Alessandra Ghigo

Alessandra Ghigo

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Alessandra Ghigo

Alessandra Ghigo

Publications by authors named "Alessandra Ghigo"

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New avenues in cardio-oncology.

Aging (Albany NY) 2019 Feb 6. Epub 2019 Feb 6.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino 10126, Italy.

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http://dx.doi.org/10.18632/aging.101817DOI Listing
February 2019

Inhaled Biologicals for the Treatment of Cystic Fibrosis.

Recent Pat Inflamm Allergy Drug Discov 2018 Oct 11. Epub 2018 Oct 11.

Universita di Torino - Biotecnologie Molecolari e Scienze per la Salute Torino, TO. Italy.

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http://dx.doi.org/10.2174/1872213X12666181012101444DOI Listing
October 2018

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

Oxid Med Cell Longev 2018 26;2018:6419805. Epub 2018 Feb 26.

Department of Molecular Biotechnology and Health Science, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1155/2018/6419805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846462PMC
September 2018

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

Food Chem 2018 May 7;247:56-65. Epub 2017 Dec 7.

Department of Clinical Analysis, Centre of Health Sciences, Federal University of Santa Catarina, Campus Universitário - Trindade, 88040-970 Florianopolis, SC, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2017.12.015DOI Listing
May 2018

PI3K signaling in chronic obstructive pulmonary disease: mechanisms, targets, and therapy.

Curr Med Chem 2018 Mar 20. Epub 2018 Mar 20.

Dept. of Molecular Biotechnology and Health Sciences, University of Torino, Torino. Italy.

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http://dx.doi.org/10.2174/0929867325666180320120054DOI Listing
March 2018

PI3Ks in Diabetic Cardiomyopathy.

J Cardiovasc Pharmacol 2017 Dec;70(6):422-429

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1097/FJC.0000000000000511DOI Listing
December 2017

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Free Radic Biol Med 2017 07 8;108:452-464. Epub 2017 Apr 8.

Dept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.04.003DOI Listing
July 2017

PI3K and Calcium Signaling in Cardiovascular Disease.

Circ Res 2017 Jul;121(3):282-292

From the Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Italy (A.G., M. Li, E.H.); and INSERM U1048, I2MC and Université Toulouse III, France (M. Laffargue).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310183DOI Listing
July 2017

Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).

Curr Heart Fail Rep 2017 06;14(3):187-196

Department of Molecular Biotechnology, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/s11897-017-0331-2DOI Listing
June 2017

A novel protective role for activating transcription factor 3 in the cardiac response to metabolic stress.

Cardiovasc Res 2017 02 12;113(2):113-114. Epub 2017 Jan 12.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, Latina (LT) 04100, Italy;

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http://dx.doi.org/10.1093/cvr/cvw252DOI Listing
February 2017

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

Sci Signal 2016 12 20;9(459):ra124. Epub 2016 Dec 20.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1126/scisignal.aah5882DOI Listing
December 2016

New signal transduction paradigms in anthracycline-induced cardiotoxicity.

Biochim Biophys Acta 2016 Jul 29;1863(7 Pt B):1916-25. Epub 2016 Jan 29.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.01.021DOI Listing
July 2016

Models of Heart Failure Based on the Cardiotoxicity of Anticancer Drugs.

J Card Fail 2016 Jun 18;22(6):449-58. Epub 2016 Apr 18.

Laboratory of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.

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http://dx.doi.org/10.1016/j.cardfail.2016.04.008DOI Listing
June 2016

Crossroads of PI3K and Rac pathways.

Small GTPases 2015 5;6(2):71-80. Epub 2015 May 5.

a Molecular Biotechnology Center; Department of Molecular Biotechnology and Health Sciences; University of Torino ; Torino , Italy.

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http://dx.doi.org/10.4161/21541248.2014.989789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601376PMC
April 2016

Phosphoinositide 3-kinase: friend and foe in cardiovascular disease.

Front Pharmacol 2015 13;6:169. Epub 2015 Aug 13.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino , Torino, Italy.

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http://dx.doi.org/10.3389/fphar.2015.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534856PMC
August 2015

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

EMBO Mol Med 2015 Jul;7(7):904-17

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli (IS), Italy Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

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http://dx.doi.org/10.15252/emmm.201404697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520656PMC
July 2015

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Biochem J 2015 Jul;469(1):59-69

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany

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http://biochemj.org/lookup/doi/10.1042/BJ20150099
Publisher Site
http://dx.doi.org/10.1042/BJ20150099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655608PMC
July 2015

Phosphoinositide 3-kinases in health and disease.

Subcell Biochem 2012 ;58:183-213

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/978-94-007-3012-0_6DOI Listing
August 2014

Myocyte signalling in leucocyte recruitment to the heart.

Cardiovasc Res 2014 May 5;102(2):270-80. Epub 2014 Feb 5.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, Italy.

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http://dx.doi.org/10.1093/cvr/cvu030DOI Listing
May 2014

Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis.

Cardiovasc Res 2014 Apr 11;102(1):1-2. Epub 2014 Feb 11.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1093/cvr/cvu038DOI Listing
April 2014

Phosphoinositides and cardiovascular diseases.

Curr Top Microbiol Immunol 2012 ;362:43-60

Department of Genetics, Biology and Biochemistry, University of Torino, Molecular Biotechnology Center, Italy.

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http://dx.doi.org/10.1007/978-94-007-5025-8_2DOI Listing
April 2013

NADPH oxidases in heart failure: poachers or gamekeepers?

Antioxid Redox Signal 2013 Mar 27;18(9):1024-41. Epub 2012 Aug 27.

Cardiovascular Division, James Black Centre, King's College London British Heart Foundation Centre of Excellence, London, UK.

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http://dx.doi.org/10.1089/ars.2012.4550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567780PMC
March 2013

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Circulation 2013 Mar 27;127(12):1317-29. Epub 2013 Feb 27.

Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.130179DOI Listing
March 2013

Therapeutic applications of PI3K inhibitors in cardiovascular diseases.

Future Med Chem 2013 Mar;5(4):479-92

University of Torino, Molecular Biotechnology Center, Department of Molecular Biotechnology & Health Sciences, Via Nizza 52, 10126, Torino, Italy.

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http://dx.doi.org/10.4155/fmc.13.11DOI Listing
March 2013

Anchoring proteins as regulators of signaling pathways.

Circ Res 2012 Aug;111(4):482-92

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.262899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508715PMC
August 2012

Specific PI3K isoform modulation in heart failure: lessons from transgenic mice.

Curr Heart Fail Rep 2011 Sep;8(3):168-75

Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126, Torino, Italy.

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http://dx.doi.org/10.1007/s11897-011-0059-3DOI Listing
September 2011

Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema.

Intensive Care Med 2010 Nov 19;36(11):1935-45. Epub 2010 Aug 19.

Department of Anesthesia and Critical Care, Ospedale S. Giovanni Battista-Molinette, University of Torino, Corso Dogliotti 14, 10126, Turin, Italy.

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http://dx.doi.org/10.1007/s00134-010-2018-yDOI Listing
November 2010

Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Trends Cardiovasc Med 2010 Nov;20(8):273-6

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.tcm.2011.12.007DOI Listing
November 2010

PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.

Bioessays 2010 Mar;32(3):185-96

Molecular Biotechnology Center, University of Torino, Italy.

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http://dx.doi.org/10.1002/bies.200900150DOI Listing
March 2010

Taming the PI3K team to hold inflammation and cancer at bay.

Pharmacol Ther 2008 May 5;118(2):192-205. Epub 2008 Mar 5.

Molecular Biotechnology Center, University of Torino, via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.pharmthera.2008.02.004DOI Listing
May 2008

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential.

Recent Pat Inflamm Allergy Drug Discov 2008 Jan;2(1):1-10

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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January 2008