Publications by authors named "Alex Kentsis"

74Publications

Developmental Mutators and Early Onset Cancer.

Front Pediatr 2020 28;8:189. Epub 2020 Apr 28.

Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA, United States.

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http://dx.doi.org/10.3389/fped.2020.00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198762PMC
April 2020

Why do young people get cancer?

Authors:
Alex Kentsis

Pediatr Blood Cancer 2020 07 11;67(7):e28335. Epub 2020 May 11.

Sloan Kettering Institute and Department of Pediatrics, Weill Medical College of Cornell University and Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/pbc.28335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582786PMC
July 2020

A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis.

iScience 2019 Sep 17;19:74-82. Epub 2019 Jul 17.

Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664223PMC
September 2019

Optimized Cross-Linking Mass Spectrometry for in Situ Interaction Proteomics.

J Proteome Res 2019 06 24;18(6):2545-2558. Epub 2019 May 24.

Department of Pediatrics, Pharmacology, and Physiology & Biophysics, Weill Cornell Medical College , Cornell University , New York , New York 10065 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.9b00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473601PMC
June 2019

HIV Detection via a Carbon Nanotube RNA Sensor.

ACS Sens 2019 05 6;4(5):1236-1244. Epub 2019 May 6.

Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.

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http://dx.doi.org/10.1021/acssensors.9b00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556989PMC
May 2019

A Chemical Strategy for Protease Substrate Profiling.

Cell Chem Biol 2019 06 18;26(6):901-907.e6. Epub 2019 Apr 18.

Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588500PMC
June 2019

Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.

JCI Insight 2018 10 18;3(20). Epub 2018 Oct 18.

Departments of Pediatrics, Pharmacology, and Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, USA.

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https://insight.jci.org/articles/view/123172
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http://dx.doi.org/10.1172/jci.insight.123172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237467PMC
October 2018

ProteomeGenerator: A Framework for Comprehensive Proteomics Based on de Novo Transcriptome Assembly and High-Accuracy Peptide Mass Spectral Matching.

J Proteome Res 2018 11 19;17(11):3681-3692. Epub 2018 Oct 19.

Molecular Pharmacology Program , Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York City , New York 10065 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00295
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http://dx.doi.org/10.1021/acs.jproteome.8b00295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727203PMC
November 2018

Disabling an oncogenic transcription factor by targeting of control kinases.

Oncotarget 2018 Aug 17;9(64):32276-32277. Epub 2018 Aug 17.

Molecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.25971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122356PMC
August 2018

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.

Cell 2018 02;172(5):1007-1021.e17

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02210, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052445PMC
February 2018

Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy.

Br J Haematol 2018 03 14;180(6):919-924. Epub 2018 Feb 14.

Molecular Pharmacology Program, Sloan Kettering Institute, and Department of Pediatrics, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1111/bjh.15129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837942PMC
March 2018

High Sensitivity Quantitative Proteomics Using Automated Multidimensional Nano-flow Chromatography and Accumulated Ion Monitoring on Quadrupole-Orbitrap-Linear Ion Trap Mass Spectrometer.

Mol Cell Proteomics 2017 11 18;16(11):2006-2016. Epub 2017 Aug 18.

From the ‡Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.1074/mcp.RA117.000023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672005PMC
November 2017

Germline mutations detected in pediatric sequencing studies impact parents' evaluation and care.

Cold Spring Harb Mol Case Stud 2017 Nov 21;3(6). Epub 2017 Nov 21.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/mcs.a001925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701310PMC
November 2017

ProteoModlR for functional proteomic analysis.

BMC Bioinformatics 2017 Mar 4;18(1):153. Epub 2017 Mar 4.

Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1186/s12859-017-1563-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336658PMC
March 2017

Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma.

J Pediatr Hematol Oncol 2017 11;39(8):e443-e445

Departments of *Pediatrics †Medicine ‡Surgery ∥Radiation Oncology ¶Radiology #Pathology **Human Oncology and Pathogenesis Program, Molecular Pharmacology Program ††Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center §Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.

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http://dx.doi.org/10.1097/MPH.0000000000000754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498269PMC
November 2017

Towards comprehensive and quantitative proteomics for diagnosis and therapy of human disease.

Proteomics 2017 01 21;17(1-2). Epub 2016 Dec 21.

Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1002/pmic.201600079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243792PMC
January 2017

Forward genetic screen of human transposase genomic rearrangements.

BMC Genomics 2016 Aug 4;17:548. Epub 2016 Aug 4.

Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1186/s12864-016-2877-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973553PMC
August 2016

Osteosarcoma With Apparent Ewing Sarcoma Gene Rearrangement.

J Pediatr Hematol Oncol 2016 07;38(5):e166-8

Departments of *Pediatrics†Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/MPH.0000000000000553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928585PMC
July 2016

Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization.

J Mol Diagn 2016 Jan 21;18(1):92-9. Epub 2015 Nov 21.

Department of Laboratory Medicine, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2015.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715224PMC
January 2016

Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer.

J Proteome Res 2015 Nov 22;14(11):4752-62. Epub 2015 Oct 22.

Departments of Pathology, Boston Children's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.jproteome.5b00826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993212PMC
November 2015

Genomic DNA transposition induced by human PGBD5.

Elife 2015 Sep 25;4. Epub 2015 Sep 25.

Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.

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http://dx.doi.org/10.7554/eLife.10565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625184PMC
September 2015

MStern Blotting-High Throughput Polyvinylidene Fluoride (PVDF) Membrane-Based Proteomic Sample Preparation for 96-Well Plates.

Mol Cell Proteomics 2015 Oct 29;14(10):2814-23. Epub 2015 Jul 29.

From the ‡Proteomics Center and Department of Pathology and ¶Department of Pathology and F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurology, Harvard Medical School, Boston, Massachusetts,

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http://dx.doi.org/10.1074/mcp.O115.049650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597154PMC
October 2015

A High-Efficiency Cellular Extraction System for Biological Proteomics.

J Proteome Res 2015 Aug 14;14(8):3403-8. Epub 2015 Jul 14.

§Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acs.jproteome.5b00547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529808PMC
August 2015

Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia.

Front Oncol 2015 2;5:16. Epub 2015 Feb 2.

Molecular Pharmacology and Chemistry Program, Department of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University , New York, NY , USA.

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https://pdfs.semanticscholar.org/ee49/a5dc5623c3280645527e15
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http://journal.frontiersin.org/Article/10.3389/fonc.2015.000
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http://dx.doi.org/10.3389/fonc.2015.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313608PMC
February 2015

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

Br J Haematol 2015 Jan 26;168(2):230-8. Epub 2014 Sep 26.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Haematology, UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1111/bjh.13115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303513PMC
January 2015

Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease.

EMBO Mol Med 2013 Feb 20;5(2):210-20. Epub 2012 Dec 20.

Division of Hematology/Oncology, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/emmm.201201494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569638PMC
February 2013

Detection and diagnostic value of urine leucine-rich α-2-glycoprotein in children with suspected acute appendicitis.

Ann Emerg Med 2012 Jul 2;60(1):78-83.e1. Epub 2012 Feb 2.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.annemergmed.2011.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726720PMC
July 2012

Challenges and opportunities for discovery of disease biomarkers using urine proteomics.

Authors:
Alex Kentsis

Pediatr Int 2011 Feb;53(1):1-6

Division of Hematology/Oncology, Children's Hospital Boston, and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://doi.wiley.com/10.1111/j.1442-200X.2010.03253.x
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http://dx.doi.org/10.1111/j.1442-200X.2010.03253.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636200PMC
February 2011

Urine proteomics for profiling of human disease using high accuracy mass spectrometry.

Proteomics Clin Appl 2009 Sep;3(9):1052-1061

Department of Medicine, Children's Hospital Boston and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/prca.200900008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994589PMC
September 2009

Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry.

Ann Emerg Med 2010 Jan 25;55(1):62-70.e4. Epub 2009 Jun 25.

Division of Emergency Medicine, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.annemergmed.2009.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422167PMC
January 2010

Calculation of the free energy and cooperativity of protein folding.

PLoS One 2007 May 16;2(5):e446. Epub 2007 May 16.

Department of Molecular Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000446PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865387PMC
May 2007

Correspondence patterns: mechanisms and models of human dynamics.

Authors:
Alex Kentsis

Nature 2006 May;441(7092):E5; discussion E5-6

Department of Physiology & Biophysics, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA

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http://dx.doi.org/10.1038/nature04901DOI Listing
May 2006

Further evidence that ribavirin interacts with eIF4E.

RNA 2005 Dec 26;11(12):1762-6. Epub 2005 Oct 26.

Mount Sinai School of Medicine, New York University, New York, NY 10029, USA.

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http://www.rnajournal.org/cgi/doi/10.1261/rna.2238705
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http://dx.doi.org/10.1261/rna.2238705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370864PMC
December 2005

Origin of the sequence-dependent polyproline II structure in unfolded peptides.

Proteins 2005 Dec;61(4):769-76

Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA.

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http://dx.doi.org/10.1002/prot.20655DOI Listing
December 2005

Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.

Mol Cell Biol 2005 Feb;25(3):1100-12

Institute for Research in Immunovirology and Cancer, University of Montreal, Montreal, Quebec H3T 1J4, Canada.

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http://dx.doi.org/10.1128/MCB.25.3.1100-1112.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544005PMC
February 2005

Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.

J Biol Chem 2005 Mar 20;280(9):7985-96. Epub 2004 Dec 20.

Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, New York 10029-6574, USA.

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http://dx.doi.org/10.1074/jbc.M413160200DOI Listing
March 2005

Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.

Proc Natl Acad Sci U S A 2004 Dec 15;101(52):18105-10. Epub 2004 Dec 15.

Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.0406927102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539790PMC
December 2004

Unfolded state of polyalanine is a segmented polyproline II helix.

Proteins 2004 May;55(3):493-501

Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA.

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http://dx.doi.org/10.1002/prot.20051DOI Listing
May 2004

Physical mechanisms and biological significance of supramolecular protein self-assembly.

Curr Protein Pept Sci 2004 Apr;5(2):125-34

Structural Biology Program, Department of Physiology & Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA.

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http://dx.doi.org/10.2174/1389203043486856DOI Listing
April 2004

Nedd8 on cullin: building an expressway to protein destruction.

Oncogene 2004 Mar;23(11):1985-97

Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

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http://www.nature.com/articles/1207414
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http://dx.doi.org/10.1038/sj.onc.1207414DOI Listing
March 2004

MC-PHS: a Monte Carlo implementation of the primary hydration shell for protein folding and design.

Biophys J 2003 Feb;84(2 Pt 1):805-15

Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1302661PMC
http://dx.doi.org/10.1016/S0006-3495(03)74900-5DOI Listing
February 2003

Control of biochemical reactions through supramolecular RING domain self-assembly.

Proc Natl Acad Sci U S A 2002 Nov 18;99(24):15404-9. Epub 2002 Nov 18.

Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York 10029, USA.

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http://dx.doi.org/10.1073/pnas.202608799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137729PMC
November 2002

Self-assembly properties of a model RING domain.

Proc Natl Acad Sci U S A 2002 Jan 15;99(2):667-72. Epub 2002 Jan 15.

Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.012317299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117363PMC
January 2002