Publications by authors named "Alessandro Sette"

100Publications

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4 T Cells in COVID-19.

Cell 2020 Oct 5. Epub 2020 Oct 5.

La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534589PMC
October 2020

Cross-reactive memory T cells and herd immunity to SARS-CoV-2.

Nat Rev Immunol 2020 Nov 6;20(11):709-713. Epub 2020 Oct 6.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41577-020-00460-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537578PMC
November 2020

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.

Cell 2020 Sep 16. Epub 2020 Sep 16.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494270PMC
September 2020

Inflammation in Experimental Models of α-Synucleinopathies.

Mov Disord 2020 Oct 3. Epub 2020 Oct 3.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.28264DOI Listing
October 2020

Disease extent and anti-tubercular treatment response correlates with -specific CD4 T-cell phenotype regardless of HIV-1 status.

Clin Transl Immunology 2020 28;9(9):e1176. Epub 2020 Sep 28.

Wellcome Centre for Infectious Disease Research in Africa Institute of Infectious Disease and Molecular Medicine University of Cape Town Observatory South Africa.

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http://dx.doi.org/10.1002/cti2.1176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520805PMC
September 2020

Lack of evidence supporting a role of IFN-β and TGF-β in differential polarization of Bordetella pertussis specific-T cell responses.

Cytokine 2020 Sep 28;137:155313. Epub 2020 Sep 28.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United States; School of Medicine, University of California San Diego, La Jolla, CA, United States.

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http://dx.doi.org/10.1016/j.cyto.2020.155313DOI Listing
September 2020

Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination.

J Virol 2020 Sep 30. Epub 2020 Sep 30.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States

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http://dx.doi.org/10.1128/JVI.01641-20DOI Listing
September 2020

Lack of evidence for BCG vaccine protection from severe COVID-19.

Proc Natl Acad Sci U S A 2020 10 29;117(41):25203-25204. Epub 2020 Sep 29.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.2016733117DOI Listing
October 2020

HLA Class I Binding of Mutant EGFR Peptides in NSCLC Is Associated With Improved Survival.

J Thorac Oncol 2020 Sep 11. Epub 2020 Sep 11.

Division of Medical Oncology, School of Medicine, University of Colorado, Aurora, Colorado.

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http://dx.doi.org/10.1016/j.jtho.2020.08.023DOI Listing
September 2020

Author Correction: Pre-existing immunity to SARS-CoV-2: the knowns and unknowns.

Nat Rev Immunol 2020 Oct;20(10):644

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41577-020-00430-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430209PMC
October 2020

Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis.

Mucosal Immunol 2020 Jul 16. Epub 2020 Jul 16.

Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, 7925, South Africa.

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http://dx.doi.org/10.1038/s41385-020-0322-6DOI Listing
July 2020

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns.

Nat Rev Immunol 2020 08;20(8):457-458

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41577-020-0389-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339790PMC
August 2020

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.

Cell 2020 06 20;181(7):1489-1501.e15. Epub 2020 May 20.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901PMC
June 2020

Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system.

PLoS Comput Biol 2020 05 26;16(5):e1007757. Epub 2020 May 26.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1007757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274474PMC
May 2020

The Challenge of Distinguishing Cell-Cell Complexes from Singlet Cells in Non-Imaging Flow Cytometry and Single-Cell Sorting.

Cytometry A 2020 May 13. Epub 2020 May 13.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, California, USA.

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http://dx.doi.org/10.1002/cyto.a.24027DOI Listing
May 2020

Development and Validation of a Whole-Genome Screening Strategy.

J Immunol Res 2020 2;2020:8202067. Epub 2020 Apr 2.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, San Diego, California, USA.

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http://dx.doi.org/10.1155/2020/8202067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154976PMC
April 2020

A structured model for immune exposures.

Database (Oxford) 2020 01;2020

Division for Vaccine Discovery, 9420 Athena Circle La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/database/baaa016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153954PMC
January 2020

Inhibition of protective immunity against infection by MHC-restricted immunodominance is overcome by vaccination.

Sci Adv 2020 04 1;6(14):eaaw7713. Epub 2020 Apr 1.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

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http://dx.doi.org/10.1126/sciadv.aaw7713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112766PMC
April 2020

A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2.

Cell Host Microbe 2020 04 16;27(4):671-680.e2. Epub 2020 Mar 16.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2020.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142693PMC
April 2020

Major Histocompatibility Complex Binding, Eluted Ligands, and Immunogenicity: Benchmark Testing and Predictions.

Front Immunol 2019 5;10:3151. Epub 2020 Feb 5.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.03151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012937PMC
February 2020

T Cell Epitope Predictions.

Annu Rev Immunol 2020 Apr 11;38:123-145. Epub 2020 Feb 11.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, California 92037, USA; email:

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http://dx.doi.org/10.1146/annurev-immunol-082119-124838DOI Listing
April 2020

Howard Grey 1932-2019.

Authors:
Alessandro Sette

Nat Immunol 2020 03;21(3):242

Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41590-020-0604-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223305PMC
March 2020

Transcriptomic immune profiles of human flavivirus-specific T-cell responses.

Immunology 2020 May 7;160(1):3-9. Epub 2020 Jan 7.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/imm.13161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160650PMC
May 2020

The Immune Epitope Database and Analysis Resource Program 2003-2018: reflections and outlook.

Immunogenetics 2020 02 25;72(1-2):57-76. Epub 2019 Nov 25.

Division of Vaccine Discovery, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s00251-019-01137-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970984PMC
February 2020

Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice.

Mucosal Immunol 2020 01 21;13(1):140-148. Epub 2019 Oct 21.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA.

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http://dx.doi.org/10.1038/s41385-019-0217-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161428PMC
January 2020

Benchmark datasets of immune receptor-epitope structural complexes.

BMC Bioinformatics 2019 Oct 10;20(1):490. Epub 2019 Oct 10.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1186/s12859-019-3109-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785892PMC
October 2019

Human T Cell Response to Dengue Virus Infection.

Front Immunol 2019 4;10:2125. Epub 2019 Sep 4.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.02125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737489PMC
October 2020

A survey of known immune epitopes in the enteroviruses strains associated with acute flaccid myelitis.

Hum Immunol 2019 Nov 23;80(11):923-929. Epub 2019 Aug 23.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, CA 92093, USA.

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http://dx.doi.org/10.1016/j.humimm.2019.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876747PMC
November 2019

Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases.

Curr Opin Immunol 2019 08 17;59:115-120. Epub 2019 Aug 17.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.coi.2019.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774843PMC
August 2019

Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids.

J Immunol 2019 09 7;203(6):1619-1628. Epub 2019 Aug 7.

Boston Children's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.4049/jimmunol.1900536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736755PMC
September 2019

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses.

Nat Commun 2019 06 28;10(1):2846. Epub 2019 Jun 28.

Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.

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http://dx.doi.org/10.1038/s41467-019-10661-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599079PMC
June 2019

Nontuberculous Mycobacteria and Heterologous Immunity to Tuberculosis.

J Infect Dis 2019 08;220(7):1091-1098

Tuberculosis Research and Training Center, Department of Medicine, University of Washington, Seattle.

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http://dx.doi.org/10.1093/infdis/jiz285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736075PMC
August 2019

Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.

Eur J Immunol 2019 08 2;49(8):1167-1185. Epub 2019 May 2.

Department of Pathology, University of Massachusetts Medical School, Worcester, MA.

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http://dx.doi.org/10.1002/eji.201948126DOI Listing
August 2019

Comprehensive Review of Human -Specific CD8+ T Cell Epitopes.

Front Immunol 2019 21;10:397. Epub 2019 Mar 21.

Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438266PMC
September 2020

New epitopes in ovalbumin provide insights for cancer neoepitopes.

JCI Insight 2019 03 14;5. Epub 2019 Mar 14.

Department of Immunology, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1172/jci.insight.127882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538383PMC
March 2019

Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells.

Front Immunol 2019 25;10:303. Epub 2019 Feb 25.

Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397885PMC
September 2020

Host Transcriptomics as a Tool to Identify Diagnostic and Mechanistic Immune Signatures of Tuberculosis.

Front Immunol 2019 19;10:221. Epub 2019 Feb 19.

Department of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389658PMC
October 2020

Counter-regulation of regulatory T cells by autoreactive CD8 T cells in rheumatoid arthritis.

J Autoimmun 2019 05 16;99:81-97. Epub 2019 Feb 16.

Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, 00161, Rome, Italy; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy; Istituto Pasteur - Fondazione Cenci Bolognetti, 00185, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.02.001DOI Listing
May 2019

Most viral peptides displayed by class I MHC on infected cells are immunogenic.

Proc Natl Acad Sci U S A 2019 02 4;116(8):3112-3117. Epub 2019 Feb 4.

John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia;

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http://dx.doi.org/10.1073/pnas.1815239116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386720PMC
February 2019

Poor Antigen Processing of Poxvirus Particles Limits CD4 T Cell Recognition and Impacts Immunogenicity of the Inactivated Vaccine.

J Immunol 2019 03 30;202(5):1340-1349. Epub 2019 Jan 30.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.4049/jimmunol.1801099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394857PMC
March 2019

Hepatitis D Virus-Specific CD8 T Cells Have a Memory-Like Phenotype Associated With Viral Immune Escape in Patients With Chronic Hepatitis D Virus Infection.

Gastroenterology 2019 05 18;156(6):1805-1819.e9. Epub 2019 Jan 18.

Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367679PMC
May 2019

Investigation of Outbreak-Specific Nonsynonymous Mutations on Ebolavirus GP in the Context of Known Immune Reactivity.

J Immunol Res 2018 15;2018:1846207. Epub 2018 Nov 15.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1155/2018/1846207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276448PMC
February 2019

Footprints of antigen processing boost MHC class II natural ligand predictions.

Genome Med 2018 11 16;10(1):84. Epub 2018 Nov 16.

Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, CP1650, San Martín, Argentina.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-018-0594-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240193PMC
November 2018

Mapping the MHC Class I-Spliced Immunopeptidome of Cancer Cells.

Cancer Immunol Res 2019 01 13;7(1):62-76. Epub 2018 Nov 13.

Centre for Inflammation Biology and Cancer Immunology (CIBCI) and Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0424DOI Listing
January 2019

The Immune Epitope Database (IEDB): 2018 update.

Nucleic Acids Res 2019 01;47(D1):D339-D343

La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/nar/gky1006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324067PMC
January 2019

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA.

Hum Immunol 2018 Dec 29;79(12):821-822. Epub 2018 Sep 29.

Division of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183077
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http://dx.doi.org/10.1016/j.humimm.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537871PMC
December 2018