Dr Alessia Volpe, PhD - Memorial Sloan Kettering Cancer Center - Postdoctoral Research Scholar in Cancer Immunotherapy

Dr Alessia Volpe

PhD

Memorial Sloan Kettering Cancer Center

Postdoctoral Research Scholar in Cancer Immunotherapy

New York, NY | United States

Main Specialties: Nuclear Medicine, Oncology

ORCID logohttps://orcid.org/0000-0003-3087-9178

Dr Alessia Volpe, PhD - Memorial Sloan Kettering Cancer Center - Postdoctoral Research Scholar in Cancer Immunotherapy

Dr Alessia Volpe

PhD

Introduction

I am a scientist with an interest in pursuing the new advancements of medical imaging to improve delivery, efficacy, monitoring and long-term follow-up of anti-cancer cell-based immunotherapies with a direct translation into patients. I have extensive experience in in vivo cancer models, radionuclide-based reporter gene imaging and CAR T-cell therapy.

Primary Affiliation: Memorial Sloan Kettering Cancer Center - New York, NY , United States

Specialties:

Research Interests:

Education

Dec 2017
King's College London
CRUK Postdoctoral Research Associate in Cancer Imaging
Dec 2012
King's College London
PhD in Cancer Imaging
Dec 2012
University of Naples "Federico II"
MSc in Molecular Diagnosis
Dec 2012
Italian National Research Council - Institute for Experimental Endocrinology and Oncology "Gaetano Salvatore" IEOS
Intern Student in Molecular Oncology
Dec 2011
University of Naples "Federico II"
BSc in Biological Sciences

Publications

7Publications

169Reads

41Profile Views

Spatiotemporal PET Imaging Reveals Differences in CAR-T Tumor Retention in Triple-Negative Breast Cancer Models.

Mol Ther 2020 Jun 27. Epub 2020 Jun 27.

Imaging Therapies and Cancer Group, Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2020.06.028DOI Listing
June 2020
6.227 Impact Factor

Ga-Sienna+ for PET-MRI Guided Sentinel Lymph Node Biopsy: Synthesis and Preclinical Evaluation in a Metastatic Breast Cancer Model.

Nanotheranostics 2019 6;3(3):255-265. Epub 2019 Jun 6.

Department of Imaging Chemistry and Biology, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom.

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http://dx.doi.org/10.7150/ntno.34727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584137PMC
June 2020
4 Reads

In Vivo PET Tracking of Zr-Labeled Vγ9Vδ2 T Cells to Mouse Xenograft Breast Tumors Activated with Liposomal Alendronate.

Mol Ther 2019 01 16;27(1):219-229. Epub 2018 Oct 16.

School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183049
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http://dx.doi.org/10.1016/j.ymthe.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318719PMC
January 2019
37 Reads
6.227 Impact Factor

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.

Int J Biochem Cell Biol 2018 09 28;102:40-50. Epub 2018 Jun 28.

Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, SE1 7EH, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2018.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593261PMC
September 2018
15 Reads
4.046 Impact Factor

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models.

J Vis Exp 2018 03 13(133). Epub 2018 Mar 13.

Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London;

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http://dx.doi.org/10.3791/57088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931757PMC
March 2018
20 Reads

[F]tetrafluoroborate-PET/CT enables sensitive tumor and metastasis in vivo imaging in a sodium iodide symporter-expressing tumor model.

Sci Rep 2017 04 19;7(1):946. Epub 2017 Apr 19.

King's College London, Imaging Chemistry and Biology, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St. Thomas' Hospital, London, SE1 7EH, UK.

Cancer cell metastasis is responsible for most cancer deaths. Non-invasive in vivo cancer cell tracking in spontaneously metastasizing tumor models still poses a challenge requiring highest sensitivity and excellent contrast. The goal of this study was to evaluate if the recently introduced PET radiotracer [F]tetrafluoroborate ([F]BF) is useful for sensitive and specific metastasis detection in an orthotopic xenograft breast cancer model expressing the human sodium iodide symporter (NIS) as a reporter. In vivo imaging was complemented by ex vivo fluorescence microscopy and ?-counting of harvested tissues. Radionuclide imaging with [F]BF (PET/CT) was compared to the conventional tracer [I]iodide (sequential SPECT/CT). We found that [F]BF was superior due to better pharmacokinetics, i.e. faster tumor uptake and faster and more complete clearance from circulation. [F]BF-PET was also highly specific as in all detected tissues cancer cell presence was confirmed microscopically. Undetected comparable tissues were similarly found to be free of metastasis. Metastasis detection by routine metabolic imaging with [F]FDG-PET failed due to low standard uptake values and low contrast caused by adjacent metabolically active organs in this model. [F]BF-PET combined with NIS expressing disease models is particularly useful whenever preclinical in vivo cell tracking is of interest.

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http://dx.doi.org/10.1038/s41598-017-01044-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430436PMC
April 2017
9 Reads
5.078 Impact Factor

Top co-authors

Gilbert O Fruhwirth
Gilbert O Fruhwirth

King's College London

5
Philip J Blower
Philip J Blower

King's College London

3
Francis Man
Francis Man

Sackler Institute of Pulmonary Pharmacology

3
Lindsay Lim
Lindsay Lim

The Institute of Cancer Research

3
Alberto Gabizon
Alberto Gabizon

Shaare Zedek Medical Center and Hebrew University-School of Medicine

2
Hilary Shmeeda
Hilary Shmeeda

Shaare Zedek Medical Center

2
John Maher
John Maher

King's College London

2