Alejandro Bertorello

Alejandro Bertorello

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Alejandro Bertorello

Alejandro Bertorello

Publications by authors named "Alejandro Bertorello"

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Increased arterial blood pressure and vascular remodeling in mice lacking salt-inducible kinase 1 (SIK1).

Circ Res 2015 Feb 2;116(4):642-52. Epub 2015 Jan 2.

From the Department of Medicine, Membrane Signaling Networks, Karolinska Institutet, Stockholm, Sweden (A.M.B., L.B.); Department of Research and Development, Bial-Portela & Cª, S.A., S. Mamede do Coronado, Portugal (N.P., B.I., P.S.-d.-S.); MedInUP-Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal (M.J.P., P.S.-d.-S.); Department of Medicine, Cardiovascular Genetics and Genomics, Karolinska Institutet, Stockholm, Sweden (E.V., D.W., A.H., P.E.); Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden (E.V., D.W.); and Bioscience, Cardiovascular and Metabolic Diseases, AstraZeneca R&D, Mölndal, Sweden (J.W., M.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304529DOI Listing
February 2015

Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability.

FASEB J 2012 Aug 20;26(8):3230-9. Epub 2012 Apr 20.

Membrane Signaling Networks, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital-Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1096/fj.12-205609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405263PMC
August 2012

Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line.

Am J Physiol Heart Circ Physiol 2012 Jul 30;303(1):H57-65. Epub 2012 Mar 30.

Membrane Signaling Networks, Atherosclerosis Research Unit, Department of Medicine, CMM, Karolinska Institutet, Karolinska University Hospital-Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1152/ajpheart.00512.2011DOI Listing
July 2012

Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5.

Synapse 2012 Jan 3;66(1):61-70. Epub 2011 Nov 3.

Laboratoire d'Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS, Université de Strasbourg, Strasbourg, France.

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http://doi.wiley.com/10.1002/syn.20988
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http://dx.doi.org/10.1002/syn.20988DOI Listing
January 2012

Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport.

Biochem Biophys Res Commun 2011 May 28;409(1):28-33. Epub 2011 Apr 28.

Membrane Signaling Networks, Atherosclerosis Research Unit, Department of Medicine, CMM, Karolinska Institutet, Karolinska University Hospital-Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2011.04.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106424PMC
May 2011

Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure.

Biochim Biophys Acta 2010 Dec 27;1802(12):1140-9. Epub 2010 Mar 27.

Department of Medicine, Karolinska Institutet, Karolinska University Hospital-Solna, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbadis.2010.03.009DOI Listing
December 2010

Salt, Na+,K+-ATPase and hypertension.

Life Sci 2010 Jan 10;86(3-4):73-8. Epub 2009 Nov 10.

Membrane Signaling Networks, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital-Solna, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.lfs.2009.10.019DOI Listing
January 2010

Blocking the salt-inducible kinase 1 network prevents the increases in cell sodium transport caused by a hypertension-linked mutation in human alpha-adducin.

J Hypertens 2009 Dec;27(12):2452-7

Membrane Signaling Networks, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital-Solna, Stockholm, Sweden.

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https://insights.ovid.com/crossref?an=00004872-200912000-000
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http://dx.doi.org/10.1097/HJH.0b013e328330cf15DOI Listing
December 2009

SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways.

Pflugers Arch 2009 Jul 27;458(3):613-9. Epub 2009 Feb 27.

Membrane Signaling Networks, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital-Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00424-009-0646-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691526PMC
July 2009

SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process.

Proc Natl Acad Sci U S A 2007 Oct 15;104(43):16922-7. Epub 2007 Oct 15.

Membrane Signaling Networks, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, S-171 76 Stockholm, Sweden.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0706838104
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http://dx.doi.org/10.1073/pnas.0706838104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040423PMC
October 2007

FRET analysis reveals a critical conformational change within the Na,K-ATPase alpha1 subunit N-terminus during GPCR-dependent endocytosis.

FEBS Lett 2006 Sep 28;580(21):5067-70. Epub 2006 Aug 28.

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4800 Calhoun Road, Houston, TX 77204-5037, USA.

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http://dx.doi.org/10.1016/j.febslet.2006.08.035DOI Listing
September 2006

Na+, K+ -ATPase: an indispensable ion pumping-signaling mechanism across mammalian cell membranes.

Semin Nephrol 2006 Sep;26(5):386-92

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S027092950600079
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http://dx.doi.org/10.1016/j.semnephrol.2006.07.002DOI Listing
September 2006

The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks.

Am J Respir Cell Mol Biol 2005 Nov;33(5):432-7

Department of Medicine, Atherosclerosis Research Unit, Membrane Signaling Networks, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2005-0297TR
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http://dx.doi.org/10.1165/rcmb.2005-0297TRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715350PMC
November 2005

Inhibition of Na,K-ATPase by dopamine in proximal tubule epithelial cells.

Semin Nephrol 2005 Sep;25(5):322-7

College of Pharmacy, University of Houston, Houston, TX 77204, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S027092950500050
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http://dx.doi.org/10.1016/j.semnephrol.2005.03.007DOI Listing
September 2005

The 14-3-3 protein translates the NA+,K+-ATPase {alpha}1-subunit phosphorylation signal into binding and activation of phosphoinositide 3-kinase during endocytosis.

J Biol Chem 2005 Apr 18;280(16):16272-7. Epub 2005 Feb 18.

Department of Medicine, Atherosclerosis Research Unit, Membrane Signaling Networks, Karolinska Institutet, Karolinska University Hospital-Solna, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M500486200DOI Listing
April 2005

Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium.

Circ Res 2004 Nov 4;95(11):1100-8. Epub 2004 Nov 4.

Department of Medicine, Atherosclerosis Research Unit, Membrane Signaling Networks, Karolinska Institutet, Karolinska University Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1161/01.RES.0000149570.20845.89DOI Listing
November 2004

Clathrin-mediated endocytosis of Na+,K+-ATPase in response to parathyroid hormone requires ERK-dependent phosphorylation of Ser-11 within the alpha1-subunit.

J Biol Chem 2004 Apr 19;279(17):17418-27. Epub 2004 Feb 19.

Department of Medicine, University of Louisville, Louisville, Kentucky, USA.

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http://dx.doi.org/10.1074/jbc.M311715200DOI Listing
April 2004

Augmentation of endogenous dopamine production increases lung liquid clearance.

Am J Respir Crit Care Med 2004 Mar 30;169(6):757-63. Epub 2003 Dec 30.

Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611-3010, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200207-744OC
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http://dx.doi.org/10.1164/rccm.200207-744OCDOI Listing
March 2004

Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis.

J Biol Chem 2003 Nov 25;278(45):44753-7. Epub 2003 Aug 25.

Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, SE-171 76 Stockholm, Sweden.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M308664200
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http://dx.doi.org/10.1074/jbc.M308664200DOI Listing
November 2003

Intracellular Na+ regulates dopamine and angiotensin II receptors availability at the plasma membrane and their cellular responses in renal epithelia.

J Biol Chem 2003 Aug 20;278(31):28719-26. Epub 2003 May 20.

College of Pharmacy, University of Houston, Houston, Texas 77204, USA.

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http://dx.doi.org/10.1074/jbc.M303741200DOI Listing
August 2003

Isoform-specific regulation of Na+,K+-ATPase endocytosis and recruitment to the plasma membrane.

Ann N Y Acad Sci 2003 Apr;986:587-94

Department of Medicine, Atherosclerosis Research Unit, Karolinska Institutet, Karolinska Hospital, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb07257.xDOI Listing
April 2003

Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis.

J Biol Chem 2002 Nov 29;277(46):44108-14. Epub 2002 Aug 29.

Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, Karolinska Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M205173200DOI Listing
November 2002

[Respiratory distress. New Perspectives to lung edema treatment].

Medicina (B Aires) 2002 ;62(2):181-8

Departament of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.

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June 2002

Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis.

J Biol Chem 2002 May 21;277(19):17108-11. Epub 2002 Feb 21.

Department of Molecular Medicine, Karolinska Institutet, The Rolf Luft Centrum for Diabetes Research, Karolinska Hospital, 171 76 Stockholm, Sweden.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M201326200
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http://dx.doi.org/10.1074/jbc.M201326200DOI Listing
May 2002

Agonist-dependent regulation of renal Na+,K+-ATPase activity is modulated by intracellular sodium concentration.

J Biol Chem 2002 Mar 16;277(13):11489-96. Epub 2002 Jan 16.

College of Pharmacy, University of Houston, Houston, Texas 77204, USA.

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http://dx.doi.org/10.1074/jbc.M108182200DOI Listing
March 2002