Publications by authors named "Alex Odermatt"

100Publications

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction.

Int J Mol Sci 2020 Sep 26;21(19). Epub 2020 Sep 26.

Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University Salzburg, Strubergasse 21, 5020 Salzburg, Austria.

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http://dx.doi.org/10.3390/ijms21197102DOI Listing
September 2020

Management of posaconazole-induced pseudohyperaldosteronism.

J Antimicrob Chemother 2020 Aug 24. Epub 2020 Aug 24.

Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Health, Sacramento, CA, USA.

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http://dx.doi.org/10.1093/jac/dkaa366DOI Listing
August 2020

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples.

Metabolites 2020 Jul 9;10(7). Epub 2020 Jul 9.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.3390/metabo10070282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408441PMC
July 2020

Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211.

Mol Cell Endocrinol 2020 Jun 22:110873. Epub 2020 Jun 22.

Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Missionsstrasse 64, 4055, Basel, Switzerland; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2020.110873DOI Listing
June 2020

Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals.

J Steroid Biochem Mol Biol 2020 05 23;199:105605. Epub 2020 Jan 23.

Swiss Centre for Applied Human Toxicology (SCAHT) and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2020.105605DOI Listing
May 2020

Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α.

Toxicol Lett 2020 Apr 9;322:39-49. Epub 2020 Jan 9.

Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2020.01.001DOI Listing
April 2020

Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis.

Biochem Pharmacol 2020 02 27;172:113781. Epub 2019 Dec 27.

Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Basel, Switzerland; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.113781DOI Listing
February 2020

Reply to DiPippo and Kontoyiannis.

Clin Infect Dis 2020 Jul;71(2):469

Department of Internal Medicine, Division of Infectious Diseases and the Department of Medical Microbiology and Immunology, University of California Davis Medical Center, Sacramento, California, USA.

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http://dx.doi.org/10.1093/cid/ciz945DOI Listing
July 2020

Posaconazole Serum Drug Levels Associated With Pseudohyperaldosteronism.

Clin Infect Dis 2020 Jun;70(12):2593-2598

Department of Medical Microbiology and Immunology, University of California-Davis Health, Sacramento, California, USA, Basel, Switzerland.

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286374PMC
June 2020

Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration.

Cell Mol Life Sci 2020 Mar 13;77(6):1153-1175. Epub 2019 Jul 13.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00018-019-03227-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109200PMC
March 2020

Posaconazole-Induced Hypertension Due to Inhibition of 11-Hydroxylase and 11-Hydroxysteroid Dehydrogenase 2.

J Endocr Soc 2019 Jul 6;3(7):1361-1366. Epub 2019 Jun 6.

Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1210/js.2019-00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608555PMC
July 2019

11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ.

J Lipid Res 2019 09 4;60(9):1535-1546. Epub 2019 Jul 4.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland

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http://dx.doi.org/10.1194/jlr.M092908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718442PMC
September 2019

Drug-induced endocrine blood pressure elevation.

Pharmacol Res 2020 04 15;154:104311. Epub 2019 Jun 15.

Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.104311DOI Listing
April 2020

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase.

J Steroid Biochem Mol Biol 2019 09 6;192:105358. Epub 2019 Apr 6.

Institute of Pharmacy / Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria; Department of Medicinal and Pharmaceutical Chemistry, Institute of Pharmacy, Paracelsus Medical University, Strubergasse 22, 5020, Salzburg, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.04.007DOI Listing
September 2019

Profiling withanolide A for therapeutic targets in neurodegenerative diseases.

Bioorg Med Chem 2019 06 13;27(12):2508-2520. Epub 2019 Mar 13.

Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.03.022DOI Listing
June 2019

Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2.

J Steroid Biochem Mol Biol 2019 06 19;190:19-28. Epub 2019 Mar 19.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.03.011DOI Listing
June 2019

Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases.

Mol Cell Endocrinol 2019 06 7;489:98-106. Epub 2018 Jul 7.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2018.07.003DOI Listing
June 2019

The Binding of Human IgG to Minipig FcγRs - Implications for Preclinical Assessment of Therapeutic Antibodies.

Pharm Res 2019 Feb 5;36(3):47. Epub 2019 Feb 5.

Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland.

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http://dx.doi.org/10.1007/s11095-019-2574-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373530PMC
February 2019

Removal of batch effects using stratified subsampling of metabolomic data for in vitro endocrine disruptors screening.

Talanta 2019 Apr 8;195:77-86. Epub 2018 Nov 8.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Universities of Basel and Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.talanta.2018.11.019DOI Listing
April 2019

The genomic organization and expression pattern of the low-affinity Fc gamma receptors (FcγR) in the Göttingen minipig.

Immunogenetics 2019 02 18;71(2):123-136. Epub 2018 Dec 18.

Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00251-018-01099-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327001PMC
February 2019

Effects of lisdexamfetamine on plasma steroid concentrations compared with d-amphetamine in healthy subjects: A randomized, double-blind, placebo-controlled study.

J Steroid Biochem Mol Biol 2019 02 28;186:212-225. Epub 2018 Oct 28.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.10.016DOI Listing
February 2019

Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11β-hydroxysteroid dehydrogenase 1.

Bioorg Med Chem 2018 10 12;26(18):5128-5139. Epub 2018 Sep 12.

DSM Nutritional Products Ltd., Wurmisweg 576, 4303 Kaiseraugst, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183116
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http://dx.doi.org/10.1016/j.bmc.2018.09.009DOI Listing
October 2018

Absence of hexose-6-phosphate dehydrogenase results in reduced overall glucose consumption but does not prevent 11β-hydroxysteroid dehydrogenase-1-dependent glucocorticoid activation.

FEBS J 2018 11 6;285(21):3993-4004. Epub 2018 Sep 6.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland.

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http://doi.wiley.com/10.1111/febs.14642
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http://dx.doi.org/10.1111/febs.14642DOI Listing
November 2018

Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.

JCI Insight 2018 07 26;3(14). Epub 2018 Jul 26.

Physiology and Behavior Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.

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http://dx.doi.org/10.1172/jci.insight.99015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124420PMC
July 2018

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis.

Heliyon 2018 Feb 1;4(2):e00527. Epub 2018 Feb 1.

Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.heliyon.2018.e00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857625PMC
February 2018

Acute effects of lisdexamfetamine and D-amphetamine on social cognition and cognitive performance in a placebo-controlled study in healthy subjects.

Psychopharmacology (Berl) 2018 05 9;235(5):1389-1402. Epub 2018 Feb 9.

Psychopharmacology Research, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel and University of Basel, Schanzenstrasse 55, 4056, Basel, CH, Switzerland.

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http://dx.doi.org/10.1007/s00213-018-4849-0DOI Listing
May 2018

Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance.

FASEB J 2018 05 2;32(5):2690-2705. Epub 2018 Jan 2.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1096/fj.201700870RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901385PMC
May 2018

Accelerated skin wound healing by selective 11β-Hydroxylase (CYP11B1) inhibitors.

Eur J Med Chem 2018 Jan 21;143:591-597. Epub 2017 Nov 21.

Pharmaceutical and Medicinal Chemistry, Saarland University, Campus E8.1, 66123 Saarbrücken, Germany; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123 Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.11.018DOI Listing
January 2018

11β-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation.

Endocrinology 2017 11;158(11):4047-4063

Department of Basic Medical Sciences, Institute of Biomedical Technologies and Center for Biomedical Research of the Canary Islands, Universidad de La Laguna, 38200 Tenerife, Spain.

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http://dx.doi.org/10.1210/en.2017-00440DOI Listing
November 2017

Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects.

Front Pharmacol 2017 7;8:617. Epub 2017 Sep 7.

Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel and University of BaselBasel, Switzerland.

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http://dx.doi.org/10.3389/fphar.2017.00617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594082PMC
September 2017

Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases.

Int J Mol Sci 2017 Sep 19;18(9). Epub 2017 Sep 19.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.3390/ijms18092007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618656PMC
September 2017

Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation.

Atherosclerosis 2017 Oct 19;265:78-86. Epub 2017 Aug 19.

Department of Clinical Research, University of Bern, Switzerland; The National Centre of Competence in Research (NCCR) "Kidney.CH - Kidney Control of Homeostasis", Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.08.012DOI Listing
October 2017

Biochemical Analysis of Four Missense Mutations in the HSD17B3 Gene Associated With 46,XY Disorders of Sex Development in Egyptian Patients.

J Sex Med 2017 09;14(9):1165-1174

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17436095173134
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http://dx.doi.org/10.1016/j.jsxm.2017.07.006DOI Listing
September 2017

Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis.

Bioorg Med Chem Lett 2017 07 4;27(13):2982-2985. Epub 2017 May 4.

Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.05.005DOI Listing
July 2017

Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Dec 23;1071:11-18. Epub 2017 Apr 23.

School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, 1211 Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2017.04.032DOI Listing
December 2017

DHRS7 (SDR34C1) - A new player in the regulation of androgen receptor function by inactivation of 5α-dihydrotestosterone?

J Steroid Biochem Mol Biol 2017 07 27;171:288-295. Epub 2017 Apr 27.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2017.04.013DOI Listing
July 2017

Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome.

Nutrients 2017 Apr 26;9(5). Epub 2017 Apr 26.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.3390/nu9050426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452156PMC
April 2017

Virtual screening applications in short-chain dehydrogenase/reductase research.

J Steroid Biochem Mol Biol 2017 07 9;171:157-177. Epub 2017 Mar 9.

Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2017.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831487PMC
July 2017

Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids.

Toxicology 2017 04 22;381:51-63. Epub 2017 Feb 22.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Universities of Basel and Geneva, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.02.010DOI Listing
April 2017

Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole.

Biochem Pharmacol 2017 04 25;130:93-103. Epub 2017 Jan 25.

Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Pharmazentrum, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828556PMC
April 2017

Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish.

J Endocrinol 2017 02 7;232(2):323-335. Epub 2016 Dec 7.

Division of Molecular and Systems ToxicologyDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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https://joe.bioscientifica.com/view/journals/joe/232/2/323.x
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http://dx.doi.org/10.1530/JOE-16-0495DOI Listing
February 2017

Evaluation of tetrabromobisphenol A effects on human glucocorticoid and androgen receptors: A comparison of results from human- with yeast-based in vitro assays.

Toxicology 2016 Aug 28;370:70-77. Epub 2016 Sep 28.

Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2016.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828555PMC
August 2016

IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes.

Arch Toxicol 2017 May 12;91(5):2223-2234. Epub 2016 Oct 12.

Division of Clinical Pharmacology and Toxicology, University Hospital, 4031, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00204-016-1871-zDOI Listing
May 2017

Calcification of vascular smooth muscle cells is induced by secondary calciprotein particles and enhanced by tumor necrosis factor-α.

Atherosclerosis 2016 08 27;251:404-414. Epub 2016 May 27.

Department of Clinical Research, University of Bern, Switzerland; National Centre of Competence in Research (NCCR) Kidney.ch, Switzerland; Department of Clinical Chemistry, University Hospital Bern, Inselspital, Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.044DOI Listing
August 2016

Development and characterization of a pseudo multiple reaction monitoring method for the quantification of human uromodulin in urine.

Bioanalysis 2016 Jun 17;8(12):1279-96. Epub 2016 May 17.

Proteomics Core Facility, Biozentrum, University of Basel, Klingelbergstrasse 50-70, 4056, Basel, Switzerland.

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http://dx.doi.org/10.4155/bio-2016-0055DOI Listing
June 2016

Novel cases of Tunisian patients with mutations in the gene encoding 17β-hydroxysteroid dehydrogenase type 3 and a founder effect.

J Steroid Biochem Mol Biol 2017 01 5;165(Pt A):86-94. Epub 2016 Mar 5.

Human Molecular Genetic Laboratory, Faculty of Medicine of Sfax, 3030, University of Sfax, Tunisia; Department of Medical Genetics, Hedi Chaker Hospital, 3029 Sfax, Tunisia.

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http://dx.doi.org/10.1016/j.jsbmb.2016.03.007DOI Listing
January 2017

Role of Pro-637 and Gln-642 in human glucocorticoid receptors and Ser-843 and Leu-848 in mineralocorticoid receptors in their differential responses to cortisol and aldosterone.

J Steroid Biochem Mol Biol 2016 May 22;159:31-40. Epub 2016 Feb 22.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.02.017DOI Listing
May 2016

Disruption of steroidogenesis: Cell models for mechanistic investigations and as screening tools.

J Steroid Biochem Mol Biol 2016 Apr 22;158:9-21. Epub 2016 Jan 22.

Swiss Center for Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jsbmb.2016.01.009DOI Listing
April 2016

Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.

Pflugers Arch 2016 05 14;468(5):895-908. Epub 2016 Jan 14.

Department of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 27, CH-1011, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00424-015-1785-2DOI Listing
May 2016

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases.

Molecules 2015 Dec 19;20(12):22799-832. Epub 2015 Dec 19.

Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), Computer Aided Molecular Design Group, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.3390/molecules201219880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332202PMC
December 2015

Recommendations for description and validation of antibodies for research use.

J Steroid Biochem Mol Biol 2016 Feb 2;156:40-2. Epub 2015 Dec 2.

Helmholtz Zentrum München, Institute of Experimental Genetics, Genome Analysis Center, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2015.11.021DOI Listing
February 2016

Biochemical analyses and molecular modeling explain the functional loss of 17β-hydroxysteroid dehydrogenase 3 mutant G133R in three Tunisian patients with 46, XY Disorders of Sex Development.

J Steroid Biochem Mol Biol 2016 Jan 3;155(Pt A):147-54. Epub 2015 Nov 3.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Pharmacenter, University of Basel, Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09600760153012
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http://dx.doi.org/10.1016/j.jsbmb.2015.10.023DOI Listing
January 2016

Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney.

Am J Physiol Renal Physiol 2015 Nov 2;309(9):F779-90. Epub 2015 Sep 2.

Institute of Anatomy, University of Zurich, Zurich, Switzerland; Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland; National Center of Competence in Research "Kidney.CH," Switzerland; and

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http://dx.doi.org/10.1152/ajprenal.00139.2015DOI Listing
November 2015

A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer.

Cancer Med 2015 Nov 26;4(11):1717-29. Epub 2015 Aug 26.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056, Basel, Switzerland.

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http://dx.doi.org/10.1002/cam4.517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673999PMC
November 2015

Reprint of "In silico methods in the discovery of endocrine disrupting chemicals".

J Steroid Biochem Mol Biol 2015 Sep 19;153:93-101. Epub 2015 Aug 19.

Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck - CMBI, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria. Electronic address:

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September 2015

Determination of the topology of endoplasmic reticulum membrane proteins using redox-sensitive green-fluorescence protein fusions.

Biochim Biophys Acta 2015 Jul 15;1853(7):1672-82. Epub 2015 Apr 15.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.04.002DOI Listing
July 2015

Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells.

J Neuroinflammation 2014 Nov 19;11:190. Epub 2014 Nov 19.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.

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http://dx.doi.org/10.1186/s12974-014-0190-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240888PMC
November 2014

11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story.

J Steroid Biochem Mol Biol 2015 Jul 23;151:85-92. Epub 2014 Aug 23.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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July 2015

Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure.

Toxicology 2014 Oct 7;324:136-46. Epub 2014 Aug 7.

Clinical Pharmacology & Toxicology, University Hospital Basel, Switzerland; Department of Biomedicine, University of Basel, Switzerland; Swiss Center of Applied Human Toxicology (SCAHT), Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.08.002DOI Listing
October 2014

11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.

Mol Metab 2014 Aug 2;3(5):554-64. Epub 2014 May 2.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.molmet.2014.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099504PMC
August 2014

Evaluation of sparfloxacin distribution by mass spectrometry imaging in a phototoxicity model.

J Am Soc Mass Spectrom 2014 Oct 8;25(10):1803-9. Epub 2014 Jul 8.

Novartis Institutes for BioMedical Research, Preclinical Safety, 4002, Basel, Switzerland.

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October 2014

Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17β-hydroxysteroid dehydrogenase 2 inhibitors.

J Med Chem 2014 Jul 10;57(14):5995-6007. Epub 2014 Jul 10.

Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck - CMBI, University of Innsbruck , Innrain 80/82, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1021/jm5004914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111740PMC
July 2014

Acute effects of 3,4-methylenedioxymethamphetamine and methylphenidate on circulating steroid levels in healthy subjects.

Neuroendocrinology 2014 5;100(1):17-25. Epub 2014 Jun 5.

Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1159/000364879DOI Listing
July 2015

Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids.

Toxicol Sci 2014 Aug 5;140(2):462-9. Epub 2014 May 5.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK.

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http://dx.doi.org/10.1093/toxsci/kfu080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120102PMC
August 2014

Dibutyltin promotes oxidative stress and increases inflammatory mediators in BV-2 microglia cells.

Toxicol Lett 2014 Oct 13;230(2):177-87. Epub 2014 Mar 13.

Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2014.03.001DOI Listing
October 2014

Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio).

Sci Total Environ 2014 Apr 24;476-477:207-17. Epub 2014 Jan 24.

University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, 4132 Muttenz, Switzerland; Swiss Federal Institute of Technology (ETH Zürich), Institute of Biogeochemistry and Pollution Dynamics, Department of Environmental System Sciences, 8092 Zürich, Switzerland. Electronic address:

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April 2014

Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism.

FEBS Lett 2014 Jan 24;588(3):490-6. Epub 2013 Dec 24.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2013.12.014DOI Listing
January 2014

Pharmacophore Model Refinement for 11β-Hydroxysteroid Dehydrogenase Inhibitors: Search for Modulators of Intracellular Glucocorticoid Concentrations.

Mol Inform 2014 Jan 2;33(1):15-25. Epub 2013 Oct 2.

Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck - CMBI, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria phone/fax: +43 512 507 58253/+43 512 507 58299.

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http://dx.doi.org/10.1002/minf.201300063DOI Listing
January 2014

Cysteine-10 on 17 β -Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals.

Int J Cell Biol 2013 17;2013:769536. Epub 2013 Nov 17.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstraße 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1155/2013/769536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855964PMC
December 2013

Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters.

Am J Physiol Renal Physiol 2014 Jan 6;306(1):F130-7. Epub 2013 Nov 6.

Dept. of Clinical Pharmacology and Toxicology, Univ. Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.

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http://dx.doi.org/10.1152/ajprenal.00114.2013DOI Listing
January 2014

Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity.

Aquat Toxicol 2013 Nov 7;144-145:96-104. Epub 2013 Oct 7.

University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Institute for Ecopreneurship, Gründenstrasse 40, 4132 Muttenz, Switzerland; University of Basel, Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.aquatox.2013.09.030DOI Listing
November 2013

Characterization of vemurafenib phototoxicity in a mouse model.

Toxicol Sci 2014 Jan 23;137(1):259-67. Epub 2013 Oct 23.

* Preclinical Safety, Novartis Institutes of BioMedical Research, 4002 Basel, Switzerland.

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http://dx.doi.org/10.1093/toxsci/kft237DOI Listing
January 2014

Synthesis of sterically encumbered 11β-aminoprogesterone derivatives and evaluation as 11β-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists.

Bioorg Med Chem 2013 Nov 7;21(21):6274-81. Epub 2013 Sep 7.

Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, Alberta T6G 2G2, Canada.

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http://dx.doi.org/10.1016/j.bmc.2013.08.068DOI Listing
November 2013

Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors.

Bioorg Med Chem Lett 2013 Oct 31;23(19):5397-400. Epub 2013 Jul 31.

Institute of Pharmacy, Department of Pharmaceutical Chemistry, Leopold-Franzens-Universität, Centrum für Chemie und Biomedizin, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.bmcl.2013.07.047DOI Listing
October 2013

Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid.

J Lipid Res 2013 Oct 9;54(10):2874-83. Epub 2013 Aug 9.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M042499
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770100PMC
October 2013

Formation of threohydrobupropion from bupropion is dependent on 11β-hydroxysteroid dehydrogenase 1.

Drug Metab Dispos 2013 Sep 26;41(9):1671-8. Epub 2013 Jun 26.

Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.113.052936
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http://dx.doi.org/10.1124/dmd.113.052936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876805PMC
September 2013

Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise.

Front Genet 2013 13;4:108. Epub 2013 Jun 13.

Division of Molecular & Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel Basel, Switzerland.

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http://dx.doi.org/10.3389/fgene.2013.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680709PMC
June 2013

In silico methods in the discovery of endocrine disrupting chemicals.

J Steroid Biochem Mol Biol 2013 Sep 17;137:18-26. Epub 2013 May 17.

Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck - CMBI, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.jsbmb.2013.04.009DOI Listing
September 2013

Endoplasmic reticulum: reduced and oxidized glutathione revisited.

J Cell Sci 2013 Apr 19;126(Pt 7):1604-17. Epub 2013 Feb 19.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.117218
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April 2013

Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1.

Biochem Pharmacol 2013 May 16;85(9):1370-8. Epub 2013 Feb 16.

Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://www.xerr.uzh.ch/prodoc/publications/Meyer_BiochemPhar
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http://dx.doi.org/10.1016/j.bcp.2013.02.014DOI Listing
May 2013

Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells.

J Neuroinflammation 2012 Nov 28;9:260. Epub 2012 Nov 28.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1186/1742-2094-9-260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526453PMC
November 2012

The microsomal enzyme 17β-hydroxysteroid dehydrogenase 3 faces the cytoplasm and uses NADPH generated by glucose-6-phosphate dehydrogenase.

Endocrinology 2013 Jan 26;154(1):205-13. Epub 2012 Nov 26.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1210/en.2012-1778DOI Listing
January 2013