Publications by authors named "Alessandra Balduini"

80Publications

Increased β4GALT1 expression associates with platelet surface galactosylation and thrombopoietin plasma levels in MPNs.

Blood 2020 Nov 25. Epub 2020 Nov 25.

Department of Biomedical Engineering, Tufts University, Medford, MA, United States.

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http://dx.doi.org/10.1182/blood.2020007265DOI Listing
November 2020

Low penetrance COL5A1 variants in a young patient with intracranial aneurysm and very mild signs of Ehlers-Danlos syndrome.

Eur J Med Genet 2020 Nov 12:104099. Epub 2020 Nov 12.

Medical Genetics Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1016/j.ejmg.2020.104099DOI Listing
November 2020

A Gold Standard Protocol for Human Megakaryocyte Culture Based on the Analysis of 1,500 Umbilical Cord Blood Samples.

Thromb Haemost 2020 Nov 7. Epub 2020 Nov 7.

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1055/s-0040-1719028DOI Listing
November 2020

Pathogenetic and clinical study of a patient with thrombocytopenia due to the p.E527K gain-of-function variant of SRC.

Haematologica 2020 Sep 28;Online ahead of print. Epub 2020 Sep 28.

Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia.

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http://dx.doi.org/10.3324/haematol.2020.268516DOI Listing
September 2020

Mechanisms of platelet release: studies and modeling.

Platelets 2020 Aug 11;31(6):717-723. Epub 2020 Jun 11.

Department of Molecular Medicine, University of Pavia , Pavia, Italy.

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http://dx.doi.org/10.1080/09537104.2020.1774532DOI Listing
August 2020

β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.

Nat Commun 2020 01 17;11(1):356. Epub 2020 Jan 17.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-14178-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968998PMC
January 2020

Megakaryocytes from fat: a new recipe for platelets.

Blood 2019 02;133(7):623-625

University of Pavia.

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http://dx.doi.org/10.1182/blood-2018-12-889766DOI Listing
February 2019

Mechanisms of thrombocytopenia in platelet-type von Willebrand disease.

Haematologica 2019 07 17;104(7):1473-1481. Epub 2019 Jan 17.

Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia

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http://dx.doi.org/10.3324/haematol.2018.200378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601082PMC
July 2019

Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver.

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018068. Epub 2018 Nov 1.

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.4084/MJHID.2018.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223581PMC
November 2018

Three-Dimensional Tissue Models for Studying Ex Vivo Megakaryocytopoiesis and Platelet Production.

Methods Mol Biol 2018 ;1812:177-193

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1007/978-1-4939-8585-2_11DOI Listing
March 2019

Sub-Cellular Localization of Metalloproteinases in Megakaryocytes.

Cells 2018 Jul 20;7(7). Epub 2018 Jul 20.

Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.

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http://dx.doi.org/10.3390/cells7070080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071070PMC
July 2018

Multi-channel silk sponge mimicking bone marrow vascular niche for platelet production.

Biomaterials 2018 09 17;178:122-133. Epub 2018 Jun 17.

Department of Biomedical Engineering, Tufts University, Medford, MA, USA; Department of Molecular Medicine, University of Pavia, Pavia, Italy; Biotechnology Research Laboratories, IRCCS San Matteo Foundation, Pavia, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183043
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http://dx.doi.org/10.1016/j.biomaterials.2018.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082392PMC
September 2018

Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases.

Eur J Med Genet 2018 Nov 13;61(11):715-722. Epub 2018 Mar 13.

University of Pavia, Pavia, Italy; IRCCS Policlinico San Matteo Foundation, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2018.01.014DOI Listing
November 2018

Label free monitoring of megakaryocytic development and proplatelet formation in vitro.

Biomed Opt Express 2017 Oct 27;8(10):4742-4755. Epub 2017 Sep 27.

Department of Biomedical Engineering, Tufts University, 4 Colby St., 02155 Medford MA, USA.

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http://dx.doi.org/10.1364/BOE.8.004742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654814PMC
October 2017

Autoantibodies in immune thrombocytopenia affect the physiological interaction between megakaryocytes and bone marrow extracellular matrix proteins.

Br J Haematol 2018 10 26;183(2):319-323. Epub 2017 Oct 26.

Institute of Medical Research A Lanari, University of Buenos Aires, Buenos Aires, Argentina.

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http://dx.doi.org/10.1111/bjh.14977DOI Listing
October 2018

Modular flow chamber for engineering bone marrow architecture and function.

Biomaterials 2017 Nov 8;146:60-71. Epub 2017 Aug 8.

Department of Molecular Medicine, University of Pavia, Pavia, Italy; Biotechnology Research Laboratories, IRCCS San Matteo Foundation, Pavia, Italy; Department of Biomedical Engineering, Tufts University, Medford, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056889PMC
November 2017

Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis.

Am J Pathol 2017 Aug;187(8):1879-1892

Vascular Biology Laboratory, The FIRC Institute of Molecular Oncology (IFOM) Foundation, Milan, Italy; Department of Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.04.006DOI Listing
August 2017

Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis.

Blood 2017 08 7;130(6):829-831. Epub 2017 Jun 7.

Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA; and.

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http://dx.doi.org/10.1182/blood-2017-04-777417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553577PMC
August 2017

The Plant Hormone Abscisic Acid Is a Prosurvival Factor in Human and Murine Megakaryocytes.

J Biol Chem 2017 02 3;292(8):3239-3251. Epub 2017 Jan 3.

From the Departments of Molecular Medicine, Laboratories of Biotechnology, IRCCS San Matteo Foundation, and

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http://dx.doi.org/10.1074/jbc.M116.751693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336159PMC
February 2017

Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis.

Int J Mol Sci 2016 Dec 8;17(12). Epub 2016 Dec 8.

Laboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.

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http://dx.doi.org/10.3390/ijms17122055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187855PMC
December 2016

Studies of the interaction of ticagrelor with the P2Y receptor and with P2Y-dependent pro-platelet formation by human megakaryocytes.

Thromb Haemost 2016 Nov 8;116(6):1079-1088. Epub 2016 Sep 8.

Marco Cattaneo, Medicina 3, Ospedale San Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano. Milan, Italy, Tel.: +39 0250323095, Fax: +39 0250323089, E-mail:

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http://dx.doi.org/10.1160/TH15-10-0829DOI Listing
November 2016

Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation.

Mediators Inflamm 2016 31;2016:8512417. Epub 2016 Jul 31.

Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., Laboratory for Endocrine Disruptors and Chair of Endocrinology University of Pavia, 27100 Pavia, Italy.

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http://dx.doi.org/10.1155/2016/8512417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983361PMC
August 2017

Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease: effects of anti-TNF-α treatment.

Thromb Haemost 2016 08 16;116(3):486-95. Epub 2016 Jun 16.

Prof. Giovanni Davì, Internal Medicine and Center of Excellence on Aging, "G. D'Annunzio" University Foundation, Via Colle dell'Ara, 66013 Chieti, Italy, E-mail:

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http://dx.doi.org/10.1160/TH16-02-0167DOI Listing
August 2016

SLFN14-related thrombocytopenia: identification within a large series of patients with inherited thrombocytopenia.

Thromb Haemost 2016 05 14;115(5):1076-9. Epub 2016 Jan 14.

Alessandro Pecci, Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Piazzale Golgi, 27100 Pavia, Italy, Tel.: +39 0382 501358, Fax: +39 0382 526223, E-mail:

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http://dx.doi.org/10.1160/TH15-11-0884DOI Listing
May 2016

TNF-α increases the membrane expression of the chemokine receptor CCR6 in thyroid tumor cells, but not in normal thyrocytes: potential role in the metastatic spread of thyroid cancer.

Tumour Biol 2016 Apr 17;37(4):5569-75. Epub 2015 Nov 17.

Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Fondazione Salvatore Maugeri I.R.C.C.S., Via Maugeri 10, 27100, Pavia, Italy.

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http://dx.doi.org/10.1007/s13277-015-4418-7DOI Listing
April 2016

Translational approaches to functional platelet production ex vivo.

Thromb Haemost 2016 Jan 10;115(2):250-6. Epub 2015 Sep 10.

David L. Kaplan, Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA, Tel.: +1 617 627 2580, Fax: +1 617 627 3231, E-mail:

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http://dx.doi.org/10.1160/TH15-07-0570DOI Listing
January 2016

Human megakaryocytes confer tissue factor to a subset of shed platelets to stimulate thrombin generation.

Thromb Haemost 2015 Aug 11;114(3):579-92. Epub 2015 Jun 11.

Marina Camera, Ph.D., Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy, Tel. : +39 02 58 00 22 55, Fax: +39 02 58 00 23 42, E-mail:

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http://dx.doi.org/10.1160/TH14-10-0830DOI Listing
August 2015

Hyaluronan based hydrogels provide an improved model to study megakaryocyte-matrix interactions.

Exp Cell Res 2016 08 29;346(1):1-8. Epub 2015 May 29.

Department of Molecular Medicine, University of Pavia, Pavia, Italy; Laboratory of Biotechnology, IRCCS San Matteo Foundation, Pavia, Italy; Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071306PMC
http://dx.doi.org/10.1016/j.yexcr.2015.05.014DOI Listing
August 2016

Altered fibronectin expression and deposition by myeloproliferative neoplasm-derived mesenchymal stromal cells.

Br J Haematol 2016 Jan 5;172(1):140-4. Epub 2015 May 5.

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1111/bjh.13471DOI Listing
January 2016

Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies.

Blood 2015 Apr 9;125(14):2254-64. Epub 2015 Jan 9.

Department of Molecular Medicine, University of Pavia, Pavia, Italy; Biotechnology Research Laboratories, Istituto di Ricovero e Cura a Carattere Scientifico San Matteo Foundation, Pavia, Italy; Department of Biomedical Engineering, Tufts University, Medford, MA;

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http://dx.doi.org/10.1182/blood-2014-08-595561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383799PMC
April 2015

The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control.

Cell Mol Life Sci 2015 Apr 9;72(8):1517-36. Epub 2015 Jan 9.

Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy.

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http://dx.doi.org/10.1007/s00018-014-1813-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369169PMC
April 2015

Characteristics of platelet gels combined with silk.

Biomaterials 2014 Apr 27;35(11):3678-87. Epub 2014 Jan 27.

Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, MA 02155, USA; University of Pavia, Department of Molecular Medicine, Via Forlanini 6, Pavia 27100, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2013.12.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004629PMC
April 2014

Definition of the native and denatured type II collagen binding site for fibronectin using a recombinant collagen system.

J Biol Chem 2014 Feb 29;289(8):4941-51. Epub 2013 Dec 29.

From the Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155 and.

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http://dx.doi.org/10.1074/jbc.M113.530808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931055PMC
February 2014

Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and laminin.

Stem Cells 2014 Apr;32(4):926-37

Department of Molecular Medicine, University of Pavia, Pavia, Italy; Biotechnology Research Laboratories, IRCCS San Matteo Foundation, Pavia, Italy.

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http://dx.doi.org/10.1002/stem.1626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096110PMC
April 2014

Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions.

J Biol Chem 2013 Jun 24;288(23):16738-46. Epub 2013 Mar 24.

Biotechnology Research Laboratories, Department of Molecular Medicine, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Matteo Foundation, University of Pavia, 27100 Pavia, Italy.

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http://dx.doi.org/10.1074/jbc.M112.431528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675607PMC
June 2013

Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis.

Haematologica 2013 Apr 12;98(4):514-7. Epub 2013 Feb 12.

Biotechnology Laboratories, Department of Molecular Medicine, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

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http://dx.doi.org/10.3324/haematol.2012.076752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659980PMC
April 2013

High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes.

PLoS One 2013 24;8(1):e54723. Epub 2013 Jan 24.

Department of Molecular Medicine, Biotechnology Laboratories, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054723PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554640PMC
September 2013

Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes.

Haematologica 2012 Nov 11;97(11):1657-65. Epub 2012 Jun 11.

Biotechnology Laboratories, Department of Molecular Medicine, IRCCS San Matteo Foundation, Università degli Studi di Pavia, Pavia, Italy.

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http://dx.doi.org/10.3324/haematol.2011.059212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487437PMC
November 2012

Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes.

PLoS One 2012 23;7(4):e34449. Epub 2012 Apr 23.

Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034449PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335122PMC
September 2012

Blood platelet production and morphology.

Thromb Res 2012 Mar 5;129(3):241-4. Epub 2012 Jan 5.

Department of Biochemistry, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1016/j.thromres.2011.11.042DOI Listing
March 2012

Three-dimensional system for the in vitro study of megakaryocytes and functional platelet production using silk-based vascular tubes.

Tissue Eng Part C Methods 2011 Dec 6;17(12):1223-32. Epub 2011 Sep 6.

Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA.

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http://dx.doi.org/10.1089/ten.tec.2011.0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226422PMC
December 2011

New aspects of Filamin A versatility.

Blood 2011 Aug;118(8):2029-30

University of Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2011-06-361303DOI Listing
August 2011

Extracellular matrix structure and nano-mechanics determine megakaryocyte function.

Blood 2011 Oct 9;118(16):4449-53. Epub 2011 Aug 9.

Department of Biochemistry, Istituto di Ricovero e Cura a Carattere Scientifico San Matteo Foundation, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2011-04-345876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291488PMC
October 2011

Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A.

Blood 2011 Feb 3;117(8):2476-83. Epub 2010 Dec 3.

Department of Biochemistry, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Matteo Foundation, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2010-06-288795DOI Listing
February 2011

Evaluation of the bioactive and total transforming growth factor β1 levels in primary myelofibrosis.

Cytokine 2011 Jan 30;53(1):100-6. Epub 2010 Aug 30.

Laboratory of Clinical Epidemiology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.cyto.2010.07.427DOI Listing
January 2011

Megakaryocytes of patients with MYH9-related thrombocytopenia present an altered proplatelet formation.

Thromb Haemost 2009 Jul;102(1):90-6

Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1160/TH09-01-0068DOI Listing
July 2009

Tissue factor in patients with acute coronary syndromes: expression in platelets, leukocytes, and platelet-leukocyte aggregates.

Arterioscler Thromb Vasc Biol 2008 May 21;28(5):947-53. Epub 2008 Feb 21.

Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133 Milan, Italy.

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http://dx.doi.org/10.1161/ATVBAHA.107.161471DOI Listing
May 2008

Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations.

Hum Mol Genet 2005 Nov 14;14(21):3169-78. Epub 2005 Sep 14.

Department of Internal Medicine, University of Pavia, Italy.

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http://dx.doi.org/10.1093/hmg/ddi344DOI Listing
November 2005

Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes.

Exp Cell Res 2004 Oct;300(1):84-93

Center of Excellence for Applied Biology, Department of Biochemistry, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1016/j.yexcr.2004.07.011DOI Listing
October 2004