Alex Gutteridge

Alex Gutteridge

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Alex Gutteridge

Alex Gutteridge

Publications by authors named "Alex Gutteridge"

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33Publications

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Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle.

FASEB J 2017 12 17;31(12):5268-5282. Epub 2017 Aug 17.

Stem Cells, Ageing, and Molecular Physiology Research Unit, Exercise Metabolism and Adaptation Research Group, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom;

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http://dx.doi.org/10.1096/fj.201700089RRDOI Listing
December 2017

Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage.

Stem Cells Transl Med 2017 02 24;6(2):490-501. Epub 2016 Aug 24.

Pfizer Neuroscience and Pain Research Unit, Great Abington, Cambridge, United Kingdom.

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http://dx.doi.org/10.5966/sctm.2016-0088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442825PMC
February 2017

Interpreting transcriptional changes using causal graphs: new methods and their practical utility on public networks.

BMC Bioinformatics 2016 Aug 24;17(1):318. Epub 2016 Aug 24.

Department of Mathematics, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, 02125, USA.

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http://dx.doi.org/10.1186/s12859-016-1181-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995651PMC
August 2016

Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation.

Stem Cells 2015 Oct 29;33(10):3006-16. Epub 2015 Jul 29.

Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/stem.2095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832383PMC
October 2015

Optimizing the leveraging of real-world data to improve the development and use of medicines.

Value Health 2015 Jan 27;18(1):127-30. Epub 2014 Nov 27.

Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.jval.2014.10.009DOI Listing
January 2015

Molecular causes of transcriptional response: a Bayesian prior knowledge approach.

Bioinformatics 2013 Dec 26;29(24):3167-73. Epub 2013 Sep 26.

Computational Sciences Center of Emphasis, Pfizer Worldwide Research & Development, Cambridge, MA 02140, USA, Department of Mathematics, University of Massachusetts Boston, Boston, MA 02125, USA, Drug Safety Research & Development, Pfizer, Groton, CT 06340, USA and Neusentis, Pfizer Worldwide Research & Development, Cambridge CB21 6GS, UK.

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http://dx.doi.org/10.1093/bioinformatics/btt557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994944PMC
December 2013

Directing differentiation of human embryonic stem cells toward anterior neural ectoderm using small molecules.

Stem Cells 2012 Sep;30(9):1875-84

Neusentis, The Portway Building, Granta Park, Cambridge, United Kingdom.

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http://doi.wiley.com/10.1002/stem.1166
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http://dx.doi.org/10.1002/stem.1166DOI Listing
September 2012

The genetic control of growth rate: a systems biology study in yeast.

BMC Syst Biol 2012 Jan 13;6. Epub 2012 Jan 13.

Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1186/1752-0509-6-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398284PMC
January 2012

Functional expression of parasite drug targets and their human orthologs in yeast.

PLoS Negl Trop Dis 2011 Oct 4;5(10):e1320. Epub 2011 Oct 4.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0001320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186757PMC
October 2011

Nutrient control of eukaryote cell growth: a systems biology study in yeast.

BMC Biol 2010 May 24;8:68. Epub 2010 May 24.

Cambridge Systems Biology Centre & Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1186/1741-7007-8-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895586PMC
May 2010

Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.

Bioinformatics 2008 Jul;24(13):i232-40

Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.

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http://dx.doi.org/10.1093/bioinformatics/btn162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718640PMC
July 2008

Regulation of metabolic networks by small molecule metabolites.

BMC Bioinformatics 2007 Mar 13;8:88. Epub 2007 Mar 13.

Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto, Japan 611-0011.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-8-88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839110PMC
March 2007

MIMOX: a web tool for phage display based epitope mapping.

BMC Bioinformatics 2006 Oct 12;7:451. Epub 2006 Oct 12.

Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.

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http://dx.doi.org/10.1186/1471-2105-7-451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618411PMC
October 2006

Understanding nature's catalytic toolkit.

Trends Biochem Sci 2005 Nov 7;30(11):622-9. Epub 2005 Oct 7.

EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://www.plantsciences.ucdavis.edu/bis103/2007/Toolkit.pdf
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http://dx.doi.org/10.1016/j.tibs.2005.09.006DOI Listing
November 2005

Effective function annotation through catalytic residue conservation.

Proc Natl Acad Sci U S A 2005 Aug 21;102(35):12299-304. Epub 2005 Jul 21.

Inpharmatica, 60 Charlotte Street, London W1T 2NU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0504833102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1178014PMC
August 2005

Conformational changes observed in enzyme crystal structures upon substrate binding.

J Mol Biol 2005 Feb 23;346(1):21-8. Epub 2004 Dec 23.

European Bioinformatics Institute, EMBL Outstation-Hinxton, Wellcome Trust Genome Campus, CB10 1SD Hinxton Cambridge, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360401439
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http://dx.doi.org/10.1016/j.jmb.2004.11.013DOI Listing
February 2005

Conformational change in substrate binding, catalysis and product release: an open and shut case?

FEBS Lett 2004 Jun;567(1):67-73

EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.

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http://dx.doi.org/10.1016/j.febslet.2004.03.067DOI Listing
June 2004

Using a neural network and spatial clustering to predict the location of active sites in enzymes.

J Mol Biol 2003 Jul;330(4):719-34

EBI, Wellcome Trust Genome Campus, EMBL Outstation, Hinxton, Cambridgeshire CB10 1SD, UK.

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http://dx.doi.org/10.1016/s0022-2836(03)00515-1DOI Listing
July 2003