Publications Authored by Alejandro Leal

Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures.

Authors:

Luis Rosero-Bixby David H Rehkopf William H Dow Jue Lin Elissa S Epel Jorge Azofeifa Alejandro Leal

PLoS One 2019 11;14(10):e0223766. Epub 2019 Oct 11.

Escuela de Biología, Universidad de Costa Rica, San Jose, Costa Rica.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223766	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788698	PMC

October 2019

DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria.

Authors:

Luis Bermúdez-Guzmán Alejandro Leal

Transl Neurodegener 2019 9;8:14. Epub 2019 May 9.

1Section of Genetics and Biotechnology, School of Biology, Universidad de Costa Rica, San José, 11501 Costa Rica.

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https://translationalneurodegeneration.biomedcentral.com/art	Publisher Site
http://dx.doi.org/10.1186/s40035-019-0156-x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511134	PMC

May 2019

The polynucleotide kinase 3'-phosphatase gene (PNKP) is involved in Charcot-Marie-Tooth disease (CMT2B2) previously related to MED25.

Authors:

Alejandro Leal Sixto Bogantes-Ledezma Arif B Ekici Steffen Uebe Christian T Thiel Heinrich Sticht Martin Berghoff Corinna Berghoff Bernal Morera Michael Meisterernst André Reis

Neurogenetics 2018 12 24;19(4):215-225. Epub 2018 Jul 24.

Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

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http://dx.doi.org/10.1007/s10048-018-0555-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280876	PMC

December 2018

Amerindian ancestry and extended longevity in Nicoya, Costa Rica.

Authors:

Jorge Azofeifa Edward A Ruiz-Narváez Alejandro Leal Hanna Gerlovin Luis Rosero-Bixby

Am J Hum Biol 2018 01 8;30(1). Epub 2017 Sep 8.

Emeritus Professor, Escuela de Estadística and Centro Centroamericano de Población, Universidad de Costa Rica, Ciudad Universitaria Rodrigo Facio, San Pedro, 2060 San José, Costa Rica.

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http://dx.doi.org/10.1002/ajhb.23055	DOI Listing

January 2018

A Homozygous Mutation in GPT2 Associated with Nonsyndromic Intellectual Disability in a Consanguineous Family from Costa Rica.

Authors:

Tanya Lobo-Prada Heinrich Sticht Sixto Bogantes-Ledezma Arif Ekici Steffen Uebe André Reis Alejandro Leal

JIMD Rep 2017 28;36:59-66. Epub 2017 Jan 28.

Section of Genetics and Biotechnology, School of Biology, University of Costa Rica, 11501-2060, San Jose, Costa Rica.

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http://dx.doi.org/10.1007/8904_2016_40	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680285	PMC

January 2017

Eight further individuals with intellectual disability and epilepsy carrying bi-allelic CNTNAP2 aberrations allow delineation of the mutational and phenotypic spectrum.

Authors:

Mateja Smogavec Alison Cleall Juliane Hoyer Damien Lederer Marie-Cécile Nassogne Elizabeth E Palmer Marie Deprez Valérie Benoit Isabelle Maystadt Charlotte Noakes Alejandro Leal Marie Shaw Jozef Gecz Lucy Raymond André Reis Deborah Shears Knut Brockmann Christiane Zweier

J Med Genet 2016 12 20;53(12):820-827. Epub 2016 Jul 20.

Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

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http://dx.doi.org/10.1136/jmedgenet-2016-103880	DOI Listing

December 2016

A Costa Rican family affected with Charcot-Marie-Tooth disease due to the myelin protein zero (MPZ) p.Thr124Met mutation shares the Belgian haplotype.

Authors:

Alejandro Leal Corinna Berghoff Martin Berghoff Melissa Rojas-Araya Ortiz Carolina Dieter Heuss Gerardo Del Valle Bernd Rautenstrauss

Rev Biol Trop 2014 Dec;62(4):1285-93

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http://dx.doi.org/10.15517/rbt.v62i4.13473	DOI Listing

December 2014

Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy.

Authors:

Thomas E Ichim Doru T Alexandrescu Fabio Solano Fabian Lara Rosalia De Necochea Campion Eugenia Paris Erik J Woods Michael P Murphy Constantin A Dasanu Amit N Patel Annette M Marleau Alejandro Leal Neil H Riordan

Cell Immunol 2010 ;260(2):75-82

Medistem Inc., San Diego, CA 92122, USA.

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http://dx.doi.org/10.1016/j.cellimm.2009.10.006	DOI Listing

January 2010

Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.

Neurogenetics 2009 Oct 17;10(4):275-87. Epub 2009 Mar 17.

Institute of Human Genetics, Friedrich-Alexander University, Schwabachanlage 10, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1007/s10048-009-0183-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847151	PMC

October 2009

Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.

Neurogenetics 2009 Oct;10(4):375-376

Institute of Human Genetics, Friedrich-Alexander University, Schwabachanlage 10, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1007/s10048-009-0213-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847162	PMC

October 2009

Late onset autosomal dominant Charcot-Marie-Tooth 2 neuropathy in a Costa Rican family.

Authors:

Corinna Berghoff Martin Berghoff Alejandro Leal Bernal Morera Carlos Contreras Ramiro Barrantes Bernd Rautenstrauss Gerardo Del Valle Dieter Heuss

Neurol Res 2009 Apr 29;31(3):283-8. Epub 2008 Sep 29.

Department of Psychiatry, LWL-Klinik Muenster, Münster, Germany.

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http://dx.doi.org/10.1179/174313208X346080	DOI Listing

April 2009

Immune effects of mesenchymal stem cells: implications for Charcot-Marie-Tooth disease.

Authors:

Alejandro Leal Thomas E Ichim Annette M Marleau Fabian Lara Shalesh Kaushal Neil H Riordan

Cell Immunol 2008 May-Jun;253(1-2):11-5. Epub 2008 Jul 15.

School of Biology and Neuroscience Research Program, University of Costa Rica, San José, Costa Rica, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000887490800109	Publisher Site
http://dx.doi.org/10.1016/j.cellimm.2008.06.003	DOI Listing

October 2008

The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences.

Authors:

Yun Chen Alejandro D Leal Sejal Patel David H Gorski

J Biol Chem 2007 Jan 30;282(1):507-17. Epub 2006 Oct 30.

Division of Surgical Oncology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, The Cancer Institute of New Jersey, New Brunswick, New Jersey 088901, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M606604200	Publisher Site
http://dx.doi.org/10.1074/jbc.M606604200	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865102	PMC

January 2007

The homeobox gene Gax inhibits angiogenesis through inhibition of nuclear factor-kappaB-dependent endothelial cell gene expression.

Authors:

Sejal Patel Alejandro D Leal David H Gorski

Cancer Res 2005 Feb;65(4):1414-24

Division of Surgical Oncology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.

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