Alex F Vos

Alex F de Vos

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Alex F Vos

Alex F de Vos

Publications by authors named "Alex F de Vos"

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1PubMed Central Citations

Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.

J Pathol 2019 Oct 9. Epub 2019 Oct 9.

Center of Experimental & Molecular Medicine, Amsterdam University Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.5354DOI Listing
October 2019

Effect of C1-inhibitor in adults with mild asthma: A randomized controlled trial.

Allergy 2019 Sep 19. Epub 2019 Sep 19.

Center of Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/all.14053DOI Listing
September 2019

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis.

Infect Immun 2019 Aug 23;87(8). Epub 2019 Jul 23.

Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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http://dx.doi.org/10.1128/IAI.00409-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652761PMC
August 2019

C3a signaling is not involved in eosinophil migration during experimental allergic lung inflammation in mice.

Allergy 2019 Aug 13. Epub 2019 Aug 13.

Center of Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/all.14021DOI Listing
August 2019

Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis.

Thromb Haemost 2019 Jun 14;119(6):930-940. Epub 2019 Mar 14.

Center for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1055/s-0039-1681046DOI Listing
June 2019

Neutrophils mitigate the systemic host response during endotoxemia in mice.

Immunology 2019 03 18;156(3):277-281. Epub 2018 Dec 18.

Center of Experimental & Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://doi.wiley.com/10.1111/imm.13026
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http://dx.doi.org/10.1111/imm.13026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376271PMC
March 2019

Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model.

Am J Physiol Lung Cell Mol Physiol 2019 Jan 25;316(1):L187-L196. Epub 2018 Oct 25.

Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00162.2018DOI Listing
January 2019

Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia.

Mol Med 2019 01 15;25(1). Epub 2019 Jan 15.

Center for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-132, 1105, AZ, Amsterdam, the Netherlands.

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https://molmed.biomedcentral.com/articles/10.1186/s10020-018
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http://dx.doi.org/10.1186/s10020-018-0069-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332549PMC
January 2019

Platelet-Dense Granules Worsen Pre-Infection Thrombocytopenia during Gram-Negative Pneumonia-Derived Sepsis.

J Innate Immun 2019 17;11(2):168-180. Epub 2018 Dec 17.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000494147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738263PMC
December 2018

Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis.

Arterioscler Thromb Vasc Biol 2018 08;38(8):1772-1784

From the Center for Experimental and Molecular Medicine (T.A.M.C., S.F.d.S., A.F.d.V., C.v.V., T.v.d.P.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311332DOI Listing
August 2018

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.

Immunity 2018 07 10;49(1):120-133.e9. Epub 2018 Jul 10.

Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany; Institut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; AP-HP, Hôpital Necker Enfants Malades, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057275PMC
July 2018

Expression and Function of Granzymes A and B in Peritonitis and Sepsis.

Mediators Inflamm 2017 12;2017:4137563. Epub 2017 Jun 12.

Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1155/2017/4137563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485334PMC
April 2018

Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria.

Blood 2018 02 29;131(8):864-876. Epub 2017 Nov 29.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2017-06-788067DOI Listing
February 2018

ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice.

Eur J Immunol 2018 01 3;48(1):66-79. Epub 2017 Nov 3.

Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/eji.201646554DOI Listing
January 2018

Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.

J Innate Immun 2016 20;8(3):258-68. Epub 2016 Feb 20.

Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000443401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738821PMC
September 2017

Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study.

Gut 2017 09 15;66(9):1623-1630. Epub 2016 Jun 15.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-312132DOI Listing
September 2017

Differences in Inflammation Patterns Induced by African and Asian Isolates in Mice.

Am J Trop Med Hyg 2017 Jun;96(6):1365-1369

Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4269/ajtmh.16-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462573PMC
June 2017

Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types.

Crit Care Med 2017 May;45(5):e524-e531

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2Center for Infection and Immunity Amsterdam, Amsterdam, The Netherlands. 3Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 5Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002294DOI Listing
May 2017

The gut microbiota as a modulator of innate immunity during melioidosis.

PLoS Negl Trop Dis 2017 04 19;11(4):e0005548. Epub 2017 Apr 19.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0005548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411098PMC
April 2017

Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis.

Shock 2016 11;46(5):566-574

*Center for Infection and Immunity Amsterdam (CINIMA)/Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands †Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands ‡Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand §Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK ||Novartis Institutes for BioMedical Research, Basel, Switzerland ¶Department of Internal medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000000625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058638PMC
November 2016

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.

Cell Rep 2016 10;17(3):684-696

Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, the Netherlands; Institute for Cardiovascular Prevention (IPEK), Ludwig Maximillian's University, Pettenkoferstrasse 9, Munich 80336, Germany.

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http://dx.doi.org/10.1016/j.celrep.2016.09.008DOI Listing
October 2016

TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-x03B3.

J Innate Immun 2015 9;7(6):637-46. Epub 2015 Jun 9.

Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000430913DOI Listing
August 2016

Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism.

Am J Physiol Lung Cell Mol Physiol 2016 08 10;311(2):L219-28. Epub 2016 Jun 10.

Center of Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00078.2016DOI Listing
August 2016

Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia.

Am J Physiol Lung Cell Mol Physiol 2016 08 24;311(2):L507-16. Epub 2016 Jun 24.

Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00116.2016DOI Listing
August 2016

Antibiotic-Induced Gut Microbiota Disruption Decreases TNF-α Release by Mononuclear Cells in Healthy Adults.

Clin Transl Gastroenterol 2016 Aug 4;7(8):e186. Epub 2016 Aug 4.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ctg.2016.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543405PMC
August 2016

Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia.

PLoS One 2016 29;11(1):e0141000. Epub 2016 Jan 29.

Laboratory of Biomedical Science, Feinstein Institute for Medical Research, North Shore Long Island University Hospital, Manhassat, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141000PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732606PMC
July 2016

Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis.

PLoS Negl Trop Dis 2016 06 2;10(6):e0004747. Epub 2016 Jun 2.

Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0004747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890812PMC
June 2016

The impact of HIV infection on blood leukocyte responsiveness to bacterial stimulation in asymptomatic patients and patients with bloodstream infection.

J Int AIDS Soc 2016;19(1):20759. Epub 2016 May 16.

Center of Experimental and Molecular Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870384PMC
http://dx.doi.org/10.7448/IAS.19.1.20759DOI Listing
May 2016

The polysaccharide capsule of Streptococcus pneumonia partially impedes MyD88-mediated immunity during pneumonia in mice.

PLoS One 2015 20;10(2):e0118181. Epub 2015 Feb 20.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336322PMC
January 2016

Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia.

J Pathol 2016 Jan 19;238(1):74-84. Epub 2015 Oct 19.

Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.4637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909154PMC
January 2016

Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial.

Eur Respir J 2015 Dec 17;46(6):1636-44. Epub 2015 Sep 17.

Center of Infection and Immunity Amsterdam, and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1183/13993003.00459-2015DOI Listing
December 2015

Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis.

J Infect 2015 Dec 15;71(6):706-9. Epub 2015 Sep 15.

Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands; Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jinf.2015.09.002DOI Listing
December 2015

Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment.

J Innate Immun 2014 18;6(2):219-26. Epub 2013 Oct 18.

Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000354984DOI Listing
November 2015

The receptor for advanced glycation end products promotes bacterial growth at distant body sites in Staphylococcus aureus skin infection.

Microbes Infect 2015 Sep 16;17(9):622-7. Epub 2015 Jun 16.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.micinf.2015.06.002DOI Listing
September 2015

Increased intra- and extracellular granzyme expression in patients with tuberculosis.

Tuberculosis (Edinb) 2015 Sep 20;95(5):575-80. Epub 2015 Jun 20.

Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2015.05.016DOI Listing
September 2015

Myeloid-related protein-14 deficiency promotes inflammation in staphylococcal pneumonia.

Eur Respir J 2015 Aug 18;46(2):464-73. Epub 2015 Mar 18.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1183/09031936.00183814DOI Listing
August 2015

Single immunoglobulin interleukin-1 receptor-related molecule impairs host defense during pneumonia and sepsis caused by Streptococcus pneumoniae.

J Innate Immun 2014 14;6(4):542-52. Epub 2014 Feb 14.

Center of Experimental and Molecular Medicine, Center of Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000358239DOI Listing
May 2015

Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model.

PLoS Negl Trop Dis 2015 Apr 10;9(4):e0003663. Epub 2015 Apr 10.

Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam (CINIMA), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0003663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393299PMC
April 2015

DNAX-activating protein of 12 kDa impairs host defense in pneumococcal pneumonia.

Crit Care Med 2014 Dec;42(12):e783-90

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 3Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000000686DOI Listing
December 2014

Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia.

Thorax 2014 Nov 1;69(11):1034-42. Epub 2014 Sep 1.

Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/thoraxjnl-2014-205668DOI Listing
November 2014

Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis.

PLoS Pathog 2014 Sep 25;10(9):e1004368. Epub 2014 Sep 25.

Center of Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands; Center of Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands; Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1004368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177915PMC
September 2014

Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation.

Innate Immun 2014 Aug 18;20(6):618-25. Epub 2013 Sep 18.

Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1177/1753425913503387DOI Listing
August 2014

Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia.

J Pathol 2014 Aug 3;233(4):357-67. Epub 2014 Jun 3.

Center for Experimental and Molecular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands; Centre for Infection and Immunity, Academic Medical Centre, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.4361DOI Listing
August 2014

Limited role of the receptor for advanced glycation end products during Streptococcus pneumoniae bacteremia.

J Innate Immun 2013 15;5(6):603-12. Epub 2013 Jun 15.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000348739DOI Listing
July 2014

The thrombomodulin lectin-like domain does not change host responses to tuberculosis.

Thromb Haemost 2014 Feb 17;111(2):345-53. Epub 2013 Oct 17.

Liesbeth M. Kager, MD, Center for Experimental and Molecular Medicine (CEMM), Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands, Tel.: +31 20 566 5910, Fax: +31 20 697 7192, E-mail:

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http://dx.doi.org/10.1160/TH13-08-0719DOI Listing
February 2014

Role of interleukin 1 receptor like 1 (ST2) in gram-negative and gram-positive sepsis in mice.

Shock 2013 Oct;40(4):290-6

*Center of Experimental and Molecular Medicine, Center of Infection and Immunity Amsterdam, †Department of Pathology, and ‡Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/SHK.0b013e3182a35f02DOI Listing
October 2013

Limited anti-inflammatory role for interleukin-1 receptor like 1 (ST2) in the host response to murine postinfluenza pneumococcal pneumonia.

PLoS One 2013 6;8(3):e58191. Epub 2013 Mar 6.

Center of Experimental and Molecular Medicine, Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058191PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590127PMC
September 2013

The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.

Thromb Haemost 2013 Apr 24;109(4):726-37. Epub 2013 Jan 24.

Center for Experimental and Molecular Medicine (CEMM), Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands.

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH12-11-0859
Publisher Site
http://dx.doi.org/10.1160/TH12-11-0859DOI Listing
April 2013

Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice.

Am J Respir Cell Mol Biol 2013 Mar 13;48(3):382-9. Epub 2012 Dec 13.

Center of Infection and Immunity Amsterdam and Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1165/rcmb.2012-0331OCDOI Listing
March 2013

Differential roles of MyD88 and TRIF in hematopoietic and resident cells during murine gram-negative pneumonia.

J Infect Dis 2012 Nov 16;206(9):1415-23. Epub 2012 Aug 16.

Center of Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/infdis/jis505DOI Listing
November 2012

Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia.

J Infect Dis 2012 Jun 5;205(12):1849-57. Epub 2012 Apr 5.

Center for Infection and Immunity Amsterdam, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/infdis/jis290DOI Listing
June 2012

A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.

PLoS One 2011 3;6(10):e24431. Epub 2011 Oct 3.

Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024431PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184942PMC
January 2012

Delineation of the role of Toll-like receptor signaling during peritonitis by a gradually growing pathogenic Escherichia coli.

J Biol Chem 2011 Oct 20;286(42):36603-18. Epub 2011 Jun 20.

Center for Infection and Immunity Amsterdam, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M110.189126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196080PMC
October 2011

Osteopontin impairs host defense during pneumococcal pneumonia.

J Infect Dis 2011 Jun;203(12):1850-8

Center for Infection and Immunity Amsterdam (CINIMA), Amsterdam, the Netherlands.

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http://dx.doi.org/10.1093/infdis/jir185DOI Listing
June 2011

Loss of suppression of tumorigenicity 2 (ST2) gene reverses sepsis-induced inhibition of lung host defense in mice.

Am J Respir Crit Care Med 2011 Apr 19;183(7):932-40. Epub 2010 Oct 19.

University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1164/rccm.201006-0934OCDOI Listing
April 2011

The role of CD44 in the acute and resolution phase of the host response during pneumococcal pneumonia.

Lab Invest 2011 Apr 17;91(4):588-97. Epub 2011 Jan 17.

Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/labinvest.2010.206DOI Listing
April 2011

Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A.

J Immunol 2011 Feb 10;186(4):1934-42. Epub 2011 Jan 10.

Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MB Amsterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1001672DOI Listing
February 2011

Gene expression profiling of apoptosis regulators in patients with sepsis.

J Innate Immun 2010 23;2(5):461-8. Epub 2010 Jun 23.

Centers for Infection and Immunity Amsterdam, and Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000317035DOI Listing
January 2011

Role of CD14 in lung inflammation and infection.

Crit Care 2010 9;14(2):209. Epub 2010 Mar 9.

Center for Experimental and Molecular Medicine, Center of Infection and Immunity, Academic Medical Center, Meibergdreef 9, Amsterdam, Netherlands.

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http://dx.doi.org/10.1186/cc8850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887102PMC
November 2010

CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumonia.

Am J Pathol 2010 Nov 23;177(5):2483-94. Epub 2010 Sep 23.

Center for Infection and Immunity Amsterdam, Department of Pathology, Academic Medical Center, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401060299
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http://dx.doi.org/10.2353/ajpath.2010.100562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966805PMC
November 2010

Role of CD14 in a mouse model of acute lung inflammation induced by different lipopolysaccharide chemotypes.

PLoS One 2010 Apr 16;5(4):e10183. Epub 2010 Apr 16.

Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010183PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855719PMC
April 2010

Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lung.

Am J Respir Cell Mol Biol 2010 Mar 15;42(3):349-56. Epub 2009 May 15.

Academic Medical Center, Center for Experimental and Molecular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1165/rcmb.2008-0362OCDOI Listing
March 2010

The complement system facilitates clearance of Enterococcus faecium during murine peritonitis.

J Infect Dis 2010 Feb;201(4):544-52

Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam. The Netherlands.

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http://dx.doi.org/10.1086/650341DOI Listing
February 2010

Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice.

PLoS One 2009 Nov 24;4(11):e7993. Epub 2009 Nov 24.

Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776357PMC
November 2009

Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice.

J Infect Dis 2009 Sep;200(5):765-73

Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1086/604730DOI Listing
September 2009

TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.

J Immunol 2009 Aug 13;183(3):2027-36. Epub 2009 Jul 13.

Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Vienna, Austria.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0803862
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August 2009

In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands.

J Immunol 2009 Jul;183(1):533-42

Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0802189
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July 2009

Activation of coagulation and inhibition of fibrinolysis in the human lung on bronchial instillation of lipoteichoic acid and lipopolysaccharide.

Crit Care Med 2009 Feb;37(2):619-25

Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0b013e31819584f9DOI Listing
February 2009

The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice.

Crit Care Med 2009 Feb;37(2):614-8

Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam.

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http://dx.doi.org/10.1097/CCM.0b013e31819599b6DOI Listing
February 2009

CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice.

J Infect Dis 2008 Nov;198(9):1388-97

Centers for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1086/592220DOI Listing
November 2008

Pre-ERCP infusion of semapimod, a mitogen-activated protein kinases inhibitor, lowers post-ERCP hyperamylasemia but not pancreatitis incidence.

Gastrointest Endosc 2008 Aug 2;68(2):246-54. Epub 2008 May 2.

Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gie.2008.01.034DOI Listing
August 2008

Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans.

Am J Respir Crit Care Med 2008 Jul 10;178(1):34-41. Epub 2008 Apr 10.

Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1164/rccm.200708-1261OCDOI Listing
July 2008

Inflammation patterns induced by different Burkholderia species in mice.

Cell Microbiol 2008 Jan 20;10(1):81-7. Epub 2007 Jul 20.

Center for Infection and Immunity Amsterdam (CINIMA), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1462-5822.2007.01016.xDOI Listing
January 2008