 Feb 5.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/bcp.12851
Publisher Site
http://dx.doi.org/10.1111/bcp.12851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799926PMC
April 2016

Therapeutic Optimization as Part of the Precision Medicine Paradigm.

Clin Pharmacol Ther 2016 Apr;99(4):340-2

Cincinnati Children's Hospital Medical Center, Division of Clinical Pharmacology, and Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.339DOI Listing
April 2016

Obesity and overweight as CAE comorbidities and differential drug response modifiers.

Neurology 2016 Apr 30;86(17):1613-21. Epub 2016 Mar 30.

From the Comprehensive Epilepsy Center (R.A., M.D., P.C., T.A.G.), Division of Neurology, and Division of Clinical Pharmacology (A.A.V., K.M.), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Children's National Health System (C.W.G., A.C.), Washington, DC; and Montefiore Medical Center (S.S.), Albert Einstein College of Medicine, Bronx, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000002611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844235PMC
April 2016

Pharmacokinetics and pharmacogenomics of β-lactam-induced neutropenia.

Pharmacogenomics 2016 04 5;17(6):547-59. Epub 2016 Apr 5.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 452294, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2015-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558518PMC
April 2016

Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations.

J Clin Pharmacol 2016 Mar 21;56(3):291-7. Epub 2015 Sep 21.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.601DOI Listing
March 2016

Increased Vancomycin Exposure and Nephrotoxicity in Children: Therapeutic Does Not Mean Safe.

J Pediatric Infect Dis Soc 2016 Mar 29;5(1):65-7. Epub 2014 Dec 29.

Division of Clinical Pharmacology College of Medicine, University of Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jpids/piu122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765492PMC
March 2016

Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review.

J Cardiovasc Pharmacol 2016 Feb;67(2):175-81

*Department of Pediatrics, University of Colorado, Children's Hospital Colorado, The Heart Institute, Aurora, CO; †Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Center for Acute Care Nephrology, Cincinnati, OH; ‡Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO; and §Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FJC.0000000000000327DOI Listing
February 2016

Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1-Erratum.

Ther Drug Monit 2016 01 21. Epub 2016 Jan 21.

1Division of Pharmacy, Cincinnati Children's Hospital Medical Center 2Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center 3Department of Pediatrics, University of Cincinnati, College of Medicine 4Cancer & Blood Disease Institute, Division of Oncology, Cincinnati Children's Hospital Medical Center 5Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 6Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0000000000000275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956590PMC
January 2016

The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model.

Br J Clin Pharmacol 2015 Dec 28;80(6):1438-46. Epub 2015 Oct 28.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.12743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693485PMC
December 2015

Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs.

Ther Drug Monit 2015 Dec;37(6):718-24

*iC42 Clinical Research and Development, University of Colorado, Aurora; †Department of Pediatrics, Division of Clinical Pharmacology, Cincinnati Children's Hospital and Medical Center, College of Medicine, University of Cincinnati, Ohio; ‡Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; §Department of Clinical Toxicology, Johns Hopkins School of Medicine, Baltimore, Maryland; ¶Department of Pharmacology, Toxicology and Pharmacovigilance, University Hospital of Limoges, France; ‖Cliniques Universitaires St. Luc, UCL, Brussels, Belgium; **Departments of Hospital Pharmacy and Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands; ††Navigant Consulting Inc, New York, New York; and ‡‡Novartis Pharmaceutical Corp, East Hanover, New Jersey.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/drug-monitoring/2015/12000/Impa
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/FTD.0000000000000205DOI Listing
December 2015

Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study.

J Pediatr 2015 Dec 11;167(6):1214-20.e3. Epub 2015 Sep 11.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2015.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662899PMC
December 2015

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS.

J Vis Exp 2015 Nov 8(105):e52424. Epub 2015 Nov 8.

iC42 Clinical Research and Development, University of Colorado, Anschutz Medical Campus;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/52424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692696PMC
November 2015

Evaluation of Target Attainment of Vancomycin Area Under the Curve in Children With Methicillin-Resistant Staphylococcus Aureus Bacteremia.

Ther Drug Monit 2015 Oct;37(5):619-25

*Division of Infectious Disease, Children's National Medical Center, Washington, DC; †Division of Infectious Disease, Cincinnati Children's Hospital Medical Center; ‡Department of Pediatrics, University of Cincinnati College of Medicine; §Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center; and ¶Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Ohio.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/drug-monitoring/2015/10000/Eval
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/FTD.0000000000000190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576725PMC
October 2015

Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

Ther Drug Monit 2015 Jun;37(3):395-9

*Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center; †Department of Pediatrics, College of Medicine, University of Cincinnati, OH; ‡iC42 Integrated Solutions in Clinical Research and Development, University of Colorado, Aurora; §Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD; ¶Division of Oncology, The Children's Hospital of Philadelphia; ‖Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia; **Division of Oncology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center; and ††Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0000000000000130DOI Listing
June 2015

Validation of a pediatric population pharmacokinetic model for vancomycin.

Ther Drug Monit 2015 Jun;37(3):413-6

*Division of Infectious Disease, Cincinnati Children's Hospital Medical Center; †Department of Pediatrics, University of Cincinnati College of Medicine; ‡Division of Biostatistics and Epidemiology; and §Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, OH.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/drug-monitoring/2015/06000/Vali
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/FTD.0000000000000153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431905PMC
June 2015

Effects of unbound mycophenolic acid on inosine monophosphate dehydrogenase inhibition in pediatric kidney transplant patients.

Ther Drug Monit 2014 Dec;36(6):716-23

*Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; †Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; ‡Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah; and §Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/drug-monitoring/2014/12000/Effe
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/FTD.0000000000000081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687018PMC
December 2014

Meropenem in children receiving continuous renal replacement therapy: clinical trial simulations using realistic covariates.

J Clin Pharmacol 2014 Dec 16;54(12):1421-8. Epub 2014 Jul 16.

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.360DOI Listing
December 2014

Optimization of mycophenolic acid therapy using clinical pharmacometrics.

Drug Metab Pharmacokinet 2014 17;29(1):4-11. Epub 2013 Dec 17.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center.

View Article

Download full-text PDF

Source
October 2014

Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure.

J Pediatr 2014 Sep 16;165(3):440-6. Epub 2014 Jun 16.

Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2014.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144410PMC
September 2014

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.

Pharmacogenomics 2014 Jul;15(10):1297-309

Department of Anesthesia, Cincinnati Children's Hospital Medical Center; 3333 Burnet Avenue, MLC 2001, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.14.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190075PMC
July 2014

Similar MPA exposure on modified release and regular tacrolimus.

Ther Drug Monit 2014 Jun;36(3):353-7

Departments of *Medicine, Division of Nephrology; and †Pediatrics, Division of Pediatric Nephrology, Children's Hospital, London Health Science Centre and Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada; and ‡Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, University of Cincinnati; and §Department of Pediatrics, College of Medicine, University of Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0000000000000021DOI Listing
June 2014

The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma.

Ther Drug Monit 2014 Jun;36(3):310-6

*Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan; †Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center; ‡Department of Pediatrics, College of Medicine, University of Cincinnati, Ohio; and §Department of Urology, Graduate School of Medicine, Kyoto University, Japan. Dr Terada is now with the Department of Pharmacy, Shiga University of Medical Science Hospital, Japan; Dr Katsura is now with the College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan; and Dr Inui is now with the Kyoto Pharmaceutical University, Japan.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/drug-monitoring/2014/06000/The_
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/FTD.0000000000000025DOI Listing
June 2014

Evaluation of propofol anesthesia in morbidly obese children and adolescents.

BMC Anesthesiol 2013 21;13. Epub 2013 Apr 21.

Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden, Netherlands ; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2253-13-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644256PMC
May 2014

Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children.

Br J Clin Pharmacol 2014 May;77(5):910-2

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto University, Kyoto.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.12211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004414PMC
May 2014

Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics.

Int J Antimicrob Agents 2014 Mar 17;43(3):223-30. Epub 2013 Dec 17.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijantimicag.2013.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965635PMC
March 2014

Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study.

Curr Clin Pharmacol 2014 Feb;9(1):64-9

Clinical Anesthesia and Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2001, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564389PMC
February 2014

Lower vancomycin serum trough concentrations might not be the answer.

Pediatr Infect Dis J 2013 Dec;32(12):1403-4

Division of Infectious Disease Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/INF.0000000000000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937855PMC
December 2013

Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Oct 28;937:79-83. Epub 2013 Aug 28.

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2013.08.014DOI Listing
October 2013

Update in fetal anesthesia for the ex utero intrapartum treatment (EXIT) procedure.

Int Anesthesiol Clin 2012 ;50(4):26-40

Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/AIA.0b013e31826df966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756472PMC
June 2013

Federal legislation and the advancement of neonatal drug studies.

J Pediatr 2013 Jan 27;162(1):12-5. Epub 2012 Oct 27.

Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2012.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723457PMC
January 2013

UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients.

Ther Drug Monit 2012 Dec;34(6):671-9

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0b013e3182708f84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498586PMC
December 2012

Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents.

Ther Drug Monit 2012 Oct;34(5):535-44

Division of Clinical Pharmacology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229-3039, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0b013e318261c240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442132PMC
October 2012

Morphine clearance in children: does race or genetics matter?

J Opioid Manag 2012 Jul-Aug;8(4):217-26

Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5055/jom.2012.0119DOI Listing
October 2012

Pharmacogenetics in perioperative medicine.

Curr Opin Anaesthesiol 2012 Aug;25(4):419-27

Department of Anesthesiology, Children's Hospital Colorado, Aurora, USA.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00001503-201208000-000
Publisher Site
http://dx.doi.org/10.1097/ACO.0b013e3283556129DOI Listing
August 2012

Propofol Clearance in Morbidly Obese Children and Adolescents : Influence of Age and Body Size.

Clin Pharmacokinet 2012 Aug;51(8):543-551

Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/BF03261930DOI Listing
August 2012

Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation.

Transplantation 2012 Apr;93(8):806-12

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0b013e318247a6c7DOI Listing
April 2012