Alejandro Vaquero

Alejandro Vaquero

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Alejandro Vaquero

Alejandro Vaquero

Publications by authors named "Alejandro Vaquero"

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41Publications

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SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons.

Cell Death Dis 2018 05 1;9(5):531. Epub 2018 May 1.

Institut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

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http://www.nature.com/articles/s41419-018-0553-6
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http://dx.doi.org/10.1038/s41419-018-0553-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945655PMC
May 2018

Complex role of SIRT6 in NF-κB pathway regulation.

Mol Cell Oncol 2018 24;5(4):e1445942. Epub 2018 May 24.

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, SPAIN.

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https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1
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http://dx.doi.org/10.1080/23723556.2018.1445942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149701PMC
May 2018

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway.

Nat Commun 2018 01 9;9(1):101. Epub 2018 Jan 9.

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Via de l'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat (Barcelona), Spain.

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http://dx.doi.org/10.1038/s41467-017-02586-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760577PMC
January 2018

Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization.

Cell Rep 2017 Nov;21(8):2048-2057

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Av. Gran Via de l'Hospitalet, 199-203, 08907- L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.092DOI Listing
November 2017

Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1.

Proc Natl Acad Sci U S A 2017 10 18;114(40):E8352-E8361. Epub 2017 Sep 18.

Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany;

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http://dx.doi.org/10.1073/pnas.1706945114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635888PMC
October 2017

Raising the list of SirT7 targets to a new level.

Proteomics 2017 Jul;17(13-14)

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/pmic.201700137DOI Listing
July 2017

An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions.

Epigenetics 2017 02 6;12(2):166-175. Epub 2017 Jan 6.

a Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , L'Hospitalet de Llobregat, Barcelona , Spain.

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http://dx.doi.org/10.1080/15592294.2016.1278096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330444PMC
February 2017

KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.

Cancer Res 2015 Sep 24;75(18):3936-45. Epub 2015 Jul 24.

Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3702DOI Listing
September 2015

Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity.

FEBS J 2015 May 13;282(9):1745-67. Epub 2014 Oct 13.

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program, Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain.

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http://doi.wiley.com/10.1111/febs.13053
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http://dx.doi.org/10.1111/febs.13053DOI Listing
May 2015

Methods to study the role of sirtuins in genome stability.

Methods Mol Biol 2013 ;1077:273-83

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://link.springer.com/10.1007/978-1-62703-637-5_18
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http://dx.doi.org/10.1007/978-1-62703-637-5_18DOI Listing
April 2014

The embryonic linker histone H1 variant of Drosophila, dBigH1, regulates zygotic genome activation.

Dev Cell 2013 Sep 19;26(6):578-90. Epub 2013 Sep 19.

Institute of Molecular Biology of Barcelona, CSIC, 08028 Barcelona, Spain; Institute for Research in Biomedicine, IRB Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.devcel.2013.08.011DOI Listing
September 2013

A view on the role of epigenetics in the biology of malaria parasites.

PLoS Pathog 2012 13;8(12):e1002943. Epub 2012 Dec 13.

Barcelona Centre for International Health Research, CRESIB, Hospital Clínic-Universitat de Barcelona, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1371/journal.ppat.1002943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521673PMC
May 2013

The diversity of histone versus nonhistone sirtuin substrates.

Genes Cancer 2013 Mar;4(3-4):148-63

Cancer Epigenetics and Biology Program, Chromatin Biology Laboratory, Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain.

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http://gan.sagepub.com/lookup/doi/10.1177/1947601913483767
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http://dx.doi.org/10.1177/1947601913483767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764476PMC
March 2013

Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity.

Nucleic Acids Res 2012 Jul 9;40(12):5402-14. Epub 2012 Mar 9.

Institute of Molecular Biology of Barcelona, CSIC and Institute for Research in Biomedicine, IRB Barcelona, Spain.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384340PMC
July 2012

A big step for SIRT7, one giant leap for Sirtuins… in cancer.

Cancer Cell 2012 Jun;21(6):719-21

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Avinguda Gran Via de l'Hospitalet, 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ccr.2012.05.028DOI Listing
June 2012

The dual role of sirtuins in cancer.

Genes Cancer 2011 Jun;2(6):648-62

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.

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http://gan.sagepub.com/lookup/doi/10.1177/1947601911417862
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http://dx.doi.org/10.1177/1947601911417862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174263PMC
June 2011

Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.

Mol Cell 2011 Apr;42(2):210-23

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program, Institut d'Investigació Biomèdica de Bellvitge, Avinguda Gran Via de l'Hospitalet 199-203, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

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http://www.cell.com/cms/attachment/616340/4975918/mmc1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S109727651100213
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http://dx.doi.org/10.1016/j.molcel.2011.02.034DOI Listing
April 2011

At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins.

Cell Cycle 2010 May 15;9(10):1907-12. Epub 2010 May 15.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.4161/cc.9.10.11481DOI Listing
May 2010

The conserved role of sirtuins in chromatin regulation.

Int J Dev Biol 2009 ;53(2-3):303-22

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), ICREA and Catalan Institute of Oncology (ICO)/IDiBELL, Barcelona, Spain.

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http://www.intjdevbiol.com/paper.php?doi=082675av
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http://dx.doi.org/10.1387/ijdb.082675avDOI Listing
September 2009

Calorie restriction and the exercise of chromatin.

Genes Dev 2009 Aug 16;23(16):1849-69. Epub 2009 Jul 16.

Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), ICREA, and IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1807009
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http://dx.doi.org/10.1101/gad.1807009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725938PMC
August 2009

Characterization of Drosophila melanogaster JmjC+N histone demethylases.

Nucleic Acids Res 2008 May 29;36(9):2852-63. Epub 2008 Mar 29.

Institute of Molecular Biology of Barcelona, CSIC, Institute for Research in Biomedicine (IRB Barcelona), Parc Científic de Barcelona, Josep Samitier, 1-5, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1093/nar/gkn098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396428PMC
May 2008

Activation properties of GAGA transcription factor.

Biochim Biophys Acta 2008 May 16;1779(5):312-7. Epub 2008 Feb 16.

Departament de Biologia Molecular i Cellular Institut de Biologia Molecular de Barcelona, CSIC Parc Científic de Barcelona Josep Samitier, 1-5 08028 Barcelona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S187493990800048
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http://dx.doi.org/10.1016/j.bbagrm.2008.02.005DOI Listing
May 2008

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.

Nature 2007 Nov;450(7168):440-4

Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Jersey 08854, USA.

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http://dx.doi.org/10.1038/nature06268DOI Listing
November 2007

L3MBTL1, a histone-methylation-dependent chromatin lock.

Cell 2007 Jun;129(5):915-28

Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740700517
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http://dx.doi.org/10.1016/j.cell.2007.03.048DOI Listing
June 2007

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress.

Genes Dev 2007 Apr;21(8):920-8

Howard Hughes Medical Institute, New York University Medical School, New York, New York 10016, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1527307
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http://dx.doi.org/10.1101/gad.1527307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847710PMC
April 2007

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.

Proc Natl Acad Sci U S A 2005 Feb 31;102(6):1859-64. Epub 2005 Jan 31.

Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1073/pnas.0409875102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548563PMC
February 2005

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

Mol Cell 2004 Oct;16(1):93-105

Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.08.031DOI Listing
October 2004

The constantly changing face of chromatin.

Sci Aging Knowledge Environ 2003 Apr 9;2003(14):RE4. Epub 2003 Apr 9.

Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1126/sageke.2003.14.re4DOI Listing
April 2003