Publications by authors named "Alessandro Poggi"

100Publications

Physical Characterization of Colorectal Cancer Spheroids and Evaluation of NK Cell Infiltration Through a Flow-Based Analysis.

Authors:
Azzurra Sargenti Francesco Musmeci Francesco Bacchi Cecilia Delprete Domenico Andrea Cristaldi Federica Cannas Simone Bonetti Simone Pasqua Daniele Gazzola Delfina Costa Federico Villa Maria Raffaella Zocchi Alessandro Poggi

Front Immunol 2020 23;11:564887. Epub 2020 Dec 23.

Molecular Oncology and Angiogenesis Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Genoa, Italy.

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December 2020

Three-Dimensional (3D) Culture Models in Cancer Investigation, Drug Testing and Immune Response Evaluation.

Authors:
Roberto Benelli Maria Raffaella Zocchi Alessandro Poggi

Int J Mol Sci 2020 Dec 25;22(1). Epub 2020 Dec 25.

Unit of MolecularOncology and Angiogenesis, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

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December 2020

Characterization of soluble PD-L1 in pleural effusions of mesothelioma patients: potential implications in the immune response and prognosis.

Authors:
Roberta Carosio Vincenzo Fontana Luca Mastracci Paola Ferro Federica Grillo Barbara Banelli Pier Aldo Canessa Paolo Dessanti Antonella Vigani Anna Morabito Ulrich Pfeffer Alessandro Poggi Silvio Roncella Maria Pia Pistillo

J Cancer Res Clin Oncol 2020 Nov 20. Epub 2020 Nov 20.

Tumor Epigenetics Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, 16132, Genoa, Italy.

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November 2020

Editorial: ADAM10 in Cancer Immunology and Autoimmunity: More Than a Simple Biochemical Scissor.

Authors:
Armando Rossello Alexander Steinle Alessandro Poggi Maria R Zocchi

Front Immunol 2020 16;11:1483. Epub 2020 Jul 16.

Division of Immunology Transplants and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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July 2020

Cancer Nanomedicine Special Issue Review Anticancer Drug Delivery with Nanoparticles: Extracellular Vesicles or Synthetic Nanobeads as Therapeutic Tools for Conventional Treatment or Immunotherapy.

Authors:
Maria Raffaella Zocchi Francesca Tosetti Roberto Benelli Alessandro Poggi

Cancers (Basel) 2020 Jul 13;12(7). Epub 2020 Jul 13.

Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

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July 2020

Checkpoint Inhibitors and Engineered Cells: New Weapons for Natural Killer Cell Arsenal Against Hematological Malignancies.

Authors:
Massimo Giuliani Alessandro Poggi

Cells 2020 06 29;9(7). Epub 2020 Jun 29.

Molecular Oncology and Angiogenesis Unit, IRCCS AOU San Martino IST, 16132 Genoa, Italy.

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June 2020

Aspartate β-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1α/GSK3β crosstalk.

Authors:
Paola Barboro Roberto Benelli Francesca Tosetti Delfina Costa Matteo Capaia Simonetta Astigiano Roberta Venè Alessandro Poggi Nicoletta Ferrari

Carcinogenesis 2020 Sep;41(9):1246-1252

Department of Scientific Direction, Molecular Oncology & Angiogenesis, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

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September 2020

Serum adiponectin levels are associated with presence of carotid plaque in women with systemic lupus erythematosus.

Authors:
Federico Carbone Fabrizio Montecucco Alessandro Poggi Flavio Nobili Fabio Cacciapaglia Antonella Afeltra Tiziano Moccetti Barbara M Colombo

Nutr Metab Cardiovasc Dis 2020 06 27;30(7):1147-1151. Epub 2020 Mar 27.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132 Genoa, Italy.

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June 2020

Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. , , 971.

Authors:
Roberto Benelli Delfina Costa Luca Mastracci Federica Grillo Mark Jon Olsen Paola Barboro Alessandro Poggi Nicoletta Ferrari

Cancers (Basel) 2020 05 13;12(5). Epub 2020 May 13.

SSD Oncologia Molecolare e Angiogenesi, IRCCS Ospedale Policlinico San Martino, largo Rosanna Benzi 10, 16132 Genova, Italy.

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May 2020

The Ovarian Cancer Tumor Immune Microenvironment (TIME) as Target for Therapy: A Focus on Innate Immunity Cells as Therapeutic Effectors.

Authors:
Denisa Baci Annalisa Bosi Matteo Gallazzi Manuela Rizzi Douglas M Noonan Alessandro Poggi Antonino Bruno Lorenzo Mortara

Int J Mol Sci 2020 Apr 28;21(9). Epub 2020 Apr 28.

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.

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April 2020

Phenotypic characterization of tumor CTLA-4 expression in melanoma tissues and its possible role in clinical response to Ipilimumab.

Authors:
Maria Pia Pistillo Roberta Carosio Federica Grillo Vincenzo Fontana Luca Mastracci Anna Morabito Barbara Banelli Enrica Tanda Federica Cecchi Beatrice Dozin Marina Gualco Sandra Salvi Francesco Spagnolo Alessandro Poggi Paola Queirolo

Clin Immunol 2020 Jun 25;215:108428. Epub 2020 Apr 25.

IEO, Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, European Institute of Oncology IRCCS, Milan, Italy.

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June 2020

Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer.

Authors:
Roberto Benelli Delfina Costa Luca Mastracci Federica Grillo Mark Jon Olsen Paola Barboro Alessandro Poggi Nicoletta Ferrari

Cancers (Basel) 2020 Apr 14;12(4). Epub 2020 Apr 14.

SSD Oncologia Molecolare e Angiogenesi, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.

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April 2020

Evaluation of Glycosylated PTGS2 in Colorectal Cancer for NSAIDS-Based Adjuvant Therapy.

Authors:
Roberta Venè Delfina Costa Raffaella Augugliaro Sebastiano Carlone Stefano Scabini Gianmaria Casoni Pattacini Maurizio Boggio Simonetta Zupo Federica Grillo Luca Mastracci Francesca Pitto Simona Minghelli Nicoletta Ferrari Francesca Tosetti Emanuele Romairone Maria C Mingari Alessandro Poggi Roberto Benelli

Cells 2020 03 11;9(3). Epub 2020 Mar 11.

OU Immunology, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy.

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March 2020

Characterisation of innate lymphoid cell subsets infiltrating colorectal carcinoma.

Authors:
Paolo Carrega Paola Orecchia Linda Quatrini Nicola Tumino Roberta Venè Roberto Benelli Alessandro Poggi Stefano Scabini Maria Cristina Mingari Lorenzo Moretta Paola Vacca

Gut 2020 Dec 5;69(12):2261-2263. Epub 2020 Mar 5.

Immunology Area, Bambino Gesu Pediatric Hospital, Roma, Lazio, Italy.

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December 2020

Response to ipilimumab therapy in metastatic melanoma patients: potential relevance of CTLA-4 tumor infiltrating lymphocytes and their in situ localization.

Authors:
Luca Mastracci Vincenzo Fontana Paola Queirolo Roberta Carosio Federica Grillo Anna Morabito Barbara Banelli Enrica Tanda Andrea Boutros Beatrice Dozin Marina Gualco Sandra Salvi Massimo Romani Francesco Spagnolo Alessandro Poggi Maria Pia Pistillo

Cancer Immunol Immunother 2020 Apr 5;69(4):653-662. Epub 2020 Feb 5.

Tumor Epigenetics Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, 16132, Genoa, Italy.

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April 2020

Nanoformulated Zoledronic Acid Boosts the Vδ2 T Cell Immunotherapeutic Potential in Colorectal Cancer.

Authors:
Daniele Di Mascolo Serena Varesano Roberto Benelli Hilaria Mollica Annalisa Salis Maria Raffaella Zocchi Paolo Decuzzi Alessandro Poggi

Cancers (Basel) 2019 Dec 31;12(1). Epub 2019 Dec 31.

Molecular Oncology and Angiogenesis Unit, IRCCS Policlinico San Martino, 16132 Genoa, Italy.

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December 2019

Multifocal Signal Modulation Therapy by Celecoxib: A Strategy for Managing Castration-Resistant Prostate Cancer.

Authors:
Roberto Benelli Paola Barboro Delfina Costa Simonetta Astigiano Ottavia Barbieri Matteo Capaia Alessandro Poggi Nicoletta Ferrari

Int J Mol Sci 2019 Dec 3;20(23). Epub 2019 Dec 3.

Molecular Oncology & Angiogenesis, IRCCS Ospedale Policlinico San Martino, L.go R. Benzi 10, 16132 Genova, Italy.

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December 2019

IFN-γ upregulates membranous and soluble PD-L1 in mesothelioma cells: potential implications for the clinical response to PD-1/PD-L1 blockade.

Authors:
Maria Pia Pistillo Roberta Carosio Barbara Banelli Anna Morabito Luca Mastracci Paola Ferro Serena Varesano Roberta Venè Alessandro Poggi Silvio Roncella

Cell Mol Immunol 2020 04 19;17(4):410-411. Epub 2019 Jun 19.

AIL, Associazione italiana contro le leucemie, linfomi e mieloma, 19121 La Spezia, Italy.

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April 2020

Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells.

Authors:
Abril Saint-Martin Jacobo Martínez-Ríos M Cristina Castañeda-Patlán Miguel Angel Sarabia-Sánchez Nydia Tejeda-Muñoz Alberto Chinney-Herrera Gloria Soldevila Roberto Benelli Paula Santoyo-Ramos Alessandro Poggi Martha Robles-Flores

Cancers (Basel) 2019 May 30;11(6). Epub 2019 May 30.

Department of Biochemistry, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.

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May 2019

Human Gut-Associated Natural Killer Cells in Health and Disease.

Authors:
Alessandro Poggi Roberto Benelli Roberta Venè Delfina Costa Nicoletta Ferrari Francesca Tosetti Maria Raffaella Zocchi

Front Immunol 2019 3;10:961. Epub 2019 May 3.

Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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October 2020

Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects.

Authors:
Barbara Bassani Denisa Baci Matteo Gallazzi Alessandro Poggi Antonino Bruno Lorenzo Mortara

Cancers (Basel) 2019 Apr 1;11(4). Epub 2019 Apr 1.

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, Via Monte Generoso, n. 71, 21100 Varese, Italy.

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April 2019

Serum osteopontin negatively impacts on intima-media thickness in patients with systemic lupus erythematosus.

Authors:
Federico Carbone Franco Dallegri Fabrizio Montecucco Alessandro Poggi Flavio Mariano Nobili Fabio Cacciapaglia Antonella Afeltra Tiziano Moccetti Barbara M Colombo

Eur J Clin Invest 2019 May 3;49(5):e13089. Epub 2019 Mar 3.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascolar Network, Genoa, Italy.

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May 2019

Anti-cancer Therapies Employing IL-2 Cytokine Tumor Targeting: Contribution of Innate, Adaptive and Immunosuppressive Cells in the Anti-tumor Efficacy.

Authors:
Lorenzo Mortara Enrica Balza Antonino Bruno Alessandro Poggi Paola Orecchia Barbara Carnemolla

Front Immunol 2018 18;9:2905. Epub 2018 Dec 18.

UOC Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

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November 2019

Design and Synthesis of Ionic Liquid-Based Matrix Metalloproteinase Inhibitors (MMPIs): A Simple Approach to Increase Hydrophilicity and to Develop MMPI-Coated Gold Nanoparticles.

Authors:
Felicia D'Andrea Elisa Nuti Stefano Becherini Doretta Cuffaro Elena Husanu Caterina Camodeca Elena De Vita Maria Raffaella Zocchi Alessandro Poggi Cristina D'Arrigo Valentina Cappello Mauro Gemmi Susanna Nencetti Cinzia Chiappe Armando Rossello

ChemMedChem 2019 03 14;14(6):686-698. Epub 2019 Feb 14.

Department of Pharmacy, University of Pisa, via Bonanno 6/33, 56126, Pisa, Italy.

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March 2019

Immunomodulatory Properties of Mesenchymal Stromal Cells: Still Unresolved "Yin and Yang".

Authors:
Alessandro Poggi Maria R Zocchi

Curr Stem Cell Res Ther 2019 ;14(4):344-350

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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November 2019

Tumor Vasculature Targeted TNFα Therapy: Reversion of Microenvironment Anergy and Enhancement of the Anti-tumor Efficiency.

Authors:
Enrica Balza Barbara Carnemolla Paola Orecchia Anna Rubartelli Alessandro Poggi Lorenzo Mortara

Curr Med Chem 2020 ;27(25):4233-4248

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences (DBSV), University of Insubria, Via Monte Generoso, n. 71, 21100 Varese, Italy.

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September 2020

Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes.

Authors:
Caterina Camodeca Elisa Nuti Francesca Tosetti Alessandro Poggi Cristina D'Arrigo Maria Raffaella Zocchi Armando Rossello

ChemMedChem 2018 10 12;13(19):2119-2131. Epub 2018 Sep 12.

Department of Pharmacy, University of Pisa, via Bonanno 6, 56126, Pisa, Italy.

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October 2018

Corrigendum: Zoledronate Triggers Vδ2 T Cells to Destroy and Kill Spheroids of Colon Carcinoma: Quantitative Image Analysis of Three-Dimensional Cultures.

Authors:
Serena Varesano Maria Raffaella Zocchi Alessandro Poggi

Front Immunol 2018 13;9:1343. Epub 2018 Jun 13.

Molecular Oncology and Angiogenesis Unit, Ospedale Policlinico San Martino, Genoa, Italy.

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June 2018

Corrigendum: How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive.

Authors:
Alessandro Poggi Serena Varesano Maria Raffaella Zocchi

Front Immunol 2018 11;9:1342. Epub 2018 Jun 11.

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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June 2018

Targeting the Epidermal Growth Factor Receptor Can Counteract the Inhibition of Natural Killer Cell Function Exerted by Colorectal Tumor-Associated Fibroblasts.

Authors:
Delfina Costa Roberta Venè Roberto Benelli Emanuele Romairone Stefano Scabini Silvia Catellani Barbara Rebesco Luca Mastracci Federica Grillo Simona Minghelli Fabrizio Loiacono Maria Raffaella Zocchi Alessandro Poggi

Front Immunol 2018 29;9:1150. Epub 2018 May 29.

Molecular Oncology and Angiogenesis Unit, Ospedale Policlinico San Martino, Genoa, Italy.

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July 2019

Zoledronate Triggers Vδ2 T Cells to Destroy and Kill Spheroids of Colon Carcinoma: Quantitative Image Analysis of Three-Dimensional Cultures.

Authors:
Serena Varesano Maria Raffaella Zocchi Alessandro Poggi

Front Immunol 2018 8;9:998. Epub 2018 May 8.

Molecular Oncology and Angiogenesis Unit, Ospedale Policlinico San Martino, Genoa, Italy.

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July 2019

Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells.

Authors:
Francesca Tosetti Roberta Venè Caterina Camodeca Elisa Nuti Armando Rossello Cristina D'Arrigo Denise Galante Nicoletta Ferrari Alessandro Poggi Maria Raffaella Zocchi

Oncoimmunology 2018;7(5):e1421889. Epub 2018 Jan 19.

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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January 2018

How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive.

Authors:
Alessandro Poggi Serena Varesano Maria Raffaella Zocchi

Front Immunol 2018 19;9:262. Epub 2018 Feb 19.

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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April 2019

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.

Authors:
Patrizia Damonte Giovanna Sociali Marco Daniele Parenti Debora Soncini Inga Bauer Silvia Boero Alessia Grozio Maria von Holtey Francesco Piacente Pamela Becherini Roberta Sanguineti Annalisa Salis Gianluca Damonte Michele Cea Maximilien Murone Alessandro Poggi Alessio Nencioni Alberto Del Rio Santina Bruzzone

Bioorg Med Chem 2017 10 19;25(20):5849-5858. Epub 2017 Sep 19.

Department of Experimental Medicine, Section of Biochemistry, University of Genoa, V.le Benedetto XV 1, 16132 Genoa, Italy; CEBR, University of Genova, V.le Benedetto XV, 7, 16132 Genoa, Italy. Electronic address:

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October 2017

The ErbB family and androgen receptor signaling are targets of Celecoxib in prostate cancer.

Authors:
Antonella Brizzolara Roberto Benelli Roberta Venè Paola Barboro Alessandro Poggi Francesca Tosetti Nicoletta Ferrari

Cancer Lett 2017 08 25;400:9-17. Epub 2017 Apr 25.

Molecular Oncology & Angiogenesis, IRCCS AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, 16132 Genoa, Italy. Electronic address:

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August 2017

Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity.

Authors:
Maria Raffaella Zocchi Delfina Costa Roberta Venè Francesca Tosetti Nicoletta Ferrari Simona Minghelli Roberto Benelli Stefano Scabini Emanuele Romairone Silvia Catellani Aldo Profumo Alessandro Poggi

Oncoimmunology 2017;6(3):e1278099. Epub 2017 Jan 6.

Molecular Oncology and Angiogenesis, IRCCS AOU San Martino-IST , Genoa, Italy.

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January 2017

The therapeutic T-cell response induced by tumor delivery of TNF and melphalan is dependent on early triggering of natural killer and dendritic cells.

Authors:
Enrica Balza Silvia Zanellato Alessandro Poggi Daniele Reverberi Anna Rubartelli Lorenzo Mortara

Eur J Immunol 2017 04 6;47(4):743-753. Epub 2017 Mar 6.

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

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April 2017

Effects on Energy Metabolism of Two Guanidine Molecules, (Boc) -Creatine and Metformin.

Authors:
Patrizia Garbati Silvia Ravera Sonia Scarfì Annalisa Salis Camillo Rosano Alessandro Poggi Gianluca Damonte Enrico Millo Maurizio Balestrino

J Cell Biochem 2017 09 13;118(9):2700-2711. Epub 2017 Feb 13.

Department of Neuroscience, Ophthalmology, Genetics, Maternal-Infantile Sciences, University of Genova, Largo Paolo Daneo 3, Genova 16132, Italy.

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September 2017

The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells.

Authors:
Ilaria Penna Arianna Gigoni Delfina Costa Serena Vella Debora Russo Alessandro Poggi Federico Villa Antonella Brizzolara Claudio Canale Andrea Mescola Antonio Daga Claudio Russo Mario Nizzari Tullio Florio Paola Menichini Aldo Pagano

Oncotarget 2017 Jan;8(5):8189-8205

Department of Experimental Medicine (DIMES), University of Genova, Genova, Italy.

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January 2017

Allogeneic platelet-rich plasma affects monocyte differentiation to dendritic cells causing an anti-inflammatory microenvironment, putatively fostering wound healing.

Authors:
Andrea Papait Ranieri Cancedda Maddalena Mastrogiacomo Alessandro Poggi

J Tissue Eng Regen Med 2018 01 11;12(1):30-43. Epub 2017 May 11.

Unit of Molecular Oncology and Angiogenesis, IRCCS San Martino Hospital-IST- National Institute for Cancer Research, Genoa, Italy.

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January 2018

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment.

Authors:
Alessandro Poggi Massimo Giuliani

Vaccines (Basel) 2016 Nov 8;4(4). Epub 2016 Nov 8.

Laboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, Luxembourg City L-1526, Luxembourg.

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November 2016

Human Articular Chondrocytes Regulate Immune Response by Affecting Directly T Cell Proliferation and Indirectly Inhibiting Monocyte Differentiation to Professional Antigen-Presenting Cells.

Authors:
Rui C Pereira Daniela Martinelli Ranieri Cancedda Chiara Gentili Alessandro Poggi

Front Immunol 2016 24;7:415. Epub 2016 Oct 24.

Molecular Oncology and Angiogenesis Unit, Department of Integrated Oncological Therapies, IRCCS AOU San Martino IST , Genova , Italy.

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October 2016

ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing.

Authors:
Maria Raffaella Zocchi Caterina Camodeca Elisa Nuti Armando Rossello Roberta Venè Francesca Tosetti Irene Dapino Delfina Costa Alessandra Musso Alessandro Poggi

Oncoimmunology 2016 May 29;5(5):e1123367. Epub 2015 Dec 29.

Unit of Molecular Oncology and Angiogenesis, IRCCS AOU San Martino-IST , Genoa, Italy.

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May 2016

CTLA-4 in mesothelioma patients: tissue expression, body fluid levels and possible relevance as a prognostic factor.

Authors:
Silvio Roncella Stefania Laurent Vincenzo Fontana Paola Ferro Maria Cristiana Franceschini Sandra Salvi Serena Varesano Simona Boccardo Antonella Vigani Anna Morabito Pier Aldo Canessa Ugo Giannoni Ilan Rosenberg Alessandro Valentino Franco Fedeli Domenico Franco Merlo Marcello Ceppi Salvatore Riggio Massimo Romani Daniele Saverino Alessandro Poggi Maria Pia Pistillo

Cancer Immunol Immunother 2016 08 20;65(8):909-17. Epub 2016 May 20.

Unit of Tumor Epigenetics, IRCCS AOU San Martino-IST, Genoa, Italy.

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August 2016

Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.

Authors:
Caterina Camodeca Elisa Nuti Livia Tepshi Silvia Boero Tiziano Tuccinardi Enrico A Stura Alessandro Poggi Maria Raffaella Zocchi Armando Rossello

Eur J Med Chem 2016 Mar 29;111:193-201. Epub 2016 Jan 29.

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address:

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March 2016

Erratum to: Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines.

Authors:
Silvia Boero Anna Morabito Barbara Banelli Barbara Cardinali Beatrice Dozin Gianluigi Lunardi Patrizia Piccioli Sonia Lastraioli Roberta Carosio Sandra Salvi Alessia Levaggi Francesca Poggio Alessia D'Alonzo Massimo Romani Lucia Del Mastro Alessandro Poggi Maria Pia Pistillo

J Transl Med 2016 Jan 22;14:24. Epub 2016 Jan 22.

Unit of Tumor Epigenetics, IRCCS AOU San Martino-IST, Genoa, Italy.

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January 2016

Sirt6 regulates dendritic cell differentiation, maturation, and function.

Authors:
Denise Lasigliè Silvia Boero Inga Bauer Sara Morando Patrizia Damonte Michele Cea Fiammetta Monacelli Patrizio Odetti Alberto Ballestrero Antonio Uccelli Raul Mostoslavsky Alessandro Poggi Alessio Nencioni

Aging (Albany NY) 2016 Jan;8(1):34-49

Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

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January 2016

Combined platelet and plasma derivatives enhance proliferation of stem/progenitor cells maintaining their differentiation potential.

Authors:
Anita Muraglia Maria Rosa Todeschi Andrea Papait Alessandro Poggi Raffaele Spanò Paolo Strada Ranieri Cancedda Maddalena Mastrogiacomo

Cytotherapy 2015 Dec;17(12):1793-806

DIMES, University of Genoa, Genoa, Italy; IRCCS AOU San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. Electronic address:

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December 2015

Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines.

Authors:
Silvia Boero Anna Morabito Barbara Banelli Barbara Cardinali Beatrice Dozin Gianluigi Lunardi Patrizia Piccioli Sonia Lastraioli Roberta Carosio Sandra Salvi Alessia Levaggi Francesca Poggio Alessia D'Alonzo Massimo Romani Lucia Del Mastro Alessandro Poggi Maria Pia Pistillo

J Transl Med 2015 Oct 8;13:324. Epub 2015 Oct 8.

Unit of Tumor Epigenetics, IRCCS AOU San Martino-IST, Genoa, Italy.

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October 2015

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.

Authors:
Giovanna Sociali Lauretta Galeno Marco Daniele Parenti Alessia Grozio Inga Bauer Mario Passalacqua Silvia Boero Alessandra Donadini Enrico Millo Marta Bellotti Laura Sturla Patrizia Damonte Alessandra Puddu Claudia Ferroni Greta Varchi Claudio Franceschi Alberto Ballestrero Alessandro Poggi Santina Bruzzone Alessio Nencioni Alberto Del Rio

Eur J Med Chem 2015 Sep 14;102:530-9. Epub 2015 Aug 14.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy; Institute of Organic Synthesis and Photoreactivity (ISOF), National Research Council (CNR), Via P. Gobetti 101, 40129 Bologna, Italy. Electronic address:

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September 2015

Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation.

Authors:
Roberta Venè Francesca Tosetti Simona Minghelli Alessandro Poggi Nicoletta Ferrari Roberto Benelli

Oncotarget 2015 May;6(14):12310-25

Immunology Lab, IRCCS AOU San Martino - IST, Genoa, Italy.

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May 2015

Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response.

Authors:
Fabrizio Montecucco Sébastien Lenglet Federico Carbone Silvia Boero Graziano Pelli Fabienne Burger Aline Roth Maria Bertolotto Alessio Nencioni Michele Cea Franco Dallegri Rodrigo A Fraga-Silva Laëtitia Fougère Claire Elfakir Anne-Laure Gassner Serge Rudaz Xavier Parissaux Daniel Wils Marc Salomé Nicolas Vuilleumier Alessandro Poggi François Mach

Vascul Pharmacol 2015 Sep 25;72:197-208. Epub 2015 Apr 25.

Division of Cardiology, Foundation for Medical Researches, Department of Medical Specialties, University of Geneva, 64 avenue de la Roseraie, 1211 Geneva, Switzerland.

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September 2015

Mesenchymal stromal cells as regulators of anti-tumour immune response.

Authors:
Alessandro Poggi M R Zocchi

Indian J Med Res 2015 Feb;141(2):139-42

Molecular Oncology & Angiogenesis Unit, IRCCS AOU San Martino IST, 16132 Genoa, Italy.

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February 2015

γδ T Lymphocytes as a First Line of Immune Defense: Old and New Ways of Antigen Recognition and Implications for Cancer Immunotherapy.

Authors:
Alessandro Poggi Maria Raffaella Zocchi

Front Immunol 2014 11;5:575. Epub 2014 Nov 11.

Division of Immunology, Transplants and Infectious Diseases, IRCCS San Raffaele , Milan , Italy.

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November 2014

Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity.

Authors:
Debora Soncini Irene Caffa Gabriele Zoppoli Michele Cea Antonia Cagnetta Mario Passalacqua Luca Mastracci Silvia Boero Fabrizio Montecucco Giovanna Sociali Denise Lasigliè Patrizia Damonte Alessia Grozio Elena Mannino Alessandro Poggi Vito G D'Agostino Fiammetta Monacelli Alessandro Provenzani Patrizio Odetti Alberto Ballestrero Santina Bruzzone Alessio Nencioni

J Biol Chem 2014 Dec 20;289(49):34189-204. Epub 2014 Oct 20.

From the Department of Internal Medicine, the Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-Istituto Scientifico Tumori, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy,

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December 2014

Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.

Authors:
Roberta Venè Barbara Cardinali Giuseppe Arena Nicoletta Ferrari Roberto Benelli Simona Minghelli Alessandro Poggi Douglas M Noonan Adriana Albini Francesca Tosetti

Neoplasia 2014 Sep;16(9):710-22

IRCCS Azienda Ospedaliera Universitaria S. Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genova 16132, Italy. Electronic address:

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September 2014

Bacterial adhesion to poly-(D,L)lactic acid blended with vitamin E: toward gentle anti-infective biomaterials.

Authors:
Davide Campoccia Livia Visai Filippo Renò Ilaria Cangini Manuela Rizzi Alessandro Poggi Lucio Montanaro Lia Rimondini Carla Renata Arciola

J Biomed Mater Res A 2015 Apr 4;103(4):1447-58. Epub 2014 Aug 4.

Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy.

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April 2015

Mechanisms of tumor escape from immune system: role of mesenchymal stromal cells.

Authors:
Alessandro Poggi Alessandra Musso Irene Dapino Maria Raffaella Zocchi

Immunol Lett 2014 May-Jun;159(1-2):55-72. Epub 2014 Mar 20.

Division of Immunology, Transplants and Infectious Diseases, Istituto Scientifico San Raffaele Milan, 20132 Milan, Italy.

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December 2014

NK cell autoreactivity and autoimmune diseases.

Authors:
Alessandro Poggi Maria Raffaella Zocchi

Front Immunol 2014 4;5:27. Epub 2014 Feb 4.

Division of Immunology, Transplants and Infectious Diseases, Scientific Institute San Raffaele , Milan , Italy.

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June 2014

How to exploit stress-related immunity against Hodgkin's lymphoma: Targeting ERp5 and ADAM sheddases.

Authors:
Alessandro Poggi Maria Raffaella Zocchi

Oncoimmunology 2013 Dec 5;2(12):e27089. Epub 2013 Dec 5.

Division of Immunology, Transplants, and Infectious Diseases; IRCCS San Raffaele; Milan, Italy.

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December 2013

Accelerated repair and reduced mutagenicity of DNA damage induced by cigarette smoke in human bronchial cells transfected with E.coli formamidopyrimidine DNA glycosylase.

Authors:
Mara Foresta Alberto Izzotti Sebastiano La Maestra Rosanna Micale Alessandro Poggi Donatella Vecchio Guido Frosina

PLoS One 2014 31;9(1):e87984. Epub 2014 Jan 31.

Mutagenesis Unit, IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

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October 2014

Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019.

Authors:
Donatella Vecchio Antonio Daga Elisa Carra Daniela Marubbi Gabriella Baio Carlo E Neumaier Stefano Vagge Renzo Corvò Maria Pia Brisigotti Jean Louis Ravetti Annalisa Zunino Alessandro Poggi Samantha Mascelli Alessandro Raso Guido Frosina

Int J Cancer 2014 Jul 8;135(2):479-91. Epub 2014 Jan 8.

Mutagenesis Unit, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

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July 2014

Stress immunity in lymphomas: mesenchymal cells as a target of therapy.

Authors:
Alessandro Poggi Maria Raffaella Zocchi

Front Biosci (Landmark Ed) 2014 Jan 1;19:281-90. Epub 2014 Jan 1.

Division of Immunology, Transplants and Infectious Diseases, IRCCS San Raffaele, I-20132 Milan.

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January 2014

Antibiofilm activity of a monolayer of silver nanoparticles anchored to an amino-silanized glass surface.

Authors:
Angelo Taglietti Carla Renata Arciola Agnese D'Agostino Giacomo Dacarro Lucio Montanaro Davide Campoccia Lucia Cucca Marco Vercellino Alessandro Poggi Piersandro Pallavicini Livia Visai

Biomaterials 2014 Feb 7;35(6):1779-88. Epub 2013 Dec 7.

Center for Tissue Engineering (C.I.T.), Department of Molecular Medicine, INSTM UdR of Pavia, University of Pavia, Pavia, Italy; Nanotechnology Laboratory, Department of Occupational Medicine, Ergonomy and Disability, Salvatore Maugeri Foundation, IRCCS, Pavia, Italy.

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February 2014

The effect of preoperative chemoradiotherapy on lymph nodes harvested in TME for rectal cancer.

Authors:
Stefano Scabini Fabrizio Montecucco Alessio Nencioni Gabriele Zoppoli Marina Sartini Edoardo Rimini Andrea Massobrio Luisito De Marini Alessandro Poggi Roberto Boaretto Emanuele Romairone Alberto Ballestrero Valter Ferrando

World J Surg Oncol 2013 Nov 18;11:292. Epub 2013 Nov 18.

Oncologic Surgery and Implantable Systems Unit, Department of Emergency, IRCCS San Martino IST, Genoa, Italy.

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November 2013

Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ 2 T lymphocytes in non-Hodgkin lymphomas.

Authors:
Alessandra Musso Silvia Catellani Paolo Canevali Sara Tavella Roberta Venè Silvia Boero Ivana Pierri Marco Gobbi Annalisa Kunkl Jean-Louis Ravetti Maria Raffaella Zocchi Alessandro Poggi

Haematologica 2014 Jan 25;99(1):131-9. Epub 2013 Oct 25.

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January 2014

Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by Gefitinib and Cetuximab triggered antibody-dependent cellular cytotoxicity.

Authors:
Adriana Amaro Valentina Mirisola Giovanna Angelini Alessandra Musso Francesca Tosetti Alessia I Esposito Patrizia Perri Francesco Lanza Francesca Nasciuti Carlo Mosci Roberto Puzone Sandra Salvi Mauro Truini Alessandro Poggi Ulrich Pfeffer

Eur J Cancer 2013 Oct 9;49(15):3353-65. Epub 2013 Jul 9.

Integrated Molecular Pathology, IRCCS A.O.U. San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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October 2013

Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells.

Authors:
Alessandro Poggi Silvia Boero Alessandra Musso Maria Raffaella Zocchi

PLoS One 2013 7;8(5):e62932. Epub 2013 May 7.

Molecular Oncology and Angiogenesis Unit, IRCCS AOU San Martino - IST National Institute for Cancer Research, Genoa, Italy.

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December 2013

The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-α production.

Authors:
Stefania Laurent Paola Queirolo Silvia Boero Sandra Salvi Patrizia Piccioli Simona Boccardo Simona Minghelli Anna Morabito Vincenzo Fontana Gabriella Pietra Paolo Carrega Nicoletta Ferrari Francesca Tosetti Lung-Ji Chang Maria Cristina Mingari Guido Ferlazzo Alessandro Poggi Maria Pia Pistillo

J Transl Med 2013 May 1;11:108. Epub 2013 May 1.

Department of Internal Medicine, University of Genoa, Genoa, Italy.

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May 2013

A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing.

Authors:
Ilaria Penna Irene Vassallo Mario Nizzari Debora Russo Delfina Costa Paola Menichini Alessandro Poggi Claudio Russo Giorgio Dieci Tullio Florio Ranieri Cancedda Aldo Pagano

Biochim Biophys Acta 2013 Jun 26;1833(6):1511-26. Epub 2013 Feb 26.

Dept. of Experimental Medicine, University of Genova, Genova, Italy.

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June 2013

The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.

Authors:
Inga Bauer Alessia Grozio Denise Lasigliè Giovanna Basile Laura Sturla Mirko Magnone Giovanna Sociali Debora Soncini Irene Caffa Alessandro Poggi Gabriele Zoppoli Michele Cea Georg Feldmann Raul Mostoslavsky Alberto Ballestrero Franco Patrone Santina Bruzzone Alessio Nencioni

J Biol Chem 2012 Nov 18;287(49):40924-37. Epub 2012 Oct 18.

Department of Internal Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy.

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November 2012

Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment.

Authors:
Alessandro Poggi Maria Raffaella Zocchi

Oncoimmunology 2012 Mar;1(2):214-216

Unit of Molecular Oncology and Angiogenesis; San Martino Hospital-National Institute for Cancer Research; University of Genoa; Genoa, Italy.

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March 2012

NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes.

Authors:
Mirko Magnone Inga Bauer Alessandro Poggi Elena Mannino Laura Sturla Marisa Brini Elena Zocchi Antonio De Flora Alessio Nencioni Santina Bruzzone

J Biol Chem 2012 Jun 30;287(25):21067-81. Epub 2012 Apr 30.

Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy.

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June 2012

Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction.

Authors:
Fabrizio Montecucco Inga Bauer Vincent Braunersreuther Santina Bruzzone Alexander Akhmedov Thomas F Lüscher Timo Speer Alessandro Poggi Elena Mannino Graziano Pelli Katia Galan Maria Bertolotto Sébastien Lenglet Anna Garuti Christophe Montessuit René Lerch Corinne Pellieux Nicolas Vuilleumier Franco Dallegri Jacqueline Mage Carlos Sebastian Raul Mostoslavsky Angèle Gayet-Ageron Franco Patrone François Mach Alessio Nencioni

Antioxid Redox Signal 2013 Feb 14;18(6):630-41. Epub 2012 May 14.

Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.

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February 2013

The -346T polymorphism of the SH2D1A gene is a risk factor for development of autoimmunity/lymphoproliferation in males with defective Fas function.

Authors:
Elena Boggio Matteo Melensi Sara Bocca Annalisa Chiocchetti Cristoforo Comi Nausicaa Clemente Elisabetta Orilieri Maria Felicia Soluri Sandra D'Alfonso Rosella Mechelli Giovanna Gentile Alessandro Poggi Marco Salvetti Ugo Ramenghi Umberto Dianzani

Hum Immunol 2012 May 7;73(5):585-92. Epub 2012 Mar 7.

Interdisciplinary Research Center of Autoimmune Diseases (IRCAD) and Department of Health Sciences, A. Avogadro, University of Eastern Piedmont, Novara, Italy.

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May 2012

Defective expression and function of the leukocyte associated Ig-like receptor 1 in B lymphocytes from systemic lupus erythematosus patients.

Authors:
Barbara M Colombo Paolo Canevali Ottavia Magnani Edoardo Rossi Francesco Puppo Maria Raffaella Zocchi Alessandro Poggi

PLoS One 2012 15;7(2):e31903. Epub 2012 Feb 15.

Department of Internal Medicine, University of Genoa, Genoa, Italy.

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June 2012

Higher frequencies of CD161+ circulating T lymphocytes in allergic rhinitis patients compared to healthy donors.

Authors:
Alessandro Poggi Paolo Canevali Miriam Contatore Giorgio Ciprandi

Int Arch Allergy Immunol 2012 25;158(2):151-6. Epub 2012 Jan 25.

Molecular Oncology and Angiogenesis Unit, National Institute for Cancer Research, Genoa, Italy.

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August 2012

Characterization of glioma stem cells through multiple stem cell markers and their specific sensitization to double-strand break-inducing agents by pharmacological inhibition of ataxia telangiectasia mutated protein.

Authors:
Alessandro Raso Donatella Vecchio Enrico Cappelli Monica Ropolo Alessandro Poggi Paolo Nozza Roberto Biassoni Samantha Mascelli Valeria Capra Fotios Kalfas Paolo Severi Guido Frosina

Brain Pathol 2012 Sep 21;22(5):677-88. Epub 2012 Feb 21.

Neurosurgery Unit, Istituto Giannina Gaslini, Genova, Italy.

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September 2012

Targeting the microenvironment in hematological malignancies: how to condition both stromal and effector cells to overcome cancer spreading.

Authors:
Maria Raffaella Zocchi Alessandro Poggi

Curr Med Chem 2011 ;18(34):5172-3

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June 2012

High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.

Authors:
Maria Raffaella Zocchi Silvia Catellani Paolo Canevali Sara Tavella Anna Garuti Barbara Villaggio Annalisa Zunino Marco Gobbi Giulio Fraternali-Orcioni Annalisa Kunkl Jean-Louis Ravetti Silvia Boero Alessandra Musso Alessandro Poggi

Blood 2012 Feb 13;119(6):1479-89. Epub 2011 Dec 13.

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.

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February 2012

Extracellular DNA in biofilms.

Authors:
Lucio Montanaro Alessandro Poggi Livia Visai Stefano Ravaioli Davide Campoccia Pietro Speziale Carla Renata Arciola

Int J Artif Organs 2011 Sep;34(9):824-31

Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy.

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September 2011

Internalization by osteoblasts of two Staphylococcus aureus clinical isolates differing in their adhesin gene pattern.

Authors:
Francesca Testoni Lucio Montanaro Alessandro Poggi Livia Visai Davide Campoccia Carla Renata Arciola

Int J Artif Organs 2011 Sep;34(9):789-98

Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy.

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September 2011

Emerging pathogenetic mechanisms of the implant-related osteomyelitis by Staphylococcus aureus.

Authors:
Lucio Montanaro Francesca Testoni Alessandro Poggi Livia Visai Pietro Speziale Carla Renata Arciola

Int J Artif Organs 2011 Sep;34(9):781-8

Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy.

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September 2011

Imatinib treatment induces CD5+ B lymphocytes and IgM natural antibodies with anti-leukemic reactivity in patients with chronic myelogenous leukemia.

Authors:
Silvia Catellani Ivana Pierri Marco Gobbi Alessandro Poggi Maria Raffaella Zocchi

PLoS One 2011 Apr 18;6(4):e18925. Epub 2011 Apr 18.

Clinical Oncohaematology, Department of Internal Medicine, University of Genoa, Genoa, Italy.

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April 2011

Recruitment of host's progenitor cells to sites of human amniotic fluid stem cells implantation.

Authors:
Teodelinda Mirabella Alessandro Poggi Monica Scaranari Massimo Mogni Mario Lituania Chiara Baldo Ranieri Cancedda Chiara Gentili

Biomaterials 2011 Jun 2;32(18):4218-27. Epub 2011 Apr 2.

Department of Oncology, Biology, and Genetics, University of Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy.

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June 2011

Defective resolution of pH2AX foci and enhanced DNA breakage in ionizing radiation-treated cockayne syndrome B cells.

Authors:
Monica Ropolo Enrico Cappelli Mara Foresta Alessandro Poggi Luca Proietti-De-Santis Guido Frosina

IUBMB Life 2011 Apr 24;63(4):272-6. Epub 2011 Mar 24.

Laboratory of Molecular Mutagenesis and DNA Repair, Department of Epidemiology, Prevention and Special Functions, Istituto Nazionale Ricerca Cancro, Genova, Italy.

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April 2011

Down regulation of human natural killer cell-mediated cytolysis induced by blood transfusion: role of transforming growth factor-β(1), soluble Fas ligand, and soluble Class I human leukocyte antigen.

Authors:
Massimo Ghio Paola Contini Simone Negrini Clemente Mazzei Maria R Zocchi Alessandro Poggi

Transfusion 2011 Jul 7;51(7):1567-73. Epub 2011 Jan 7.

Laboratory of Clinical Immunology, Azienda Ospedaliera Universitaria San Martino-DIMI, Genoa, Italy.

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July 2011

Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival.

Authors:
Alessandra Musso Maria Raffaella Zocchi Alessandro Poggi

Haematologica 2011 Jan 30;96(1):16-23. Epub 2010 Sep 30.

Molecular Oncology and Angiogenesis, Department of Translational Oncology, National Institute for Cancer Research Genoa, Genoa, Italy.

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January 2011

Differential survival of γδT cells, αβT cells and NK cells upon engagement of NKG2D by NKG2DL-expressing leukemic cells.

Authors:
Alessandro Poggi Marta Zancolli Silvia Boero Silvia Catellani Alessandra Musso Maria Raffaella Zocchi

Int J Cancer 2011 Jul 3;129(2):387-96. Epub 2010 Nov 3.

Unit of Molecular Oncology and Angiogenesis, National Institute for Cancer Research, I-16132 Genoa.

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July 2011

Engagement of CD31 delivers an activating signal that contributes to the survival of chronic lymphocytic leukaemia cells.

Authors:
Alessandro Poggi Claudia Prevosto Silvia Catellani Ilaria Rocco Anna Garuti Maria R Zocchi

Br J Haematol 2010 Nov 31;151(3):252-64. Epub 2010 Aug 31.

Laboratory of Molecular Oncology and Angiogenesis, National Institute for Cancer Research, University of Genoa, Italy.

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November 2010

Defective repair of 5-hydroxy-2'-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III.

Authors:
Mara Foresta Monica Ropolo Paolo Degan Ilaria Pettinati Yoke W Kow Gianluca Damonte Alessandro Poggi Guido Frosina

Free Radic Biol Med 2010 Mar 21;48(5):681-90. Epub 2009 Dec 21.

Molecular Mutagenesis and DNA Repair, Istituto Nazionale Ricerca Cancro, 16132 Genova, Italy.

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March 2010

Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

Authors:
Santina Bruzzone Floriana Fruscione Sara Morando Tiziana Ferrando Alessandro Poggi Anna Garuti Agustina D'Urso Martina Selmo Federica Benvenuto Michele Cea Gabriele Zoppoli Eva Moran Debora Soncini Alberto Ballestrero Bernard Sordat Franco Patrone Raul Mostoslavsky Antonio Uccelli Alessio Nencioni

PLoS One 2009 Nov 19;4(11):e7897. Epub 2009 Nov 19.

Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy.

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November 2009

Soluble HLA-I-mediated secretion of TGF-beta1 by human NK cells and consequent down-regulation of anti-tumor cytolytic activity.

Authors:
Massimo Ghio Paola Contini Simone Negrini Silvia Boero Alessandra Musso Alessandro Poggi

Eur J Immunol 2009 Dec;39(12):3459-68

Department of Internal Medicine, University of Genoa and San Martino Hospital of Genoa, 16132-Italy.

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December 2009

Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans.

Authors:
Daniela Fenoglio Alessandro Poggi Silvia Catellani Florinda Battaglia Alessandra Ferrera Maurizio Setti Giuseppe Murdaca Maria Raffaella Zocchi

Blood 2009 Jun 24;113(26):6611-8. Epub 2009 Apr 24.

Centre of Excellence for Biological Sciences, University of Genoa, Genoa, Italy.

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June 2009

Comparative analysis of DNA repair in stem and nonstem glioma cell cultures.

Authors:
Monica Ropolo Antonio Daga Fabrizio Griffero Mara Foresta Gianluigi Casartelli Annalisa Zunino Alessandro Poggi Enrico Cappelli Gianluigi Zona Renato Spaziante Giorgio Corte Guido Frosina

Mol Cancer Res 2009 Mar 10;7(3):383-92. Epub 2009 Mar 10.

Molecular Mutagenesis and DNA Repair Laboratory, Istituto Nazionale Ricerca Cancro, University of Genova, Genova, Italy.

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March 2009

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity.

Authors:
Raffaella Ponassi Barbara Biasotti Valeria Tomati Silvia Bruno Alessandro Poggi Davide Malacarne Guido Cimoli Annalisa Salis Sarah Pozzi Maurizio Miglino Gianluca Damonte Pietro Cozzini Francesca Spyrakis Francesca Spyraki Barbara Campanini Luca Bagnasco Nicoletta Castagnino Lorenzo Tortolina Anna Mumot Francesco Frassoni Antonio Daga Michele Cilli Federica Piccardi Ilaria Monfardini Miriam Perugini Gabriele Zoppoli Cristina D'Arrigo Raffaele Pesenti Silvio Parodi

Cell Cycle 2008 Oct 20;7(20):3211-24. Epub 2008 Oct 20.

Department of Oncology, University of Genoa, Genoa, Italy.

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October 2008

Role of bone marrow stromal cells in the generation of human CD8+ regulatory T cells.

Authors:
Alessandro Poggi Maria Raffaella Zocchi

Hum Immunol 2008 Nov 24;69(11):755-9. Epub 2008 Sep 24.

Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy.

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November 2008

Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors.

Authors:
Scott Patterson Aristeidis Chaidos David C A Neville Alessandro Poggi Terry D Butters Irene A G Roberts Anastasios Karadimitris

J Immunol 2008 Sep;181(5):3268-76

Department of Hematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.

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September 2008

Sensitivity of different resistant tumour cell lines to the two novel compounds (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate and (1E,3E)-1,4-bis(2-naphthyl)-2,3-dinitro-1,3-butadiene.

Authors:
Maurizio Viale Giovanni Petrillo Massimo Maccagno Patrizio Castagnola Cinzia Aiello Cinzia Cordazzo Maria A Mariggiò Sushilkumar A Jadhav Lara Bianchi Giuseppe Leto Egon Rizzato Alessandro Poggi Domenico Spinelli

Eur J Pharmacol 2008 Jun 12;588(1):47-51. Epub 2008 Apr 12.

Istituto Nazionale per la Ricerca sul Cancro, S.C. Terapia Immunologica, L.go R. Benzi 10, 16132 Genova, Italy.

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June 2008

Paroxysmal nocturnal hemoglobinuria: significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population.

Authors:
Maria Luisa Lombardi Giuseppe Terrazzano Elena Cosentini Lucia Gargiulo Antonio Risitano Rosa Camerlingo Michela Sica Daniela Aufiero Alessandro Poggi Giuseppe Pirozzi Lucio Luzzatto Bruno Rotoli Rosario Notaro Fiorella Alfinito Giuseppina Ruggiero

Hum Immunol 2008 Mar 10;69(3):202-6. Epub 2008 Mar 10.

Dipartimento di Oncologia Sperimentale, Istituto Nazionale Tumori di Napoli, Napoli, Italy.

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March 2008