Publications Authored by Alex von Kriegsheim

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.

Nat Commun 2019 Nov 15;10(1):5177. Epub 2019 Nov 15.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1038/s41467-019-13168-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858455	PMC

November 2019

A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Authors:

John C Dawson Bryan Serrels Adam Byron Morwenna T Muir Ashraff Makda Amaya García-Muñoz Alex von Kriegsheim Daniel Lietha Neil O Carragher Margaret C Frame

Mol Cancer Ther 2019 Nov 29. Epub 2019 Nov 29.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0330	DOI Listing

November 2019

EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance.

Authors:

Shuijie Li Javier Rodriguez Wenyu Li Petra Bullova Stuart M Fell Olga Surova Isabelle Westerlund Danijal Topcic Maria Bergsland Adam Stenman Jonas Muhr Monica Nistér Johan Holmberg C Christofer Juhlin Catharina Larsson Alex von Kriegsheim William G Kaelin Susanne Schlisio

Proc Natl Acad Sci U S A 2019 Aug 2;116(34):16997-17006. Epub 2019 Aug 2.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-17177 Stockholm, Sweden;

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http://dx.doi.org/10.1073/pnas.1900748116	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708352	PMC

August 2019

Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Authors:

Gabrielle Olley Morad Ansari Hemant Bengani Graeme R Grimes James Rhodes Alex von Kriegsheim Ana Blatnik Fiona J Stewart Emma Wakeling Nicola Carroll Alison Ross Soo-Mi Park Wendy A Bickmore Madapura M Pradeepa David R FitzPatrick

Nat Genet 2019 Jul;51(7):1192

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41588-019-0448-1	DOI Listing

July 2019

Uncovering Bistability in the Rac1/RhoA Signaling Network Through Integrating Computational Modeling and Experimentation.

Authors:

Alex von Kriegsheim Lan K Nguyen

Methods Mol Biol 2018 ;1821:21-36

Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-8612-5_2	DOI Listing

March 2019

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy.

PLoS Genet 2019 03 11;15(3):e1007605. Epub 2019 Mar 11.

MRC Human Genetics Unit, Institute of Genomic and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007605	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428344	PMC

March 2019

An Integrated Global Analysis of Compartmentalized HRAS Signaling.

Authors:

Tapesh Santra Ana Herrero Javier Rodriguez Alex von Kriegsheim Luis F Iglesias-Martinez Thomas Schwarzl Des Higgins Thin-Thin Aye Albert J R Heck Fernando Calvo Lorena Agudo-Ibáñez Piero Crespo David Matallanas Walter Kolch

Cell Rep 2019 03;26(11):3100-3115.e7

Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland; Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Ireland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193020	Publisher Site
http://dx.doi.org/10.1016/j.celrep.2019.02.038	DOI Listing

March 2019

Mass Spectrometry and Bioinformatic Analysis of Hydroxylation-Dependent Protein-Protein Interactions.

Authors:

Javier Rodriguez Alex von Kriegsheim

Methods Mol Biol 2018 ;1742:27-36

Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1007/978-1-4939-7665-2_3	DOI Listing

January 2019

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183030	Publisher Site
http://dx.doi.org/10.1016/j.chembiol.2018.09.005	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309505	PMC

December 2018

Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Sci Rep 2018 Aug 21;8(1):12771. Epub 2018 Aug 21.

The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.

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http://dx.doi.org/10.1038/s41598-018-30922-8	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104100	PMC

August 2018

Rac1 and RhoA: Networks, loops and bistability.

Authors:

Lan K Nguyen Boris N Kholodenko Alex von Kriegsheim

Small GTPases 2018 07 10;9(4):316-321. Epub 2016 Sep 10.

e Edinburgh Cancer Research Center , IGMM, University of Edinburgh , Edinburgh , UK.

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http://dx.doi.org/10.1080/21541248.2016.1224399	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997137	PMC

July 2018

Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.

Authors:

Petra Zur Lage Panagiota Stefanopoulou Katarzyna Styczynska-Soczka Niall Quinn Girish Mali Alex von Kriegsheim Pleasantine Mill Andrew P Jarman

J Cell Biol 2018 07 9;217(7):2583-2598. Epub 2018 May 9.

Centre for Discovery Brain Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, Scotland, UK

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http://www.jcb.org/lookup/doi/10.1083/jcb.201709026	Publisher Site
http://dx.doi.org/10.1083/jcb.201709026	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028525	PMC

July 2018

Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.

Authors:

Jingyu Chen Ian T Lobb Pierre Morin Sonia M Novo James Simpson Kathrin Kennerknecht Alex von Kriegsheim Emily E Batchelor Fiona Oakley Lesley A Stark

Nucleic Acids Res 2018 07;46(12):6188-6205

University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Rd., Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/nar/gky455	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158704	PMC

July 2018

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Sci Rep 2018 Jul 13;8(1):10614. Epub 2018 Jul 13.

The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.

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http://dx.doi.org/10.1038/s41598-018-29043-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045584	PMC

July 2018

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.

Cell Rep 2018 07;24(3):630-641

Richard Dimbleby Department of Cancer Research, Randall Division and Division of Cancer and Pharmaceutical Sciences, King's College London, Guy's Medical School Campus, London SE1 1UL, UK; KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy's Hospital, King's College London, London SE1 9RT, UK; UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.066	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077252	PMC

July 2018

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.

Authors:

Javier Rodriguez Ana Herrero Shuijie Li Nora Rauch Andrea Quintanilla Kieran Wynne Aleksandar Krstic Juan Carlos Acosta Cormac Taylor Susanne Schlisio Alex von Kriegsheim

Cell Rep 2018 07;24(5):1316-1329

Systems Biology Ireland, University College Dublin, Dublin 4, Ireland; Cancer Research UK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.108	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088137	PMC

July 2018

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

Authors:

Ioanna Oikonomidi Emma Burbridge Miguel Cavadas Graeme Sullivan Blanka Collis Heike Naegele Danielle Clancy Jana Brezinova Tianyi Hu Andrea Bileck Christopher Gerner Alfonso Bolado Alex von Kriegsheim Seamus J Martin Florian Steinberg Kvido Strisovsky Colin Adrain

Elife 2018 06 13;7. Epub 2018 Jun 13.

Membrane Traffic Lab, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

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http://dx.doi.org/10.7554/eLife.35032	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042963	PMC

June 2018

Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Authors:

Gabrielle Olley Morad Ansari Hemant Bengani Graeme R Grimes James Rhodes Alex von Kriegsheim Ana Blatnik Fiona J Stewart Emma Wakeling Nicola Carroll Alison Ross Soo-Mi Park Wendy A Bickmore Madapura M Pradeepa David R FitzPatrick

Nat Genet 2018 05;50(5):767

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41588-018-0069-0	DOI Listing

May 2018

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein.

Elife 2018 04 11;7. Epub 2018 Apr 11.

Edinburgh Cancer Research United Kingdom Centre, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.7554/eLife.35069	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947990	PMC

April 2018

BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Authors:

Gabrielle Olley Morad Ansari Hemant Bengani Graeme R Grimes James Rhodes Alex von Kriegsheim Ana Blatnik Fiona J Stewart Emma Wakeling Nicola Carroll Alison Ross Soo-Mi Park Wendy A Bickmore Madapura M Pradeepa David R FitzPatrick

Nat Genet 2018 03 29;50(3):329-332. Epub 2018 Jan 29.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41588-018-0042-y	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469577	PMC

March 2018

WT1-Associated Protein-Protein Interaction Networks.

Authors:

Ruthrothaselvi Bharathavikru Alex von Kriegsheim

Methods Mol Biol 2016 ;1467:189-96

Systems Biology Ireland, Conway Institute, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1007/978-1-4939-4023-3_16	DOI Listing

January 2018

Potential mechanisms of calcium dependent regulation of the mammalian cell cycle revealed by comprehensive unbiased label-free nLC-MS/MS quantitative proteomics.

Authors:

Anna Kwasnik Alex von Kriegsheim Andrew Irving Stephen R Pennington

J Proteomics 2018 01 18;170:151-166. Epub 2017 Aug 18.

School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield Dublin 4, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2017.08.006	DOI Listing

January 2018

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

Authors:

Matthew D Smith Margaret E Harley Alain J Kemp Jimi Wills Martin Lee Mark Arends Alex von Kriegsheim Christian Behrends Simon Wilkinson

Dev Cell 2018 01 28;44(2):217-232.e11. Epub 2017 Dec 28.

Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.11.024	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791736	PMC

January 2018

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

Nat Commun 2018 01 30;9(1):424. Epub 2018 Jan 30.

CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1038/s41467-017-02786-5	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789973	PMC

January 2018

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

Authors:

Miguel Cavadas Ioanna Oikonomidi Catarina J Gaspar Emma Burbridge Marina Badenes Inês Félix Alfonso Bolado Tianyi Hu Andrea Bileck Christopher Gerner Pedro M Domingos Alex von Kriegsheim Colin Adrain

Cell Rep 2017 Oct;21(3):745-757

Membrane Traffic Lab, Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.074	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656746	PMC

October 2017

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure.

EMBO Mol Med 2017 08;9(8):1011-1029

Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

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http://dx.doi.org/10.15252/emmm.201607156	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538298	PMC

August 2017

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.

Am J Hum Genet 2017 May 13;100(5):706-724. Epub 2017 Apr 13.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297173011	Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2017.03.008	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420347	PMC

May 2017

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.

Authors:

John J Reynolds Louise S Bicknell Paula Carroll Martin R Higgs Ranad Shaheen Jennie E Murray Dimitrios K Papadopoulos Andrea Leitch Olga Murina Žygimantė Tarnauskaitė Sarah R Wessel Anastasia Zlatanou Audrey Vernet Alex von Kriegsheim Rachel M A Mottram Clare V Logan Hannah Bye Yun Li Alexander Brean Sateesh Maddirevula Rachel C Challis Kassiani Skouloudaki Agaadir Almoisheer Hessa S Alsaif Ariella Amar Natalie J Prescott Michael B Bober Angela Duker Eissa Faqeih Mohammed Zain Seidahmed Saeed Al Tala Abdulrahman Alswaid Saleem Ahmed Jumana Yousuf Al-Aama Janine Altmüller Mohammed Al Balwi Angela F Brady Luciana Chessa Helen Cox Rita Fischetto Raoul Heller Bertram D Henderson Emma Hobson Peter Nürnberg E Ferda Percin Angela Peron Luigina Spaccini Alan J Quigley Seema Thakur Carol A Wise Grace Yoon Maha Alnemer Pavel Tomancak Gökhan Yigit A Malcolm R Taylor Martin A M Reijns Michael A Simpson David Cortez Fowzan S Alkuraya Christopher G Mathew Andrew P Jackson Grant S Stewart

Nat Genet 2017 Apr 13;49(4):537-549. Epub 2017 Feb 13.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1038/ng.3790	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450907	PMC

April 2017

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.

Authors:

Patricia L Yeyati Rachel Schiller Girish Mali Ioannis Kasioulis Akane Kawamura Ian R Adams Christopher Playfoot Nick Gilbert Veronica van Heyningen Jimi Wills Alex von Kriegsheim Andrew Finch Juro Sakai Christopher J Schofield Ian J Jackson Pleasantine Mill

J Cell Biol 2017 04 28;216(4):999-1013. Epub 2017 Feb 28.

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU Scotland, UK

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http://dx.doi.org/10.1083/jcb.201607032	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379941	PMC

April 2017

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

Authors:

Kevin B Myant Patrizia Cammareri Michael C Hodder Jimi Wills Alex Von Kriegsheim Balázs Győrffy Mamun Rashid Simona Polo Elena Maspero Lynsey Vaughan Basanta Gurung Evan Barry Angeliki Malliri Fernando Camargo David J Adams Antonio Iavarone Anna Lasorella Owen J Sansom

EMBO Mol Med 2017 02;9(2):181-197

Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK

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http://dx.doi.org/10.15252/emmm.201606684	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286368	PMC

February 2017

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.

Authors:

Lorenzo Rinaldi Debayan Datta Judit Serrat Lluis Morey Guiomar Solanas Alexandra Avgustinova Enrique Blanco José Ignacio Pons David Matallanas Alex Von Kriegsheim Luciano Di Croce Salvador Aznar Benitah

Cell Stem Cell 2016 10 28;19(4):491-501. Epub 2016 Jul 28.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; ICREA, Passeig de Lluís Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.06.020	DOI Listing

October 2016

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

Authors:

Layal Dernayka Nora Rauch Mohamed-Ali Jarboui Armin Zebisch Yves Texier Nicola Horn David Romano Christian Johannes Gloeckner Alex von Kriegsheim Marius Ueffing Walter Kolch Karsten Boldt

Cell Signal 2016 09 21;28(9):1432-9. Epub 2016 Jun 21.

Medical Proteome Center, Division for Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.06.016	DOI Listing

September 2016

NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.

Authors:

Luis A Alvarez Lidija Kovačič Javier Rodríguez Jan-Hendrik Gosemann Malgorzata Kubica Gratiela G Pircalabioru Florian Friedmacher Ada Cean Alina Ghişe Mihai B Sărăndan Prem Puri Simon Daff Erika Plettner Alex von Kriegsheim Billy Bourke Ulla G Knaus

Proc Natl Acad Sci U S A 2016 09 25;113(37):10406-11. Epub 2016 Aug 25.

National Children's Research Center, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland; Conway Institute, School of Medicine, University College Dublin, Dublin 4, Ireland;

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http://www.pnas.org/content/113/37/10406.full.pdf	Web Search
http://dx.doi.org/10.1073/pnas.1605443113	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027431	PMC

September 2016

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.

Biochem Biophys Res Commun 2016 06 27;474(3):579-586. Epub 2016 Apr 27.

School of Medicine and Medical Science, The Conway Institute, University College Dublin, Belfield, Dublin 4 Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.04.085	DOI Listing

June 2016

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.

Authors:

Javier Rodriguez Ruth Pilkington Amaya Garcia Munoz Lan K Nguyen Nora Rauch Susan Kennedy Naser Monsefi Ana Herrero Cormac T Taylor Alex von Kriegsheim

Cell Rep 2016 Mar 10;14(11):2745-60. Epub 2016 Mar 10.

Systems Biology Ireland, University College Dublin, Dublin 4, Ireland; Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.043	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805855	PMC

March 2016

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

Authors:

Carsten C Scholz Javier Rodriguez Christina Pickel Stephen Burr Jacqueline-Alba Fabrizio Karen A Nolan Patrick Spielmann Miguel A S Cavadas Bianca Crifo Doug N Halligan James A Nathan Daniel J Peet Roland H Wenger Alex Von Kriegsheim Eoin P Cummins Cormac T Taylor

PLoS Biol 2016 Jan 11;14(1):e1002347. Epub 2016 Jan 11.

Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland.

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http://dx.plos.org/10.1371/journal.pbio.1002347	Publisher Site
http://dx.doi.org/10.1371/journal.pbio.1002347	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709136	PMC

January 2016

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches.

Authors:

Kate M Byrne Naser Monsefi John C Dawson Andrea Degasperi Jimi-Carlo Bukowski-Wills Natalia Volinsky Maciej Dobrzyński Marc R Birtwistle Mikhail A Tsyganov Anatoly Kiyatkin Katarzyna Kida Andrew J Finch Neil O Carragher Walter Kolch Lan K Nguyen Alex von Kriegsheim Boris N Kholodenko

Cell Syst 2016 01 27;2(1):38-48. Epub 2016 Jan 27.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland; Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.

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http://dx.doi.org/10.1016/j.cels.2016.01.003	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802415	PMC

January 2016

Network-based identification of feedback modules that control RhoA activity and cell migration.

Authors:

Tae-Hwan Kim Naser Monsefi Je-Hoon Song Alex von Kriegsheim Drieke Vandamme Olivier Pertz Boris N Kholodenko Walter Kolch Kwang-Hyun Cho

J Mol Cell Biol 2015 Jun 16;7(3):242-52. Epub 2015 Mar 16.

Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea

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http://dx.doi.org/10.1093/jmcb/mjv017	DOI Listing

June 2015

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.

Authors:

Francesca Moretti Chiara Rolando Moritz Winker Robert Ivanek Javier Rodriguez Alex Von Kriegsheim Verdon Taylor Michael Bustin Olivier Pertz

Mol Cell Biol 2015 Jun 30;35(11):2035-50. Epub 2015 Mar 30.

Cell Migration and Neuritogenesis, Department of Biomedicine, University of Basel, Basel, Switzerland

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http://dx.doi.org/10.1128/MCB.00133-15	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420918	PMC

June 2015

Signalling mechanisms regulating phenotypic changes in breast cancer cells.

Authors:

Natalia Volinsky Cormac J McCarthy Alex von Kriegsheim Nina Saban Mariko Okada-Hatakeyama Walter Kolch Boris N Kholodenko

Biosci Rep 2015 Mar 18;35(2). Epub 2015 Mar 18.

*Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

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http://www.bioscirep.org/content/ppbioscirep/35/2/e00178.ful	Web Search
http://bioscirep.org/cgi/doi/10.1042/BSR20140172	Publisher Site
http://dx.doi.org/10.1042/BSR20140172	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370098	PMC

March 2015

Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK.

Authors:

Devrim Kilinc Anna Lesniak Suad A Rashdan Dhruv Gandhi Agata Blasiak Paul C Fannin Alex von Kriegsheim Walter Kolch Gil U Lee

Adv Healthc Mater 2015 Feb 9;4(3):395-404. Epub 2014 Oct 9.

UCD Nanomedicine Centre, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.

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http://doi.wiley.com/10.1002/adhm.201400391	Publisher Site
http://dx.doi.org/10.1002/adhm.201400391	DOI Listing

February 2015

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.

PLoS Genet 2014 Sep 18;10(9):e1004577. Epub 2014 Sep 18.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine at The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.

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