Alex F Drake

Alex F Drake

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Alex F Drake

Alex F Drake

Publications by authors named "Alex F Drake"

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Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities.

Sci Rep 2019 Jul 29;9(1):10934. Epub 2019 Jul 29.

Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1038/s41598-019-47327-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662694PMC
July 2019

Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity.

Sci Rep 2019 Feb 4;9(1):1385. Epub 2019 Feb 4.

Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1038/s41598-018-37630-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362004PMC
February 2019

Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes.

Sci Rep 2016 11 22;6:37639. Epub 2016 Nov 22.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1038/srep37639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118786PMC
November 2016

Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites.

Biochem J 2016 Jan 20;473(1):43-54. Epub 2015 Oct 20.

Diabetes and Nutritional Sciences Division, Franklin Wilkins Building, 150 Stamford Street, King's College London, London SE1 9NH, U.K. Department of Structural and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, U.K.

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http://dx.doi.org/10.1042/BJ20150836DOI Listing
January 2016

Structure and stability insights into tumour suppressor p53 evolutionary related proteins.

PLoS One 2013 4;8(10):e76014. Epub 2013 Oct 4.

King's College London, School of Biomedical Sciences, Department of Biochemistry & Randall Division of Cell and Molecular Biophysics, New Hunt's House, London, United Kingdom ; Department of Pharmacy, University of Naples "Federico II", Napoli, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076014PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790848PMC
July 2014

Stability of sugar solutions: a novel study of the epimerization kinetics of lactose in water.

Mol Pharm 2014 Jul 3;11(7):2224-38. Epub 2014 Jun 3.

Institute of Pharmaceutical Science, King's College London , Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, U.K.

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http://dx.doi.org/10.1021/mp400509tDOI Listing
July 2014

Enzymatically cross-linked gelatin/chitosan hydrogels: tuning gel properties and cellular response.

Macromol Biosci 2014 Jun 18;14(6):817-30. Epub 2014 Feb 18.

King's College London, Institute of Pharmaceutical Science, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1002/mabi.201300472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412957PMC
June 2014

Strong and weak zinc binding sites in human zinc-α2-glycoprotein.

FEBS Lett 2013 Dec 1;587(24):3949-54. Epub 2013 Nov 1.

Department of Biochemistry, King's College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.febslet.2013.10.026DOI Listing
December 2013

Spectroscopic studies on nicotine and nornicotine in the UV region.

Chirality 2013 May 14;25(5):288-93. Epub 2013 Mar 14.

British American Tobacco, Group R&D, Regents Park Road, Southampton, SO15 8TL, UK.

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http://dx.doi.org/10.1002/chir.22141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654167PMC
May 2013

Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo.

ACS Nano 2012 Oct 15;6(10):9335-46. Epub 2012 Aug 15.

Nanomedicine Lab, Centre for Drug Delivery Research, UCL School of Pharmacy, University College London, London WC1N 1AX, United Kingdom.

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http://dx.doi.org/10.1021/nn302148pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480335PMC
October 2012

The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties.

Chem Commun (Camb) 2012 Sep 27;48(70):8760-2. Epub 2012 Jul 27.

Department of Pharmacy, King's College London, Stamford Street, London, SE18WA, UK.

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http://dx.doi.org/10.1039/c2cc31277hDOI Listing
September 2012

Control of pH responsive peptide self-association during endocytosis is required for effective gene transfer.

Biochim Biophys Acta 2012 May 29;1818(5):1332-41. Epub 2011 Dec 29.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.bbamem.2011.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378503PMC
May 2012

Solution model of the intrinsically disordered polyglutamine tract-binding protein-1.

Biophys J 2012 Apr 3;102(7):1608-16. Epub 2012 Apr 3.

Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.bpj.2012.02.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318138PMC
April 2012

The measurement of the β/α anomer composition within amorphous lactose prepared by spray and freeze drying using a simple (1)H-NMR method.

Pharm Res 2012 Feb 8;29(2):511-24. Epub 2011 Sep 8.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1007/s11095-011-0575-6DOI Listing
February 2012

Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct.

J Am Chem Soc 2011 Dec 9;133(48):19376-85. Epub 2011 Nov 9.

Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.1021/ja205395rDOI Listing
December 2011

Enzymatically cross-linked tilapia gelatin hydrogels: physical, chemical, and hybrid networks.

Biomacromolecules 2011 Oct 26;12(10):3741-52. Epub 2011 Aug 26.

Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1021/bm2009894DOI Listing
October 2011

Stability of human growth hormone: influence of methionine oxidation on thermal folding.

J Pharm Sci 2011 Feb;100(2):451-63

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

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http://dx.doi.org/10.1002/jps.22293DOI Listing
February 2011

Structural contributions to the intracellular targeting strategies of antimicrobial peptides.

Biochim Biophys Acta 2010 Oct 15;1798(10):1934-43. Epub 2010 Jul 15.

King's College London, Pharmaceutical Science Division, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.bbamem.2010.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309561PMC
October 2010

Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.

Nucleic Acids Res 2010 Jul 9;38(12):4052-66. Epub 2010 Mar 9.

Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK.

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http://dx.doi.org/10.1093/nar/gkq141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896528PMC
July 2010

Fate of silica nanoparticles in simulated primary wastewater treatment.

Environ Sci Technol 2009 Nov;43(22):8622-8

NERC Centre for Ecology and Hydrology, Maclean Building, Benson Lane, Crowmarsh Gifford, Wallingford OX10 8BB, UK.

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http://dx.doi.org/10.1021/es901399qDOI Listing
November 2009

The p73 DNA binding domain displays enhanced stability relative to its homologue, the tumor suppressor p53, and exhibits cooperative DNA binding.

Biochemistry 2008 Mar 9;47(10):3235-44. Epub 2008 Feb 9.

Department of Biochemistry, School of Biomedical & Health Sciences, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.

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http://pubs.acs.org/doi/abs/10.1021/bi7023207
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http://dx.doi.org/10.1021/bi7023207DOI Listing
March 2008

Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream.

Biochemistry 2007 Dec 1;46(51):15175-87. Epub 2007 Dec 1.

UMR 7177, Institut de Chimie, Université Louis Pasteur/CNRS, 4 rue Blaise Pascal, 67070 Strasbourg, France.

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http://dx.doi.org/10.1021/bi701344mDOI Listing
December 2007

The effect of electrolyte on the encapsulation efficiency of vesicles formed by the nonionic surfactant, 2C18E12.

J Colloid Interface Sci 2007 Nov 10;315(2):648-61. Epub 2007 Jul 10.

Pharmaceutical Sciences Division, King's College London, Franklin Wilkins Building, Waterloo Campus, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.jcis.2007.06.076DOI Listing
November 2007

Interplay between core and peripheral chirality in polyethers.

Org Lett 2007 Aug 31;9(18):3487-90. Epub 2007 Jul 31.

Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.1021/ol070934tDOI Listing
August 2007

UV irradiation affects melanocyte stimulatory activity and protein binding of piperine.

Photochem Photobiol 2006 Nov-Dec;82(6):1541-8

Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK.

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April 2007

A novel methodological approach for the analysis of host-ligand interactions.

Chemphyschem 2007 Feb;8(2):270-8

Dage Precision Industries Ltd, 1 Davey Close, Colchester, Essex, CO1 2XL, UK.

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http://dx.doi.org/10.1002/cphc.200600442DOI Listing
February 2007

Characterization of protein aggregation: the case of a therapeutic immunoglobulin.

Biochim Biophys Acta 2007 Jan 27;1774(1):146-53. Epub 2006 Oct 27.

Department of Pharmaceutics and Biopharmaceutics, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30 quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.bbapap.2006.10.010DOI Listing
January 2007

Chiral separation and CD characterisation of enantiomeric cyclotriphosphazene derivatives.

Chirality 2005 Oct;17(8):438-43

Department of Pharmacy, Kings College (University of London), London, England.

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http://dx.doi.org/10.1002/chir.20187DOI Listing
October 2005

The multi-mode polarization modulation spectrometer: part 1: simultaneous detection of absorption, turbidity, and optical activity.

Anal Biochem 2004 Sep;332(1):46-57

Section de Pharmacie, Universitéde Genève, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S000326970400484
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http://dx.doi.org/10.1016/j.ab.2004.05.045DOI Listing
September 2004