Publications by authors named "Alessandro Poggi"

100Publications

Three-Dimensional (3D) Culture Models in Cancer Investigation, Drug Testing and Immune Response Evaluation.

Int J Mol Sci 2020 Dec 25;22(1). Epub 2020 Dec 25.

Unit of MolecularOncology and Angiogenesis, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

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December 2020

Editorial: ADAM10 in Cancer Immunology and Autoimmunity: More Than a Simple Biochemical Scissor.

Front Immunol 2020 16;11:1483. Epub 2020 Jul 16.

Division of Immunology Transplants and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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July 2020

Checkpoint Inhibitors and Engineered Cells: New Weapons for Natural Killer Cell Arsenal Against Hematological Malignancies.

Cells 2020 06 29;9(7). Epub 2020 Jun 29.

Molecular Oncology and Angiogenesis Unit, IRCCS AOU San Martino IST, 16132 Genoa, Italy.

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June 2020

Aspartate β-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1α/GSK3β crosstalk.

Carcinogenesis 2020 Sep;41(9):1246-1252

Department of Scientific Direction, Molecular Oncology & Angiogenesis, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

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September 2020

Serum adiponectin levels are associated with presence of carotid plaque in women with systemic lupus erythematosus.

Nutr Metab Cardiovasc Dis 2020 06 27;30(7):1147-1151. Epub 2020 Mar 27.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132 Genoa, Italy.

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June 2020

Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. , , 971.

Cancers (Basel) 2020 05 13;12(5). Epub 2020 May 13.

SSD Oncologia Molecolare e Angiogenesi, IRCCS Ospedale Policlinico San Martino, largo Rosanna Benzi 10, 16132 Genova, Italy.

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May 2020

The Ovarian Cancer Tumor Immune Microenvironment (TIME) as Target for Therapy: A Focus on Innate Immunity Cells as Therapeutic Effectors.

Int J Mol Sci 2020 Apr 28;21(9). Epub 2020 Apr 28.

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.

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April 2020

Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer.

Cancers (Basel) 2020 Apr 14;12(4). Epub 2020 Apr 14.

SSD Oncologia Molecolare e Angiogenesi, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.

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April 2020

Nanoformulated Zoledronic Acid Boosts the Vδ2 T Cell Immunotherapeutic Potential in Colorectal Cancer.

Cancers (Basel) 2019 Dec 31;12(1). Epub 2019 Dec 31.

Molecular Oncology and Angiogenesis Unit, IRCCS Policlinico San Martino, 16132 Genoa, Italy.

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December 2019

Multifocal Signal Modulation Therapy by Celecoxib: A Strategy for Managing Castration-Resistant Prostate Cancer.

Int J Mol Sci 2019 Dec 3;20(23). Epub 2019 Dec 3.

Molecular Oncology & Angiogenesis, IRCCS Ospedale Policlinico San Martino, L.go R. Benzi 10, 16132 Genova, Italy.

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December 2019

Human Gut-Associated Natural Killer Cells in Health and Disease.

Front Immunol 2019 3;10:961. Epub 2019 May 3.

Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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October 2020

Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects.

Cancers (Basel) 2019 Apr 1;11(4). Epub 2019 Apr 1.

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, Via Monte Generoso, n. 71, 21100 Varese, Italy.

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April 2019

Immunomodulatory Properties of Mesenchymal Stromal Cells: Still Unresolved "Yin and Yang".

Curr Stem Cell Res Ther 2019 ;14(4):344-350

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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November 2019

Tumor Vasculature Targeted TNFα Therapy: Reversion of Microenvironment Anergy and Enhancement of the Anti-tumor Efficiency.

Curr Med Chem 2020 ;27(25):4233-4248

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences (DBSV), University of Insubria, Via Monte Generoso, n. 71, 21100 Varese, Italy.

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September 2020

Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes.

ChemMedChem 2018 10 12;13(19):2119-2131. Epub 2018 Sep 12.

Department of Pharmacy, University of Pisa, via Bonanno 6, 56126, Pisa, Italy.

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October 2018

Corrigendum: How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive.

Front Immunol 2018 11;9:1342. Epub 2018 Jun 11.

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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June 2018

Zoledronate Triggers Vδ2 T Cells to Destroy and Kill Spheroids of Colon Carcinoma: Quantitative Image Analysis of Three-Dimensional Cultures.

Front Immunol 2018 8;9:998. Epub 2018 May 8.

Molecular Oncology and Angiogenesis Unit, Ospedale Policlinico San Martino, Genoa, Italy.

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July 2019

How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive.

Front Immunol 2018 19;9:262. Epub 2018 Feb 19.

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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April 2019

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.

Bioorg Med Chem 2017 10 19;25(20):5849-5858. Epub 2017 Sep 19.

Department of Experimental Medicine, Section of Biochemistry, University of Genoa, V.le Benedetto XV 1, 16132 Genoa, Italy; CEBR, University of Genova, V.le Benedetto XV, 7, 16132 Genoa, Italy. Electronic address:

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October 2017

The ErbB family and androgen receptor signaling are targets of Celecoxib in prostate cancer.

Cancer Lett 2017 08 25;400:9-17. Epub 2017 Apr 25.

Molecular Oncology & Angiogenesis, IRCCS AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, 16132 Genoa, Italy. Electronic address:

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August 2017

The therapeutic T-cell response induced by tumor delivery of TNF and melphalan is dependent on early triggering of natural killer and dendritic cells.

Eur J Immunol 2017 04 6;47(4):743-753. Epub 2017 Mar 6.

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

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April 2017

Effects on Energy Metabolism of Two Guanidine Molecules, (Boc) -Creatine and Metformin.

J Cell Biochem 2017 09 13;118(9):2700-2711. Epub 2017 Feb 13.

Department of Neuroscience, Ophthalmology, Genetics, Maternal-Infantile Sciences, University of Genova, Largo Paolo Daneo 3, Genova 16132, Italy.

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September 2017

Allogeneic platelet-rich plasma affects monocyte differentiation to dendritic cells causing an anti-inflammatory microenvironment, putatively fostering wound healing.

J Tissue Eng Regen Med 2018 01 11;12(1):30-43. Epub 2017 May 11.

Unit of Molecular Oncology and Angiogenesis, IRCCS San Martino Hospital-IST- National Institute for Cancer Research, Genoa, Italy.

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January 2018

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment.

Vaccines (Basel) 2016 Nov 8;4(4). Epub 2016 Nov 8.

Laboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, Luxembourg City L-1526, Luxembourg.

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November 2016

Human Articular Chondrocytes Regulate Immune Response by Affecting Directly T Cell Proliferation and Indirectly Inhibiting Monocyte Differentiation to Professional Antigen-Presenting Cells.

Front Immunol 2016 24;7:415. Epub 2016 Oct 24.

Molecular Oncology and Angiogenesis Unit, Department of Integrated Oncological Therapies, IRCCS AOU San Martino IST , Genova , Italy.

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October 2016

Combined platelet and plasma derivatives enhance proliferation of stem/progenitor cells maintaining their differentiation potential.

Cytotherapy 2015 Dec;17(12):1793-806

DIMES, University of Genoa, Genoa, Italy; IRCCS AOU San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. Electronic address:

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December 2015

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.

Eur J Med Chem 2015 Sep 14;102:530-9. Epub 2015 Aug 14.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy; Institute of Organic Synthesis and Photoreactivity (ISOF), National Research Council (CNR), Via P. Gobetti 101, 40129 Bologna, Italy. Electronic address:

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September 2015

Mesenchymal stromal cells as regulators of anti-tumour immune response.

Indian J Med Res 2015 Feb;141(2):139-42

Molecular Oncology & Angiogenesis Unit, IRCCS AOU San Martino IST, 16132 Genoa, Italy.

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February 2015

γδ T Lymphocytes as a First Line of Immune Defense: Old and New Ways of Antigen Recognition and Implications for Cancer Immunotherapy.

Front Immunol 2014 11;5:575. Epub 2014 Nov 11.

Division of Immunology, Transplants and Infectious Diseases, IRCCS San Raffaele , Milan , Italy.

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November 2014

Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.

Neoplasia 2014 Sep;16(9):710-22

IRCCS Azienda Ospedaliera Universitaria S. Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genova 16132, Italy. Electronic address:

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September 2014

Mechanisms of tumor escape from immune system: role of mesenchymal stromal cells.

Immunol Lett 2014 May-Jun;159(1-2):55-72. Epub 2014 Mar 20.

Division of Immunology, Transplants and Infectious Diseases, Istituto Scientifico San Raffaele Milan, 20132 Milan, Italy.

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December 2014

NK cell autoreactivity and autoimmune diseases.

Front Immunol 2014 4;5:27. Epub 2014 Feb 4.

Division of Immunology, Transplants and Infectious Diseases, Scientific Institute San Raffaele , Milan , Italy.

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June 2014

How to exploit stress-related immunity against Hodgkin's lymphoma: Targeting ERp5 and ADAM sheddases.

Oncoimmunology 2013 Dec 5;2(12):e27089. Epub 2013 Dec 5.

Division of Immunology, Transplants, and Infectious Diseases; IRCCS San Raffaele; Milan, Italy.

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December 2013

Accelerated repair and reduced mutagenicity of DNA damage induced by cigarette smoke in human bronchial cells transfected with E.coli formamidopyrimidine DNA glycosylase.

PLoS One 2014 31;9(1):e87984. Epub 2014 Jan 31.

Mutagenesis Unit, IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

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October 2014

Stress immunity in lymphomas: mesenchymal cells as a target of therapy.

Front Biosci (Landmark Ed) 2014 Jan 1;19:281-90. Epub 2014 Jan 1.

Division of Immunology, Transplants and Infectious Diseases, IRCCS San Raffaele, I-20132 Milan.

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January 2014

Antibiofilm activity of a monolayer of silver nanoparticles anchored to an amino-silanized glass surface.

Biomaterials 2014 Feb 7;35(6):1779-88. Epub 2013 Dec 7.

Center for Tissue Engineering (C.I.T.), Department of Molecular Medicine, INSTM UdR of Pavia, University of Pavia, Pavia, Italy; Nanotechnology Laboratory, Department of Occupational Medicine, Ergonomy and Disability, Salvatore Maugeri Foundation, IRCCS, Pavia, Italy.

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February 2014

Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells.

PLoS One 2013 7;8(5):e62932. Epub 2013 May 7.

Molecular Oncology and Angiogenesis Unit, IRCCS AOU San Martino - IST National Institute for Cancer Research, Genoa, Italy.

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December 2013

Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment.

Oncoimmunology 2012 Mar;1(2):214-216

Unit of Molecular Oncology and Angiogenesis; San Martino Hospital-National Institute for Cancer Research; University of Genoa; Genoa, Italy.

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March 2012

NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes.

J Biol Chem 2012 Jun 30;287(25):21067-81. Epub 2012 Apr 30.

Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy.

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June 2012

Higher frequencies of CD161+ circulating T lymphocytes in allergic rhinitis patients compared to healthy donors.

Int Arch Allergy Immunol 2012 25;158(2):151-6. Epub 2012 Jan 25.

Molecular Oncology and Angiogenesis Unit, National Institute for Cancer Research, Genoa, Italy.

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August 2012

Extracellular DNA in biofilms.

Int J Artif Organs 2011 Sep;34(9):824-31

Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy.

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September 2011

Emerging pathogenetic mechanisms of the implant-related osteomyelitis by Staphylococcus aureus.

Int J Artif Organs 2011 Sep;34(9):781-8

Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy.

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September 2011

Recruitment of host's progenitor cells to sites of human amniotic fluid stem cells implantation.

Biomaterials 2011 Jun 2;32(18):4218-27. Epub 2011 Apr 2.

Department of Oncology, Biology, and Genetics, University of Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy.

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June 2011

Defective resolution of pH2AX foci and enhanced DNA breakage in ionizing radiation-treated cockayne syndrome B cells.

IUBMB Life 2011 Apr 24;63(4):272-6. Epub 2011 Mar 24.

Laboratory of Molecular Mutagenesis and DNA Repair, Department of Epidemiology, Prevention and Special Functions, Istituto Nazionale Ricerca Cancro, Genova, Italy.

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April 2011

Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival.

Haematologica 2011 Jan 30;96(1):16-23. Epub 2010 Sep 30.

Molecular Oncology and Angiogenesis, Department of Translational Oncology, National Institute for Cancer Research Genoa, Genoa, Italy.

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January 2011

Differential survival of γδT cells, αβT cells and NK cells upon engagement of NKG2D by NKG2DL-expressing leukemic cells.

Int J Cancer 2011 Jul 3;129(2):387-96. Epub 2010 Nov 3.

Unit of Molecular Oncology and Angiogenesis, National Institute for Cancer Research, I-16132 Genoa.

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July 2011

Engagement of CD31 delivers an activating signal that contributes to the survival of chronic lymphocytic leukaemia cells.

Br J Haematol 2010 Nov 31;151(3):252-64. Epub 2010 Aug 31.

Laboratory of Molecular Oncology and Angiogenesis, National Institute for Cancer Research, University of Genoa, Italy.

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November 2010

Soluble HLA-I-mediated secretion of TGF-beta1 by human NK cells and consequent down-regulation of anti-tumor cytolytic activity.

Eur J Immunol 2009 Dec;39(12):3459-68

Department of Internal Medicine, University of Genoa and San Martino Hospital of Genoa, 16132-Italy.

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December 2009

Comparative analysis of DNA repair in stem and nonstem glioma cell cultures.

Mol Cancer Res 2009 Mar 10;7(3):383-92. Epub 2009 Mar 10.

Molecular Mutagenesis and DNA Repair Laboratory, Istituto Nazionale Ricerca Cancro, University of Genova, Genova, Italy.

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March 2009

Role of bone marrow stromal cells in the generation of human CD8+ regulatory T cells.

Hum Immunol 2008 Nov 24;69(11):755-9. Epub 2008 Sep 24.

Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy.

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November 2008