Alessandra Fierabracci

Alessandra Fierabracci

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Alessandra Fierabracci

Alessandra Fierabracci

Publications by authors named "Alessandra Fierabracci"

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Insights on the Effects of Resveratrol and Some of Its Derivatives in Cancer and Autoimmunity: A Molecule with a Dual Activity.

Antioxidants (Basel) 2020 Jan 22;9(2). Epub 2020 Jan 22.

Infectivology and Clinical Trials Research Department, Children's Hospital Bambino Gesù, Viale San Paolo 15, 00146 Rome, Italy.

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http://dx.doi.org/10.3390/antiox9020091DOI Listing
January 2020

Identification and functional characterization of CD8+ T regulatory cells in type 1 diabetes patients.

PLoS One 2019 16;14(1):e0210839. Epub 2019 Jan 16.

Infectivology and Clinical Trials Research Division, Bambino Gesù Children's Hospital, Rome, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210839PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334945PMC
October 2019

Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications.

Int J Mol Sci 2019 Sep 17;20(18). Epub 2019 Sep 17.

Infectivology and Clinical Trials Area, Children's Hospital Bambino Gesù, Viale San Paolo 15, 00146 Rome, Italy.

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http://dx.doi.org/10.3390/ijms20184597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770239PMC
September 2019

Insights into the Role of MicroRNAs in the Onset and Development of Diabetic Neuropathy.

Int J Mol Sci 2019 Sep 18;20(18). Epub 2019 Sep 18.

Infectivology and Clinical Trials Area, Bambino Gesù Children's Hospital, IRCCS, Viale San Paolo 15, 00146 Rome, Italy.

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http://dx.doi.org/10.3390/ijms20184627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770207PMC
September 2019

Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity.

Int J Mol Sci 2019 Jan 11;20(2). Epub 2019 Jan 11.

Infectivology and Clinical Trials Research Department, Children's Hospital Bambino Gesù, Viale San Paolo 15, 00146 Rome, Italy.

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http://www.mdpi.com/1422-0067/20/2/283
Publisher Site
http://dx.doi.org/10.3390/ijms20020283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359510PMC
January 2019

APECED in Turkey: A case report and insights on genetic and phenotypic variability.

Clin Immunol 2018 09 3;194:60-66. Epub 2018 Jul 3.

Endocrine Unit, Department of Medicine (DIMED), University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.06.012DOI Listing
September 2018

Type 1 Diabetes and Its Multi-Factorial Pathogenesis: The Putative Role of NK Cells.

Int J Mol Sci 2018 Mar 10;19(3). Epub 2018 Mar 10.

Type 1 Diabetes Centre, Infectivology and Clinical Trials Research Department, Children's Hospital Bambino Gesù, Viale San Paolo 15, 00146 Rome, Italy.

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http://dx.doi.org/10.3390/ijms19030794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877655PMC
March 2018

NK cells in autoimmune diseases: Linking innate and adaptive immune responses.

Autoimmun Rev 2018 Feb 26;17(2):142-154. Epub 2017 Nov 26.

Type 1 Diabetes Centre, Infectivology and Clinical Trials Research Department, Children's Hospital Bambino Gesù, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2017.11.018DOI Listing
February 2018

SUMO proteins: Guardians of immune system.

J Autoimmun 2017 Nov 15;84:21-28. Epub 2017 Sep 15.

Section of Pharmacology, Department of Medicine, University of Perugia, Piazzale Severi, 06132, Perugia, Italy; Foligno Nursing School, Via Oberdan 123, Foligno, PG, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.09.001DOI Listing
November 2017

Severe Toxoplasma gondii infection in a member of a NFKB2-deficient family with T and B cell dysfunction.

Clin Immunol 2017 10 14;183:273-277. Epub 2017 Sep 14.

University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.09.011DOI Listing
October 2017

Insights into the Diagnostic Potential of Extracellular Vesicles and Their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications.

Int J Mol Sci 2017 Sep 14;18(9). Epub 2017 Sep 14.

Type 1 Diabetes Centre, Infectivology and Clinical Trials Research Department, Children's Hospital Bambino Gesù, Viale San Paolo 15, 00146 Rome, Italy.

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http://dx.doi.org/10.3390/ijms18091974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618623PMC
September 2017

On the pathogenesis of insulin-dependent diabetes mellitus: the role of microbiota.

Immunol Res 2017 02;65(1):242-256

Infectivology and Clinical Trials Area, Bambino Gesù Children's Hospital, IRCCS, Viale S. Paolo 15, 00146, Rome, Italy.

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http://dx.doi.org/10.1007/s12026-016-8832-8DOI Listing
February 2017

The Immunoregulatory Activity of Mesenchymal Stem Cells: 'State of Art' and 'Future Avenues'.

Curr Med Chem 2016 ;23(27):3014-3024

Infectivology and Clinical Trials Area, Children's Hospital Bambino Gesù, 00146, Rome, Italy.

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http://dx.doi.org/10.2174/0929867323666160627112827DOI Listing
February 2017

The Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic Target.

Int J Mol Sci 2016 Nov 25;17(12). Epub 2016 Nov 25.

Infectivology and Clinical Trials Area, Children's Hospital Bambino Gesù, 00146 Rome, Italy.

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http://dx.doi.org/10.3390/ijms17121975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187775PMC
November 2016

Immunoregulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles on T Lymphocytes.

Cell Transplant 2015 18;24(12):2615-27. Epub 2015 Feb 18.

Regenerative Medicine, Bambino Gesù Children's Hospital, Rome, Italy.

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http://dx.doi.org/10.3727/096368915X687543DOI Listing
October 2016

The Use of Mesenchymal Stem Cells for the Treatment of Autoimmunity: From Animals Models to Human Disease.

Curr Drug Targets 2016 ;17(2):229-38

Immunology and Pharmacotherapy Research Area, Bambino Gesù Children's Hospital, Viale S. Paolo 15, 00146 Rome, Italy.

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http://dx.doi.org/10.2174/1389450116666150722140633DOI Listing
October 2016

Type 1 Diabetes in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome (APECED): A "Rare" Manifestation in a "Rare" Disease.

Int J Mol Sci 2016 Jul 12;17(7). Epub 2016 Jul 12.

Infectivology and Clinical Trials Area, Children's Hospital Bambino Gesù, Rome 00146, Italy.

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http://dx.doi.org/10.3390/ijms17071106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964482PMC
July 2016

The Impact of Specific Viruses on Clinical Outcome in Children Presenting with Acute Heart Failure.

Int J Mol Sci 2016 Apr 1;17(4):486. Epub 2016 Apr 1.

Department of Pathology, Children's Hospital Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy.

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http://dx.doi.org/10.3390/ijms17040486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848942PMC
April 2016

Recent advances in mesenchymal stem cell immunomodulation: the role of microvesicles.

Cell Transplant 2015 21;24(2):133-49. Epub 2013 Nov 21.

Research Laboratories, Bambino Gesù Children's Hospital, Rome, Italy.

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http://dx.doi.org/10.3727/096368913X675728DOI Listing
November 2015

Gene/environment interactions in the pathogenesis of autoimmunity: new insights on the role of Toll-like receptors.

Autoimmun Rev 2015 Nov 13;14(11):971-83. Epub 2015 Jul 13.

Immunology and Pharmacotherapy Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2015.07.006DOI Listing
November 2015

Thyrospheres From Normal or Malignant Thyroid Tissue Have Different Biological, Functional, and Genetic Features.

J Clin Endocrinol Metab 2015 Sep 7;100(9):E1168-78. Epub 2015 Jul 7.

Department of Clinical and Molecular Bio-Medicine (F.G., V.V., M.L.N., S.L., R.V., F.F.), Endocrinology Unit, Garibaldi-Nesima Medical Center, University of Catania, 95122 Catania, Italy; Immunology and Pharmacotherapy Area (A.F.), Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, 00165 Rome, Italy; Department of Motor Sciences (V.V.), School of Human and Social Sciences, "Kore" University of Enna, 94100 Enna, Italy; Division of Endocrinology (R.M., A.B.), Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy; and HUMANITAS (R.V.), Catania Oncology Center, 95126 Catania, Italy.

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http://dx.doi.org/10.1210/JC.2014-4163DOI Listing
September 2015

Expression of PD-1 Molecule on Regulatory T Lymphocytes in Patients with Insulin-Dependent Diabetes Mellitus.

Int J Mol Sci 2015 Sep 18;16(9):22584-605. Epub 2015 Sep 18.

Immunology and Pharmacotherapy Area, Children's Hospital Bambino Gesù, Viale S. Paolo 15, 00146 Rome, Italy.

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http://dx.doi.org/10.3390/ijms160922584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613325PMC
September 2015

How far are we from the clinical use of placental-derived mesenchymal stem cells?

Expert Opin Biol Ther 2015 May 5;15(5):613-7. Epub 2015 Jan 5.

Bambino Gesù Children's Hospital, Autoimmunity Laboratory, Immunology and Pharmacotherapy Area , IRCCS, Viale S. Paolo 15, 00146 Rome , Italy +39 06 6859 2656 ; +39 06 6859 2904 ;

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http://dx.doi.org/10.1517/14712598.2015.1000856DOI Listing
May 2015

Gut microbiota-derived outer membrane vesicles: under-recognized major players in health and disease?

Discov Med 2015 May;19(106):343-8

Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.

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May 2015

Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells.

Expert Opin Biol Ther 2015 Apr 25;15(4):495-504. Epub 2014 Dec 25.

Bambino Gesù Children's Hospital, Regenerative Medicine Unit, IRCCS , Piazza Sant'Onofrio 4, Rome 00165 , Italy.

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http://dx.doi.org/10.1517/14712598.2015.997706DOI Listing
April 2015

Pharmacological modulation of caspase-8 in thymus-related medical conditions.

J Pharmacol Exp Ther 2014 Oct 24;351(1):18-24. Epub 2014 Jul 24.

Foligno Nurse School, Department of Medicine (N.P.), Section of Hematology (M.P.M.), Section of Pharmacology (E.A., C.R., D.V.D.), Department of Medicine, Section of Onco-Hematology, Hospital S. Maria, Terni, Department of Surgery (A.M.L.), University of Perugia, Perugia, Italy; Autoimmunity Laboratory, Immunology and Pharmacotherapy Area, Bambin Gesù Children's Hospital IRCCS, Rome, Italy (A.F.); and Institute of Chemistry, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam (T.T.T.)

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http://dx.doi.org/10.1124/jpet.114.216572DOI Listing
October 2014

The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: the 'autophagy' hypothesis.

Med Hypotheses 2014 May 14;82(5):553-7. Epub 2014 Feb 14.

Autoimmunity Laboratory, Immunology Area, Bambino Gesù Children's Hospital IRCCS, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2014.02.010DOI Listing
May 2014

Recent insights on the putative role of autophagy in autoimmune diseases.

Autoimmun Rev 2014 Mar 1;13(3):231-41. Epub 2013 Nov 1.

Autoimmunity Laboratory, Immunology Area, Bambino Gesù Children's Hospital IRCCS, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2013.10.007DOI Listing
March 2014

The immunosuppressive effect of mesenchymal stromal cells on B lymphocytes is mediated by membrane vesicles.

Cell Transplant 2013 ;22(2):369-79

Research Laboratories, Children's Hospital Bambino Gesù Research Institute, 00165 Rome, Italy.

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http://dx.doi.org/10.3727/096368911X582769DOI Listing
January 2014

Endocrine autoimmunity in Turner syndrome.

Ital J Pediatr 2013 Dec 20;39:79. Epub 2013 Dec 20.

Autoimmunity Laboratory, Immunology Area, Bambino Gesù Children's Hospital IRCCS, Piazza S, Onofrio, 4-00165 Rome, Italy.

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http://dx.doi.org/10.1186/1824-7288-39-79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901035PMC
December 2013

Analysis of the autoimmune regulator gene in patients with autoimmune non-APECED polyendocrinopathies.

Genomics 2013 Sep 30;102(3):163-8. Epub 2013 Apr 30.

Research Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

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http://dx.doi.org/10.1016/j.ygeno.2013.04.016DOI Listing
September 2013

Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity.

Autoimmun Rev 2013 Sep 20;12(11):1091-100. Epub 2013 Jun 20.

Autoimmunity Laboratory, Immunology Area, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

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http://dx.doi.org/10.1016/j.autrev.2013.05.003DOI Listing
September 2013

Peculiar genotypes of the autoimmune regulator gene in Italian patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome.

Clin Lab 2013 ;59(5-6):675-80

Immunology Area, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

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August 2013

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.

Autoimmun Rev 2013 May 20;12(7):717-25. Epub 2012 Dec 20.

Autoimmunity Laboratory, Immunology Area, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

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http://dx.doi.org/10.1016/j.autrev.2012.12.003DOI Listing
May 2013

Multiorgan autoimmunity in a Turner syndrome patient with partial monosomy 2q and trisomy 10p.

Gene 2013 Feb 20;515(2):439-43. Epub 2012 Dec 20.

Division of Endocrinology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

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http://dx.doi.org/10.1016/j.gene.2012.12.007DOI Listing
February 2013

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies.

Autoimmun Rev 2012 Dec 7;12(2):281-8. Epub 2012 May 7.

Immunology Area, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

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http://dx.doi.org/10.1016/j.autrev.2012.04.007DOI Listing
December 2012

Proteasome inhibitors: a new perspective for treating autoimmune diseases.

Curr Drug Targets 2012 Dec;13(13):1665-75

Research Laboratories, Immunology Area, Children's Hospital Bambino Gesu, Rome, Italy.

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http://dx.doi.org/10.2174/138945012803530053DOI Listing
December 2012

Identifying thyroid stem/progenitor cells: advances and limitations.

J Endocrinol 2012 Apr 25;213(1):1-13. Epub 2011 Oct 25.

Research Laboratories, Ospedale Pediatrico Bambino Gesù Research Institute, Children's Hospital Bambino Gesù, Piazza S. Onofrio 4, Rome, Italy.

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http://dx.doi.org/10.1530/JOE-11-0183DOI Listing
April 2012

New prospects for treatment of autoimmune diseases.

Curr Pharm Des 2011 ;17(29):3092-3

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http://dx.doi.org/10.2174/138161211798157577DOI Listing
March 2012

Experimental strategies in autoimmunity: antagonists of cytokines and their receptors, nanocarriers, inhibitors of immunoproteasome, leukocyte migration and protein kinases.

Curr Pharm Des 2011 ;17(29):3094-107

Research Laboratories, Children's Hospital Bambino Gesù, Piazza S. Onofrio, 4, 00165 Rome, Italy.

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http://dx.doi.org/10.2174/138161211798157586DOI Listing
March 2012

A pathogenetic approach to autoimmune skin disease therapy: psoriasis and biological drugs, unresolved issues, and future directions.

Curr Pharm Des 2011 ;17(29):3176-90

Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia Italy.

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http://dx.doi.org/10.2174/138161211798157649DOI Listing
March 2012

Manipulating thymic apoptosis for future therapy of autoimmune diseases.

Curr Pharm Des 2011 ;17(29):3108-19

Section of Pharmacology, Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.

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http://dx.doi.org/10.2174/138161211798157621DOI Listing
March 2012

The potential of multimer technologies in type 1 diabetes prediction strategies.

Diabetes Metab Res Rev 2011 Mar;27(3):216-29

Research Laboratories, Ospedale Pediatrico Bambino Gesù, Research Institute (IRCCS), Piazza S. Onofrio 4, Rome, Italy.

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http://dx.doi.org/10.1002/dmrr.1165DOI Listing
March 2011

Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity.

Autoimmun Rev 2011 Jan 17;10(3):137-43. Epub 2010 Sep 17.

Research Laboratories, Children's Hospital Bambino Gesù, Piazza S. Onofrio, 4, 00165 Rome, Italy.

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http://dx.doi.org/10.1016/j.autrev.2010.08.019DOI Listing
January 2011

Recents patents for isolating, delivering and tracking adult stem cells in regenerative medicine.

Recent Pat Drug Deliv Formul 2010 Jun;4(2):105-13

Autoimmunity and Organ Regeneration Laboratory, Ospedale Pediatrico Bambino Gesu' Research Institute, Rome, Italy.

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http://dx.doi.org/10.2174/187221110791184980DOI Listing
June 2010

Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes.

Diabetes Res Clin Pract 2010 May 18;88(2):e14-6. Epub 2010 Feb 18.

Autoimmunity and Organ Regeneration Laboratory, Children's Hospital Bambino Gesù, Research Institute (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.

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http://dx.doi.org/10.1016/j.diabres.2010.01.018DOI Listing
May 2010

Isolation and characterization of omental adipose progenitor cells in children: a potential tool to unravel the pathogenesis of metabolic syndrome.

Horm Res 2009 21;72(6):348-58. Epub 2009 Oct 21.

Rina Balducci Center of Paediatric Endocrinology, Department of Public Health and Cell Biology, Tor Vergata University, Rome, Italy. arianna.maiorana @ hotmail.it

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http://dx.doi.org/10.1159/000249163DOI Listing
February 2010

Detection of GAD65 autoreactive T-cells by HLA class I tetramers in type 1 diabetic patients.

J Biomed Biotechnol 2009 8;2009:576219. Epub 2009 Dec 8.

Autoimmunity and Organ Regeneration Laboratory, Children's Hospital Bambino Gesù, Research Institute (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.

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http://dx.doi.org/10.1155/2009/576219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792951PMC
February 2010

Unravelling autoimmune pathogenesis by screening random peptide libraries with human sera.

Immunol Lett 2009 May 16;124(1):35-43. Epub 2009 Apr 16.

Autoimmunity and Organ Regeneration Laboratory, Ospedale Pediatrico Bambino Gesu', Research Institute, Piazza S. Onofrio 4, 00165 Rome, Italy.

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http://dx.doi.org/10.1016/j.imlet.2009.04.001DOI Listing
May 2009

Central precocious puberty and growth hormone deficiency in a boy with Prader-Willi syndrome.

Eur J Pediatr 2008 Dec 27;167(12):1455-8. Epub 2008 Feb 27.

Paediatric and Autoimmune Endocrine Diseases Unit, Bambino Gesù Children's Hospital, Research Institute, Via Torre di Palidoro, 00050 Palidoro, Rome, Italy.

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http://dx.doi.org/10.1007/s00431-008-0679-0DOI Listing
December 2008

Identification of an adult stem/progenitor cell-like population in the human thyroid.

J Endocrinol 2008 Sep 11;198(3):471-87. Epub 2008 Jun 11.

Autoimmunity and Organ Regeneration Laboratory, Ospedale Pediatrico Bambino Gesù Scientific Institute, Children's Hospital Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy.

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http://dx.doi.org/10.1677/JOE-07-0552DOI Listing
September 2008

Identification and characterization of adult stem/progenitor cells in the human bladder (bladder spheroids): perspectives of application in pediatric surgery.

Pediatr Surg Int 2007 Sep;23(9):837-9

Autoimmunity and Organ Regeneration Laboratory, Ospedale Pediatrico Bambino Gesù Scientific Institute (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.

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http://dx.doi.org/10.1007/s00383-007-1906-xDOI Listing
September 2007

Do mutations of RAG genes have a role in human autoimmunity? The Notarangelo's hypothesis revisited.

Diabetes Metab Res Rev 2006 Mar-Apr;22(2):108-10

Autoimmunity Laboratory, Bambino Gesù Research Institute (OPBG), Rome, Italy.

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http://dx.doi.org/10.1002/dmrr.593DOI Listing
May 2006

Importin beta: a novel autoantigen in human autoimmunity identified by screening random peptide libraries on phage.

J Autoimmun 2006 May 20;26(3):197-207. Epub 2006 Mar 20.

St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary College, London, UK.

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http://dx.doi.org/10.1016/j.jaut.2006.01.003DOI Listing
May 2006

The continuous discovery of autoantigens in endocrine organ-specific autoimmunity: do they help us to understand pathogenesis?

Springer Semin Immunopathol 2002 Dec;24(3):243-59

Autoimmunity Laboratory, Ospedale Pediatrico Bambino Gesu' Research Institute, Rome, Italy.

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http://dx.doi.org/10.1007/s00281-002-0114-yDOI Listing
December 2002