Publications by authors named "Alessandra Rufini"

16Publications

Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia.

Mov Disord 2019 03 9;34(3):323-334. Epub 2019 Jan 9.

Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.

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http://dx.doi.org/10.1002/mds.27604DOI Listing
March 2019

Biophysical characterisation of the recombinant human frataxin precursor.

FEBS Open Bio 2018 03 25;8(3):390-405. Epub 2018 Jan 25.

Institute of Biological Chemistry and Physicochemistry Dr Alejandro Paladini (UBA-CONICET) University of Buenos Aires Argentina.

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http://doi.wiley.com/10.1002/2211-5463.12376
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http://dx.doi.org/10.1002/2211-5463.12376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832983PMC
March 2018

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.

Cell Rep 2017 02;18(8):2007-2017

Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, 00133 Rome, Italy; Fratagene Therapeutics Srl, Viale dei Campioni 8, 00144 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329121PMC
February 2017

Src inhibitors modulate frataxin protein levels.

Hum Mol Genet 2015 Aug 6;24(15):4296-305. Epub 2015 May 6.

Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy,

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http://dx.doi.org/10.1093/hmg/ddv162DOI Listing
August 2015

Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.

Neurobiol Dis 2015 Mar 27;75:91-9. Epub 2014 Dec 27.

Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy; Fratagene Therapeutics Ltd., 22 Northumberland Rd., Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358773PMC
March 2015

Preventing the ubiquitin-proteasome-dependent degradation of frataxin, the protein defective in Friedreich's ataxia.

Hum Mol Genet 2011 Apr 7;20(7):1253-61. Epub 2011 Jan 7.

Laboratory of Signal Transduction, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

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http://dx.doi.org/10.1093/hmg/ddq566DOI Listing
April 2011

Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin.

Hum Mol Genet 2010 Apr 6;19(7):1221-9. Epub 2010 Jan 6.

Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1093/hmg/ddp592DOI Listing
April 2010

In vivo maturation of human frataxin.

Hum Mol Genet 2007 Jul 27;16(13):1534-40. Epub 2007 Apr 27.

Laboratory of Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1093/hmg/ddm102DOI Listing
July 2007

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.

EMBO J 2006 May 13;25(9):1895-905. Epub 2006 Apr 13.

Department of Experimental Medicine and Biochemical Sciences, Dulbecco Telethon Institute, University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1038/sj.emboj.7601085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456929PMC
May 2006

Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII.

J Biol Chem 2006 Feb 1;281(5):2430-40. Epub 2005 Nov 1.

The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M508454200DOI Listing
February 2006

Caspase-dependent cleavage of c-Abl contributes to apoptosis.

Mol Cell Biol 2003 Apr;23(8):2790-9

Dulbecco Telethon Institute and Laboratory of Immunology and Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152541PMC
http://dx.doi.org/10.1128/mcb.23.8.2790-2799.2003DOI Listing
April 2003

Acetylation suppresses the proapoptotic activity of GD3 ganglioside.

J Exp Med 2002 Dec;196(12):1535-41

Laboratory of Immunology and Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196066PMC
http://dx.doi.org/10.1084/jem.20020960DOI Listing
December 2002

Lipid signaling in CD95-mediated apoptosis.

Subcell Biochem 2002 ;36:285-308

Department of Experimental Medicine and Biochemical Science, University of Rome Tor Vergata, Italy.

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http://dx.doi.org/10.1007/0-306-47931-1_15DOI Listing
July 2002