Alessandra Chesi

Alessandra Chesi

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Alessandra Chesi

Alessandra Chesi

Publications by authors named "Alessandra Chesi"

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Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver.

Am J Hum Genet 2019 Jul 13;105(1):89-107. Epub 2019 Jun 13.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612522PMC
July 2019

Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls.

Bone 2019 Apr 31;121:221-226. Epub 2019 Jan 31.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America; Department of Genetics, University of Pennsylvania, Philadelphia, PA, United States of America; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193003
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http://dx.doi.org/10.1016/j.bone.2019.01.026DOI Listing
April 2019

Leveraging putative enhancer-promoter interactions to investigate two-way epistasis in Type 2 Diabetes GWAS.

Pac Symp Biocomput 2018 ;23:548-558

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, PA, 19104, USA, ²Division of Human Genetics and Endocrinology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728670PMC
August 2018

Multidimensional Bone Density Phenotyping Reveals New Insights Into Genetic Regulation of the Pediatric Skeleton.

J Bone Miner Res 2018 May 30;33(5):812-821. Epub 2018 Mar 30.

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/jbmr.3362DOI Listing
May 2018

Leveraging epigenomics and contactomics data to investigate SNP pairs in GWAS.

Hum Genet 2018 May 24;137(5):413-425. Epub 2018 May 24.

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00439-018-1893-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996751PMC
May 2018

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

Am J Hum Genet 2018 01;102(1):88-102

Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777980PMC
January 2018

Association Between Linear Growth and Bone Accrual in a Diverse Cohort of Children and Adolescents.

JAMA Pediatr 2017 09 5;171(9):e171769. Epub 2017 Sep 5.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamapediatrics.2017.1769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632753PMC
September 2017

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.

Authors:
Maggie C Y Ng Mariaelisa Graff Yingchang Lu Anne E Justice Poorva Mudgal Ching-Ti Liu Kristin Young Lisa R Yanek Mary F Feitosa Mary K Wojczynski Kristin Rand Jennifer A Brody Brian E Cade Latchezar Dimitrov Qing Duan Xiuqing Guo Leslie A Lange Michael A Nalls Hayrettin Okut Salman M Tajuddin Bamidele O Tayo Sailaja Vedantam Jonathan P Bradfield Guanjie Chen Wei-Min Chen Alessandra Chesi Marguerite R Irvin Badri Padhukasahasram Jennifer A Smith Wei Zheng Matthew A Allison Christine B Ambrosone Elisa V Bandera Traci M Bartz Sonja I Berndt Leslie Bernstein William J Blot Erwin P Bottinger John Carpten Stephen J Chanock Yii-Der Ida Chen David V Conti Richard S Cooper Myriam Fornage Barry I Freedman Melissa Garcia Phyllis J Goodman Yu-Han H Hsu Jennifer Hu Chad D Huff Sue A Ingles Esther M John Rick Kittles Eric Klein Jin Li Barbara McKnight Uma Nayak Barbara Nemesure Adesola Ogunniyi Andrew Olshan Michael F Press Rebecca Rohde Benjamin A Rybicki Babatunde Salako Maureen Sanderson Yaming Shao David S Siscovick Janet L Stanford Victoria L Stevens Alex Stram Sara S Strom Dhananjay Vaidya John S Witte Jie Yao Xiaofeng Zhu Regina G Ziegler Alan B Zonderman Adebowale Adeyemo Stefan Ambs Mary Cushman Jessica D Faul Hakon Hakonarson Albert M Levin Katherine L Nathanson Erin B Ware David R Weir Wei Zhao Degui Zhi Donna K Arnett Struan F A Grant Sharon L R Kardia Olufunmilayo I Oloapde D C Rao Charles N Rotimi Michele M Sale L Keoki Williams Babette S Zemel Diane M Becker Ingrid B Borecki Michele K Evans Tamara B Harris Joel N Hirschhorn Yun Li Sanjay R Patel Bruce M Psaty Jerome I Rotter James G Wilson Donald W Bowden L Adrienne Cupples Christopher A Haiman Ruth J F Loos Kari E North

PLoS Genet 2017 Apr 21;13(4):e1006719. Epub 2017 Apr 21.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419579PMC
April 2017

The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

Diabetologia 2016 11 18;59(11):2360-2368. Epub 2016 Aug 18.

Divisions of Human Genetics and Endocrinology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Room 1102D, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00125-016-4077-2DOI Listing
November 2016

Rare EN1 Variants and Pediatric Bone Mass.

J Bone Miner Res 2016 08 31;31(8):1513-7. Epub 2016 Mar 31.

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/jbmr.2833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970877PMC
August 2016

Genetics of pediatric bone strength.

Bonekey Rep 2016 20;5:823. Epub 2016 Jul 20.

Department of Pediatrics, Division of Human Genetics, The Children's Hospital of Philadelphia , Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/bonekey.2016.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954586PMC
August 2016

Infant BMI or Weight-for-Length and Obesity Risk in Early Childhood.

Pediatrics 2016 05;137(5)

Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1542/peds.2015-3492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845873PMC
May 2016

Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density.

J Bone Miner Res 2016 Apr 14;31(4):789-95. Epub 2015 Dec 14.

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/jbmr.2744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826827PMC
April 2016

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.

Nat Commun 2016 Apr 15;7:11253. Epub 2016 Apr 15.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

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http://dx.doi.org/10.1038/ncomms11253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835537PMC
April 2016

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

Authors:
Janine F Felix Jonathan P Bradfield Claire Monnereau Ralf J P van der Valk Evie Stergiakouli Alessandra Chesi Romy Gaillard Bjarke Feenstra Elisabeth Thiering Eskil Kreiner-Møller Anubha Mahajan Niina Pitkänen Raimo Joro Alana Cavadino Ville Huikari Steve Franks Maria M Groen-Blokhuis Diana L Cousminer Julie A Marsh Terho Lehtimäki John A Curtin Jesus Vioque Tarunveer S Ahluwalia Ronny Myhre Thomas S Price Natalia Vilor-Tejedor Loïc Yengo Niels Grarup Ioanna Ntalla Wei Ang Mustafa Atalay Hans Bisgaard Alexandra I Blakemore Amelie Bonnefond Lisbeth Carstensen Johan Eriksson Claudia Flexeder Lude Franke Frank Geller Mandy Geserick Anna-Liisa Hartikainen Claire M A Haworth Joel N Hirschhorn Albert Hofman Jens-Christian Holm Momoko Horikoshi Jouke Jan Hottenga Jinyan Huang Haja N Kadarmideen Mika Kähönen Wieland Kiess Hanna-Maaria Lakka Timo A Lakka Alexandra M Lewin Liming Liang Leo-Pekka Lyytikäinen Baoshan Ma Per Magnus Shana E McCormack George McMahon Frank D Mentch Christel M Middeldorp Clare S Murray Katja Pahkala Tune H Pers Roland Pfäffle Dirkje S Postma Christine Power Angela Simpson Verena Sengpiel Carla M T Tiesler Maties Torrent André G Uitterlinden Joyce B van Meurs Rebecca Vinding Johannes Waage Jane Wardle Eleftheria Zeggini Babette S Zemel George V Dedoussis Oluf Pedersen Philippe Froguel Jordi Sunyer Robert Plomin Bo Jacobsson Torben Hansen Juan R Gonzalez Adnan Custovic Olli T Raitakari Craig E Pennell Elisabeth Widén Dorret I Boomsma Gerard H Koppelman Sylvain Sebert Marjo-Riitta Järvelin Elina Hyppönen Mark I McCarthy Virpi Lindi Niinikoski Harri Antje Körner Klaus Bønnelykke Joachim Heinrich Mads Melbye Fernando Rivadeneira Hakon Hakonarson Susan M Ring George Davey Smith Thorkild I A Sørensen Nicholas J Timpson Struan F A Grant Vincent W V Jaddoe

Hum Mol Genet 2016 Jan 24;25(2):389-403. Epub 2015 Nov 24.

The Generation R Study Group, Department of Pediatrics, Department of Epidemiology.

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http://hmg.oxfordjournals.org/content/early/2015/12/16/hmg.d
Web Search
http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
Publisher Site
http://dx.doi.org/10.1093/hmg/ddv472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854022PMC
January 2016

The Genetics of Pediatric Obesity.

Trends Endocrinol Metab 2015 Dec 1;26(12):711-721. Epub 2015 Oct 1.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10432760150016
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http://dx.doi.org/10.1016/j.tem.2015.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673034PMC
December 2015

BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures.

Mol Biol Evol 2015 Nov 29;32(11):2961-72. Epub 2015 Jul 29.

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

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http://dx.doi.org/10.1093/molbev/msv170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651235PMC
November 2015

A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius.

Hum Mol Genet 2015 Sep 3;24(17):5053-9. Epub 2015 Jun 3.

Division of Human Genetics, Center for Applied Genomics, Division of Endocrinology and, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/hmg/ddv210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527490PMC
September 2015

Body mass index (BMI) trajectories in infancy differ by population ancestry and may presage disparities in early childhood obesity.

J Clin Endocrinol Metab 2015 Apr 30;100(4):1551-60. Epub 2015 Jan 30.

Division of Endocrinology and Diabetes (S.M.R., A.K., S.F.A.G, S.E.M.), Division of Human Genetics (A.C., H.H., S.F.A.G.), Center for Applied Genomics (F.M., R.C., H.H., S.F.A.G.), Division of Gastroenterology, Hepatology, and Nutrition (B.S.Z.), The Children's Hospital of Philadelphia, and Departments of Biostatistics and Epidemiology (R.X., J.A.M.) and Pediatrics (A.K., H.H., S.F.A.G., B.S.Z, S.E.M.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2014-4028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399305PMC
April 2015

The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast.

PLoS One 2012 23;7(3):e34178. Epub 2012 Mar 23.

Department of Genetics, Stanford University School of Medicine, Stanford University, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034178PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311584PMC
August 2012

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS.

PLoS Biol 2011 Apr 26;9(4):e1000614. Epub 2011 Apr 26.

Department of Cell and Developmental Biology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1000614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082519PMC
April 2011