Alex von Kriegsheim

Alex von Kriegsheim

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Alex von Kriegsheim

Alex von Kriegsheim

Publications by authors named "Alex von Kriegsheim"

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54Publications

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A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Mol Cancer Ther 2019 Nov 29. Epub 2019 Nov 29.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0330DOI Listing
November 2019

Uncovering Bistability in the Rac1/RhoA Signaling Network Through Integrating Computational Modeling and Experimentation.

Methods Mol Biol 2018 ;1821:21-36

Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-8612-5_2DOI Listing
March 2019

An Integrated Global Analysis of Compartmentalized HRAS Signaling.

Cell Rep 2019 03;26(11):3100-3115.e7

Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland; Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Ireland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193020
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http://dx.doi.org/10.1016/j.celrep.2019.02.038DOI Listing
March 2019

Mass Spectrometry and Bioinformatic Analysis of Hydroxylation-Dependent Protein-Protein Interactions.

Methods Mol Biol 2018 ;1742:27-36

Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1007/978-1-4939-7665-2_3DOI Listing
January 2019

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183030
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http://dx.doi.org/10.1016/j.chembiol.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309505PMC
December 2018

Rac1 and RhoA: Networks, loops and bistability.

Small GTPases 2018 07 10;9(4):316-321. Epub 2016 Sep 10.

e Edinburgh Cancer Research Center , IGMM, University of Edinburgh , Edinburgh , UK.

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http://dx.doi.org/10.1080/21541248.2016.1224399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997137PMC
July 2018

Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.

Nucleic Acids Res 2018 07;46(12):6188-6205

University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Rd., Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/nar/gky455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158704PMC
July 2018

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.

Cell Rep 2018 07;24(3):630-641

Richard Dimbleby Department of Cancer Research, Randall Division and Division of Cancer and Pharmaceutical Sciences, King's College London, Guy's Medical School Campus, London SE1 1UL, UK; KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy's Hospital, King's College London, London SE1 9RT, UK; UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077252PMC
July 2018

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.

Cell Rep 2018 07;24(5):1316-1329

Systems Biology Ireland, University College Dublin, Dublin 4, Ireland; Cancer Research UK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088137PMC
July 2018

WT1-Associated Protein-Protein Interaction Networks.

Methods Mol Biol 2016 ;1467:189-96

Systems Biology Ireland, Conway Institute, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1007/978-1-4939-4023-3_16DOI Listing
January 2018

Potential mechanisms of calcium dependent regulation of the mammalian cell cycle revealed by comprehensive unbiased label-free nLC-MS/MS quantitative proteomics.

J Proteomics 2018 01 18;170:151-166. Epub 2017 Aug 18.

School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield Dublin 4, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2017.08.006DOI Listing
January 2018

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

Dev Cell 2018 01 28;44(2):217-232.e11. Epub 2017 Dec 28.

Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791736PMC
January 2018

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.

J Cell Biol 2017 04 28;216(4):999-1013. Epub 2017 Feb 28.

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU Scotland, UK

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http://dx.doi.org/10.1083/jcb.201607032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379941PMC
April 2017

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.

Cell Stem Cell 2016 10 28;19(4):491-501. Epub 2016 Jul 28.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; ICREA, Passeig de Lluís Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.06.020DOI Listing
October 2016

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

Cell Signal 2016 09 21;28(9):1432-9. Epub 2016 Jun 21.

Medical Proteome Center, Division for Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.06.016DOI Listing
September 2016

NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.

Proc Natl Acad Sci U S A 2016 09 25;113(37):10406-11. Epub 2016 Aug 25.

National Children's Research Center, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland; Conway Institute, School of Medicine, University College Dublin, Dublin 4, Ireland;

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http://www.pnas.org/content/113/37/10406.full.pdf
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http://dx.doi.org/10.1073/pnas.1605443113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027431PMC
September 2016

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.

Cell Rep 2016 Mar 10;14(11):2745-60. Epub 2016 Mar 10.

Systems Biology Ireland, University College Dublin, Dublin 4, Ireland; Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805855PMC
March 2016

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches.

Cell Syst 2016 01 27;2(1):38-48. Epub 2016 Jan 27.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland; Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.

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http://dx.doi.org/10.1016/j.cels.2016.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802415PMC
January 2016

Network-based identification of feedback modules that control RhoA activity and cell migration.

J Mol Cell Biol 2015 Jun 16;7(3):242-52. Epub 2015 Mar 16.

Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea

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http://dx.doi.org/10.1093/jmcb/mjv017DOI Listing
June 2015

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.

Mol Cell Biol 2015 Jun 30;35(11):2035-50. Epub 2015 Mar 30.

Cell Migration and Neuritogenesis, Department of Biomedicine, University of Basel, Basel, Switzerland

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http://dx.doi.org/10.1128/MCB.00133-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420918PMC
June 2015

Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK.

Adv Healthc Mater 2015 Feb 9;4(3):395-404. Epub 2014 Oct 9.

UCD Nanomedicine Centre, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.

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http://doi.wiley.com/10.1002/adhm.201400391
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http://dx.doi.org/10.1002/adhm.201400391DOI Listing
February 2015

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

Proc Natl Acad Sci U S A 2013 Nov 21;110(46):18490-5. Epub 2013 Oct 21.

Systems Biology Ireland, School of Medicine and Medical Science, and Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1073/pnas.1309718110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832034PMC
November 2013

Cell fate decisions are specified by the dynamic ERK interactome.

Nat Cell Biol 2009 Dec 22;11(12):1458-64. Epub 2009 Nov 22.

Signalling and Proteomics Laboratory, The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb1994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839079PMC
December 2009

Mapping of signaling pathways by functional interaction proteomics.

Methods Mol Biol 2008 ;484:177-92

Cancer Research Beatson Laboratories, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-59745-398-1_12DOI Listing
February 2009

Proteomics and phosphoproteomics for the mapping of cellular signalling networks.

Proteomics 2008 Nov;8(21):4402-15

The Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.1002/pmic.200800136DOI Listing
November 2008

Phosphatase and feedback regulation of Raf-1 signaling.

Cell Cycle 2007 Jan 9;6(1):3-7. Epub 2007 Jan 9.

Signaling and Proteomics Group, Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.4161/cc.6.1.3593DOI Listing
January 2007

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.

Nat Cell Biol 2006 Sep 6;8(9):1011-6. Epub 2006 Aug 6.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb1465DOI Listing
September 2006