Publications by authors named "Alejandra Bruna"

33Publications

Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER Breast Cancer.

Cancer Cell 2020 Oct 24;38(4):516-533.e9. Epub 2020 Sep 24.

Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Cancer Centre, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.08.016DOI Listing
October 2020

Landscape of G-quadruplex DNA structural regions in breast cancer.

Nat Genet 2020 Sep 3;52(9):878-883. Epub 2020 Aug 3.

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41588-020-0672-8DOI Listing
September 2020

MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.

Cell Res 2018 07 24;28(7):719-729. Epub 2018 May 24.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands.

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http://dx.doi.org/10.1038/s41422-018-0044-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028652PMC
July 2018

Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts.

BMC Genomics 2018 01 5;19(1):19. Epub 2018 Jan 5.

CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.

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http://dx.doi.org/10.1186/s12864-017-4414-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755132PMC
January 2018

Modeling Breast Cancer Intertumor and Intratumor Heterogeneity Using Xenografts.

Cold Spring Harb Symp Quant Biol 2016 5;81:227-230. Epub 2017 Apr 5.

Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, United Kingdom.

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http://dx.doi.org/10.1101/sqb.2016.81.031112DOI Listing
February 2018

Patient-derived tumour xenografts for breast cancer drug discovery.

Endocr Relat Cancer 2016 12 4;23(12):T259-T270. Epub 2016 Oct 4.

Department of OncologyUniversity of Cambridge, Cambridge, UK

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http://dx.doi.org/10.1530/ERC-16-0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118939PMC
December 2016

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.

Cell 2016 09 15;167(1):260-274.e22. Epub 2016 Sep 15.

Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK; Cambridge Breast Unit, NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre at Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037319PMC
http://dx.doi.org/10.1016/j.cell.2016.08.041DOI Listing
September 2016

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.

Cell Rep 2015 Dec 10;13(11):2480-2490. Epub 2015 Dec 10.

Cancer Research UK Cambridge Institute, Department of Oncology, University of Cambridge, Cambridge CB2 0RE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695334PMC
December 2015

Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts.

Cancer Res 2015 Aug 15;75(15):2963-8. Epub 2015 Jul 15.

Breast Cancer Functional Genomics, Cancer Research UK Cambridge Institute, Department of Oncology, University of Cambridge, Li Ka-Shing Centre, Cambridge, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-0727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539570PMC
August 2015

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

Nature 2015 Feb 26;518(7539):422-6. Epub 2014 Nov 26.

1] Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada [2] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada [3] Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada [4] Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada.

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http://dx.doi.org/10.1038/nature13952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864027PMC
February 2015

Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids.

EMBO J 2003 Nov;22(22):6035-44

Institut de Recerca Biomèdica de Barcelona-Parc Científic de Barcelona (IRBB-PCB), Department of Bioquímica i Biologia Molecular, Universitat de Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1093/emboj/cdg590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275446PMC
November 2003

Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.

Neuropharmacology 2003 Oct;45(5):672-83

Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/s0028-3908(03)00204-1DOI Listing
October 2003