Alessandro Laganà

Alessandro Laganà

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Alessandro Laganà

Alessandro Laganà

Publications by authors named "Alessandro Laganà"

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44Publications

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Discovery of a first-in-class EZH2 selective degrader.

Nat Chem Biol 2020 02 9;16(2):214-222. Epub 2019 Dec 9.

Mount Sinai Center for Therapeutics Discovery, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41589-019-0421-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982609PMC
February 2020

A Network Analysis of Multiple Myeloma Related Gene Signatures.

Cancers (Basel) 2019 Sep 27;11(10). Epub 2019 Sep 27.

Sema4, a Mount Sinai Venture, 333 Ludlow St., Stamford, CT 06902, USA.

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http://dx.doi.org/10.3390/cancers11101452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827160PMC
September 2019

KRAS induces lung tumorigenesis through microRNAs modulation.

Cell Death Dis 2018 02 13;9(2):219. Epub 2018 Feb 13.

Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1038/s41419-017-0243-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833396PMC
February 2018

Discovery and characterization of the feline miRNAome.

Sci Rep 2017 08 23;7(1):9263. Epub 2017 Aug 23.

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1038/s41598-017-10164-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569061PMC
August 2017

Selective targeting of point-mutated KRAS through artificial microRNAs.

Proc Natl Acad Sci U S A 2017 05 8;114(21):E4203-E4212. Epub 2017 May 8.

Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210;

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http://dx.doi.org/10.1073/pnas.1620562114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448175PMC
May 2017

Noncoding RNA: Current Deep Sequencing Data Analysis Approaches and Challenges.

Hum Mutat 2016 12 5;37(12):1283-1298. Epub 2016 Sep 5.

Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, 43210.

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http://dx.doi.org/10.1002/humu.23066DOI Listing
December 2016

microRNA editing in seed region aligns with cellular changes in hypoxic conditions.

Nucleic Acids Res 2016 07 13;44(13):6298-308. Epub 2016 Jun 13.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA

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http://dx.doi.org/10.1093/nar/gkw532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994866PMC
July 2016

Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries).

PLoS One 2015 24;10(11):e0143313. Epub 2015 Nov 24.

Department of Surgery, The Ohio State University, Columbus, OH, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143313PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657999PMC
June 2016

Computational Prediction of microRNA Targets.

Adv Exp Med Biol 2015 ;887:231-52

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Pl, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/978-3-319-22380-3_12DOI Listing
May 2016

MicroRNAs and Targeted Therapies in Non-small Cell Lung Cancer: Minireview.

Anticancer Agents Med Chem 2015 ;15(6):694-700

Division of Oncology- Department of Oncology, Azienda USL-6 of Livorno, Viale Alfieri 36, 57100 LIVORNO, Italy.

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http://dx.doi.org/10.2174/1871520615666150121122054DOI Listing
March 2016

Editorial: Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges.

Front Bioeng Biotechnol 2015 8;3:156. Epub 2015 Oct 8.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University , Columbus, OH , USA.

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http://dx.doi.org/10.3389/fbioe.2015.00156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597103PMC
October 2015

Computational design of artificial RNA molecules for gene regulation.

Methods Mol Biol 2015 ;1269:393-412

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1007/978-1-4939-2291-8_25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425273PMC
September 2015

Quaking and miR-155 interactions in inflammation and leukemogenesis.

Oncotarget 2015 Sep;6(28):24599-610

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Wexner Medical Center and Comprehensive Cancer Center, Columbus, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.5248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694781PMC
September 2015

MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):8650-5. Epub 2015 Jun 29.

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1500886112
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http://dx.doi.org/10.1073/pnas.1500886112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507199PMC
July 2015

Synthetic RNAs for Gene Regulation: Design Principles and Computational Tools.

Front Bioeng Biotechnol 2014 11;2:65. Epub 2014 Dec 11.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University , Columbus, OH , USA.

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http://dx.doi.org/10.3389/fbioe.2014.00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263176PMC
January 2015

Imprint cytopathology of core needle biopsies: a "first responder" role for cytotechnologists.

J Am Soc Cytopathol 2015 Jan - Feb;4(1):16-24. Epub 2014 Aug 1.

Department of Pathology, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, Columbus, Ohio. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132945140018
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http://dx.doi.org/10.1016/j.jasc.2014.07.003DOI Listing
August 2014

miR-Synth: a computational resource for the design of multi-site multi-target synthetic miRNAs.

Nucleic Acids Res 2014 May 13;42(9):5416-25. Epub 2014 Mar 13.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210 USA.

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http://dx.doi.org/10.1093/nar/gku202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027198PMC
May 2014

VIRGO: visualization of A-to-I RNA editing sites in genomic sequences.

BMC Bioinformatics 2013 22;14 Suppl 7:S5. Epub 2013 Apr 22.

Department of Mathematics and Computer Science - University of Catania, Catania, Italy.

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http://dx.doi.org/10.1186/1471-2105-14-S7-S5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837470PMC
December 2013

Neuropilin-2 Is upregulated in lung cancer cells during TGF-β1-induced epithelial-mesenchymal transition.

Cancer Res 2013 Dec 11;73(23):7111-21. Epub 2013 Oct 11.

Authors' Affiliations: Division of Hematology-Oncology, Department of Public Health Sciences, Department of Biochemistry, The Hollings Cancer Center and Medical University of South Carolina, Charleston, South Carolina; Department of Biostatistics and informatics; Division of Medical Oncology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado; and Department of Molecular Virology, Immunology, and Medical Genetics, School of Medicine, The Ohio State University, Columbus, Ohio.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-1755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926507PMC
December 2013

Elucidating the role of microRNAs in cancer through data mining techniques.

Adv Exp Med Biol 2013 ;774:291-315

Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy.

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http://dx.doi.org/10.1007/978-94-007-5590-1_15DOI Listing
June 2013

Extracellular circulating viral microRNAs: current knowledge and perspectives.

Front Genet 2013 24;4:120. Epub 2013 Jun 24.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University Columbus, OH, USA.

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http://dx.doi.org/10.3389/fgene.2013.00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690336PMC
June 2013

A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model.

Blood 2013 May 16;121(21):4355-8. Epub 2013 Apr 16.

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1182/blood-2013-02-486035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663428PMC
May 2013

Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2.

Proc Natl Acad Sci U S A 2013 May 6;110(21):8573-8. Epub 2013 May 6.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1302107110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666747PMC
May 2013

miR-EdiTar: a database of predicted A-to-I edited miRNA target sites.

Bioinformatics 2012 Dec 7;28(23):3166-8. Epub 2012 Oct 7.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1093/bioinformatics/bts589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509495PMC
December 2012

Prediction of human targets for viral-encoded microRNAs by thermodynamics and empirical constraints.

J RNAi Gene Silencing 2010 May 24;6(1):379-85. Epub 2010 May 24.

Department of Mathematics and Computer Science, University of Catania, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902144PMC
May 2010