Publications by authors named "Alex Soltermann"

100Publications

Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors.

Front Oncol 2020 3;10:581217. Epub 2020 Nov 3.

Department of Medical Oncology and Haematology, Cantonal Hospital, St. Gallen, Switzerland.

View Article and Find Full Text PDF
November 2020

Prognostic Immune Cell Profiling of Malignant Pleural Effusion Patients by Computerized Immunohistochemical and Transcriptional Analysis.

Cancers (Basel) 2019 Dec 5;11(12). Epub 2019 Dec 5.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, CH-8091 Zurich, Switzerland.

View Article and Find Full Text PDF
December 2019

Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections.

Microsyst Nanoeng 2019 6;5:59. Epub 2019 Nov 6.

1Laboratory of Microsystems, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, CH Switzerland.

View Article and Find Full Text PDF
November 2019

Surgical Outcomes and Risk Analysis of Primary Pulmonary Sarcoma.

Thorac Cardiovasc Surg 2019 Sep 9. Epub 2019 Sep 9.

Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
September 2019

Oncogenic driver mutations in Swiss never smoker patients with lung adenocarcinoma and correlation with clinicopathologic characteristics and outcome.

PLoS One 2019 6;14(8):e0220691. Epub 2019 Aug 6.

Institute of Pathology and Molecular Pathology, Clinical Pathology, University Hospital Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
March 2020

Adjuvant Chemotherapy Increases Programmed Death-Ligand 1 (PD-L1) Expression in Non-small Cell Lung Cancer Recurrence.

Clin Lung Cancer 2019 09 5;20(5):391-396. Epub 2019 Jun 5.

Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

View Article and Find Full Text PDF
September 2019

Analysis of the frequency of oncogenic driver mutations and correlation with clinicopathological characteristics in patients with lung adenocarcinoma from Northeastern Switzerland.

Diagn Pathol 2019 Feb 11;14(1):18. Epub 2019 Feb 11.

Institute of Pathology and Molecular Pathology, Clinical Pathology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

View Article and Find Full Text PDF
February 2019

Microfluidics-based immunofluorescence for fast staining of ALK in lung adenocarcinoma.

Diagn Pathol 2018 Oct 16;13(1):79. Epub 2018 Oct 16.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, CH-8091, Zurich, Switzerland.

View Article and Find Full Text PDF
October 2018

Comparison of PI3K Pathway in HPV-Associated Oropharyngeal Cancer With and Without Tobacco Exposure.

Laryngoscope Investig Otolaryngol 2018 Aug 9;3(4):283-289. Epub 2018 Aug 9.

Department of Otorhinolaryngology, Head and Neck Surgery Cantonal Hospital of St. Gallen St. Gallen Switzerland.

View Article and Find Full Text PDF
August 2018

Ein kleiner Einstieg zu Diagnostik und Prädiktion des Lungenkarzinoms.

Authors:
Alex Soltermann

Ther Umsch 2017 Sep;74(4):157-164

1 Institut für Pathologie und Molekularpathologie, Universitätsspital Zürich, Zürich.

View Article and Find Full Text PDF
September 2017

A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo.

J Control Release 2017 Oct 1;264:211-218. Epub 2017 Sep 1.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Vladimir-Prelog-Weg 4, CH-8093 Zürich, Switzerland. Electronic address:

View Article and Find Full Text PDF
October 2017

Potency-matched Dual Cytokine-Antibody Fusion Proteins for Cancer Therapy.

Mol Cancer Ther 2017 11 17;16(11):2442-2451. Epub 2017 Jul 17.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.

View Article and Find Full Text PDF
November 2017

The inhibitor of differentiation-1 (Id1) enables lung cancer liver colonization through activation of an EMT program in tumor cells and establishment of the pre-metastatic niche.

Cancer Lett 2017 08 24;402:43-51. Epub 2017 May 24.

Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain; Program of Solid Tumors and Biomarkers, Center for Applied Medical Research, Pamplona, Spain; Health Research Institute of Navarra (IDISNA), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain. Electronic address:

View Article and Find Full Text PDF
August 2017

RAD51 as a potential surrogate marker for DNA repair capacity in solid malignancies.

Int J Cancer 2017 10 19;141(7):1286-1294. Epub 2017 May 19.

Department of Medical Oncology and Hematology, Cantonal Hospital, St.Gallen, Switzerland.

View Article and Find Full Text PDF
October 2017

Alveolar ridge preservation with autologous particulated dentin-a case series.

Int J Implant Dent 2017 Dec 30;3(1):12. Epub 2017 Mar 30.

Clinic of Cranio-Maxillofacial and Oral Surgery, Center of Dental Medicine, University of Zurich, University Hospital Zurich, Plattenstrasse 11, 8032, Zürich, Switzerland.

View Article and Find Full Text PDF
December 2017

Low tissue levels of miR-125b predict malignancy in solitary fibrous tumors of the pleura.

Respir Res 2017 03 2;18(1):43. Epub 2017 Mar 2.

Department of Pulmonology, University Hospital Zurich, University of Zurich, Rämistr. 100, 8091, Zurich, Switzerland.

View Article and Find Full Text PDF
March 2017

Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the subendothelial extracellular matrix.

Int J Cancer 2017 04 30;140(7):1670-1679. Epub 2016 Dec 30.

Department of Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, CH-8093, Switzerland.

View Article and Find Full Text PDF
April 2017

Prognostic value of immunohistochemical markers in malignant thymic epithelial tumors.

J Thorac Dis 2016 Sep;8(9):2580-2591

Division of Thoracic Surgery, University Hospital Zurich, Zurich 8091, Switzerland.

View Article and Find Full Text PDF
September 2016

Comprehensive genomic profiles of small cell lung cancer.

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

View Article and Find Full Text PDF
August 2015

Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN.

BMC Cancer 2015 Feb 20;15:74. Epub 2015 Feb 20.

Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091, Zurich, Switzerland.

View Article and Find Full Text PDF
February 2015

Multicenter immunohistochemical ALK-testing of non-small-cell lung cancer shows high concordance after harmonization of techniques and interpretation criteria.

J Thorac Oncol 2014 Nov;9(11):1685-92

*Institute of Pathology, Charité BERLIN, Berlin, Germany; †Institute of Pathology, University of Heidelberg, Heidelberg, Germany; ‡Department of Pathology, Aberdeen University Medical School, Aberdeen, United Kingdom; §Department of Pathology and Cytology, Karolinska University Hospital, Solna, Stockholm, Sweden; ‖Department of Pathology, University Hospital Cologne, Cologne, Germany; ¶Laboratorio de Dianas Terapeuticas, Hospital Universitario Sanchinarro, Madrid, Spain; #Institute of Pathology, Klinikum Großhadern Ludwig-Maximilians-Universität, Munich, Germany; **Institute of Pathology, UZ ANTWERPEN, Edegem, Belgium; ††Institute of Pathology, Klinikum rechts der Isar, TU, Munich, Germany; ‡‡Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany; §§Institute of Pathology, Universitätsspital Basel, Basel, Germany; ‖‖Institute of Pathology, HSK Dr.-Horst-Schmidt-Kliniken GmbH, Wiesbaden, Germany; ¶¶Institute of Pathology, Universitäts Spital Zürich, Zurich, Switzerland; ##Institute of Pathology, Centre Jean Perrin, Clermont-Ferrand, France; ***Patologisk Institut, Århus Universitetshospital, Århus, Denmark; †††Pathology-Berlin, Bioptisches Institut Gemeinschaftspraxis für Pathologie, Berlin, Germany.

View Article and Find Full Text PDF
November 2014

Determinants of outcome of solitary fibrous tumors of the pleura: an observational cohort study.

BMC Pulm Med 2014 Aug 12;14:138. Epub 2014 Aug 12.

Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

View Article and Find Full Text PDF
August 2014

Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform Lungscape Project.

J Clin Oncol 2014 Sep 28;32(25):2780-7. Epub 2014 Jul 28.

Fiona H. Blackhall and Daisuke Nonaka, Manchester University and The Christie National Health Services Foundation Trust, Manchester; Keith M. Kerr, Aberdeen University Medical School, Aberdeen Royal Infirmary, Aberdeen, United Kingdom; Solange Peters and Igor Letovanec, Centre Hospitalier Universitaire Vaudois, Lausanne; Lukas Bubendorf and Spasenija Savic, Institute for Pathology, University Hospital Basel, Basel; Alex Soltermann and Rolf A. Stahel, University Hospital Zurich, Zurich, Switzerland; Urania Dafni, Frontier Science Foundation-Hellas and University of Athens, Athens, Greece; Henrik Hager, University Hospital, Aarhus, Denmark; Kenneth J. O'Byrne, St James's Hospital, Dublin, Ireland; Christoph Dooms, University Hospital KU Leuven, Leuven, Belgium; Aleksandra Sejda, Medical University of Gdansk, Gdansk, Poland; Javier Hernández-Losa, Vall d'Hebron University Hospital, Barcelona; Miguel Martorell, Universitat de Valencia and Hospital General Universitario de Valencia, Valencia; Rafael Rosell, Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Badalona, Spain; Antonio Marchetti, Center of Predictive Molecular Medicine, University Foundation, Chieti, Italy; Qiang Tan, Shanghai Lung Cancer Center, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Erik Thunnissen, VU University Medical Clinic Center; Jeroen de Jong, Netherlands Cancer Institute, Amsterdam; Ernst-Jan M. Speel, Maastricht University Medical Centre, Maastricht, the Netherlands; and Richard Cheney, Roswell Park Cancer Institute, Buffalo, NY.

View Article and Find Full Text PDF
September 2014

Human papilloma virus and survival of oropharyngeal cancer patients treated with surgery and adjuvant radiotherapy.

Eur Arch Otorhinolaryngol 2015 Jul 1;272(7):1755-62. Epub 2014 Jun 1.

Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland,

View Article and Find Full Text PDF
July 2015

PI3K/mTOR signaling in mesothelioma patients treated with induction chemotherapy followed by extrapleural pneumonectomy.

J Thorac Oncol 2014 Feb;9(2):239-47

*Division of Thoracic Surgery, University Hospital of Zürich, Zürich, Switzerland; †Institute of Surgical Pathology, University Hospital Zürich, Zürich, Switzerland; ‡Laboratory of Molecular Oncology, University of Zürich, Zürich, Switzerland; §Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; ‖Division of Thoracic Surgery, Toronto General Hospital, Toronto, Canada; and ¶Division of Biostatistics, Institute for Social and Preventative Medicine, University of Zürich, Zürich, Switzerland.

View Article and Find Full Text PDF
February 2014

Pulmonary malignant peripheral nerve sheath tumour.

Eur J Cardiothorac Surg 2014 Aug 25;46(2):331-2. Epub 2013 Nov 25.

Department of Thoracic Surgery, University Hospital, Zurich, Switzerland.

View Article and Find Full Text PDF
August 2014

Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization.

Head Neck 2014 Nov 12;36(11):1562-6. Epub 2013 Dec 12.

Division of Otorhinolaryngology - Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
November 2014

Dynamics of tumor hypoxia in response to patupilone and ionizing radiation.

PLoS One 2012 10;7(12):e51476. Epub 2012 Dec 10.

Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
June 2013

Quality of life of oropharyngeal cancer patients with respect to treatment strategy and p16-positivity.

Laryngoscope 2013 Jan 14;123(1):164-70. Epub 2012 Nov 14.

Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St.Gallen, Switzerland.

View Article and Find Full Text PDF
January 2013

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Nat Genet 2012 Oct 2;44(10):1104-10. Epub 2012 Sep 2.

Department of Translational Genomics, University of Cologne, Cologne, Germany.

View Article and Find Full Text PDF
October 2012

Primary sclerosing epithelioid fibrosarcoma of the lung in a patient with Lynch syndrome.

Lung 2012 Dec 6;190(6):691-5. Epub 2012 Jul 6.

Division of Thoracic Surgery, University Hospital Zurich, Raemistr. 100, 8091, Zurich, Switzerland.

View Article and Find Full Text PDF
December 2012

Role of hedgehog signaling in malignant pleural mesothelioma.

Clin Cancer Res 2012 Sep 25;18(17):4646-56. Epub 2012 Jun 25.

Laboratory of Molecular Oncology, Clinic and Policlinic of Oncology, Division of Thoracic Surgery, Institute of Surgical Pathology, University Hospital Zürich, Zurich, Switzerland.

View Article and Find Full Text PDF
September 2012

Validity of frozen section in sentinel lymph node biopsy for the staging in oral and oropharyngeal squamous cell carcinoma.

J Surg Oncol 2012 Dec 14;106(7):816-9. Epub 2012 May 14.

Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, Switzerland.

View Article and Find Full Text PDF
December 2012

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors.

BMC Cancer 2012 Jan 24;12:35. Epub 2012 Jan 24.

Institute of Molecular Cancer Research, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

View Article and Find Full Text PDF
January 2012

KRAS mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma.

Cancer Genomics Proteomics 2012 Jan;9(1):51-4

Division of Thoracic Surgery, Institute of Surgical Pathology, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland.

View Article and Find Full Text PDF
January 2012

Characterization of periostin isoform pattern in non-small cell lung cancer.

Lung Cancer 2012 May 12;76(2):183-90. Epub 2011 Nov 12.

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
May 2012

Automated ERCC1 immunochemistry on hybrid cytology/tissue microarray of malignant effusions: evaluation of antibodies 8F1 and D-10.

J Clin Bioinforma 2011 Sep 30;1:25. Epub 2011 Sep 30.

Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.

View Article and Find Full Text PDF
September 2011

Proteomic surfaceome analysis of mesothelioma.

Lung Cancer 2012 Feb 10;75(2):189-96. Epub 2011 Aug 10.

Clinic of Oncology, University Hospital Zürich, 8044 Zürich, Switzerland.

View Article and Find Full Text PDF
February 2012

Relevance of periostin splice variants in renal cell carcinoma.

Am J Pathol 2011 Sep 18;179(3):1513-21. Epub 2011 Jul 18.

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
September 2011

Pleural mesothelioma side populations have a precursor phenotype.

Carcinogenesis 2011 Sep 5;32(9):1324-32. Epub 2011 Jul 5.

Laboratory of Molecular Oncology, Clinic of Oncology, University Hospital Zürich, Haeldeliweg 4, 8044 Zurich, Switzerland.

View Article and Find Full Text PDF
September 2011

Histological evaluation of microsurgical revascularized bone in the intraoral cavity: does it remain alive?

Microsurgery 2011 Feb 28;31(2):98-103. Epub 2011 Jan 28.

Department of Craniomaxillofacial Surgery, University Hospital of Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
February 2011

Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: an exploratory analysis.

Eur J Cancer 2011 Jan 29;47(2):326-32. Epub 2010 Oct 29.

Laboratory of Molecular Oncology, Clinic and Policlinic of Oncology, University Hospital of Zürich, Häldeliweg 4, 8044 Zürich, Switzerland.

View Article and Find Full Text PDF
January 2011

Automated ERCC1 immunohistochemistry in non-small cell lung cancer: comparison of anti-ERCC1 antibodies 8F1, D-10, and FL-297.

Appl Immunohistochem Mol Morphol 2011 Mar;19(2):99-105

Institute for Surgical Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
March 2011

Contrast-enhanced ¹⁸F-FDG-PET/CT for the assessment of necrotic lymph node metastases.

Head Neck 2011 Mar;33(3):324-9

Department of Otolaryngology, Head and Neck Surgery, University Hospital Zurich, CH-8091 Zurich, Switzerland.

View Article and Find Full Text PDF
March 2011

Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma.

Eur J Cardiothorac Surg 2010 Mar 24;37(3):566-72. Epub 2009 Sep 24.

Division of Thoracic Surgery, University Hospital Zürich, Rämistrasse 100, Zürich CH-8091, Switzerland.

View Article and Find Full Text PDF
March 2010

Comparative immunohistochemical staining of atherosclerotic plaques using F16, F8 and L19: Three clinical-grade fully human antibodies.

Atherosclerosis 2010 Feb 30;208(2):382-9. Epub 2009 Jul 30.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.

View Article and Find Full Text PDF
February 2010