Alessandra S Eustáquio

Alessandra S Eustáquio

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Alessandra S Eustáquio

Alessandra S Eustáquio

Publications by authors named "Alessandra S Eustáquio"

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Heterologous Production of Lasso Peptide Capistruin in a Host.

ACS Synth Biol 2020 Feb 13;9(2):241-248. Epub 2020 Jan 13.

Department of Pharmaceutical Sciences and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60607 , United States.

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http://dx.doi.org/10.1021/acssynbio.9b00438DOI Listing
February 2020

Scytodecamide from the Cultured Scytonema sp. UIC 10036 Expands the Chemical and Genetic Diversity of Cyanobactins.

Chembiochem 2019 Nov 26. Epub 2019 Nov 26.

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1002/cbic.201900511DOI Listing
November 2019

Heterologous expression of the diazaquinomycin biosynthetic gene cluster.

J Ind Microbiol Biotechnol 2019 Oct 15;46(9-10):1359-1364. Epub 2019 May 15.

Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.

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http://dx.doi.org/10.1007/s10295-019-02187-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801048PMC
October 2019

as a Source of Natural Products.

J Nat Prod 2019 Jul 11;82(7):2018-2037. Epub 2019 Jul 11.

Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60607 , United States.

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http://dx.doi.org/10.1021/acs.jnatprod.8b01068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871192PMC
July 2019

Genome Sequence of Marine-Derived sp. Strain F001, a Producer of Akashin A and Diazaquinomycins.

Microbiol Resour Announc 2019 May 9;8(19). Epub 2019 May 9.

Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/MRA.00165-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509518PMC
May 2019

Natural Products and Synthetic Biology: Where We Are and Where We Need To Go.

mSystems 2019 May 14;4(3). Epub 2019 May 14.

Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

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http://msystems.asm.org/lookup/doi/10.1128/mSystems.00113-19
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http://dx.doi.org/10.1128/mSystems.00113-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529544PMC
May 2019

Preparation, Assay, and Application of Chlorinase SalL for the Chemoenzymatic Synthesis of S-Adenosyl-l-Methionine and Analogs.

Methods Enzymol 2018 2;604:367-388. Epub 2018 Apr 2.

University of Illinois at Chicago, College of Pharmacy, and Center for Biomolecular Sciences, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625345PMC
April 2019

Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes.

J Nat Prod 2019 Apr 21;82(4):937-946. Epub 2019 Mar 21.

Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60607 , United States.

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http://dx.doi.org/10.1021/acs.jnatprod.8b01028DOI Listing
April 2019

Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete.

J Nat Prod 2018 09 15;81(9):2057-2068. Epub 2018 Aug 15.

Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60607 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00394
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http://dx.doi.org/10.1021/acs.jnatprod.8b00394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174880PMC
September 2018

Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.

Chem Rev 2017 Apr 20;117(8):5619-5674. Epub 2017 Jan 20.

Center for Oceans and Human Health, Scripps Institution of Oceanography, University of California San Diego , La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acs.chemrev.6b00571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575885PMC
April 2017

Biosynthetic engineering and fermentation media development leads to gram-scale production of spliceostatin natural products in Burkholderia sp.

Metab Eng 2016 Jan 24;33:67-75. Epub 2015 Nov 24.

Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, USA.

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http://dx.doi.org/10.1016/j.ymben.2015.11.003DOI Listing
January 2016

Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase.

Proc Natl Acad Sci U S A 2014 Aug 5;111(33):E3376-85. Epub 2014 Aug 5.

Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT 06340.

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http://dx.doi.org/10.1073/pnas.1408300111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143056PMC
August 2014

Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A.

FEBS J 2012 Apr 1;279(7):1243-51. Epub 2012 Mar 1.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2012.08517.xDOI Listing
April 2012

Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.

Chem Biol 2011 Dec;18(12):1527-36

Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204, USA.

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http://dx.doi.org/10.1016/j.chembiol.2011.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246214PMC
December 2011

Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria.

J Am Chem Soc 2011 Aug 9;133(34):13311-3. Epub 2011 Aug 9.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, United States.

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http://dx.doi.org/10.1021/ja205655wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161154PMC
August 2011

Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide.

J Nat Prod 2010 Mar;73(3):378-82

Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093-0204, USA.

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http://dx.doi.org/10.1021/np900719uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846182PMC
March 2010

Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62).

Chembiochem 2009 Oct;10(15):2455-9

Centre for Biomolecular Sciences, School of Chemistry, University of St. Andrews, St. Andrews, KY16 9ST, UK.

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http://dx.doi.org/10.1002/cbic.200900369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063057PMC
October 2009

Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.

J Am Chem Soc 2009 Aug;131(30):10376-7

Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA.

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http://dx.doi.org/10.1021/ja9042824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737082PMC
August 2009

novE and novG act as positive regulators of novobiocin biosynthesis.

Arch Microbiol 2008 Nov 21;190(5):509-19. Epub 2008 Jun 21.

Pharmaceutical Biology, Pharmaceutical Institute, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1007/s00203-008-0396-0DOI Listing
November 2008

S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases.

Chembiochem 2008 Sep;9(14):2215-9

Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204, USA.

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http://dx.doi.org/10.1002/cbic.200800341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692205PMC
September 2008

Advances in and applications of proteasome inhibitors.

Curr Opin Chem Biol 2008 Aug 24;12(4):434-40. Epub 2008 Jul 24.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.cbpa.2008.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2560982PMC
August 2008

Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome.

Angew Chem Int Ed Engl 2008 ;47(21):3936-8

Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204, USA.

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http://dx.doi.org/10.1002/anie.200800177DOI Listing
July 2008

Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors.

J Am Chem Soc 2008 Jun 31;130(25):7822-3. Epub 2008 May 31.

Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1021/ja8029398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814216PMC
June 2008

Discovery and characterization of a marine bacterial SAM-dependent chlorinase.

Nat Chem Biol 2008 Jan 2;4(1):69-74. Epub 2007 Dec 2.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nchembio.2007.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762381PMC
January 2008

NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis.

Microbiology 2005 Jun;151(Pt 6):1949-1961

Pharmazeutische Biologie, Pharmazeutisches Institut, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1099/mic.0.27669-0DOI Listing
June 2005

Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters.

Appl Environ Microbiol 2005 May;71(5):2452-9

Pharmazeutische Biologie, Pharmazeutisches Institut, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.

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http://aem.asm.org/cgi/doi/10.1128/AEM.71.5.2452-2459.2005
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http://dx.doi.org/10.1128/AEM.71.5.2452-2459.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087579PMC
May 2005

Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains.

Chem Biol 2004 Nov;11(11):1561-72

Pharmazeutische Biologie, Pharmazeutisches Institut, Eberhard-Karls-Universität Tübingen Auf der Morgenstelle 8, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.chembiol.2004.09.009DOI Listing
November 2004

Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation.

Arch Microbiol 2003 Jul 8;180(1):25-32. Epub 2003 May 8.

Pharmazeutische Biologie, Pharmazeutisches Institut, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1007/s00203-003-0555-2DOI Listing
July 2003

Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs.

Chem Biol 2003 Mar;10(3):279-88

Pharmazeutische Biologie, Pharmazeutisches Institut, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

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http://dx.doi.org/10.1016/s1074-5521(03)00051-6DOI Listing
March 2003