Alex Toker

Alex Toker

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Double trouble for cancer gene.

Authors:
Alex Toker

Science 2019 11;366(6466):685-686

Beth Israel Deaconess Medical Center, Department of Pathology, Harvard University Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1126/science.aaz4016DOI Listing
November 2019

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.

Nat Cell Biol 2019 02 28;21(2):226-237. Epub 2019 Jan 28.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-018-0261-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377565PMC
February 2019

PI 3-Kinase Signaling: AKTing up inside the Cell.

Mol Cell 2018 09;71(6):875-876

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.09.006DOI Listing
September 2018

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

Sci Signal 2018 03 13;11(521). Epub 2018 Mar 13.

Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aao3810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902813PMC
March 2018

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.

Sci Signal 2017 Dec 19;10(510). Epub 2017 Dec 19.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aao6604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808948PMC
December 2017

Cross-talk between the CK2 and AKT signaling pathways in cancer.

Adv Biol Regul 2017 05 28;64:1-8. Epub 2017 Mar 28.

Cell Signaling Unit, Department of Surgery, Medicine, Dentistry and Morphology, University of Modena and Reggio Emilia, 41124 Modena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2017.03.002DOI Listing
May 2017

Adaptive Reprogramming of Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer.

Cancer Discov 2017 04 2;7(4):391-399. Epub 2017 Mar 2.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-16-0611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380483PMC
April 2017

PI3K signaling in cancer: beyond AKT.

Curr Opin Cell Biol 2017 04 24;45:62-71. Epub 2017 Mar 24.

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2017.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482768PMC
April 2017

AKT/PKB Signaling: Navigating the Network.

Cell 2017 04;169(3):381-405

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, and Ludwig Center at Harvard, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546324PMC
April 2017

Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling.

Cancer Res 2017 02 9;77(3):790-801. Epub 2016 Dec 9.

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290090PMC
February 2017

Nonessential amino acid metabolism in breast cancer.

Adv Biol Regul 2016 09 21;62:11-17. Epub 2016 Jan 21.

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2016.01.001DOI Listing
September 2016

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Mol Cell 2016 06 26;62(6):929-942. Epub 2016 May 26.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.molcel.2016.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912424PMC
June 2016

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Nat Cell Biol 2016 05 18;18(5):572-8. Epub 2016 Apr 18.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncb3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848114PMC
May 2016

Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis.

Oncotarget 2016 Apr;7(14):17301-13

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.8191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951213PMC
April 2016

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Cancer Discov 2015 Nov 20;5(11):1194-209. Epub 2015 Aug 20.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631654PMC
November 2015

PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?

Cancer Cell 2015 Aug;28(2):143-5

Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.07.010DOI Listing
August 2015

MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy.

Cell Rep 2015 Jun 28;11(9):1358-66. Epub 2015 May 28.

Departments of Pathology and Medicine and Cancer Center, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464897PMC
June 2015

The phosphoinositide 3-kinase pathway and therapy resistance in cancer.

F1000Prime Rep 2015 3;7:13. Epub 2015 Feb 3.

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School 330 Brookline Avenue, EC/CLS 633A, Boston, MA 02215 USA.

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http://dx.doi.org/10.12703/P7-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335789PMC
March 2015

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.

Mol Cell 2014 Nov 30;56(4):595-607. Epub 2014 Oct 30.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255362PMC
November 2014

Signalling specificity in the Akt pathway in breast cancer.

Biochem Soc Trans 2014 Oct;42(5):1349-55

*Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, U.S.A.

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http://dx.doi.org/10.1042/BST20140160DOI Listing
October 2014

Phosphoinositide 3-kinases-a historical perspective.

Authors:
Alex Toker

Subcell Biochem 2012 ;58:95-110

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, EC/CLS-633A, 02130, Boston, MA, USA,

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http://dx.doi.org/10.1007/978-94-007-3012-0_4DOI Listing
August 2014

PTEN-deficient tumors depend on AKT2 for maintenance and survival.

Cancer Discov 2014 Aug 16;4(8):942-55. Epub 2014 May 16.

Department of Pathology and

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http://dx.doi.org/10.1158/2159-8290.CD-13-0873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125464PMC
August 2014

Signaling specificity in the Akt pathway in biology and disease.

Adv Biol Regul 2014 May 19;55:28-38. Epub 2014 Apr 19.

Department of Surgery, Medicine, Dentistry and Morphology, University of Modena and Reggio Emilia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2014.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062840PMC
May 2014

Akt-ing up on SRPK1: oncogene or tumor suppressor?

Mol Cell 2014 May;54(3):329-30

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089875PMC
May 2014

The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration.

Mol Cancer Res 2014 Mar 22;12(3):464-76. Epub 2013 Nov 22.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962723PMC
March 2014

Targeting Akt3 signaling in triple-negative breast cancer.

Cancer Res 2014 Feb 12;74(3):964-73. Epub 2013 Dec 12.

Authors' Affiliations: Department of Pathology, Beth Israel Deaconess Medical Center; Department of Medicine, Harvard Medical School; Department of Medical Oncology, Dana-Farber Cancer Institute; and Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946502PMC
February 2014

Using phospho-motif antibodies to determine kinase substrates.

Curr Protoc Mol Biol 2013 Jan;Chapter 18:Unit 18.20.

Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/0471142727.mb1820s101DOI Listing
January 2013

Achieving specificity in Akt signaling in cancer.

Authors:
Alex Toker

Adv Biol Regul 2012 Jan;52(1):78-87

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.advenzreg.2011.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614006PMC
January 2012

Akt isoform-specific signaling in breast cancer: uncovering an anti-migratory role for palladin.

Cell Adh Migr 2011 May-Jun;5(3):211-4. Epub 2011 May 1.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210203PMC
http://dx.doi.org/10.4161/cam.5.3.15790DOI Listing
December 2011

NFAT promotes carcinoma invasive migration through glypican-6.

Biochem J 2011 Nov;440(1):157-66

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1042/BJ20110530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204871PMC
November 2011

Akt2 regulates expression of the actin-bundling protein palladin.

FEBS Lett 2010 Dec 2;584(23):4769-74. Epub 2010 Nov 2.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://doi.wiley.com/10.1016/j.febslet.2010.10.056
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http://dx.doi.org/10.1016/j.febslet.2010.10.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997733PMC
December 2010

Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration.

Cancer Res 2010 Oct 24;70(20):8187-98. Epub 2010 Aug 24.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-4231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955804PMC
October 2010

Regulation of oxysterol-binding protein Golgi localization through protein kinase D-mediated phosphorylation.

Mol Biol Cell 2010 Jul 5;21(13):2327-37. Epub 2010 May 5.

Departments of Pathology and Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1091/mbc.e10-02-0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893995PMC
July 2010

The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.

Mol Cell 2010 May;38(3):333-44

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765100024
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http://dx.doi.org/10.1016/j.molcel.2010.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872630PMC
May 2010

TTC3 ubiquitination terminates Akt-ivation.

Authors:
Alex Toker

Dev Cell 2009 Dec;17(6):752-4

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.devcel.2009.12.003DOI Listing
December 2009

NFAT proteins: emerging roles in cancer progression.

Nat Rev Cancer 2009 Nov;9(11):810-20

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrc2735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866640PMC
November 2009

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

Mol Cell Biol 2009 Sep 29;29(18):4906-17. Epub 2009 Jun 29.

Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Griffin Building, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1128/MCB.00077-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738298PMC
September 2009

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

Cell Signal 2009 Apr 7;21(4):470-6. Epub 2008 Dec 7.

Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, EC/CLS-528, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cellsig.2008.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719559PMC
April 2009

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.

Nat Cell Biol 2009 Apr 8;11(4):397-408. Epub 2009 Mar 8.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.nature.com/articles/ncb1847
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http://dx.doi.org/10.1038/ncb1847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910589PMC
April 2009

Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.

Mol Cancer Res 2009 Mar 3;7(3):425-32. Epub 2009 Mar 3.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667900PMC
March 2009

Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association.

Proc Natl Acad Sci U S A 2008 Nov 14;105(47):18378-83. Epub 2008 Nov 14.

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.0809661105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587537PMC
November 2008

Akt signaling: a damaging interaction makes good.

Authors:
Alex Toker

Trends Biochem Sci 2008 Aug 26;33(8):356-9. Epub 2008 Jun 26.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.tibs.2008.05.003DOI Listing
August 2008

mTOR and Akt signaling in cancer: SGK cycles in.

Authors:
Alex Toker

Mol Cell 2008 Jul;31(1):6-8

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.06.007DOI Listing
July 2008

Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.

J Biol Chem 2007 Mar 21;282(9):6733-42. Epub 2006 Dec 21.

Department of Pharmacology and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M608086200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921767PMC
March 2007

NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.

J Biol Chem 2006 May 27;281(18):12210-7. Epub 2006 Feb 27.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M600184200DOI Listing
May 2006

Akt signaling and cancer: surviving but not moving on.

Cancer Res 2006 Apr;66(8):3963-6

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02215, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0743DOI Listing
April 2006

Akt/PKB signaling in cancer: a function in cell motility and invasion.

Cell Cycle 2006 Mar 15;5(6):603-5. Epub 2006 Mar 15.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.4161/cc.5.6.2561DOI Listing
March 2006

Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.

Mol Cell 2005 Nov;20(4):539-50

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.10.033DOI Listing
November 2005

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species.

Mol Cell Biol 2005 Oct;25(19):8520-30

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1128/MCB.25.19.8520-8530.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265746PMC
October 2005

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex.

Nat Cell Biol 2005 Sep 14;7(9):880-6. Epub 2005 Aug 14.

Institute for Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.

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http://dx.doi.org/10.1038/ncb1289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458033PMC
September 2005

A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions.

Cancer Res 2005 Jun;65(11):4728-38

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4449DOI Listing
June 2005

Functional dichotomy of A20 in apoptotic and necrotic cell death.

Biochem J 2005 Apr;387(Pt 1):47-55

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1042/BJ20041443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134931PMC
April 2005

A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D.

J Biol Chem 2005 Apr 22;280(15):15013-9. Epub 2005 Feb 22.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.C400575200DOI Listing
April 2005

The biology and biochemistry of diacylglycerol signalling. Meeting on molecular advances in diacylglycerol signalling.

Authors:
Alex Toker

EMBO Rep 2005 Apr;6(4):310-4

Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/sj.embor.7400378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299288PMC
April 2005

Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion.

Invest Ophthalmol Vis Sci 2004 Nov;45(11):3974-81

Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1167/iovs.04-0508DOI Listing
November 2004

Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.

Mol Pharmacol 2004 Oct 29;66(4):870-9. Epub 2004 Jun 29.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1124/mol.104.000687DOI Listing
October 2004

A rapid method for determining protein kinase phosphorylation specificity.

Nat Methods 2004 Oct;1(1):27-9

Division of Signal Transduction, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nmeth708DOI Listing
October 2004

Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.

Mol Cell Biol 2004 Apr;24(7):2614-26

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC371115PMC
http://dx.doi.org/10.1128/mcb.24.7.2614-2626.2004DOI Listing
April 2004

PDK-1 and protein kinase C phosphorylation.

Authors:
Alex Toker

Methods Mol Biol 2003 ;233:171-89

Department of Pathology, Beth Israel Deaconess Medical School, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1385/1-59259-397-6:171DOI Listing
February 2004

Identifying protein kinase C substrates: an introduction.

Authors:
Alex Toker

Methods Mol Biol 2003 ;233:247-51

Department of Pathology, Beth Israel Deaconess Medical School, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1385/1-59259-397-6:247DOI Listing
February 2004

Genetic manipulation of protein kinase C in vivo.

Authors:
Alex Toker

Methods Mol Biol 2003 ;233:475-89

Department of Pathology, Beth Israel Deaconess Medical School, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1385/1-59259-397-6:475DOI Listing
February 2004

NF-kappaB signaling--an alternate pathway for oxidative stress responses.

Cell Cycle 2003 Jan-Feb;2(1):9-10

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.4161/cc.2.1.234DOI Listing
August 2003

Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion.

Adv Exp Med Biol 2002 ;506(Pt A):237-41

Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1007/978-1-4615-0717-8_32DOI Listing
May 2003

Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation.

J Biol Chem 2003 May 11;278(20):17969-76. Epub 2003 Mar 11.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M213224200DOI Listing
May 2003

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway.

EMBO J 2003 Jan;22(1):109-20

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1093/emboj/cdg009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140053PMC
January 2003

The role of NFAT transcription factors in integrin-mediated carcinoma invasion.

Nat Cell Biol 2002 Jul;4(7):540-4

Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, 200 Longwood Avenue, Boston MA 02115, USA.

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http://www.nature.com/articles/ncb816
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http://dx.doi.org/10.1038/ncb816DOI Listing
July 2002

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling.

Front Biosci 2002 Apr 1;7:d886-902. Epub 2002 Apr 1.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.2741/storzDOI Listing
April 2002