Alexander A Soukas

Alexander A Soukas

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Alexander A Soukas

Alexander A Soukas

Publications by authors named "Alexander A Soukas"

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Suppressing the dark side of autophagy.

Autophagy 2019 Oct 18;15(10):1852-1853. Epub 2019 Jul 18.

Department of Medicine, Diabetes Unit, and Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15548627.2019.1644077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735539PMC
October 2019

Metformin as Anti-Aging Therapy: Is It for Everyone?

Trends Endocrinol Metab 2019 Oct 9;30(10):745-755. Epub 2019 Aug 9.

Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and School of Life Sciences, Westlake University, Hangzhou, 310024, China. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2019.07.015DOI Listing
October 2019

Metformin: Mechanisms in Human Obesity and Weight Loss.

Curr Obes Rep 2019 Jun;8(2):156-164

Department of Medicine, Diabetes Unit, Endocrine Division, and Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN6224, Boston, MA, 02114, USA.

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http://link.springer.com/10.1007/s13679-019-00335-3
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http://dx.doi.org/10.1007/s13679-019-00335-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520185PMC
June 2019

The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans.

PLoS Pathog 2019 Jun 17;15(6):e1007893. Epub 2019 Jun 17.

Program in Innate Immunity, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597122PMC
June 2019

Surviving starvation simply without TFEB.

PLoS Biol 2019 May 28;17(5):e3000285. Epub 2019 May 28.

Department of Medicine, Diabetes Unit, and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555529PMC
May 2019

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension.

Cell 2019 Apr 28;177(2):299-314.e16. Epub 2019 Mar 28.

Department of Medicine, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610881PMC
April 2019

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival.

Cell Rep 2017 07;20(3):627-640

Department of Medicine, Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578715PMC
July 2017

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.

Cell 2016 Dec;167(7):1705-1718.e13

Department of Medicine, Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.11.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390486PMC
December 2016

Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):15378-83. Epub 2015 Nov 30.

Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089; Dornsife College of Letters, Arts, and Sciences, Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089;

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http://dx.doi.org/10.1073/pnas.1514012112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687584PMC
December 2015

β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

Cell Metab 2014 Jan;19(1):96-108

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017355PMC
January 2014

Genetic regulation of Caenorhabditis elegans lysosome related organelle function.

PLoS Genet 2013 Oct 24;9(10):e1003908. Epub 2013 Oct 24.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812091PMC
October 2013

A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2.

Development 2013 Sep 24;140(17):3601-12. Epub 2013 Jul 24.

Center for Human Genetic Research and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1242/dev.094292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742143PMC
September 2013

Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans.

J Vis Exp 2013 Mar 30(73). Epub 2013 Mar 30.

Center for Human Genetic Research and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Massachusetts, USA.

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http://dx.doi.org/10.3791/50180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944676PMC
March 2013

Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2.

J Biol Chem 2012 Aug 7;287(35):29579-88. Epub 2012 Jul 7.

Center for Human Genetics and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.386854
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http://dx.doi.org/10.1074/jbc.M112.386854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436168PMC
August 2012

C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.

Cell Metab 2009 Nov;10(5):430-5

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.cmet.2009.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921818PMC
November 2009

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.

Genes Dev 2009 Feb;23(4):496-511

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1101/gad.1775409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648650PMC
February 2009

Induction of leptin receptor expression in the liver by leptin and food deprivation.

J Biol Chem 2005 Mar 11;280(11):10034-9. Epub 2005 Jan 11.

Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA.

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http://dx.doi.org/10.1074/jbc.M413684200DOI Listing
March 2005

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.

Science 2002 Jul;297(5579):240-3

Laboratory of Molecular Genetics, Center for Studies in Physics and Biology, Rogosin Institute, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1071527DOI Listing
July 2002