Alex S Holehouse

Alex S Holehouse

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Alex S Holehouse

Alex S Holehouse

Publications by authors named "Alex S Holehouse"

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29Publications

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Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana.

Mol Cell 2019 Oct 14;76(1):177-190.e5. Epub 2019 Aug 14.

Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Engineering MechanoBiology, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778021PMC
October 2019

Phase Separation of Intrinsically Disordered Proteins.

Methods Enzymol 2018 31;611:1-30. Epub 2018 Oct 31.

Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.09.035DOI Listing
July 2019

Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations.

Curr Opin Struct Biol 2019 06 12;56:1-10. Epub 2018 Nov 12.

Department of Biomedical Engineering and Center for Biological Systems Engineering Washington University in St. Louis, St. Louis, MO, 63130, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0959440X183008
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http://dx.doi.org/10.1016/j.sbi.2018.10.003DOI Listing
June 2019

Unfolded states under folding conditions accommodate sequence-specific conformational preferences with random coil-like dimensions.

Proc Natl Acad Sci U S A 2019 Jun 5;116(25):12301-12310. Epub 2019 Jun 5.

Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400;

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http://dx.doi.org/10.1073/pnas.1818206116DOI Listing
June 2019

Sequence-to-Conformation Relationships of Disordered Regions Tethered to Folded Domains of Proteins.

J Mol Biol 2018 08 12;430(16):2403-2421. Epub 2018 May 12.

Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, One Brookings Drive, Campus Box 1097, St. Louis, MO 63130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.05.012DOI Listing
August 2018

The Unfolded State of the C-Terminal Domain of L9 Expands at Low but Not at Elevated Temperatures.

Biophys J 2018 08 23;115(4):655-663. Epub 2018 Jul 23.

Graduate Program in Biochemistry & Structural Biology, Stony Brook, New York; Department of Chemistry, Stony Brook University, Stony Brook, New York; Institute of Structural and Molecular Biology, University of College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104559PMC
August 2018

Functional Implications of Intracellular Phase Transitions.

Biochemistry 2018 05 24;57(17):2415-2423. Epub 2018 Jan 24.

Department of Biomedical Engineering and Center for Biological Systems Engineering , Washington University in St. Louis , St. Louis , Missouri 63130 , United States.

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http://dx.doi.org/10.1021/acs.biochem.7b01136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538385PMC
May 2018

A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain.

Cell Syst 2018 Apr 7;6(4):444-455.e6. Epub 2018 Mar 7.

The Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis School of Medicine, Saint Louis, MO 63110, USA; Department of Genetics, Washington University in St. Louis School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920710PMC
April 2018

Collapse Transitions of Proteins and the Interplay Among Backbone, Sidechain, and Solvent Interactions.

Annu Rev Biophys 2018 Jan 18. Epub 2018 Jan 18.

Department of Biomedical Engineering and center for Biological Systems Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA; email: ,

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http://dx.doi.org/10.1146/annurev-biophys-070317-032838DOI Listing
January 2018

Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution.

J Cell Sci 2017 Dec 13;130(24):4180-4192. Epub 2017 Nov 13.

Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1242/jcs.206854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769577PMC
December 2017

Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles.

Nat Chem 2017 11 26;9(11):1118-1125. Epub 2017 Jun 26.

Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, USA.

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http://www.nature.com/doifinder/10.1038/nchem.2803
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http://dx.doi.org/10.1038/nchem.2803DOI Listing
November 2017

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins.

Elife 2017 11 1;6. Epub 2017 Nov 1.

Center for Biological Systems Engineering, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, United States.

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http://dx.doi.org/10.7554/eLife.30294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703641PMC
November 2017

FUS Zigzags Its Way to Cross Beta.

Cell 2017 10;171(3):499-500

Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in Saint Louis, Saint Louis, MO 63130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.007DOI Listing
October 2017

SAXS versus FRET: A Matter of Heterogeneity?

Biophys J 2017 09 15;113(5):971-973. Epub 2017 Aug 15.

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.

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http://dx.doi.org/10.1016/j.bpj.2017.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658740PMC
September 2017

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.

Sci Adv 2017 Feb 10;3(2):e1601944. Epub 2017 Feb 10.

Center for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/sciadv.1601944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302871PMC
February 2017

To Mix, or To Demix, That Is the Question.

Biophys J 2017 02;112(4):565-567

Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.12.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340119PMC
February 2017

CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Biophys J 2017 Jan;112(1):16-21

Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.11.3200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5232785PMC
January 2017

Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation.

J Am Chem Soc 2016 11 17;138(47):15323-15335. Epub 2016 Nov 17.

Department of Structural Biology, St. Jude Children's Research Hospital , 263 Danny Thomas Place, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/jacs.6b10272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675102PMC
November 2016

Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

PLoS One 2015 14;10(12):e0144692. Epub 2015 Dec 14.

The Center for Biological Systems Engineering, Washington University, St. Louis, MO, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144692PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685989PMC
June 2016

Protein polymers: Encoding phase transitions.

Nat Mater 2015 Nov;14(11):1083-4

Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.

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http://dx.doi.org/10.1038/nmat4459DOI Listing
November 2015

Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation.

J Am Chem Soc 2015 Mar 23;137(8):2984-95. Epub 2015 Feb 23.

Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis , One Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130, United States.

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http://dx.doi.org/10.1021/ja512062hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418562PMC
March 2015

ProteomeScout: a repository and analysis resource for post-translational modifications and proteins.

Nucleic Acids Res 2015 Jan 20;43(Database issue):D521-30. Epub 2014 Nov 20.

Department of Biomedical Engineering and the Center for Biological Systems Engineering, Washington University, St Louis, MO 63130, USA

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http://dx.doi.org/10.1093/nar/gku1154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383955PMC
January 2015