Ales Cvekl

Ales Cvekl

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Ales Cvekl

Publications by authors named "Ales Cvekl"

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A distal enhancer that directs Otx2 expression in the retinal pigment epithelium and neuroretina.

Dev Dyn 2020 02 19;249(2):209-221. Epub 2019 Nov 19.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York.

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http://dx.doi.org/10.1002/dvdy.127DOI Listing
February 2020

Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3.

Open Biol 2019 12 18;9(12):190220. Epub 2019 Dec 18.

Departments of Ophthalmology and Visual Sciences and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1098/rsob.190220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936257PMC
December 2019

Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.

Cell Rep 2019 Aug;28(8):1993-2003.e5

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461, USA; Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716522PMC
August 2019

Profiling of chromatin accessibility and identification of general cis-regulatory mechanisms that control two ocular lens differentiation pathways.

Epigenetics Chromatin 2019 05 3;12(1):27. Epub 2019 May 3.

The Departments of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.

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http://dx.doi.org/10.1186/s13072-019-0272-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498704PMC
May 2019

Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids.

Proc Natl Acad Sci U S A 2019 05 9;116(22):10824-10833. Epub 2019 May 9.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461;

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http://dx.doi.org/10.1073/pnas.1901572116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561190PMC
May 2019

Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers.

Exp Eye Res 2019 02 22;179:32-46. Epub 2018 Oct 22.

Departments Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY, 10461, USA; Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183031
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http://dx.doi.org/10.1016/j.exer.2018.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360118PMC
February 2019

Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers.

Invest Ophthalmol Vis Sci 2019 01;60(1):234-244

Departments of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States.

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http://dx.doi.org/10.1167/iovs.18-25921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336207PMC
January 2019

Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus.

Biol Open 2018 Dec 7;7(12). Epub 2018 Dec 7.

Departments Ophthalmology and Visual Sciences and Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 123, Bronx, NY 10461, USA

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http://dx.doi.org/10.1242/bio.036897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310886PMC
December 2018

Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens.

Dev Dyn 2018 11 10;247(11):1186-1198. Epub 2018 Nov 10.

Departments of Ophthalmology and Visual Sciences and Genetics, Albert Einstein College of Medicine, Bronx, New York.

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http://dx.doi.org/10.1002/dvdy.24677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246825PMC
November 2018

Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation.

Cell Rep 2018 11;25(9):2510-2523.e4

Departments of Ophthalmology and Visual Sciences and Genetics, Albert Einstein College of Medicine, New York, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.10.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317371PMC
November 2018

A comprehensive spatial-temporal transcriptomic analysis of differentiating nascent mouse lens epithelial and fiber cells.

Exp Eye Res 2018 10 5;175:56-72. Epub 2018 Jun 5.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167154PMC
October 2018

BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation.

Exp Eye Res 2018 09 4;174:173-184. Epub 2018 Jun 4.

Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110959PMC
September 2018

Signaling and Gene Regulatory Networks in Mammalian Lens Development.

Trends Genet 2017 10 31;33(10):677-702. Epub 2017 Aug 31.

Departments of Ophthalmology, Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627649PMC
October 2017

N-myc regulates growth and fiber cell differentiation in lens development.

Dev Biol 2017 09 14;429(1):105-117. Epub 2017 Jul 14.

Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586101PMC
September 2017

Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice.

Authors:
Wei Liu Ales Cvekl

Dev Biol 2017 08 1;428(1):164-175. Epub 2017 Jun 1.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA; Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.ydbio.2017.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533277PMC
August 2017

Evolutionary Origins of Pax6 Control of Crystallin Genes.

Genome Biol Evol 2017 08;9(8):2075-2092

Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.

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http://dx.doi.org/10.1093/gbe/evx153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737492PMC
August 2017

PAX6: 25th anniversary and more to learn.

Exp Eye Res 2017 03 25;156:10-21. Epub 2016 Apr 25.

Laboratory of Behavioral and Developmental Genetics, K.U. Leuven, VIB, 3000, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2016.04.017DOI Listing
March 2017

Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers.

Epigenetics Chromatin 2016 9;9(1):37. Epub 2016 Sep 9.

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461 USA ; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461 USA.

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http://dx.doi.org/10.1186/s13072-016-0087-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018195PMC
September 2016

Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals.

Development 2016 08 6;143(15):2829-41. Epub 2016 Jul 6.

Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 69978, Israel

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http://dx.doi.org/10.1242/dev.136101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004910PMC
August 2016

Chromatin features, RNA polymerase II and the comparative expression of lens genes encoding crystallins, transcription factors, and autophagy mediators.

Mol Vis 2015 28;21:955-73. Epub 2015 Aug 28.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY ; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551281PMC
May 2016

Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid.

Stem Cell Reports 2016 05 28;6(5):743-756. Epub 2016 Apr 28.

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939656PMC
May 2016

Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract.

FASEB J 2016 Mar 20;30(3):1087-95. Epub 2015 Nov 20.

*Ministry of Education Key Laboratory of Bio-resource and Eco-environment, College of Life Science, Sichuan University, Sichuan China; Laboratory for Nutrition and Vision Research, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA; Department of Biological Sciences, University of Delaware, Newark, Delaware, USA; Department of Genetics and Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York, USA; and Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, Missouri, USA

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http://dx.doi.org/10.1096/fj.15-278036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750420PMC
March 2016

Lens Development and Crystallin Gene Expression.

Prog Mol Biol Transl Sci 2015 12;134:129-67. Epub 2015 Jun 12.

Departments of Genetics and Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1016/bs.pmbts.2015.05.001DOI Listing
February 2016

Lens Biology and Biochemistry.

Prog Mol Biol Transl Sci 2015 4;134:169-201. Epub 2015 Jun 4.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2015.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538311PMC
February 2016

Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.

J Biol Chem 2016 Feb 30;291(8):3947-58. Epub 2015 Dec 30.

From the Departments of Ophthalmology and Visual Sciences and Genetics, Albert Einstein College of Medicine, Bronx, New York 10461,

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http://dx.doi.org/10.1074/jbc.M115.705103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759173PMC
February 2016

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.

Nucleic Acids Res 2015 Aug 2;43(14):6827-46. Epub 2015 Jul 2.

The Departments of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA

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http://dx.doi.org/10.1093/nar/gkv589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538810PMC
August 2015

Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeat.

PLoS One 2014 5;9(5):e95151. Epub 2014 May 5.

Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095151PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010391PMC
June 2015

The cellular and molecular mechanisms of vertebrate lens development.

Development 2014 Dec 18;141(23):4432-47. Epub 2014 Nov 18.

Sackler School of Medicine and Sagol School of Neuroscience, Tel-Aviv University, 69978 Ramat Aviv, Tel Aviv, Israel

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http://dx.doi.org/10.1242/dev.107953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302924PMC
December 2014

Gene regulation by PAX6: structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204.

Mol Vis 2014 6;20:270-82. Epub 2014 Mar 6.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY ; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945805PMC
September 2014

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

Nucleic Acids Res 2013 Dec 12;41(22):10199-214. Epub 2013 Sep 12.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, Department of Surgery, Creighton University, Omaha, NE 68178, USA, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978.

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http://dx.doi.org/10.1093/nar/gkt824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905850PMC
December 2013

Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage.

Neurobiol Dis 2013 Feb 23;50:1-12. Epub 2012 Sep 23.

Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.nbd.2012.09.008DOI Listing
February 2013

Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells.

Mol Vis 2012 30;18:1773-86. Epub 2012 Jun 30.

Department of Biomedical Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398491PMC
November 2012

Focus on molecules: Brg1: a range of functions during eye development.

Exp Eye Res 2012 Oct 24;103:117-8. Epub 2011 Sep 24.

Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.exer.2011.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288191PMC
October 2012

The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.

Authors:
Qing Xie Ales Cvekl

J Biol Chem 2011 Dec 13;286(50):43259-71. Epub 2011 Oct 13.

Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M111.264580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234836PMC
December 2011

Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.

Am J Med Genet A 2010 Dec;152A(12):2947-61

Department of Otorhinolaryngology Head & Neck Surgery, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1002/ajmg.a.33670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057869PMC
December 2010

Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions.

FASEB J 2010 Sep 21;24(9):3274-83. Epub 2010 Apr 21.

Department of Ophthalmology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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http://dx.doi.org/10.1096/fj.10-157255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923359PMC
September 2010

Retinoic acid signaling in mammalian eye development.

Exp Eye Res 2009 Sep 7;89(3):280-91. Epub 2009 May 7.

The Department Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.exer.2009.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756743PMC
September 2009

Identification of pax6-dependent gene regulatory networks in the mouse lens.

PLoS One 2009 9;4(1):e4159. Epub 2009 Jan 9.

Department of Ophthalmology, Albert Einstein College of Medicine, Bronx, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004159PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612750PMC
February 2009

Dual requirement for Pax6 in retinal progenitor cells.

Development 2008 Dec 12;135(24):4037-4047. Epub 2008 Nov 12.

Sackler Faculty of Medicine, Human Molecular Genetics and Biochemistry, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel.

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http://dx.doi.org/10.1242/dev.028308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231183PMC
December 2008

Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis.

Development 2008 Sep 24;135(17):2939-48. Epub 2008 Jul 24.

Department of Biochemistry and Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1242/dev.021097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654719PMC
September 2008

Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivates.

BMC Dev Biol 2008 Sep 19;8:88. Epub 2008 Sep 19.

The Departments of Ophthalmology and Visual Sciences, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1186/1471-213X-8-88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567317PMC
September 2008

Genetic and epigenetic mechanisms of gene regulation during lens development.

Prog Retin Eye Res 2007 Nov 28;26(6):555-97. Epub 2007 Jul 28.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.preteyeres.2007.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136409PMC
November 2007

Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens.

J Mol Biol 2007 Jun 5;369(4):917-26. Epub 2007 Apr 5.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063435PMC
June 2007

Rybp, a polycomb complex-associated protein, is required for mouse eye development.

BMC Dev Biol 2007 Apr 30;7:39. Epub 2007 Apr 30.

Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1186/1471-213X-7-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1877082PMC
April 2007

Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.

Mol Biol Cell 2007 Mar 20;18(3):755-67. Epub 2006 Dec 20.

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1091/mbc.e06-09-0793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805093PMC
March 2007

Large Maf Transcription Factors: Cousins of AP-1 Proteins and Important Regulators of Cellular Differentiation.

Einstein J Biol Med 2007 ;23(1):2-11

Departments of Ophthalmology and Visual Sciences and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151748PMC
http://dx.doi.org/10.23861/ejbm20072347DOI Listing
January 2007

DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth.

Mol Cell Biol 2006 Oct;26(19):7116-29

Kimmel Cancer Center, Department of Cancer Biology, Bluemle Life Sciences Building, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1128/MCB.00268-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592900PMC
October 2006

Tissue-specific regulation of the mouse alphaA-crystallin gene in lens via recruitment of Pax6 and c-Maf to its promoter.

J Mol Biol 2005 Aug;351(3):453-69

The Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.05.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080862PMC
August 2005

Palm is expressed in both developing and adult mouse lens and retina.

BMC Ophthalmol 2005 Jun 21;5:14. Epub 2005 Jun 21.

Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.

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http://dx.doi.org/10.1186/1471-2415-5-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183217PMC
June 2005

Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.

Eur J Cancer 2004 Nov;40(16):2525-32

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095980490400622
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http://dx.doi.org/10.1016/j.ejca.2004.08.005DOI Listing
November 2004

Transcriptional regulation of mouse alphaB- and gammaF-crystallin genes in lens: opposite promoter-specific interactions between Pax6 and large Maf transcription factors.

J Mol Biol 2004 Nov;344(2):351-68

The Department of Ophthalmology, Albert Einstein College of Medicine, 909 Ullmann, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.jmb.2004.07.102DOI Listing
November 2004

Functional interactions between alternatively spliced forms of Pax6 in crystallin gene regulation and in haploinsufficiency.

Nucleic Acids Res 2004 12;32(5):1696-709. Epub 2004 Mar 12.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1093/nar/gkh334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC390332PMC
July 2004

Expression of the alpha4 integrin subunit gene promoter is modulated by the transcription factor Pax-6 in corneal epithelial cells.

Invest Ophthalmol Vis Sci 2004 Jun;45(6):1692-704

Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Québec and Laval University, Ste-Foy, Canada.

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http://dx.doi.org/10.1167/iovs.03-0908DOI Listing
June 2004

Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases.

Bioessays 2004 Apr;26(4):374-86

The Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1002/bies.20009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094210PMC
April 2004

Functional properties of natural human PAX6 and PAX6(5a) mutants.

Invest Ophthalmol Vis Sci 2004 Feb;45(2):385-92

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080871PMC
http://dx.doi.org/10.1167/iovs.03-0968DOI Listing
February 2004

DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.

J Biol Chem 2003 Dec 2;278(51):51673-84. Epub 2003 Oct 2.

Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, D. C. 20057, USA.

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http://dx.doi.org/10.1074/jbc.M310021200DOI Listing
December 2003

Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult.

Invest Ophthalmol Vis Sci 2003 May;44(5):2084-93

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080867PMC
http://dx.doi.org/10.1167/iovs.02-0882DOI Listing
May 2003

A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens.

Genes Cells 2002 Dec;7(12):1267-83

The Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080869PMC
http://dx.doi.org/10.1046/j.1365-2443.2002.00602.xDOI Listing
December 2002

Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities.

Mech Dev 2002 Oct;118(1-2):3-17

Department of Anatomy, Molecular Anatomy and Embryology, University of Erlangen-Nürnberg, Universitätsstrasse 19, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1016/s0925-4773(02)00260-5DOI Listing
October 2002

Cataract- and lens-specific upregulation of ARK receptor tyrosine kinase in Emory mouse cataract.

Invest Ophthalmol Vis Sci 2002 Jun;43(6):1870-5

Department of Biology, West Virginia University, Morgantown, West Virginia 26506-6057, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957826PMC
June 2002

Identification of differentially expressed genes in mouse Pax6 heterozygous lenses.

Invest Ophthalmol Vis Sci 2002 Jun;43(6):1884-90

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080866PMC
June 2002

Structure of the retinal determination protein Dachshund reveals a DNA binding motif.

Structure 2002 Jun;10(6):787-95

Structural Biology Program, Skirball Institute, New York University Medical Center, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/s0969-2126(02)00769-4DOI Listing
June 2002

Identification of genes downstream of Pax6 in the mouse lens using cDNA microarrays.

J Biol Chem 2002 Mar 14;277(13):11539-48. Epub 2002 Jan 14.

Department of Ophthalmology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M110531200DOI Listing
March 2002